scholarly journals Premature rupture of membranes in the second trimester of pregnancy (literature review)

2020 ◽  
pp. 102-105
Author(s):  
G.І. Ishchenko ◽  
◽  
О.А. Voloshyn ◽  
Keyword(s):  
Literature Review ◽  
Second Trimester ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture

scholarly journals Safety of vedolizumab in the treatment of pregnant women with inflammatory bowel disease: a targeted literature review

2020 ◽  
Vol 13 ◽  
pp. 175628482095259
Author(s):  
Birgit Terjung ◽  
Renate Schmelz ◽  
Robert Ehehalt ◽  
Jochen Klaus ◽  
Jana Knop ◽  
...  
Keyword(s):  
Literature Review ◽  
Pregnancy Outcomes ◽  
Placenta Previa ◽  
First Trimester ◽  
Decision Making Process ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Persistent Data ◽  
Inflammatory Bowel ◽  
Limited Scope

Background: Crohn’s disease (CD) and ulcerative colitis (UC) commonly affect women in their childbearing years. Vedolizumab (VDZ) is approved for treatment of moderate-to-severe CD and UC, but there is a knowledge gap regarding its use during pregnancy. This targeted literature review describes available evidence on safety of VDZ in pregnant patients in order to offer physicians a detailed and balanced view on persistent data during their decision-making process for an individualized treatment concept. Methods: The search included literature from the MEDLINE database and abstracts of five gastroenterological conferences published until November 2019. Publications were included if pregnancy outcomes in women receiving VDZ or neonatal outcomes in newborns of women previously exposed to VDZ were reported. Results: Out of 196 initially identified records, 18 publications reporting results of five different studies were identified. In total, for 213 of 284 VDZ-exposed documented pregnancies the following pregnancy outcomes were reported: 167 live births (172 infants due to twin births), 1 stillbirth, 35 miscarriages, 10 elective terminations (1 due to detected Down syndrome). Furthermore, during pregnancy, the following complications were observed: seven cases of (pre) eclampsia, three cases of premature rupture of membranes and one case each of placenta previa, chorioamnionitis, pneumonia, first-trimester bleeding, cholestasis, sepsis, or neonatal intraventricular hemorrhage. Based on 172 infants, 30 preterm deliveries (17.4%), 9 cases of low birth weight (5.2%), 5 infections (2.9%), and 6 cases (3.8%) with congenital anomalies were reported. Conclusion: There was no evidence for safety concerns regarding pregnancy outcomes associated with VDZ therapy. Due to the limited scope of included records, further research is needed to understand the safety profile regarding the use of VDZ during pregnancy.

scholarly journals Lactobacillus iners Is Associated with Vaginal Dysbiosis in Healthy Pregnant Women: A Preliminary Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Nengneng Zheng ◽  
Renyong Guo ◽  
Yinyu Yao ◽  
Meiyuan Jin ◽  
Yiwen Cheng ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Vaginal Microbiota ◽  
Second Trimester ◽  
Premature Rupture Of Membranes ◽  
Third Trimester ◽  
Premature Rupture ◽  
Significant Difference ◽  
Bacterial Marker ◽  
Preliminary Study ◽  
Adverse Pregnancy

Vaginal dysbiosis has been identified to be associated with adverse pregnancy outcomes, such as preterm delivery and premature rupture of membranes. However, the overall structure and composition of vaginal microbiota in different trimesters of the pregnant women has not been fully elucidated. In this study, the physiological changes of the vaginal microbiota in healthy pregnant women were investigated. A total of 83 healthy pregnant participants were enrolled, who are in the first, second, or third pregnancy trimester. Quantitative real-time PCR was used to explore the abundant bacteria in the vaginal microbiota. No significant difference in the abundance of Gardnerella, Atopobium, Megasphaera, Eggerthella, Leptotrichia/Sneathia, or Prevotella was found among different trimesters, except Lactobacillus. Compared with the first pregnancy trimester, the abundance of L. iners decreased in the second and third trimester while the abundance of L. crispatus was increased in the second trimester. Moreover, we also found that vaginal cleanliness is correlated with the present of Lactobacillus, Atopobium, and Prevotella and leukocyte esterase is associated with Lactobacillus, Atopobium, Gardnerella, Eggerthella, Leptotrichia/Sneathia, and Prevotella. For those whose vaginal cleanliness raised or leukocyte esterase became positive, the richness of L. iners increased, while that of L. crispatus decreased significantly. Our present data indicated that the altered vaginal microbiota, mainly Lactobacillus, could be observed among different trimesters of pregnancy and L. iners could be considered as a potential bacterial marker for evaluating vaginal cleanliness and leukocyte esterase.

scholarly journals Maternal exposure to ambient fine particulate matter and risk of premature rupture of membranes in Wuhan, Central China: a cohort study

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Kun Wang ◽  
Yu Tian ◽  
Huabo Zheng ◽  
Shengshuai Shan ◽  
Xiaofang Zhao ◽  
...  
Keyword(s):  
Cohort Study ◽  
Additive Model ◽  
Final Analysis ◽  
First Trimester ◽  
Maternal Exposure ◽  
Central China ◽  
Second Trimester ◽  
Premature Rupture Of Membranes ◽  
Third Trimester ◽  
Premature Rupture

Abstract Background The associations between maternal exposure to ambient PM2.5 during pregnancy and the risk of premature rupture of membranes (PROM) and preterm premature rupture of membranes (PPROM) are controversial. And no relevant study has been conducted in Asia. This study aimed to determine the association between maternal exposure to ambient PM2.5 during pregnancy and the risk of (P)PROM. Methods A cohort study including all singleton births in a hospital located in Central China from January 2015 through December 2017 was conducted. Multivariable logistic regression models, stratified analysis, generalized additive model, and two-piece-wise linear regression were conducted to evaluate how exposure to ambient PM2.5 during pregnancy is associated with the risks of PROM and PPROM. Results A total of 4364 participants were included in the final analysis, where 11.71 and 2.34% of births were complicated by PROM and PPROM, respectively. The level of PM2.5 exhibited a degree of seasonal variation, and its median concentrations were 63.7, 59.3, 55.8, and 61.8 μg/m3 for the first trimester, second trimester, third trimester, and the whole duration of pregnancy, respectively. After adjustment for potential confounders, PROM was positively associated with PM2.5 exposure (per 10 μg/m3) [Odds Ratio (OR) = 1.14, 95% Confidence Interval (CI), 1.02–1.26 for the first trimester; OR = 1.09, 95% CI, 1.00–1.18 for the second trimester; OR = 1.13, 95% CI, 1.03–1.24 for the third trimester; OR = 1.35, 95% CI, 1.12–1.63 for the whole pregnancy]. PPROM had positive relationship with PM2.5 exposure (per 10 μg/m3) (OR = 1.17, 95% CI, 0.94–1.45 for first trimester; OR = 1.11, 95% CI, 0.92–1.33 for second trimester; OR = 1.19, 95% CI, 0.99–1.44 for third trimester; OR = 1.53, 95% CI, 1.03–2.27 for the whole pregnancy) Positive trends between the acute exposure window (mean concentration of PM2.5 in the last week and day of pregnancy) and risks of PROM and PPROM were also observed. Conclusions Exposure to ambient PM2.5 during pregnancy was associated with the risk of PROM and PPROM.

LITERATUR REVIEW : FAKTOR PENYEBAB ASFIKSIA NEONATORUM

2011 ◽  
Vol 9 (2) ◽  
pp. 103-114
Author(s):  
Ditya Yankusuma Setiani
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Literature Review ◽  
Amniotic Fluid ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Asphyxia Neonatorum ◽  
Neonatal Asphyxia ◽  
Prolonged Labor ◽  
Meconium Stained Amniotic Fluid

Latar Belakang : Angka Kematian Bayi (AKB) merupakan indikator yang penting untuk mencerminkan keadaan derajat kesehatan di suatu masyarakat. Salah satu kejadian intrapartum yang memiliki kontribusi besar dalam kematian bayi baru lahir adalah asfiksia neonatorum. Asfiksia neonatorum adalah suatu kondisi yang terjadi ketika bayi tidak mendapatkan cukup oksigen selama proses kelahiran. Pengendalian faktor penyebab asfiksia neonatorum sangat penting dalam upaya menurunkan prevalensi terjadinya asfiksia neonatorum. Oleh karena itu perlu dilakukan studi literatur terkait faktor penyebab terjadinya asfiksia neonatorum. Tujuan Penelitian : Mengetahui faktor penyebab terjadinya asfiksia neonatorum. Metode Penelitian : Desain penelitian adalah literatur review. Populasi penelitian ini adalah seluruh artikel hasil penelitian tentang faktor penyebab terjadinya asfiksia neonatorum. Hasil : Hasil literatur review dari lima artikel menunjukkan bahwa faktor penyebab asfiksia neonatorum terdiri dari cairan ketuban dengan pewarnaan meconium, BBLR (Berat Badan Lahir Rendah), persalinan lama, operasi Caesar, ketuban pecah dini, ibu primipara, persalinan rumit, cairan ketuban yang bernoda darah, ibu berumur ? 35 tahun, primigravida, tali pusat ketat, gawat janin intrapartum, malpresentasi janin, dilahirkan melalui rute vagina dengan bantuan vakum, dilahirkan pada malam hari dan dilahirkan dengan bantuan dokter magang sendiri. Kesimpulan : berdasarkan review dari literatur ini dapat disimpulkan bahwa cairan ketuban bernoda meconium, BBLR, persalinan lama dan ketuban pecah dini merupakan faktor penyebab asfiksia neonatorum yang memiliki pengaruh lebih besar.   Kata Kunci : Asfiksia Neonatorum, Faktor Penyebab   REVIEW LITERATURE: FACTORS CAUSING THE OCCURRENCE OF ASPHYXIA NEONATORUM   Ditya Yankusuma Setiani, Lilik Sriwiyati   ABSTRACT Background : Infant Mortality Rate (IMR) is an important indicator to reflect the state of health status in a society. One of the intrapartum events that has a large contribution to the death of newborns is neonatal asphyxia. Asphyxia neonatorum is a condition that occurs when the baby does not get enough oxygen during the birth process. Therefore, controlling the factors that cause neonatal disease is very important in aneffort to reduce the prevalence of neonatal asphyxia. Objectives : To determine the factors causing the incidence of neonatal asphyxia. Methode : The research design of this scientific paper is a literature review. The population of this study were all journals of research results on the factors causing the occurrence of asphyxia neonatorum. Results : The results of the literature review from the 5 journals show the causes of neonatal asphyxia consisting of meconium stained amniotic fluid, low birth weight (LBW), prolonged labor, caesarean section, premature rupture of membranes, primiparous mothers, complicated labor, fluids. Blood stained amniotic fluid, mother ? 35 years old, primigravida, tight umbilical cord, intrapartum fetal distress, fetal malpresentation, via vaginal route with vacuum assistance, assistance at night and assisting with the help of the interns themselves. Conclusion : This study can show that meconium stained amniotic fluid, low birth weight, prolonged labor and premature rupture of membranes are factors causing neonatal asphyxia which have a greater effect.   Keywords: Asphyxia Neonatorum, Causative Factor

scholarly journals Klebsiella pneumoniae Chorioamnionitis: An Underrecognized Cause of Preterm Premature Rupture of Membranes in the Second Trimester

2021 ◽  
Vol 9 (1) ◽  
pp. 96
Author(s):  
Maria Paola Bonasoni ◽  
Andrea Palicelli ◽  
Giulia Dalla Dea ◽  
Giuseppina Comitini ◽  
Paola Nardini ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Maternal Blood ◽  
Community Acquired Pneumonia ◽  
Etiologic Agent ◽  
Intestinal Lumen ◽  
Second Trimester ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Threatened Abortion

Klebsiella pneumoniae is a Gram-negative, rod-shaped bacterium, responsible for hospital and community acquired pneumonia, urinary tract and wound infections, and bloodstream dissemination. K. pneumoniae infection in pregnancy, leading to acute chorioamnionitis (AC), preterm premature rupture of membranes (PPROM) and early pregnancy loss in the second trimester, has been rarely reported. Herein, we present a case of K. pneumoniae AC that caused intrauterine fetal demise (IUFD) at 19 weeks + 5 days. The 36-year-old mother was admitted at 18 weeks + 1 day of gestation for threatened abortion. IUFD occurred 11 days after. Fetal postmortem showed severe AC and funisitis, neutrophils within alveoli and intestinal lumen, associated with rod-like bacteria. Fetal blood and lung cultures grew K. pneumoniae, β-lactamase-non-producing strain. Antibiogram revealed sensitivity for piperacillin/tazobactam. Three days after IUFD, the mother presented with fever (37.8 °C) which persisted for one week. Maternal blood and urine cultures were negative. According to fetal microbiological results, available 6 days after IUFD, initial treatment with amoxicillin/clavulanic acid was replaced with piperacillin/tazobactam with full patient recovery. Therefore, in the event of PPROM and IUFD, fetal microbiological investigations should always be performed to isolate the proper etiologic agent and start the correct medical treatment.

scholarly journals Second Trimester Fetal Loss Due to Citrobacter koseri Infection: A Rare Cause of Preterm Premature Rupture of Membranes (PPROM)

Diagnostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 159
Author(s):  
Maria Paola Bonasoni ◽  
Giuseppina Comitini ◽  
Mariangela Pati ◽  
Giuseppe Russello ◽  
Loredana Vizzini ◽  
...  
Keyword(s):  
Fetal Loss ◽  
Second Trimester ◽  
Maternal Transmission ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Preterm Premature Rupture ◽  
Abdominal Organs ◽  
First Case ◽  
The Family ◽  
Severe Infections

Citrobacter koseri is a facultative anaerobic, motile, non-spore-forming Gram-negative bacillus, which belongs to the family of Enterobacteriaceae. Severe infections due to Citrobacter spp. have been reported in the urinary tract, respiratory airways, intra-abdominal organs, skin and soft tissue, eye, bone, bloodstream, and central nervous system. In newborns, C. koseri is a well-known cause of meningitis, cerebral abscesses, brain adhesions, encephalitis, and pneumocephalus. Infection can be acquired through vertical maternal transmission or horizontal hospital settings; however, in many cases, the source is unknown. Preterm premature rupture of membranes (PPROM), caused by C. koseri, has rarely been described. Herein, we describe a case of PPROM at 16 weeks and 3 days of gestation, leading to anhydramnios. The parents opted for legal termination of the pregnancy, as the prognosis was very poor. C. koseri was isolated postmortem from a placental subamniotic swab and parenchymal sample, as well as fetal blood and lung. To the best of our knowledge, this is the first case of early second-trimester PPROM in which C. koseri infection was demonstrated.

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