scholarly journals Clinical Characteristics of De Novo Heart Failure and Acute Decompensated Chronic Heart Failure: Are They Distinctive Phenotypes That Contribute to Different Outcomes?

2021 ◽  
Vol 7 ◽  
Author(s):  
Wilson Matthew Raffaello ◽  
Joshua Henrina ◽  
Ian Huang ◽  
Michael Anthonius Lim ◽  
Leonardo Paskah Suciadi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Poor Prognosis ◽  
Clinical Characteristics ◽  
De Novo ◽  
Heart Failure Patients ◽  
Treat Heart Failure ◽  
Patients With Heart Failure ◽  
New Strategies

Heart failure is currently one of the leading causes of morbidity and mortality. Patients with heart failure often present with acute symptoms and may have a poor prognosis. Recent evidence shows differences in clinical characteristics and outcomes between de novo heart failure (DNHF) and acute decompensated chronic heart failure (ADCHF). Based on a better understanding of the distinct pathophysiology of these two conditions, new strategies may be considered to treat heart failure patients and improve outcomes. In this review, the authors elaborate distinctions regarding the clinical characteristics and outcomes of DNHF and ADCHF and their respective pathophysiology. Future clinical trials of therapies should address the potentially different phenotypes between DNHF and ADCHF if meaningful discoveries are to be made.

scholarly journals Statins in the treatment of chronic heart failure: Beyond the hypolipidemic effects

2012 ◽  
Vol 18 (1) ◽  
pp. 11-17
Author(s):  
O. M. Drapkina ◽  
O. N. Korneeva ◽  
L. O. Palatkina ◽  
V. T. Ivashkin
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Poor Prognosis ◽  
Clinical Characteristics ◽  
Low Density Lipoproteins ◽  
Favourable Effect ◽  
Low Density ◽  
Common Opinion ◽  
Unique Mechanism

Despite our knowledge about pathogenesis, clinical characteristics and treatment, chronic heart failure (CHF) remains widespread disease with poor prognosis. However, there is not a common opinion whether statins are reasonable in patients with CHF. The data about efficiency and safety of statins are contradictory and demand evidences due to regular exclusion of patients with CHF from the majority of clinical trials of statins. The reduction of the level of low-density lipoproteins is not the unique mechanism of favourable effect of statins in patients with CHF, therefore, their pleiotropic effects are considered very important.

scholarly journals COVID-19 in patients with heart failure: the new and the old epidemic

2020 ◽  
Vol 97 (1145) ◽  
pp. 175-179
Author(s):  
Nicolò Sisti ◽  
Serafina Valente ◽  
Giulia Elena Mandoli ◽  
Ciro Santoro ◽  
Carlotta Sciaccaluga ◽  
...  
Keyword(s):  
Heart Failure ◽  
Intensive Care ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Poor Prognosis ◽  
Myocardial Injury ◽  
Careful Monitoring ◽  
Clinical Challenge ◽  
Patients With Heart Failure ◽  
Acute Decompensation

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread in nearly 200 countries in less than 4 months since its first identification; accordingly, the coronavirus disease 2019 (COVID 2019) has affirmed itself as a clinical challenge. The prevalence of pre-existing cardiovascular diseases in patients with COVID19 is high and this dreadful combination dictates poor prognosis along with the higher risk of intensive care mortality. In the setting of chronic heart failure, SARS-CoV-2 can be responsible for myocardial injury and acute decompensation through various mechanisms. Given the clinical and epidemiological complexity of COVID-19, patiens with heart failure may require particular care since the viral infection has been identified, considering an adequate re-evaluation of medical therapy and a careful monitoring during ventilation.

scholarly journals Clinical characteristics and outcomes of patients with heart failure admitted to the intensive care unit with coronavirus disease 2019 (COVID19): a multicenter cohort study

2021 ◽  
Vol 20 (Supplement_1) ◽  
Author(s):  
H Badreldin ◽  
DR Hafidh ◽  
DR Bin Saleh ◽  
DR Al Sulaiman ◽  
DR Al Juhani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Intensive Care Unit ◽  
Intensive Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Clinical Characteristics ◽  
P Value ◽  
Heart Failure Patients ◽  
Icu Admission ◽  
Patients With Heart Failure

Abstract Funding Acknowledgements Type of funding sources: None. Background Patients with heart failure in the setting of COVID-19 requiring admission to the intensive care unit may present a set of unique challenges. There is limited data to describe the clinical characteristics and outcomes in this subset of the patient population. Purpose The study"s purpose was to extensively describe the characteristics and outcomes of heart failure patients admitted to the intensive care unit with COVID-19 compared to non-heart failure patients . Methods We conducted a multicenter, prospective analysis for all adult critically ill patients with heart failure admitted to intensive care units (ICUs) between March 1 to August 31, 2020, with an objectively confirmed diagnosis of COVID-19. Results A total of 723 critically ill patients with COVID-19 had been admitted in ICUs, 59 patients with heart failure, and 664 patients with no heart failure before ICU admission. Heart failure patients had significantly more comorbid conditions such as diabetes mellitus, hypertension, dyslipidemia, atrial fibrillation, and acute coronary syndrome. Higher baseline severity scores (APACHE II & SOFA score) and nutritional risk (NUTRIC Score) were observed in heart failure patients. Also, heart failure patients had more acute kidney injury during ICU admission and required more mechanical ventilation within 24 hours of ICU admission. Patients with heart failure had a similar incidence of thrombosis compared to patients with no heart failure. Critically ill patients with COVID-19 and heart failure had similar ICU length of stay (LOS), mechanical ventilation duration, and hospital LOS compared to patients with no heart failure. During ICU stay, patients with heart failure had more in-hospital and ICU deaths in comparison to the non-heart failure group (64.3% vs. 44.6%, P-value <0.01) and (54.5% vs. 39%, P-value = 0.02) respectively. Conclusion In this observational study evaluating the clinical characteristics and outcomes of critically ill COVID-19 patients with heart failure, patients with COVID-19 and heart failure had similar ICU LOS, duration of MV and hospital LOS, thrombosis rate compared to patients with no heart failure. However, during ICU stay, patients with heart failure had more in-hospital and ICU deaths than the non-heart failure group.

scholarly journals Chronic heart failure: New challenges and new perspectives

2017 ◽  
Vol 89 (9) ◽  
pp. 4-9 ◽  
Author(s):  
S N Tereshchenko ◽  
I V Zhirov
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Poor Prognosis ◽  
Public Health Problem ◽  
Global Public Health ◽  
Readmission Rates ◽  
Patients With Heart Failure ◽  
Specialized Service ◽  
New Challenges ◽  
Global Public Health Problem

Chronic heart failure is an important global public health problem. This is associated with extremely poor prognosis, high readmission rates, and substantial treatment costs in patients. The paper gives the main aspects of the setting-up of a specialized service to patients with heart failure.

scholarly journals Clinical characteristics of chronic heart failure patients with an augmented peripheral chemoreflex

1997 ◽  
Vol 18 (3) ◽  
pp. 480-486 ◽  
Author(s):  
T. P. Chua ◽  
P. Ponikowski ◽  
K. Webb-Peploe ◽  
D. Harrington ◽  
S. D. Anker ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Clinical Characteristics ◽  
Heart Failure Patients ◽  
Peripheral Chemoreflex

scholarly journals Anemia in Patients with Heart Failure: Current State of the Problem

2019 ◽  
Vol 8 (1) ◽  
pp. 68-73 ◽  
Author(s):  
S. R. Gilyarevsky ◽  
M. V. Golshmid ◽  
I. M. Kuzmina ◽  
N. G. Bendeliani
Keyword(s):  
Heart Failure ◽  
Clinical Trials ◽  
Chronic Heart Failure ◽  
Intravenous Administration ◽  
Clinical Guidelines ◽  
Randomized Clinical Trials ◽  
Current State ◽  
Patients With Heart Failure

The article reports the modern tactics of treating patients with chronic heart failure and concomitant anemia. The results of the most important randomized clinical trials that are the basis for developing approaches to the treatment of anemia in such cases are discussed. Attention is also paid to unresolved problems in the treatment of anemia in patients with heart failure. The data on the intravenous administration of iron preparations as the most effective approach to the treatment of anemia in patients with heart failure in the presence of iron defciency are given. The main provisions of modern clinical guidelines on the management of patients with heart failure and anemia are considered.

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