scholarly journals Rapid weight gain in early life is associated with severity of respiratory syncytial virus (RSV) bronchiolitis in children

2021 ◽  
Vol 49 (2) ◽  
pp. 23-30
Author(s):  
You Ree Kim ◽  
Hak Kyoun Cho ◽  
Eun Hye Lee ◽  
Yong-Sung Choi ◽  
Hoi Soo Yoon ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Weight Gain ◽  
Early Life ◽  
Clinical Course ◽  
Rapid Change ◽  
Normal Weight ◽  
Rapid Weight Gain ◽  
Normal Weight Gain ◽  
Syncytial Virus ◽  
Current Weight

Objectives: This study aimed to investigate whether rapid weight gain in early life was associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children.Methods: We retrospectively reviewed 190 patients (1–24 months) hospitalized for RSV bronchiolitis. Parameters of bronchiolitis severity were compared between rapid (change in weight z-score from birth >0.67, n = 65) and normal weight gain groups (n = 125). We assessed for correlations between bronchiolitis severity and weight gain. Linear regression was performed to predict for bronchiolitis severity based on weight gain, controlling for covariates. SPSS was used for statistical analyses.Results: The rapid weight gain group had longer mean durations of tachypnea (2.3±2.0 vs. 1.7±1.8 days, P = 0.027), wheezing (3.2±2.5 vs. 1.6±1.8 days, P < 0.001), and chest retractions (1.5±2.2 vs. 0.6±1.3 days, P = 0.007). Correlations of weight gain with tachypnea (r = 0.146), wheezing (r = 0.279), and chest retractions (r = 0.179) were statistically significant. Weight gain predicted for tachypnea (B = 0.485, P = 0.013) and wheezing (B = 0.846, P = 0.001) durations after adjusting for covariates of severity (age, sex, current weight, RSV type, coin-fection, recurrent bronchiolitis, hospital stay, fever, oxygen supplementation, maximal respi-ratory and heart rates, and laboratory indices).Conclusions: Our findings suggest an association between weight gain and severity of RSV bronchiolitis in young children. Weight gain was significantly associated with the durations of tachypnea and wheezing. The trajectory of weight gain in early life may play a significant role in the clinical course of RSV bronchiolitis.

scholarly journals A risk factor for early wheezing in infants: rapid weight gain

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Lijuan Yin ◽  
Ye Song ◽  
Yongfang Liu ◽  
Zehui Ye
Keyword(s):  
Risk Factor ◽  
Weight Gain ◽  
Birth Weight ◽  
Normal Weight ◽  
Rapid Weight Gain ◽  
Group Iii ◽  
Weight Growth ◽  
Group I ◽  
Rsv Infection ◽  
Syncytial Virus

Abstract Background The aim of this study was to investigate the correlation between rapid weight gain and early wheezing. Methods This study screened 701 infants with lower respiratory tract infection who were no more than 4 months from Jan 1st to Dec 31st in 2018. According to weight-for-age Z-value (WAZ), these infants were divided into the considerably slow weight gain group (group I), the normal weight gain group (group II) and the excessively rapid weight gain group (group III), respectively. The clinical characteristics, weight growth speeds and serum lipid levels were analyzed, and multivariable Logistic model was conducted to select significant variables. Results Our results showed that male (OR = 1.841, 95%CI: 1.233–2.751), family wheezing (OR = 5.118, 95%CI: 2.118–12.365), age (OR = 1.273, 95%CI: 1.155–1.403), eczema (OR = 2.769, 95%CI: 1.793–4.275), respiratory syncytial virus (RSV) infection (OR = 1.790, 95%CI: 1.230–2.604), birth weight (OR = 1.746, 95%CI: 1.110–2.746) and total cholesterol (TC) (OR = 1.027, 95%CI: 1.019–1.036) and ΔWAZ (OR = 1.182, 95%CI: 1.022–1.368) were associated with early wheezing. Results indicated that serum TC (P = 0.018) and ΔWAZ (P = 0.023) were positive correlation with wheezing days. Conclusion Besides male, family wheezing, age, eczema, RSV infection, birth weight and TC, the rapid weight growth as a risk factor should be concerned in the early wheezing infants.

Clinical course of hospitalised children infected with human metapneumovirus and respiratory syncytial virus

2006 ◽  
Vol 42 (4) ◽  
pp. 174-178 ◽  
Author(s):  
Brenda M Morrow ◽  
Mark Hatherill ◽  
Heidi EM Smuts ◽  
Jane Yeats ◽  
Richard Pitcher ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Clinical Course ◽  
Human Metapneumovirus ◽  
Syncytial Virus

scholarly journals A single immunization with CAF08 provides newborns with Th1-mediated protection against Respiratory Syncytial Virus infection

2021 ◽  
Author(s):  
Simon van Haren ◽  
Gabriel Kristian Pedersen ◽  
Azad Kumar ◽  
Tracy Ruckwardt ◽  
Syed Moin ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Respiratory Syncytial Virus ◽  
Early Life ◽  
T Helper 1 ◽  
Newborn Mice ◽  
Cross Presentation ◽  
Lectin Receptor ◽  
Syncytial Virus ◽  
Human Dendritic Cells

Abstract Respiratory Syncytial Virus (RSV) is a leading cause of morbidity and mortality in children, due in part to their distinct immune system, characterized by impaired induction of T-helper 1 (Th1)-immunity. Here we describe cationic adjuvant formulation (CAF)-08, a liposomal vaccine formulation tailored to induce Th1 immunity in early life via synergistic engagement of Toll-like Receptor 7/8 and the C-type lectin receptor Mincle. Quantitative phosphoproteomics applied to human dendritic cells revealed a key role for Protein Kinase C-δ for enhanced Th1 cytokine production in neonatal dendritic cells and identified signaling events resulting in antigen cross-presentation. In vivo, a single immunization at birth with CAF08-adjuvanted RSV pre-fusion antigen protected newborn mice from RSV infection through induction of antigen-specific CD8+ and Th1 cells. Overall, we describe a novel pediatric adjuvant formulation and characterize its mechanism of action providing a promising avenue for development of early life vaccines against RSV and other intracellular pathogens.

scholarly journals Metabolic Reprogramming of Nasal Airway Epithelial Cells Following Infant Respiratory Syncytial Virus Infection

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2055
Author(s):  
Andrew R. Connelly ◽  
Brian M. Jeong ◽  
Mackenzie E. Coden ◽  
Jacob Y. Cao ◽  
Tatiana Chirkova ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
Epithelial Cells ◽  
Early Life ◽  
Airway Epithelial Cells ◽  
Metabolic Reprogramming ◽  
Flux Analysis ◽  
Nasal Airway ◽  
Airway Epithelial ◽  
Rsv Infection ◽  
Syncytial Virus

Respiratory syncytial virus (RSV) is a seasonal mucosal pathogen that infects the ciliated respiratory epithelium and results in the most severe morbidity in the first six months of life. RSV is a common cause of acute respiratory infection during infancy and is an important early-life risk factor strongly associated with asthma development. While this association has been repeatedly demonstrated, limited progress has been made on the mechanistic understanding in humans of the contribution of infant RSV infection to airway epithelial dysfunction. An active infection of epithelial cells with RSV in vitro results in heightened central metabolism and overall hypermetabolic state; however, little is known about whether natural infection with RSV in vivo results in lasting metabolic reprogramming of the airway epithelium in infancy. To address this gap, we performed functional metabolomics, 13C glucose metabolic flux analysis, and RNA-seq gene expression analysis of nasal airway epithelial cells (NAECs) sampled from infants between 2–3 years of age, with RSV infection or not during the first year of life. We found that RSV infection in infancy was associated with lasting epithelial metabolic reprogramming, which was characterized by (1) significant increase in glucose uptake and differential utilization of glucose by epithelium; (2) altered preferences for metabolism of several carbon and energy sources; and (3) significant sexual dimorphism in metabolic parameters, with RSV-induced metabolic changes most pronounced in male epithelium. In summary, our study supports the proposed phenomenon of metabolic reprogramming of epithelial cells associated with RSV infection in infancy and opens exciting new venues for pursuing mechanisms of RSV-induced epithelial barrier dysfunction in early life.

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