scholarly journals Vitamin D and neuropathy

2013 ◽  
Vol 154 (51) ◽  
pp. 2012-2015 ◽  
Author(s):  
Zsuzsanna Putz ◽  
Tímea Martos ◽  
Nóra Németh ◽  
Anna Erzsébet Körei ◽  
Márta Szabó ◽  
...  
Keyword(s):  
Public Health ◽  
Diabetes Mellitus ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Vitamin D Deficiency ◽  
Type 2 Diabetics ◽  
Increased Risk ◽  
Plantar Ulcers ◽  
The Relationship

Diabetes is a widespread disease and, therefore, studies dealing with diabetes and its complications are very important for public health. Numerous reports link vitamin D deficiency to the increased risk of diabetes mellitus and complications such as neuropathy. However, there are limited and conflicting data available on vitamin D deficiency in patients with diabetic peripheral neuropathy. Studies in type 2 diabetics confirmed the relationship between vitamin D deficiency and incidence of neuropathy. Recent reports suggest a relationship between the incidence of plantar ulcers and vitamin D deficiency. Orv. Hetil., 2013, 154(51), 2012–2015.

scholarly journals Is Vitamin D Deficiency Related to Increased Cancer Risk in Patients with Type 2 Diabetes Mellitus?

2021 ◽  
Vol 22 (12) ◽  
pp. 6444
Author(s):  
Anna Gabryanczyk ◽  
Sylwia Klimczak ◽  
Izabela Szymczak-Pajor ◽  
Agnieszka Śliwińska
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Cancer Risk ◽  
Vitamin D Deficiency ◽  
Cancer Development ◽  
Increased Risk

There is mounting evidence that type 2 diabetes mellitus (T2DM) is related with increased risk for the development of cancer. Apart from shared common risk factors typical for both diseases, diabetes driven factors including hyperinsulinemia, insulin resistance, hyperglycemia and low grade chronic inflammation are of great importance. Recently, vitamin D deficiency was reported to be associated with the pathogenesis of numerous diseases, including T2DM and cancer. However, little is known whether vitamin D deficiency may be responsible for elevated cancer risk development in T2DM patients. Therefore, the aim of the current review is to identify the molecular mechanisms by which vitamin D deficiency may contribute to cancer development in T2DM patients. Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors. Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor β (TGFβ), insulin-like growth factor (IGF) and Wnt-β-Cathenin. It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation. Although, numerous studies revealed that adequate vitamin D concentration prevents or delays T2DM and cancer development, little is known how the vitamin affects cancer risk among T2DM patients. There is a pressing need for randomized clinical trials to clarify whether vitamin D deficiency may be a factor responsible for increased risk of cancer in T2DM patients, and whether the use of the vitamin by patients with diabetes and cancer may improve cancer prognosis and metabolic control of diabetes.

scholarly journals The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Celil Alper Usluogullari ◽  
Fevzi Balkan ◽  
Sedat Caner ◽  
Rifki Ucler ◽  
Cafer Kaya ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Microvascular Complications ◽  
The Relationship

scholarly journals Correlative Analysis of Vitamin D Status in People Suffering from Type-2 Diabetes Mellitus in Eastern Region of Nepal

2019 ◽  
Vol 3 (3) ◽  
pp. 565-569
Author(s):  
Rajneesh Jha ◽  
Meena Kumari Mishra ◽  
Amit Mishra ◽  
Raju Kumar Chaudhary
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Eastern Region ◽  
Vitamin D Status ◽  
Blood Samples ◽  
Type 2 Diabetics

Introduction: Vitamin D deficiency exists as a common problem among population worldwide. The deficient vitamin D level leads to direct impact on various normal functioning of human body systems. It has been observed in few studies that decreased circulating concentration of 25-hydroxyvitamin D is associated with type-2 diabetes mellitus. The possible reason behind such occurrence is due to the direct effect of vitamin D on glucose metabolism. Vitamin D exerts influences on activity of pancreatic β-cell function from where insulin is secreted. In addition, the patients suffering from low vitamin D status show insulin resistance. These affected individuals with low vitamin D status exhibits impaired markers of glucose metabolism such as glycosylated hemoglobin. So, researchers have found vitamin D deficiency to correlate with type-2 diabetes and 80 % of obese adults suffering from vitamin D insufficiency state. In spite of such crucial significance, the correlative studies related to vitamin D status and type-2 diabetes still remains obscure in eastern region of Nepal. Objective: We aimed to investigate status of vitamin D among type-2 diabetics and analyze its possible correlation. Methodology: In the present study which was hospital-based and cross sectional one, antecubital venous blood samples were collected from patients (n=100) in plain vials with informed written consent. Blood samples were allowed to clot and centrifuged for separation of serum. The separated sera were further processed for determination of glucose (fasting as well as post-prandial) by spectrophotometry and estimation of vitamin D with use of microwell Enzyme-linked immunosorbant assay (ELISA) technique. The data was interpreted by using SPSS software version 16. Results: We found that 75 % type-2 diabetics had suffered from “state of vitamin D deficiency”. Among them, females, in contrast, were predominating which was interesting in an analytical point of view. Conclusion: Our study reviews evidence on disorders related to type-2 diabetes mellitus and vitamin D status, especially in older people. The biological processes that lead to synthesis of vitamin D in human body tissues become less efficient when an individual's age advances with in additional occurrences of type-2 diabetes mellitus. We should therefore maintain the repletion of vitamin D in healthy older people via supplementary intakes and sensible sun-exposure. 

scholarly journals Vitamin D and diabetes mellitus: an update 2013

2014 ◽  
Vol 58 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Luiz Henrique Maciel Griz ◽  
Francisco Bandeira ◽  
Mônica Andrade Lima Gabbay ◽  
Sergio Atala Dib ◽  
Eduardo Freese de Carvalho
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Vitamin D Deficiency ◽  
Pancreatic Beta Cells ◽  
Increased Risk ◽  
Geographical Regions

Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH)2D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases.

High Prevalence of Vitamin D Deficiency and Correlation with Cystatin-C and Other Cardiovascular and Renal Risk Biomarkers in Patients with Type 2 Diabetes Mellitus Complicated with Hypertension

2020 ◽  
Vol 17 (1) ◽  
pp. 81-90
Author(s):  
Mohammad J. Alkhatatbeh ◽  
Sajedah A. Smadi ◽  
Khalid K. Abdul-Razzak ◽  
Nesreen A. Saadeh
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Type 2 Diabetes Mellitus ◽  
Vitamin D Deficiency ◽  
Cystatin C ◽  
P Values ◽  
Renal Biomarkers ◽  
Risk Biomarkers

Background: Vitamin D is increasingly investigated as having a role in Type 2 Diabetes Mellitus (T2DM) and its cardiovascular and renal complications. Objective: This study aimed to investigate the association between 25-hydroxyvitamin D (25-OHD) and biomarkers of cardiovascular and renal complications, including cystatin-C. Methods: This cross-sectional study involved 117 participants with T2DM that was not complicated with cardiovascular or renal diseases except hypertension. 25-OHD was measured by electrochemiluminescence immunoassay, while cystatin-C was measured by enzyme-linked-immunosorbent-assay. Other biomarkers, including lipids, creatinine, urea and glycemic measures, were determined by the routine biochemistry assays. Results: The prevalence of vitamin D deficiency was 74.36%. There was no significant difference in cardiovascular and renal biomarkers, including glucose, HbA1c, lipids, urea, creatinine and cystatin-C between participants with adequate and deficient vitamin D (p-values>0.05). Participants with adequate vitamin D were older in age, more obese and having lower eGFR (p-values<0.05). 25-OHD was weakly correlated with age, duration of DM, urea, creatinine and inversely correlated with eGFR (rvalues< 0.32, p-values<0.05). Although creatinine and cystatin-C were directly correlated (r=0.42, pvalue< 0.001), cystatin-C and 25-OHD were not correlated (p-value>0.05). Hypertensive participants were more obese, having a longer duration of DM and higher urea and cystatin-C compared to nonhypertensive participants (p-values<0.05). Binary logistic regression analysis revealed that hypertension could be predicted from increased BMI. Conclusion: 25-OHD was not found to be correlated with cardiovascular risk biomarkers, but it was correlated with renal biomarkers, including urea, creatinine and eGFR. Cystatin-C and 25-OHD were not observed to be correlated to each other, but both were correlated to renal function. Obesity was a significant predictor of hypertension.

Diabetic neuropathy: Epidemiological, pathogenetic, and clinical aspects with special emphasis on type 2 diabetes mellitus

1983 ◽  
Vol 104 (4_Suppl) ◽  
pp. S89-S94
Author(s):  
E. Matikainen ◽  
J. Juntunen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Control ◽  
Clinical Aspects ◽  
Type 2 Diabetics ◽  
Insulin Dependent

ABSTRACT. Peripheral neuropathy is a frequent complication of diabetes mellitus. Alterations of the peripheral nervous system in diabetics have been studied in numerous investigations. There are many factors known to participate in the development of this complication, e.g. the age of the patient, duration of the diabetes, quality of the diabetic control etc. The role of different types of diabetes in development of neuropathy is still largely unclear since investigations on this aspect are few. It seems, however, that peripheral neuropathy in type 2 (non-insulin dependent) diabetes is common but often mild. The differential diagnosis of the peripheral neuropathy in type 2 diabetics is more difficult than in type 1 (insulin dependent) diabetics, since these patients tend to be older and also may have other concomitant disorders. In this paper the clinical features and pathogenetic mechanisms of neuropathy in type 2 diabetes are briefly discussed.

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