LOWER INCIDENCE OF SEX CHROMATIN IN BUCCAL SMEARS OF NEWBORN FEMALES

PEDIATRICS ◽  
1962 ◽  
Vol 30 (5) ◽  
pp. 707-711
Author(s):  
David W. Smith ◽  
Philip M. Marden ◽  
Michael J. McDonald ◽  
Mark Speckhard
Keyword(s):  
Newborn Infant ◽  
Lower Incidence ◽  
Postnatal Life ◽  
Buccal Cells ◽  
Buccal Smear ◽  
Sex Chromatin ◽  
Common Etiology

The incidence of the sex chromatin mass in buccal cells of newborn females is often lower during the first day or two of postnatal life, as compared to later ages. This finding allows for misinterpretation of the significance of buccal smear results during the first day or two. A similar phenomenon was noted in mothers during the day prior to delivery and for one to two days thereafter. This suggests a common etiology for this effect in both the mother and the newborn infant.

Lower Incidence of Sex Chromatin in Newborn Females Delivered by Cesarean Section

PEDIATRICS ◽  
1964 ◽  
Vol 34 (3) ◽  
pp. 419-421
Author(s):  
THOMAS C. WEGMANN ◽  
DAVID W. SMITH
Keyword(s):  
Cesarean Section ◽  
Lower Incidence ◽  
Buccal Cells ◽  
Sex Chromatin ◽  
Low Incidence

The previously reported low incidence of sex chromatin in buccal cells of newborn females has been confirmed in babies born by cesarean section. However, there was no comparable change in sex chromatin percentage for their mothers as had been reported for vaginally delivered women. Further studies on vaginally delivered mothers raised some doubt as to the validity of the previous maternal results.

scholarly journals X Chromatin inactivation in Menopause: A study on Hindu caste Bengalee population

2018 ◽  
Vol 9 (3) ◽  
pp. 41-45
Author(s):  
Koel Mukherjee ◽  
Diptendu Chatterjee ◽  
Arup Ratan Bandyopadhyay
Keyword(s):  
Hormone Receptors ◽  
Menopausal Status ◽  
Epigenetic Mechanisms ◽  
Medical Sciences ◽  
Intrinsic Factors ◽  
Buccal Smear ◽  
Increased Risk ◽  
Menopausal Women ◽  
Sex Chromatin ◽  
Post Menopausal

Background: Menopause being a physiologic event and eventually the prime time to perform risk assessment of chronic diseases and initiate preventive health measures. Previous studies reported, later menopause is independently associated to increased risk of breast and endometrial cancer. The menopausal status is determined and influenced by intrinsic factors. Majority of the studies on menopause from Indian context, especially on Bengalee Hindu Caste population confined to socio demographic issues, attitudes, problems and quality of life. However, relatively little work is attempted to unravel the complex interplay of genetics and epigenetic mechanisms, the effect on menopause. In this background it seems to be an urgent need to understand menopause status objectively, to approach the interplay of genetics and epigenetic mechanisms of menopausal status by X chromatin inactivation.Aims and Objective: Best of the knowledge it is the first attempt to evaluate the prevalence of X chromatin inactivation in menopausal women among Bengalee Hindu Caste population.Materials and Methods: Sex chromatin inactivation was evaluated from 100 each pre and post menopausal women from the buccal smear of each individuals. After fixation and staining of altogether 20000 (twenty thousand) cells were scanned from the Bengalee Hindu Caste for a comparison of menopausal women and their menarcheal counterparts.Results: Result demonstrated significantly decreased (P<0.001) prevalence of X chromatin inactivation sites among the menopausal females in comparison to their menarcheal women counterpart.Conclusion: The present study vindicated possible association between the presence of sex hormone receptors and the prevalence of sex chromatin and also envisaged the role of X chromatin inactivation for early prognosis of menopause.Asian Journal of Medical Sciences Vol.9(3) 2018 41-45

ASYMMETRICAL GONADAL DIFFERENTIATION AND GONADOBLASTOMA

1975 ◽  
Vol 80 (4) ◽  
pp. 753-760 ◽  
Author(s):  
R. Coco ◽  
H. Chemes ◽  
C. Bergada ◽  
Juan Kraizer
Keyword(s):  
Y Chromosome ◽  
Peripheral Blood ◽  
Exploratory Laparotomy ◽  
Peripheral Blood Lymphocytes ◽  
Pathological Examination ◽  
Gonadal Differentiation ◽  
Fallopian Tubes ◽  
Buccal Smear ◽  
Sex Chromatin ◽  
The Right

ABSTRACT A 1010/12 years old virilized girl with the syndrome of asymmetrical gonadal differentiation is reported. The patient had a negative sex chromatin and positive Y chromatin (bright fluorescent body of Y chromosome) in the buccal smear and 45,X/46,XY karyotype in the peripheral blood lymphocytes. An exploratory laparotomy showed a small uterus, two Fallopian tubes, a tumoural testis on the right side and a streak on the left side. Pathological examination revealed the presence of gonadoblastoma in both gonads. The Y chromatin was identified on histological sections only on the side of the testis, and was absent on the streak and its gonadoblastoma's nests. The distribution of the different cell lines and the fluorescence of the Y chromosome is discussed in relation to gonadal differentiation and the occurrence of gonadoblastoma.

High maternal milk intake in the postnatal life reduces the incidence of breast cancer during adulthood in rats

2019 ◽  
Vol 10 (4) ◽  
pp. 479-487 ◽  
Author(s):  
F. E. Santiano ◽  
L. E. Zyla ◽  
F. Campo Verde-Arboccó ◽  
C. V. Sasso ◽  
F. A. Bruna ◽  
...  
Keyword(s):  
Breast Milk ◽  
Lower Incidence ◽  
Adult Life ◽  
Female Rats ◽  
Nuclear Antigen ◽  
Caspase 8 ◽  
Postnatal Life ◽  
Special Importance ◽  
Sprague Dawley ◽  
Maternal Milk

AbstractEnvironmental factors during perinatal life can lead to changes in the mammary gland, making it susceptible to cancer in adulthood. Breastfeeding has a special importance since it takes place at a critical period of growth and development of the newborn. We aimed to analyze if an appropriate lactation protects the offspring against mammary carcinogenesis during adult life and explore the mechanisms involved in the protective effect. One-day-old Sprague-Dawley female rats were randomly distributed in litters of three (L3), eight (L8) or 12 (L12) pups per dam, to induce a differential consumption of breast milk. At 55 days of age, the animals were treated with a single dose of dimethylbenzanthracene to study tumor latency, incidence and progression. Histological, immunohistochemical and Western blot studies were performed. We observed lower incidence and higher latency in L3 compared to the other groups. The mitotic index and expression of proliferating cell nuclear antigen (PCNA) was significantly augmented in tumors of L12 rats compared to L3 and L8, while the apoptotic index was augmented in tumors of L3 v. L12. Cleaved caspase 8 was significantly higher in tumors from L3 compared to L12. Tumors developed in L3 have a greater number of apoptotic bodies and a greater expression of caspase 8. These results demonstrate that the animals that maintained a higher intake of maternal milk (L3) presented lower incidence and greater tumor latency. Lower consumption of breast milk (L12) would increase tumor mitosis and the expression of PCNA, explaining the higher tumor incidence observed in this group.

Sex Chromatin, Body Masculinity, Achievement Motivation and Smoking Behavior

1967 ◽  
Vol 20 (3) ◽  
pp. 859-866 ◽  
Author(s):  
Richard E. Carney
Keyword(s):  
Achievement Motivation ◽  
Smoking Behavior ◽  
Body Structure ◽  
Buccal Smear ◽  
Sex Chromatin ◽  
Chromatin Body ◽  
Complex Relationships

The per cent of sex chromatin in a buccal smear correlated non-linearly with measures of achievement motivation and masculinity of body structure. Smokers had more sex chromatin than non-smokers. Achievement motivation and smoking were positively correlated. Masculinity of body structure showed complex relationships with smoking which depended on Ss' sex and religion, and possibly, the cultural pressure against smoking.

LOWER INCIDENCE OF SEX CHROMATIN IN BUCCAL SMEARS OF NEWBORN FEMALES

1963 ◽  
Vol 18 (4) ◽  
pp. 616-618
Author(s):  
David W. Smith ◽  
Philip M. Marden ◽  
Michael J. McDonald ◽  
Mark Speckhard
Keyword(s):  
Lower Incidence ◽  
Sex Chromatin

CYTOGENETIC ANALYSIS OF A BOY WITH THE XXXY SYNDROME: ORIGIN OF THE X-CHROMOSOMES

PEDIATRICS ◽  
1970 ◽  
Vol 45 (4) ◽  
pp. 677-686
Author(s):  
Robert M. Greenstein ◽  
David J. Harris ◽  
Luigi Luzzatti ◽  
Howard M. Cann
Keyword(s):  
Mental Retardation ◽  
Cytogenetic Analysis ◽  
Cultured Cells ◽  
Chromosome Constitution ◽  
Mild Mental Retardation ◽  
X Chromosomes ◽  
Blood Types ◽  
Single Sex ◽  
Buccal Smear ◽  
Sex Chromatin

A 3-year-old boy with radio-ulnar synostosis and mild mental retardation was found to have a 48/XXXY chromosome constitution in blood and skin cultures without evidence of mosaicism. Autoradiography of the cultured cells identified two late-labeling X-chromosomes. His buccal smear revealed double and single sex chromatin bodies. The patient and his family were studied for segregation of Xg blood types which are controlled by X-linked genes. This revealed the father to be Xg(a+), a positive hemizygote; the mother Xg (a-) was homozygous negative; and the proband was Xg(a-). These findings suggest that the three X-chromosomes of the proband came from his mother. It is proposed that nondisjunction occurred at both the first and second meiotic divisions of oogenesis, producing a triple-X (XXX) ovum which was then fertilized by the paternal Y-bearing sperm. This communication represents the first reported case of the XXXY syndrome in which informative cytogenetic evaluation has been obtained.

Prognosis with X-Chromosomal Abnormalities: Neoplastic Disease

PEDIATRICS ◽  
1972 ◽  
Vol 49 (1) ◽  
pp. 149-149
Author(s):  
Doris Bartuska ◽  
Linda Vardaro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Vaginal Bleeding ◽  
Chromosomal Abnormalities ◽  
Newborn Infants ◽  
Neoplastic Disease ◽  
Buccal Smear ◽  
Sex Chromatin ◽  
Exophytic Type

The report of Eller, et al. on the prognosis in newborn infants with X-chromosomal abnormalities prompts this note. Because of our interest in cytogenetic factors in carcinogenesis, a routine buccal smear for sex chromatin is performed on all our patients with amenorrhea or irregular vaginal bleeding. Recently a 26-year-old woman with dysmenorrhea and irregular periods was seen. She had a mass arising from the cervix which was subsequently diagnosed as an unusual exophytic type of squamous cell carcinoma.

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