scholarly journals Primary Non-Hodgkin’s Lymphoma of the bilateral Breast and review the literature

2020 ◽  
Vol 3 (4) ◽  
pp. 926-930
Author(s):  
Mirza Mzu Bhuiyan ◽  
Hundzukani Dost Makhubele
Keyword(s):  
Postpartum Period ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Postpartum Women ◽  
Hormonal Changes ◽  
Large B Cell Lymphoma ◽  
Pregnancy And Postpartum ◽  
Immunodeficiency Virus ◽  
Advanced Stages ◽  
Hodgkin's Lymphomas

Primary bilateral breast Non-Hodgkin’s lymphomas are the rare tumors found during the pregnancy and postpartum period. Diffuse large B-cell lymphoma (DLBCL) is the most common histological diagnosis. Lymphomas in breasts grow faster in pregnant or postpartum women especially, in those who are infected with Human Immunodeficiency Virus (HIV). Confirmation of diagnosis is usually delayed because of breasts’ extraordinary engorgement, hormonal changes during the pregnancy or lactation and most of the patients are diagnosed in advanced stages. Rapidly growing breast mass in HIV patients during the antenatal and postpartum period should undergo prompt investigations and early treatment if proven lymphoma.

scholarly journals Case report of primary CD20 negative diffuse large B-cell lymphoma

2021 ◽  
Vol 2021 (11) ◽  
Author(s):  
Kanti Devi ◽  
Natashi Ali ◽  
Arsalan Ahmed
Keyword(s):  
Case Report ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Standard Chemotherapy ◽  
Large B Cell Lymphoma ◽  
Uncommon Presentation ◽  
Immunodeficiency Virus ◽  
Hodgkin's Lymphomas ◽  
Large B Cell

ABSTRACT Few groups of aggressive non-Hodgkin’s lymphomas (NHL) that are refractory to standard chemotherapy are rarely reported. Primary CD20 negative diffuse large B cell lymphoma (DLBCL) without human immunodeficiency virus infection is an uncommon presentation and this case report is challenging in terms of diagnosis and treatment as well.

Pathogenesis of Non-Hodgkin's Lymphoma

2011 ◽  
Vol 29 (14) ◽  
pp. 1803-1811 ◽  
Author(s):  
Hendrik Nogai ◽  
Bernd Dörken ◽  
Georg Lenz
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Therapeutic Strategies ◽  
Molecular Pathogenesis ◽  
Large B Cell Lymphoma ◽  
Oncogenic Pathways ◽  
Hodgkin's Lymphomas ◽  
Identification And Characterization ◽  
Lymphoma Subtype

The understanding of the molecular pathogenesis of non-Hodgkin's lymphomas (NHL) has significantly improved in recent years. Advances in molecular biology and genetics lead to the identification and characterization of several oncogenic pathways involved in lymphomagenesis. This knowledge will ultimately lead to improved diagnostic and therapeutic strategies for patients with NHL. This review summarizes current concepts of the molecular pathogenesis of the most common NHL subtypes, with a special emphasis on diffuse large B-cell lymphoma, the most common lymphoma subtype.

scholarly journals BCL2 Overexpression Associated With Chromosomal Amplification in Diffuse Large B-Cell Lymphoma

Blood ◽  
1997 ◽  
Vol 90 (3) ◽  
pp. 1168-1174 ◽  
Author(s):  
Outi Monni ◽  
Heikki Joensuu ◽  
Kaarle Franssila ◽  
Juha Klefstrom ◽  
Kari Alitalo ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Comparative Genomic ◽  
Chain Gene ◽  
Large B Cell Lymphoma ◽  
Bcl2 Protein ◽  
High Level ◽  
Hodgkin's Lymphomas ◽  
Large B Cell

Abstract Gene activation by translocation between an oncogene and an immunoglobulin heavy-chain gene, which leads to increased expression of the oncoprotein, is a well-known mechanism in the genesis of B-cell lymphomas. In contrast, the role of gene amplification in activation of oncogenes in non-Hodgkin's lymphomas is poorly characterized. To study the BCL2 amplification we performed comparative genomic hybridization (CGH), Southern blot hybridization, Western analysis, immunohistochemistry, metaphase fluorescence in situ hybridization, and chromosome analysis on 26 cases of diffuse large B-cell lymphoma (large noncleaved cell lymphoma). The gain or high-level amplification of 18q was found in eight tumors (31%) by CGH, and Southern analysis revealed BCL2 amplification in these cases, but not in the cases with normal chromosome 18 or t(14; 18)(q32; q21). Western immunoblot analysis and immunohistochemistry revealed a high-level expression of BCL2 protein in the cases with BCL2 amplification and t(14; 18)(q32; q21). However, translocation (14; 18)(q32; q21) was not detected in any of the cases with BCL2 amplification. Therefore, our results suggest that amplification of the BCL2 gene is an important mechanism for BCL2 protein overexpression in diffuse large B-cell lymphoma.

scholarly journals One Patient, Two Uncommon B-Cell Neoplasms: Solitary Plasmacytoma following Complete Remission from Intravascular Large B-Cell Lymphoma Involving Central Nervous System

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Joycelyn Lee ◽  
Soo Yong Tan ◽  
Leonard H. C. Tan ◽  
Hwei Yee Lee ◽  
Khoon Leong Chuah ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Solitary Plasmacytoma ◽  
B Cell Malignancies ◽  
Large B Cell Lymphoma ◽  
Hodgkin's Lymphomas ◽  
Large B Cell

Second lymphoid neoplasms are an uncommon but recognized feature of non-Hodgkin’s lymphomas, putatively arising secondary to common genetic or environmental risk factors. Previous limited evaluations of clonal relatedness between successive mature B-cell malignancies have yielded mixed results. We describe the case of a man with intravascular large B-cell lymphoma involving the central nervous system who went into clinical remission following immunochemotherapy and brain radiation, only to relapse 2 years later with a plasmacytoma of bone causing cauda equina syndrome. The plasmacytoma stained strongly for the cell cycle regulator cyclin D1 on immunohistochemistry, while the original intravascular large cell lymphoma was negative, a disparity providing no support for clonal identity between the 2 neoplasms. Continued efforts atcataloging and evaluating unique associations of B-cell malignancies are critical to improving understanding of overarching disease biology in B-cell malignancies.

Sign in / Sign up

Export Citation Format

Share Document