Care of the Family of the Child with Cancer

PEDIATRICS ◽  
1967 ◽  
Vol 40 (3) ◽  
pp. 498-504
Author(s):  
Stanford B. Friedman

EACH parent of a fatally ill child must adjust, in his own way, first to the threatened loss and then to the actual death of his child. The nature of this adjustment reflects, to varying degrees, the parent's mode of coping with past crises, his previous experiences with illness and death, and the idiosyncratic meaning this particular child may have to him. Thus, the physician can be of most help to the parents if he is aware of important landmarks in the history of the family and problems that they have had to face. His knowledge of previous patterns of family behavior in times of stress can aid him in encouraging parents along lines that have been successful in the past and in supporting attempts to adapt to the present situation. For many parents, this may be their first personal experience with death, and this may place additional demands and requests upon the physician. Unfortunately, such family history is usually not available to the physician who ultimately assumes the care of a fatally ill child. Furthermore, it is often difficult, and inadvisable, to obtain such information in detail at the time parents are preoccupied with an acute crisis. It therefore is useful for physicians to realize that there are many problems these parents face in common, and a number of studies have described more or less characteristic ways of reacting to them. This does not imply that stereotype behavior will be observed in parents sharing this common experience. However, if the physician is consciously aware of common modes of adjustment used by parents, he will be in the position of anticipating some of their needs, problems, and sources of anxiety.

Author(s):  
Donald W. Winnicott

Chapter 1 of Clinical Notes on Disorders of Childhood. In this chapter, Winnicott argues for the importance of history taking in child medicine: the past history of the child, the family history, and the history of onset of the illness. He gives several cases which illustrate the value to the physician of taking the time to hear a full history.


2021 ◽  
pp. 104225872110465
Author(s):  
Bingbing Ge ◽  
Alfredo De Massis ◽  
Josip Kotlar

History is increasingly recognized as a distinctive source of competitive advantage for family businesses. Taking a rhetorical history perspective, we study how a family business leveraged the family’s three generations long history of entrepreneurship to sustain profitable growth over 16 years. Through our analysis, we identify three history scripting strategies—embedding, elaborating, and building family history—that created important sources of competitive advantage for the family business, facilitating acceptance by broader communities, building a reputation of continuity, and inspiring innovation through tradition. These findings advance the history-informed understanding of family firms’ idiosyncratic sources of superior performance.


2017 ◽  
pp. 5-21 ◽  
Author(s):  
E. Yasin

The article is devoted to major events in the history of the post-Soviet economy, their influence on forming and development of modern Russia. The author considers stages of restructuring, market reforms, transformational crisis, and recovery growth (1999-2011), as well as a current period which started in2011 and is experiencing serious problems. The present situation is analyzed, four possible scenarios are put forward for Russia: “inertia”, “mobilization”, “decisive leap”, “gradual democratic development”. More than 30 experts were questioned in the process of working out the scenarios.


2021 ◽  
Vol 22 (9) ◽  
pp. 4700
Author(s):  
Michelle M. Monasky ◽  
Emanuele Micaglio ◽  
Giuseppe Ciconte ◽  
Ilaria Rivolta ◽  
Valeria Borrelli ◽  
...  

Genetic testing in Brugada syndrome (BrS) is still not considered to be useful for clinical management of patients in the majority of cases, due to the current lack of understanding about the effect of specific variants. Additionally, family history of sudden death is generally not considered useful for arrhythmic risk stratification. We sought to demonstrate the usefulness of genetic testing and family history in diagnosis and risk stratification. The family history was collected for a proband who presented with a personal history of aborted cardiac arrest and in whom a novel variant in the SCN5A gene was found. Living family members underwent ajmaline testing, electrophysiological study, and genetic testing to determine genotype-phenotype segregation, if any. Patch-clamp experiments on transfected human embryonic kidney 293 cells enabled the functional characterization of the SCN5A novel variant in vitro. In this study, we provide crucial human data on the novel heterozygous variant NM_198056.2:c.5000T>A (p.Val1667Asp) in the SCN5A gene, and demonstrate its segregation with a severe form of BrS and multiple sudden deaths. Functional data revealed a loss of function of the protein affected by the variant. These results provide the first disease association with this variant and demonstrate the usefulness of genetic testing for diagnosis and risk stratification in certain patients. This study also demonstrates the usefulness of collecting the family history, which can assist in understanding the severity of the disease in certain situations and confirm the importance of the functional studies to distinguish between pathogenic mutations and harmless genetic variants.


2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hyo Geun Choi ◽  
Wook Chun ◽  
Kuk Hyun Jung

2014 ◽  
Vol 8 (11-12) ◽  
pp. 783 ◽  
Author(s):  
Richard Walker ◽  
Alyssa Louis ◽  
Alejandro Berlin ◽  
Sheri Horsburgh ◽  
Robert G. Bristow ◽  
...  

Introduction: The prostate-specific antigen (PSA) era and resultant early detection of prostate cancer has presented clinicians with the challenge of distinguishing indolent from aggressive tumours. Mutations in the BRCA1/2 genes have been associated with prostate cancer risk and prognosis. We describe the prostate cancer screening characteristics of BRCA1/2 mutation carriers, who may be classified as genetically-defined high risk, as compared to another high-risk cohort of men with a family history of prostate cancer to evaluate the utility of a targeted screening approach for these men.Methods: We reviewed patient demographics, clinical screening characteristics, pathological features, and treatment outcomes between a group of BRCA1 or BRCA2 mutation carriers and age-matched men with a family history of prostate cancer followed at our institutional Prostate Cancer Prevention Clinic from 1995 to 2012.Results: Screening characteristics were similar between the mutation carriers (n = 53) and the family history group (n = 53). Some cancers would be missed in both groups by using a PSA cut-off of >4 ug/L. While cancer detection was higher in the family history group (21% vs. 15%), the mutation carrier group was more likely to have intermediate- or high-risk disease (88% vs. 36%). BRCA2 mutation carriers were more likely to have aggressive disease, biological recurrence, and distant metastasis.Conclusions: In our cohort, regular screening appears justified for detecting prostate cancer in BRCA1 and BRCA2 carriers and other high-risk populations. Lowering PSA cut-offs and defining monitoring of PSA velocity as part of the screening protocol may be useful. BRCA2 is associated with more aggressive disease, while the outcome for BRCA1 mutation carriers requires further study. Large multinational studies will be important to define screening techniques for this unique high-risk population.


PEDIATRICS ◽  
1957 ◽  
Vol 19 (5) ◽  
pp. 908-915
Author(s):  
Eugene F. Diamond

A study of cases of rheumatic fever admitted to La Rabida Sanitarium over a 5-year period was carried out to evaluate heredity and environment as etiologic factors in rheumatic disease. The incidence of rheumatic fever was shown to be higher in families where one or both parents were known to have a positive family history of rheumatic fever. The incidence of rheumatic fever was compared in environmental groups. A totally unfavorable environment was shown to increase the incidence of rheumatic fever. No single unfavorable environmental factor changed the incidence of rheumatic fever. The incidence of rheumatic fever in each environmental group was higher when there was a positive family history for rheumatic fever, indicating an hereditary factor in the family incidence of rheumatic fever. Analysis of the various mating types in the families with a positive rheumatic trait was carried out. Agreement with a simple autosomal recessive gene inheritance was obtained in families where both parents had a definite family history, but no agreement was obtained in cases where only one parent gave a positive family history.


Author(s):  
Justine Buck Quijada
Keyword(s):  
The Past ◽  

Chapter 6 narrates a shamanic initiation and describes the family history that is produced in the process of diagnosing the initiate’s shamanic calling. In Yuri’s initiation we see the stakes of embracing one historical genre over another. For Yuri, whose father is Buryat and his mother Russian, whether or not he accepts a shamanic genealogical genre of the past is a matter of life or death for him and his family. This chapter illustrates the kind of relationships to the past that shamanic practices can build, and shows how engaging with historical genres can transform conceptions of self for post-Soviet subjects. The shamanic genre critiques the kind of self, the New Soviet Person, that Soviet modernism sought to cultivate. Through the process of diagnosing a calling and initiation, the aspiring shaman remakes themselves into porous subject, subjected to the will of their ancestors.


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