Past, Present and Future? of Colorectal Cancer Epidemiology and Clinical Study in Misan

Background: Colorectal carcinoma is commonest cancer of GIT. It is represent third cancer in man worldwide beyond lung and prostate cancers. It is fourth cancer in woman beyond breast, lung and uterus cancers. Deaths from colorectal cancer is more in compare with other GIT cancers. The study aimed to determine epidemiological and clinical data of colorectal cancer in Misan province.Methods: Our study conducted in Misan province, Iraq. The data were collected from 2013 to 2016. Seventy one patients that found have colorectal cancer. An epidemiological, clinical and descriptive study perform which included frequency of gender, age, residency, site of cancer, family history, past history, year of onset, smoking history, alcohol intake, presentation of cancer at time of diagnosis, staging and histopathology pattern in relation to colorectal cancer.Results: Overall prevalence of colon and rectum carcinoma is 3.75%. The most age group affected was 51-60 years as 30.99%. The gender and residency of patients have no effect on cancer percent. Obesity, Family history, cigarette smoking and alcohol consumption represented risk factors for colorectal cancer. In 42.25% of patients had family history of cancer. Most common site of colorectal carcinoma was left colon, which present in 61.97%. Conclusion: There was slight increase in new cases detection of colorectal carcinoma from 2013 to 2016. Advanced stages of colorectal cancer were most common stages description as stage IIIA, IIIB, IIIC and stage IV in 12.67%, 16.90%, 19.72% and 15.49% respectively. The common histopathological pattern of colorectal cancer was moderately differentiated adenocarcinoma as 53.52%.

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Undiagnosed Esophageal Adenocarcinoma Presenting as Multiple Brain Metastases

Case Reports in Oncology ◽

10.1159/000481306 ◽

2017 ◽

Vol 10 (3) ◽

pp. 938-944 ◽

Cited By ~ 1

Author(s):

Vincent Grzywacz ◽

Ernie Balcueva

Keyword(s):

Brain Metastases ◽

Esophageal Adenocarcinoma ◽

Poor Prognosis ◽

Past History ◽

Performance Status ◽

Stage Iv ◽

Smoking History ◽

Gastrointestinal Malignancies ◽

Head Ct ◽

History Of

Brain metastases from gastrointestinal malignancies are exceedingly rare occurrences that carry a very poor prognosis. This holds especially true in cases where brain metastases from esophageal primaries are the initial presentation of a previously unidentified gastrointestinal malignancy. Our patient, a 60-year-old male with a past history of a right temporal teratoma, family history of breast cancer, and no smoking history, presented with a chief complaint of recurrent headaches. His history of present illness and physical examination included a two-month history of frontal headache, progressive fatigue, and unintentional weight loss. He underwent an extensive initial workup including CT-head, CT-abdomen/pelvis, CT-chest, bone scan, tumor marker analysis, and MRI-brain. The initial head CT revealed multiple intracranial lesions suspicious for malignancy. A PET scan later revealed his primary to be a malignancy of the distal esophagus. His treatment course thus far has been aggressive, consisting of surgical resection, systemic chemotherapy with capcetibine-oxaliplatin as well as paclitaxel-carboplatin, and radiation therapy. He has had several recurrences since starting treatment, but has continued to maintain a good performance status with only minor symptoms. Currently, the patient has survived for 17 months after his diagnosis of stage IV (T3, N2, M1) moderately differentiated adenocarcinoma and is undergoing treatment with trastuzumab and stereotactic radiosurgery. This report demonstrates that although cases of esophageal adenocarcinoma that present as brain metastases typically carry a poor prognosis, with early and aggressive treatment patients can survive well past one year after diagnosis.

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Importance of Family History of Colorectal Carcinoma In Situ Versus Invasive Colorectal Cancer: A Nationwide Cohort Study

Journal of the National Comprehensive Cancer Network ◽

10.6004/jnccn.2021.7004 ◽

2021 ◽

pp. 1-6

Author(s):

Yu Tian ◽

Elham Kharazmi ◽

Hermann Brenner ◽

Xing Xu ◽

Kristina Sundquist ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Colorectal Carcinoma ◽

Carcinoma In Situ ◽

Cumulative Risk ◽

First Degree Relatives ◽

Younger Age ◽

Increased Risk ◽

History Of

Background: The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. Patients and Methods: We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for changes during the follow-up period from 1958 to 2015. Of 12,829,251 individuals with available genealogical data, 173,796 were diagnosed with CRC and 40,558 with CCIS. Results: The lifetime (0–79 years) cumulative risk of CRC in first-degree relatives of patients with CCIS was 6.5%, which represents a 1.6-fold (95% CI, 1.5–1.7; n=752) increased risk. A similarly increased lifetime cumulative risk (6.7%) was found among first-degree relatives of patients with CRC (SIR, 1.6; 95% CI, 1.6–1.7; n=6,965). An increased risk of CRC was also found in half-siblings of patients with CCIS (SIR, 1.9; 95% CI, 1.1–3.0; n=18) and also in half-siblings of patients with CRC (SIR, 1.7; 95% CI, 1.3–2.1; n=78). Moreover, the increased risk of CRC was higher for younger age at diagnosis of CCIS in the affected first-degree relative and for younger age at diagnosis of CRC in the index person. Conclusions: Results of this study show that first-degree relatives and half-siblings of patients with CCIS have an increased risk of CRC, which is comparable in magnitude to the risk of those with a family history of invasive CRC. These findings extend available evidence on familial risk of CRC and may help to refine guidelines and recommendations for CRC screening.

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Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities

International Journal of Molecular Medicine ◽

10.3892/ijmm.2016.2666 ◽

2016 ◽

Vol 38 (3) ◽

pp. 687-702 ◽

Cited By ~ 1

Author(s):

Patrícia Silva ◽

Cristina Albuquerque ◽

Pedro Lage ◽

Vanessa Fontes ◽

Ricardo Fonseca ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

History Of ◽

Colon And Rectum ◽

Preferential Location

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Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Cells ◽

10.3390/cells10030631 ◽

2021 ◽

Vol 10 (3) ◽

pp. 631

Author(s):

Karin Alvarez ◽

Alessandra Cassana ◽

Marjorie De La Fuente ◽

Tamara Canales ◽

Mario Abedrapo ◽

...

Keyword(s):

Colorectal Cancer ◽

Family History ◽

Age Of Onset ◽

Late Onset ◽

Molecular Characteristics ◽

Family History Of Cancer ◽

Molecular Features ◽

Age Of Diagnosis ◽

History Of ◽

History Of Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51–69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan–Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.

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