Impact of heliogeophysical factors on the clinical-biochemical indices in pregnant women

2018 ◽  
Vol 8 (2) ◽  
pp. 329-333
Author(s):  
I. V. Bobina ◽  
G. G. Sokolova ◽  
E. A. Sharlaeva
Keyword(s):  
Magnetic Field ◽  
Pregnant Women ◽  
Geomagnetic Activity ◽  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Blood Platelets ◽  
Coefficient Of Determination ◽  
Functional Dependencies ◽  
Biochemical Indicators ◽  
Heliogeophysical Factors

<p>The influence of heliogeophysical factors on the clinical and biochemical parameters of pregnant women with easy and complicated births was studied. The influence of the events of the current day and the previous solar and geomagnetic activity on clinical and biochemical parameters of pregnant women with normal and complicated births was revealed. 164 pregnant women aged from 17 to 44 years, living in Barnaul, Altai region, were examined. According to the type of delivery two groups of women were identified:1) women with easy birth (46 people), 2) women with complicated birth (118 people). The following indicators were used to estimate the level of solar and geomagnetic activity: the number of sunspots, the number of Wolff, radiation at a wavelength of 10.7 cm, the average daily magnetic field perturbation (A<sub>p</sub>– index), and the local geomagnetic disturbance index (A<sub>k </sub>– index). Pregnant women were examined using the following parameters: the number of erythrocytes, leukocytes, blood platelets, leukocyte count, clotting time, erythrocyte sedimentation rate, prothrombin index, hemoglobin, sugar, fibrinogen, bilirubin (direct, indirect and total), total blood protein, and specific gravity. It has been established that the influence of heliogeophysical factors consists of immediate and delayed reactions with different latent periods: among women with normal births the most significant events are the events of the current day, as well as the 3rd, 6th and 7th days before the examination; among women with difficult births - on the 2nd, 4th, 5th and 7th days. Among heliogeophysical factors the average daily disturbance of the Earth's magnetic field has the greatest influence on clinical and biochemical parameters. 60% of the clinical and biochemical parameters analyzed among pregnant women depend on this factor. Clinical and biochemical indicators are less susceptible to heliogeophysical factors among women with complicated births. The coefficient of determination by the factors of solar activity reaches 25% (direct bilirubin) among them; factors of geomagnetic activity - 31.5% (urine protein), whereas in the group of women with normal births the coefficient of determination is 50% (total bilirubin) and 71% (total bilirubin). According to clinical-biochemical indicators 8 types of correlations were found: 1 type – at low level of solar and geomagnetic activity, 4 types – at medium and 3 types at high level. Linear and nonlinear functional dependencies of the indicators on heliogeophysical factors are revealed for each typological group.</p>

scholarly journals Role of biochemical parameters in predicting histopathological changes at 24 and 48 hours from acute pancreatitis induction

2020 ◽  
Vol 75 (1) ◽  
pp. 6168-2020
Author(s):  
JACEK BAJ ◽  
IWONA ŁUSZCZEWSKA-SIERAKOWSKA ◽  
ELŻBIETA RADZIKOWSKA ◽  
JACEK SOMPOR ◽  
MARCIN MACIEJEWSKI ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Duct ◽  
Biochemical Parameters ◽  
Total Bilirubin ◽  
Sodium Taurocholate ◽  
Fatty Tissue ◽  
Tissue Necrosis ◽  
Inflammatory Infiltration ◽  
Biochemical Indicators ◽  
Histopathological Lesions

The aim of the study was to assess the relationships between the degree of changes in concentrations of the biochemical indicators in serum such as: creatinine, uric acid, total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), lipase, amylase, glucose, iron and magnesium, and histopathological lesions occurring in the pancreas within 24 and 48 hours from the induction of acute pancreatitis (AP). An attempt was made to assess the relation between the changes in concentrations of biochemical indicators and the enhancement of histological lesions in the pancreas based on Spormann score. In the experimental model, the laboratory and histological changes in the 24th hour from administration of taurocholan correspond to the seventh day of the disease in humans. Experiments were conducted on 55 male Wistar rats weighing from 250 g to 300 g. The animals were divided into three groups: Z – a group serving to establish the ranges of studied factors and histological structure; K – a group of animals operated on which were injected with 0.9% NaCl into the biliary-pancreatic duct; E – a group of animals operated on in which acute pancreatitis was induced by an injection of 5% sodium taurocholate into the biliary-pancreatic duct. The material for biochemical and histological examinations was collected after 24 and 48 hours from the induction of AP. Whole pancreases were dissected for histological examinations and the samples were dyed with hematoxylin and saturated alcoholic eosin solution. The degree of pancreatic lesions was assessed according to the Spormann score. Quantitative variables were characterised by arithmetic mean, standard deviation, median, minimum and maximum value and 95% CI. After administration of 0.9% NaCl in the K group, foci of purulent inflammation in the fatty tissue of the pancreas and minor foci of Balser’s necrosis appeared. In the E group, after injection of 5% sodium taurocholate into the biliary-pancreatic duct, more intense lesions were observed: foci of fatty tissue necrosis, hemorrhagic necrosis, multifocal fatty tissue necrosis and inflammatory infiltration. The model was developed in order to assess histological lesions, indicating the character of AP, taking into account edema, inflammatory infiltration, fatty tissue necrosis, glandular necrosis, and ecchymoses. In the period of 24 hours, statistically significant differences between the K group and E group were observed for creatinine, total bilirubin, ALT, lipase, amylase, iron and magnesium, while in the period of 48 hours, statistically significant differences were observed for total bilirubin and ALT. In the group E, in the period of 24 hours concentrations of creatinine, total bilirubin, ALT, lipase, amylase and magnesium were significantly higher than in the group K, but concentrations of iron were significantly lower. In the period of 48 hours, in the E group total bilirubin was significantly lower and ALT was significantly higher than in the K group. In the E group, the intensity of pancreatitis increased together with an increase in ALT concentration in the period of 24 hours; in the period of 48 hours, the intensity of pancreatitis increased together with a decrease in ALT in the E group. In the K group, in the period of 48 hours, intensity of fatty tissue necrosis increased together with a decrease in ALT level. In the period of 48 hours, in the E group intensity of glandular necrosis increased together with a decrease in total bilirubin and AST concentration. In the E group, in the period of 24 hours intensity of edema increased together with an increase in magnesium level. In the period of 48 hours, in the E group intensity of glandular necrosis increased together with a decrease in magnesium or AST level, and the intensity of lesions in the form of ecchymoses increased together with an increase in glucose level. Histopathological lesions occurred prior to changes in laboratory test results, whereas significant correlations with the Spormann score concerned changes in: total bilirubin, AST, ALT, glucose and magnesium. The use of regression analysis with the Spormann score shows statistically significant differences for most of the biochemical parameters in the period of 24 hours correspond to the seventh day of the disease in humans. The presented study results confirm the fact that diagnostics of acute pancreatitis is very difficult and requires monitoring of many laboratory parameters. A search is still going on for an ideal marker of AP which would enable an early prognosis of the progress of the disease and the confirmation of its etiology. A discovery of a simple marker which is cheap to use may turn out to be useful if it is confirmed in prospective studies. The current state of knowledge based on scientific and clinical findings makes it possible to apply interdisciplinary clinical procedures based on matching appropriate laboratory and radiological tests, and on implementing therapeutic procedures...

scholarly journals Biochemical Indicators as Predictive Markers by Combining Clinical Signs in Pre-eclampsia

2020 ◽  
Vol 8 (B) ◽  
pp. 692-698
Author(s):  
Ana Daneva Markova ◽  
Katerina Nikolovska ◽  
Irena Aleksievska ◽  
Vlatko Girevski ◽  
Marija Joksimovikj
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Pregnant Women ◽  
Blood Platelets ◽  
Clinical Signs ◽  
World Health ◽  
Serum Lactate Dehydrogenase ◽  
Predictive Values ◽  
Biochemical Indicators ◽  
Elevated Systolic Blood Pressure

AIM: To determine whether previously identified risk factors are associated with the development of a severe form of pre-eclampsia in a heterogeneous cohort of women, and the predictive values of these risk factors when combined with certain biochemical indicators. MATERIALS AND METHODS: Systematic review of data collected for a doctoral case-control study plus an examination of the indicators of pre-eclampsia and maternal IL10 levels. This examination was conducted in 100 women with pregnancies complicated by varying degrees of pre-eclampsia and in 80 normotensive patients hospitalized at the University Clinic of Gynecology and Obstetrics, Skopje, Republic of Macedonia. Patients with pre-eclampsia were categorized into moderate (m PE) and severe (s PE) pre-eclampsia group according to the degree of pre-eclampsia. The severity of pre-eclampsia was determined according to the definition of the World Health Organization, Handbook for guideline development from 2010. RESULTS: The regression analysis applied in this study showed that elevated systolic blood pressure of 160 mmHg or higher, diastolic blood pressure of 100 mmHg or higher, pregnancy at an older age, nulliparity, persistent proteinuria in pregnancy, the serum lactate dehydrogenase concentration of 450 U/L or higher, and reduced serum concentrations of IL10 as significant predictors of severe pre-eclampsia in pregnant women. While other variables predicted a higher likelihood for the development of severe pre-eclampsia, IL10 decreased such likelihood. IL10 was also found to be negatively correlated with proteinuria and positively correlated with blood platelets. Significantly higher concentration of IL10 was confirmed in patients with a higher number of platelets in the blood and vice versa. On the other hand, the serum concentration of IL10 was significantly lower in patients with a higher amount of proteins in the urine and vice versa. CONCLUSIONS: Examination of clinical risk factors combined with biochemical markers can improve the predictive success of pre-eclampsia and has important clinical values in improving the prognosis of pregnant women and fetuses.

Biochemical parameters and relation to disease severity in COVID-19 patients

2021 ◽  
pp. 93-96
Keyword(s):  
Biochemical Parameters ◽  
Troponin I ◽  
Total Bilirubin ◽  
Early Stage ◽  
Length Of Hospital Stay ◽  
Rt Pcr ◽  
Sodium Potassium ◽  
Appropriate Treatment ◽  
Significant Difference ◽  
Severity Of The Disease

Aim: In this study, we aimed to evaluated whether there is an association between the biochemistry parameters obtained from the first blood test after hospitalization of COVID 19 patients and the prognosis and severity of the disease. Thus, we planned to identify patients with a severe course at an early stage and to help physicians determine the appropriate treatment. Material and Method: The study included 106 COVID 19 patients confirmed by RT-PCR. Patients were categorized into two groups: those admitted to the hospital ward and discharged with recovery (mild cases) and those admitted directly or eventually to the intensive care unit (severe cases). Biochemical parameters of the groups were compared with the Mann Whitney-U Test, as none of the compared parameters fit the normal distribution. Results: There was no statistically significant difference between the male-female numbers and ages of the two groups. Statistically significant differences were observed in the length of hospital stay, procalcitonin, hs-troponin I, ferritin, glucose, urea, creatinine, calcium, direct bilirubin, AST, LDH and CRP values (p<0,05). However, no significant difference was found in sodium, potassium, chloride, total bilirubin and ALT tests. Conclusion: The results show that some biochemistry parameters may be used to predict the prognosis of the disease. In particular, procalcitonin, hs troponin I, LDH and CRP values seem to be moderate biomarkers of the prognosis of the disease.

scholarly journals Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to action of liposomal preparation

2017 ◽  
Vol 8 (2) ◽  
pp. 304-309 ◽  
Author(s):  
B. Gutyj ◽  
T. Martyshchuk ◽  
I. Bushueva ◽  
B. Semeniv ◽  
V. Parchenko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Functional State ◽  
Total Bilirubin ◽  
Hemoglobin Content ◽  
Physiological Level ◽  
Biochemical Indicators ◽  
Liposomal Preparation ◽  
Physiological Indicators ◽  
Hematological Indicators

The article gives the results of the research on the influence of a developed complex liposomal preparation on the dynamics of morphological and biochemical indicators of the blood of rats subjected to modeled oxidative stress caused by intermuscular injection of 50% carbon tetrachloride at a dose of 0.25 ml per 100 g of body mass. We found that in conditions of intoxication by carbon tetrachloride, the physiological level of hematological indicators of the researched animals’ body was disrupted. This is indicated by the reduction in the amount of erythrocytes, hemoglobin content, concentration of hemoglobin per erythrocyte, increase in the amount of leucocytes, mass of hemoglobin per erythrocyte and increase of colour indicator. Also, we detected suppression of protein synthesis function of the liver. The levels of total protein and albumin fraction were below the normal physiological level. High indicators were observed in the levels of creatinine, urea and total bilirubin. In order to normalize the functional state of the liver under oxidative stress it is reasonable to use a liposomal preparation which contains butafosfan, interferon, thistle and vitamins. In order to normalize morphological and biochemical indicators of the blood of rats subject to intoxication of carbon tetrachloride it is reasonable to use a liposomal preparation that contains butafosfan, selenium, thistle, methionine and vitamins. Using the liposomal preparation Butaselmevit for rats under oxidative stress the morphological and biochemical indicators in the blood normalized. On the 14th day the indictors of the number of erythrocytes, the hemoglobin content, the white blood cell count and red blood indexes compared to control came within the physiological indicators, indicating a recovery of hematopoietic function of the bone marrow and normalized indicators of the functional state of the liver. 

scholarly journals The features of pregnancy at women with liver steatosis and obesity

2013 ◽  
Vol 62 (6) ◽  
pp. 47-54 ◽  
Author(s):  
Roza Nuraddinovna Rzaeva ◽  
Elena Vitalievna Mozgovaya ◽  
Ljudmila Konstantinovna Palgova ◽  
Valentina Mikchailovna Prokopenko ◽  
Zhanna Nikolaevna Tumasova
Keyword(s):  
Lipid Metabolism ◽  
Liver Function ◽  
Pregnant Women ◽  
Clinical Picture ◽  
Ultrasound Examination ◽  
Liver Steatosis ◽  
Biochemical Indicators ◽  
Comprehensive Examination ◽  
Pregnancy And Delivery ◽  
Medical Examinations

40 pregnant women with obesity were totally examined and their outcomes of pregnancy and delivery were controlled. The examination of all pregnant women included the comprehensive examination of the functional state of the hepatobiliary system, ultrasound examination of the liver to identify the liver steatosis. These medical examinations made possibility to assess the dynamics of a clinical picture, ultrasound conclusions, biochemical indicators of liver function and lipid metabolism during the treatment. The frequency and severity of obstetric complications were also assessed.

scholarly journals Effect of geomagnetic activity, solar wind and parameters of interplanetary magnetic field on regularities in intermittency of Pi2 geomagnetic pulsations

2015 ◽  
Vol 1 (3) ◽  
pp. 11-20 ◽  
Author(s):  
Надежда Куражковская ◽  
Nadezhda Kurazhkovskaya ◽  
Борис Клайн ◽  
Boris Klain
Keyword(s):  
Magnetic Field ◽  
Solar Wind ◽  
Interplanetary Magnetic Field ◽  
Geomagnetic Activity ◽  
Dynamic Pressure ◽  
Cumulative Distribution ◽  
Qualitative Assessment ◽  
Geomagnetic Pulsations ◽  
Magnetospheric Substorms ◽  
Pi2 Pulsations

We present the results of investigation of the influence of geomagnetic activity, solar wind and parameters of the interplanetary magnetic field (IMF) on properties of the intermittency of midlatitude burst series of Pi2 geomagnetic pulsations observed during magnetospheric substorms on the nightside (substorm Pi2) and in the absence of these phenomena (nonsub-storm Pi2). We considered the index α as a main characteristic of intermittency of substorm and nonsubstorm Pi2 pulsations. The index α characterizes the slope of the cumulative distribution function of Pi2 burst amplitudes. The study indicated that the value and dynamics of the index α varies depending on the planetary geomagnetic activity, auroral activity and the intensity of magnetospheric ring currents. In addition, the forms of dependences of the index α on the density n, velocity V, dynamic pressure Pd of the solar wind and IMF Bx-component are different. The behavior of the index α depending on the module of B, By- and Bz-components is similar. We found some critical values of V, Pd, B, By- and Bz-components, after reaching of which the turbulence of the magnetotail plasma during substorm development is decreased. The revealed patterns of the intermittency of Pi2 pulsations can be used for qualitative assessment of turbulence level in the magnetotail plasma depending on changing interplanetary conditions.

Predictive Value of Immunological Parameters in the Risk of Gestational Diabetes Mellitus: A Pilot Study

2020 ◽  
Author(s):  
Adnette Fagninou ◽  
Magloire Pandoua Nekoua ◽  
Salomon Ezéchiel Mahougnon Fiogbe ◽  
Kabirou Moutairou ◽  
Akadiri YESSOUFOU
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Pregnant Women ◽  
Biochemical Parameters ◽  
Predictive Power ◽  
Glycosylated Hemoglobin ◽  
Operating Characteristics ◽  
Immunological Parameters ◽  
Increased Risk

Abstract Background : Immunological and biochemical parameters are gaining more and more importance in the prognosis of diabetes and its complications. Here we assessed the predictive power of immunological parameters correlated with biochemical ones in gestational diabetes mellitus (GDM). Material and Methods : 217 pregnant women were screened for GDM between the 2 nd and the 3 rd trimester of gestation, based on IAGDP methods in this cross-sectional descriptive study. Immunological and biochemical parameters were determined using appropriate methods. Receiver operating characteristics (ROC) curve analyses were conducted to assess the optimal cutoff and value of immunological to biochemical parameter ratios for predicting GDM. Results : 11.90% of pregnant women were diagnosed GDM positive. Serum glucose levels, total cholesterol, LDL-cholesterol, triglycerides and total proteins were significantly increased while HDL-cholesterol decreased in women with GDM compared to controls. The levels of glycosylated hemoglobin and creatinine, as well as transaminase (AST and ALT) activities did not significantly differ between GDM and pregnant controls. Total leucocytes (white blood cell), lymphocyte and platelet numbers were significantly higher in women with GDM than in pregnant controls. We also found that the lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios were significantly higher in women with GDM than in pregnant controls ( p = 0.001; p = 0.009 and p = 0.004 respectively). Women with a lymphocyte:HDL-C ratio greater than 3.66 had a 4-fold increased risk of developing GDM than those with lower ratios (odds ratio 4.00; 95% CI: 1.094 – 14.630; p =0.041). Conclusion : The lymphocyte:HDL-C, monocyte:HDL-C and granulocyte:HDL-C ratios may represent valuable makers, and the lymphocyte:HDL-C ratio in particular may have strong predictive power for GDM. This ratio can be easily assessed in patients.

Sign in / Sign up

Export Citation Format

Share Document