Mumps Antibody: Placental Transfer and Disappearance During the First Year of Life

PEDIATRICS ◽  
1970 ◽  
Vol 45 (1) ◽  
pp. 99-101
Author(s):  
David Hodes ◽  
Philip A. Brunell
Keyword(s):  
Complement Fixation Test ◽  
Complement Fixation ◽  
Placental Transfer ◽  
Neutralization Test ◽  
Serum Antibody ◽  
Neutralizing Antibody ◽  
Fixation Test ◽  
First Year ◽  
First Year Of Life

Mumps neutralizing antibody was transferred quantitatively across the placenta. Antibody was still detectable (≥ 1:2) in 18 of 19 infants at 2 months of age. The finding of antibody in 13 of 19 infants at 5 months of age probably accounted for the failure to immunize infants at this age successfully in previous studies. Neutralizing antibody was not detectable sera of any of the 18 infants who were tested at 1 year of age. Although serum antibody during the early months of life was presumably all IgG since it was passively acquired, the neutralization test appeared to be far more sensitive than the complement fixation test for the determination of mumps antibody.

scholarly journals The conglutination phenomenon. III. The conglutinating complement absorption test in experimental glanders

1947 ◽  
Vol 45 (4) ◽  
pp. 497-503 ◽  
Author(s):  
N. H. Hole ◽  
R. R. A. Coombs
Keyword(s):  
Oral Administration ◽  
Antibody Titre ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Serum Antibody ◽  
Fixation Test ◽  
Absorption Test ◽  
Serum Antibodies ◽  
Serum Antibody Titre ◽  
Detectable Serum

1. Observations on the sera of ponies, taken at frequent intervals for 321 days after oral administration of P. mallei, are described.2. It was found that the conglutinating complement absorption test was more sensitive than the haemolytic complement fixation test as a means of diagnosis. It detected the antibodies earlier in the course of the disease and demonstrated their presence over a longer period of time.3. The possibility of another practical use of this reaction as an adjunct to the allergic test is considered. Ten days after an intradermo-palpebral test a pony, which had been previously sensitized and whose serum antibody titre at that time was below 10, developed a serum titre of over 160 as demonstrated by the conglutinating complement absorption test. Under similar circumstances 11 unsensitized ponies developed no detectable serum antibodies.

scholarly journals Microneutralization tests for serological typing and subtyping of foot-and-mouth disease virus strains

1978 ◽  
Vol 81 (1) ◽  
pp. 107-123 ◽  
Author(s):  
M. M. Rweyemamu ◽  
J. C. Booth ◽  
Morwen Head ◽  
T. W. F. Pay
Keyword(s):  
Complement Fixation Test ◽  
Complement Fixation ◽  
Neutralization Test ◽  
Foot And Mouth Disease ◽  
Fixation Test ◽  
Viral Contamination ◽  
Serological Typing ◽  
Mouth Disease Virus ◽  
Virus Strains ◽  
Microneutralization Test

SUMMARYA microneutralization test for serotyping of FMD viruses is described. It is based on earlier observations by Booth, Rweyemamu & Pay (1978) that dose-response relationships in quantal microneutralizations often deviated from linearity. The typing test described therefore utilizes undiluted virus preparations. In about 90% of samples a positive typing was obtained in contrast with about 50% for the complement fixation test. The test was also found to be susceptible to minimal quantities of heterotypic viral contamination.For strain differentiation the microneutralization test was carried out as a checkerboard test. When compared with the complement fixation test it was found to be more specific. The necessity to utilize virus-neutralization test systems for comparing (FMD) virus strains particularly for the purpose of vaccine selection is emphasized. The two dimensional microneutralization test has been applied to a study of comparing FMDV vaccine strains for Europe, South America, the Middle East and East Africa.

Procedure for Modified Complement Fixation Test with Turkey, Duck, and Chicken Serum Antibody

1961 ◽  
Vol 5 (3) ◽  
pp. 270 ◽  
Author(s):  
Helen P. Brumfield ◽  
Harold Benson ◽  
Benjamin S. Pomeroy
Keyword(s):  
Complement Fixation Test ◽  
Complement Fixation ◽  
Serum Antibody ◽  
Fixation Test ◽  
Chicken Serum

scholarly journals IMMUNITY IN MUMPS

1945 ◽  
Vol 81 (1) ◽  
pp. 119-135 ◽  
Author(s):  
John F. Enders ◽  
Sidney Cohen ◽  
Lewis W. Kane
Keyword(s):  
Skin Test ◽  
Specific Antibody ◽  
Complement Fixation Test ◽  
Complement Fixation ◽  
Mumps Virus ◽  
Fixation Test ◽  
The Other ◽  
Human Beings ◽  
Inapparent Infection

1. A specific antibody, demonstrable by the technique of complement fixation, regularly appears, or increases in concentration, in the sera of human beings during an attack of mumps or during convalescence. 2. Specific dermal hypersensitivity, demonstrable by the injection of heat-inactivated mumps virus, has been shown to develop in 6 human beings after recovery from mumps. 3. Complement-fixing antibody and the hypersensitive state also emerge as a result of clinically inapparent infection with the virus of mumps. 4. These two phenomena are apparently unrelated in respect to immunologic mechanisms. 5. The data presented indicate that the complement fixation test should prove of value both in diagnosis and in the determination of immunity. 6. The skin test for dermal hypersensitivity, on the other hand, becomes positive after recovery and therefore would appear to be useful only as an index of resistance.

Evaluation of the Complement Fixation Test in Amebiasis

1952 ◽  
Vol 21 (3) ◽  
pp. 391-399 ◽  
Author(s):  
Elwood Buchman ◽  
Harold J. Kullman ◽  
George F. Margonis
Keyword(s):  
Complement Fixation Test ◽  
Complement Fixation ◽  
Fixation Test
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