Terbutaline and Ephedrine in Asthmatic Children

PEDIATRICS ◽  
1977 ◽  
Vol 60 (1) ◽  
pp. 14-19
Author(s):  
Michael Z. Blumberg ◽  
David G. Tinkelman ◽  
Elliot J. Ginchansky ◽  
Barbara S. Blumberg ◽  
John C. Taylor ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Drug Treatment ◽  
Pulse Rate ◽  
Side Effect ◽  
Significant Side Effect ◽  
Onset Of Action ◽  
Hand Tremor ◽  
Bronchodilator Effect ◽  
Asthmatic Children ◽  
Pulmonary Functions

The effects of terbutaline, ephedrine, and placebo on the cardiovascular and pulmonary systems have been compared in 24 asthmatic children. Ephedrine and terbutaline were both found to be effective bronchodilators, with onset of action within 30 minutes. The bronchodilator effect of ephedrine was maintained for three hours, while terbutaline was active for five hours. Terbutaline caused significantly greater improvement in pulmonary functions than did ephedrine. Both terbutaline and ephedrine were associated with clinically insignificant changes in blood pressure and pulse rate. The only significant side effect observed was hand tremor in children receiving terbutaline and this appeared only early in the course of drug treatment. There was no evidence of tolerance to the bronchodilator effect of ephedrine or terbutaline after eight weeks of therapy.

Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect

2021 ◽  
Vol 14 (6) ◽  
pp. e243191
Author(s):  
Sandra L Brandi ◽  
Claus L Feltoft ◽  
Jørgen Serup ◽  
Ebbe Eldrup
Keyword(s):  
Blood Pressure ◽  
Adverse Effect ◽  
Side Effect ◽  
Married Couple ◽  
Daily Intake ◽  
Antifungal Treatment ◽  
Significant Side Effect ◽  
Clinically Significant ◽  
Itraconazole Treatment ◽  
Dose Dependent

We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored.

Anatomical and Morphological study of the Heart's Chambers and valves in Iraqi ducks Anser platyrhuncha

2019 ◽  
Vol 43 (1) ◽  
pp. 21-25
Author(s):  
Mohammed Senna Hassan
Keyword(s):  
Blood Pressure ◽  
Anterior Chamber ◽  
High Blood Pressure ◽  
Pulse Rate ◽  
Morphological Study ◽  
Heart Valves ◽  
Simple Manner ◽  
High Pulse ◽  
The Right ◽  
High Pulse Rate

   Twenty Iraqi ducks hearts ( 10 male and 10 female ) have been  used for   demonstration  and illustration of heart's valves  and chambers  as well as  anatomical   and morphological site of view to explain what modifications had been take place for ducks heart  to perform  his normal life at the  circumstances  of  high  blood  pressure  and  pulse  rate. The heart  which has distinctly pointed  apex  was  built   in simple  manner located  in a transparent  taught  heart  pericardial  sac. It   was pyramidal in shape  externally  and  has a longitudinal  salcus  passing  to the  right  side, the  anterior of  the   heart  is  divided  into two  unequal  anterior  chamber  similar  to  those of mammalian  hear  .The heart valves are modified  in  order to  minimize  the  fraction  that occur as a result of  high  blood  pressure  and  pulse  rate  of  the  duck  heart , also  the  muscular  trabeculae   replace  the  chordate  tendineae  , which  were  present in the  mammalian    heart  in order to  minimize  the  fraction  resulting  from high  pulse  rate..    

Antihypertensive Drug Treatment and Circadian Blood Pressure Rhythm: A Review of the Role of Chronotherapy in Hypertension

2014 ◽  
Vol 21 (6) ◽  
pp. 756-772 ◽  
Author(s):  
Giuseppe Schillaci ◽  
Francesca Battista ◽  
Laura Settimi ◽  
Luca Schillaci ◽  
Giacomo Pucci
Keyword(s):  
Blood Pressure ◽  
Drug Treatment ◽  
Antihypertensive Drug ◽  
Circadian Blood Pressure ◽  
Antihypertensive Drug Treatment

scholarly journals Differential effects of the blood pressure state on pulse rate variability and heart rate variability in critically ill patients

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Elisa Mejía-Mejía ◽  
James M. May ◽  
Mohamed Elgendi ◽  
Panayiotis A. Kyriacou
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Pulse Rate ◽  
Pulse Transit Time ◽  
Pulse Rate Variability ◽  
Physiological Factors ◽  
Ecg Signals ◽  
Non Invasive ◽  
Electrocardiogram Ecg

AbstractHeart rate variability (HRV) utilizes the electrocardiogram (ECG) and has been widely studied as a non-invasive indicator of cardiac autonomic activity. Pulse rate variability (PRV) utilizes photoplethysmography (PPG) and recently has been used as a surrogate for HRV. Several studies have found that PRV is not entirely valid as an estimation of HRV and that several physiological factors, including the pulse transit time (PTT) and blood pressure (BP) changes, may affect PRV differently than HRV. This study aimed to assess the relationship between PRV and HRV under different BP states: hypotension, normotension, and hypertension. Using the MIMIC III database, 5 min segments of PPG and ECG signals were used to extract PRV and HRV, respectively. Several time-domain, frequency-domain, and nonlinear indices were obtained from these signals. Bland–Altman analysis, correlation analysis, and Friedman rank sum tests were used to compare HRV and PRV in each state, and PRV and HRV indices were compared among BP states using Kruskal–Wallis tests. The findings indicated that there were differences between PRV and HRV, especially in short-term and nonlinear indices, and although PRV and HRV were altered in a similar manner when there was a change in BP, PRV seemed to be more sensitive to these changes.

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