Background. The article is devoted to the problem of causal relationships between the effects of social risk factors in the form of excessive consumption of psychoactive substances on medical risk factors, the consequences of which are the formation and spread of addictive health disorders. The purpose of the study: Observation and processing of causal relationships between social and medical risk factors in the formation of addictive health disorders using the example of the Dniepropetrivsk region through a correlation analysis from the perspective of forensic pharmacy. Materials and methods. When conducting the study, we used the current legislative, regulatory and instructive documents, Internet resources. We applied documentary, forensic, statistical, correlation, comparative and graphical methods of analysis. Results. The article presents the results of forensic and pharmaceutical research, substantiates their relevance, formulates a goal, develops a design, and describes materials and research methods. The establishment of causal relationships between social and medical risk factors in the formation of addictive disorders was carried out on the example of the Dniepropetrivsk region, which is most typical for the Dnieper region of Ukraine, through a correlation analysis during 2014-2018. The collection, analysis and processing of peremptory data was carried out taking into account five indicators of social risk factors: circulation of a psychoactive substances of the 1st level of ethanol strength (beer); circulation of a psychoactive substances of the 2nd level of ethanol strength (liquors); circulation of a psychoactive substance of the 3rd level of ethanol strength (vodka); consumer price index; circulation of the joint use of psychoactive substances (in particular, alcoholic beverages + tobacco). The collection, analysis and processing of data on indicators of medical risk factors was carried out taking into account of four factors: the number of newly reported cases of addictive health disorders; the number of cases of diseases of the nervous system; the number of cases of addictive health disorders due to the use of a psychoactive substance of alcohol; the number of cases of addictive health disorders due to the combined use of psychoactive substances. According to the results of the study, found that indicators of social risk factors for the circulation of psychoactive substances of the 3rd level of ethanol strength (vodka) causally affect the indicators of medical risk factors, resulting in an increase in the number of cases of diseases of the nervous system. The structure of the normalized t-criterion of social and medical risk factors in the formation of addictive health disorders is determined. Conclusions. Established that the formation of addictive health disorders is caused by social risk factors (excessive and uncontrolled use of psychoactive substances in the form of alcoholic beverages of various strength levels or the combined use of psychoactive substances of various classification and legal groups, for example, alcoholic beverages + tobacco). Social risk factors affect medical risk factors, resulting in an increase in the number of newly reported cases of addictive health disorders and the number of cases of diseases of the nervous system. The data obtained are the basis for planning further forensic pharmaceutical research in this direction and focus the attention of state authorities on the need to develop socially-oriented preventive measures aimed at improving the circulation of alcoholic beverages of the 1st, 2nd and 3rd strength levels (beer, liquors, vodka), immoderate consumption of which leads to the formation of addictive health disorders.