Relationship between Expression of EMT Transcription Factor of ZEB1 and CXCR4 Chemokine Receptor

2016 ◽  
Vol 1 (2) ◽  
pp. 70
Author(s):  
Naghmeh Ahmadiankia
Keyword(s):  
Transcription Factor ◽  
Chemokine Receptor

scholarly journals Relationship between Expression of EMT Transcription Factor of ZEB1 and CXCR4 Chemokine Receptor

2017 ◽  
Vol 3 ◽  
pp. 55
Author(s):  
Naghmeh Ahmadiankia
Keyword(s):  
Transcription Factor ◽  
Cause Of Death ◽  
Chemokine Receptor ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Critical Role ◽  
Cxcr4 Expression ◽  
Mesenchymal Transition

Metastasis is one the most leading cause of death from cancer and the chemokine receptor of CXCR4 has a critical role in cancer metastasis. Moreover, metastasis is always correlated with epithelial-mesenchymal transition (EMT). In this study, the correlation between expression of EMT-TF of ZEB1 and CXCR4 has been examined. The results revealed that in ZEB1 knocked out cells, the expression of CXCR4 decreased significantly. This indicated that ZEB1 might be one of the regulators of CXCR4 expression.

scholarly journals Correlation Network Analysis Reveals Relationships between MicroRNAs, Transcription FactorT-bet, and Deregulated Cytokine/Chemokine-Receptor Network in Pulmonary Sarcoidosis

2015 ◽  
Vol 2015 ◽  
pp. 1-16 ◽  
Author(s):  
Tereza Dyskova ◽  
Regina Fillerova ◽  
Tomas Novosad ◽  
Milos Kudelka ◽  
Monika Zurkova ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Network Analysis ◽  
Chemokine Receptor ◽  
Pulmonary Sarcoidosis ◽  
Correlation Network ◽  
Unknown Etiology ◽  
Limited Information ◽  
Functional Studies ◽  
Cytokines And Chemokines

Sarcoidosis is an inflammatory granulomatous disease with unknown etiology driven by cytokines and chemokines. There is limited information regarding the regulation of cytokine/chemokine-receptor network in bronchoalveolar lavage (BAL) cells in pulmonary sarcoidosis, suggesting contribution of miRNAs and transcription factors. We therefore investigated gene expression of 25 inflammation-related miRNAs, 27 cytokines/chemokines/receptors, and a Th1-transcription factorT-betin unseparated BAL cells obtained from 48 sarcoidosis patients and 14 control subjects using quantitative RT-PCR. We then examined both miRNA-mRNA expressions to enrich relevant relationships. This first study on miRNAs in sarcoid BAL cells detected deregulation ofmiR-146a,miR-150,miR-202,miR-204, andmiR-222expression comparing to controls. Subanalysis revealed higher number ofmiR-155,let-7ctranscripts in progressing (n=20) comparing to regressing (n=28) disease as assessed by 2-year follow-up. Correlation network analysis revealed relationships between microRNAs, transcription factorT-bet, and deregulated cytokine/chemokine-receptor network in sarcoid BAL cells. Furthermore,T-betshowed more pronounced regulatory capability to sarcoidosis-associated cytokines/chemokines/receptors than miRNAs, which may function rather as “fine-tuners” of cytokine/chemokine expression. Our correlation network study implies contribution of both microRNAs and Th1-transcription factorT-betto the regulation of cytokine/chemokine-receptor network in BAL cells in sarcoidosis. Functional studies are needed to confirm biological relevance of the obtained relationships.

scholarly journals Transcription factor RUNX2 up-regulates chemokine receptor CXCR4 to promote invasive and metastatic potentials of human gastric cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 20999-21012 ◽  
Author(s):  
Zheng-Jun Guo ◽  
Lang Yang ◽  
Feng Qian ◽  
Yan-Xia Wang ◽  
Xi Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Chemokine Receptor ◽  
Human Gastric Cancer ◽  
Chemokine Receptor Cxcr4

Transcription factor/DNA interactions visualized by electron spectroscopic imaging

1992 ◽  
Vol 50 (1) ◽  
pp. 450-451
Author(s):  
David P. Bazett-Jones ◽  
Mark L. Brown
Keyword(s):  
Transcription Factor ◽  
Dna Sequences ◽  
Transcription Initiation ◽  
Molecular Mechanisms ◽  
Phosphorus Content ◽  
Spectroscopic Imaging ◽  
Electron Spectroscopic Imaging ◽  
Dna Backbone ◽  
Two Parameters ◽  
High Level

A multisubunit RNA polymerase enzyme is ultimately responsible for transcription initiation and elongation of RNA, but recognition of the proper start site by the enzyme is regulated by general, temporal and gene-specific trans-factors interacting at promoter and enhancer DNA sequences. To understand the molecular mechanisms which precisely regulate the transcription initiation event, it is crucial to elucidate the structure of the transcription factor/DNA complexes involved. Electron spectroscopic imaging (ESI) provides the opportunity to visualize individual DNA molecules. Enhancement of DNA contrast with ESI is accomplished by imaging with electrons that have interacted with inner shell electrons of phosphorus in the DNA backbone. Phosphorus detection at this intermediately high level of resolution (≈lnm) permits selective imaging of the DNA, to determine whether the protein factors compact, bend or wrap the DNA. Simultaneously, mass analysis and phosphorus content can be measured quantitatively, using adjacent DNA or tobacco mosaic virus (TMV) as mass and phosphorus standards. These two parameters provide stoichiometric information relating the ratios of protein:DNA content.

The role of transcription factor Egr‐1 in IL‐1 up‐regulation of tubular CD44 expression

Nephrology ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. A92-A92
Author(s):  
Takazoe K ◽  
Foti R ◽  
Hurst La ◽  
Atkins Rc ◽  
Nikolic‐Paterson DJ.
Keyword(s):  
Transcription Factor ◽  
Cd44 Expression
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