Carbamazepine-Isoniazid Interaction
Keyword(s):
To the Editor.— The case report of carbamazepine intoxication secondary to isoniazid administration recently described in this journal1 is a clinically significant interaction. I have previously presented2 a similar case in which a patient receiving carbamazepine, valproate, and nitrazepam developed severe carbamazepine intoxication when isoniazid was added to the drug regimen. The patient was determined to have inherited the slow acetylator phenotype. On careful rechallenge, 300 mg of isoniazid increased carbamazepine steady-state serum concentrations by 85% and decreased carbamazepine clearance by 45%.
1987 ◽
Vol 82
(6)
◽
pp. 1102-1108
◽
Keyword(s):
2010 ◽
Vol 29
(4)
◽
pp. 358-371
◽
2020 ◽
Vol 77
(22)
◽
pp. 1846-1851
1977 ◽
Vol 5
(5)
◽
pp. 308-312
◽
1993 ◽
Vol 36
(3)
◽
pp. 263-265
◽
2007 ◽
Vol 63
(12)
◽
pp. 1147-1151
◽
1973 ◽
Vol 1
(2)
◽
pp. 391-397
Keyword(s):