SEVERE IDIOPATHIC HYPERCALCEMIA OF INFANCY

PEDIATRICS ◽  
1957 ◽  
Vol 19 (3) ◽  
pp. 362-371
Author(s):  
George L. Daeschner ◽  
C. William Daeschner
Keyword(s):  
Vitamin D ◽  
Renal Function ◽  
Impaired Renal Function ◽  
Calcium Absorption ◽  
Severe Form ◽  
Additional Case ◽  
Mild Form ◽  
Laboratory Findings ◽  
Pathologic Features ◽  
Motor Retardation

A syndrome occurring in infants and characterized clinically by anorexia, vomiting, constipation, hypotonia, hypertension, characteristic facies, and severe mental-motor retardation, and by the laboratory findings of hypercalcemia, azotemia and impaired renal function has recently been described by British and Swiss workers. The disease apparently occurs in two forms, referred to as mild and severe. The literature concerning the severe form has been reviewed and an additional case reported. Hypersensitivity to vitamin D with excessive calcium absorption has been demonstrated in the mild form of this syndrome and has also been proposed as the metabolic abnormality responsible for the pathologic features of the severe form of the disease.

scholarly journals SAT-070 Nutritional Deficiency of Calcium Mimicking P Seudohypoparathyroidism

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Yoonji Lee ◽  
Moon Bae Ahn ◽  
Na yeong Lee ◽  
Seonhwa Lee ◽  
Yujung choi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Calcium Carbonate ◽  
Serum Calcium ◽  
Calcium Absorption ◽  
Clinical Manifestations ◽  
Nutritional Deficiency ◽  
Serum Phosphorus ◽  
Vitamin D Metabolism ◽  
Laboratory Findings ◽  
Oral Calcium

Abstract BACKGROUND: Childhood hypocalcemia in general is caused by problems associated with calcium absorption and excretion, parathyroid hormone (PTH) secretion, and vitamin D metabolism. Clinical manifestations can vary from asymptomatic hypocalcemia to life-threatening conditions including convulsions, tetany and laryngeal spasm. As many symptoms are nonspecific, laboratory tests are essential for diagnosis. Nevertheless, the causes of hypocalcemia may not be determined by simple interpretation of baseline calcium, phosphorus, alkaline phosphatase (ALP), PTH and calcidiol (25OHD). Case presentation: We report a case of 11-month-old female with a generalized tonic type seizure with low serum calcium level (5.7 mg/dl), 25OHD (23.2 ng/mL) and calcitriol (1,25OH2D) (12.83 pg/mL). Serum phosphorus (5.9 mg/dL), ALP (209 mg/dL) were above normal range and PTH (484 pg/mL) was markedly elevated. She had a problem with weaning process after age of 5 months and milk powder was her main staple diet. Pseudohypoparathyroidism (PHP) was suspected due to slightly increased serum phosphorus, however Albright’s hereditary osteodystrophy manifestation was absent and no GNAS methylation defect was identified. Serum calcium was normalized by intravenous calcium-gluconate followed by oral calcium carbonate and vitamin D supplement. Two months of oral oral calcium carbonate and vitamin D supplementation alone normalized all laboratory results. Conclusions: Severe nutritional deficiency of calcium could mimic laboratory findings of PHP, therefore clinical judgement should not be made solely on biochemical markers. Keywords: Hypocalcemia, pseudohypoparathyroidism, rickets 제1저자: Yoonji Lee, Moonbae Ahn, Na yeong Lee, Seonhwa Lee, Yujung Choi, Seulki Kim, Shinhee Kim, Wonkyoung Cho, Kyoungsoon Cho, Minho Jung, and Byungkyu Suh* Department of Pediatrics, College of Medicine, Catholic University of Korea

scholarly journals Sarcoporosis Is a Part of Aging

2019 ◽  
Vol 120 (2-3) ◽  
pp. 84-94
Author(s):  
Petr Broulík
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Calcium Absorption ◽  
Serum Alkaline Phosphatase ◽  
Aging Treatment ◽  
Laboratory Findings ◽  
Senile Osteoporosis ◽  
Public Health Burden ◽  
Low Level ◽  
Age Related

Ageing is associated with the accumulation of damage to all the macromolecules within and outside cells leading to progressively more cellular and tissue defects and resulting in age-related frailty, disability and disease. As a result of the aging process the bone deteriorates in composition, structure and function. Age-related musculoskeletal losses are a major public health burden because they can cause physical disability and increased mortality. We tried to find out on a small set of old women, without risk factors for osteoporosis, what caused them the loss of bone minerals. All 492 women had just only one risk factor – the old age. Laboratory findings have shown a decreased serum C telopeptide and low serum alkaline phosphatase circulating markers, used to quantify bone resorption and formation, and very low level of vitamin D. Very low level of vitamin D that disrupted calcium absorption through the intestine, and decreased calcemia increased parathyroid hormone levels with resulting bone effect. The manifestation of physiological aging is worsening eyesight, peripheral neuropathy, depression, worsening of physical condition, skin aging, sarcopenia and bone mineral loss. Senile osteoporosis, which is not caused by known risk factors for osteoporosis, does not appear to be a separate disease, but is part of the physiological process of aging. Treatment of senile osteoporosis should be focused on the control of secondary hyperparathyroidism by administration of vitamin D and calcium. The risk of fractures in the advanced age is determined by a large number of factors ranging from hazards in the home environment to frailty and poor balance.

Vitamin D Intake and the Hypercalcemic Syndrome

PEDIATRICS ◽  
1965 ◽  
Vol 35 (6) ◽  
pp. 1022-1023
Author(s):  
Keyword(s):  
Vitamin D ◽  
Aortic Stenosis ◽  
American Academy ◽  
Severe Form ◽  
Circumstantial Evidence ◽  
Supravalvular Aortic Stenosis ◽  
Mild Form ◽  
Vitamin D Intake ◽  
American Academy Of Pediatrics ◽  
Mental Defect

The Committee on Nutrition of the American Academy of Pediatrics in 1963 published a memorandum entitled. "The Prophylactic Requirement and the Toxicity of Vitamin D," (Pediatrics, 31:512, 1963). The Committee believed at that time that there was circumstantial evidence relating vitamin D intake to the pathogenesis of the mild form of infantile hypercalcemia, and probably also of the severe form, which, in addition to hypercalcemia, manifests typical facies, supravalvular aortic stenosis, and a mental defect.

scholarly journals Clinicopathological Correlation in Asian Patients with Biopsy-Proven Lupus Nephritis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Bancha Satirapoj ◽  
Pamila Tasanavipas ◽  
Ouppatham Supasyndh
Keyword(s):  
Renal Function ◽  
Lupus Nephritis ◽  
Renal Biopsy ◽  
Impaired Renal Function ◽  
Activity Index ◽  
Clinicopathological Correlation ◽  
Laboratory Findings ◽  
Male Ratio ◽  
Asian Patients ◽  
Chronicity Index

A total of 244 patients with lupus nephritis (219 women (89.8%) with a female to male ratio of 9 : 1) were included in the study. Clinical and laboratory findings at renal biopsy are clinically valuable in identifying different renal classifications of lupus pathology, activity, and chronicity index. Patients with class IVG had significantly higher proportions of microscopic hematuria, proteinuria, hypertension, impaired renal function, anemia, hypoalbuminuria, and positive anti-DNA antibody. All of these findings correlated well with high activity index and chronicity index of lupus pathology. Considering these correlations may help to determine the clinicopathologic status of lupus patients.

Serum Concentrations of Vitamin D Metabolites in Different Degrees of Impaired Renal Function

Nephron ◽  
1985 ◽  
Vol 39 (3) ◽  
pp. 267-271 ◽  
Author(s):  
H. Rickers ◽  
C. Christiansen ◽  
P. Christensen ◽  
M. Christensen ◽  
P. Rødbro
Keyword(s):  
Vitamin D ◽  
Renal Function ◽  
Impaired Renal Function ◽  
Vitamin D Metabolites ◽  
Serum Concentrations

OCCULT MALABSORPTION CAUSING OSTEITIS FIBROSA CYSTICA

1962 ◽  
Vol 40 (4) ◽  
pp. 481-492
Author(s):  
J. G. Devlin ◽  
D. K. O'Donovan
Keyword(s):  
Vitamin D ◽  
Iron Absorption ◽  
Calcium Absorption ◽  
Calcium Balance ◽  
Gluten Free ◽  
Osteitis Fibrosa Cystica ◽  
Mucosal Atrophy ◽  
Cystic Changes ◽  
Calcium Malabsorption ◽  
Radiological Examinations

ABSTRACT A case is reported of intermittent hypercalcaemia, hypophosphataemia and severe skeletal rarefaction with cystic changes. An occult calcium malabsorption was found. Fat, triolein and iron absorption and radiological examinations were normal. There was gross intestinal mucosal atrophy. She was shown to be in a state of negative calcium balance and this was reversed by vitamin D. A gluten-free diet also improved calcium absorption. It is postulated that the patient had severe secondary hyperparathyroidism as the skeleton reverted to normal after six months of medical treatment.

Assessment of possible nephrotoxicity from iohexol in patients with normal and impaired renal function

1998 ◽  
Vol 39 (4) ◽  
pp. 362-367 ◽  
Author(s):  
Stefan Lundqvist ◽  
G. Holmberg ◽  
G. Jakobsson ◽  
F. Lithner ◽  
K. Skinningsrud ◽  
...  
Keyword(s):  
Renal Function ◽  
Impaired Renal Function
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