scholarly journals Role of epicardial adipose tissue in the development of atrial fibrillation in hypertensive patients

2020 ◽  
Vol 19 (6) ◽  
pp. 2707
Author(s):  
V. I. Podzolkov ◽  
A. I. Tarzimanova ◽  
A. E. Bragina ◽  
K. K. Osadchiy ◽  
R. G. Gataulin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Odds Ratio ◽  
Multislice Computed Tomography ◽  
Comparison Group ◽  
Epicardial Adipose Tissue ◽  
Hypertensive Patients ◽  
Group I

Obesity is a progressing epidemic, the prevalence of which has doubled over the past 30 years. The distribution of adipose tissue is an important factor in predicting the risk of cardiovascular events. The most significant inflammatory activity is characteristic of epicardial adipose tissue (EAT), the role of which in the development of atrial fibrillation (AF) remains a subject of discussion.Aim. To study the effect of EAT size on the development of AF in hypertensive (HTN) patients.Material and methods. The study included 95 patients with HTN aged 38-72 years (mean age, 61,5±1,8 years), including 45 patients with paroxysmal AF (group I) and 50 patients in the comparison group (group II). In order to assess the severity of visceral obesity, all patients underwent a general examination and echocardiography. To determine the EAT volume, cardiac multislice computed tomography was performed.Results. Echocardiography revealed that the EAT thickness was significantly greater in hypertensive patients with paroxysmal AF than in the comparison group: 11,6±0,8 and 8,6±0,4 mm, respectively (p<0,001). According to cardiac multislice computed tomography, a significant increase in EAT volume was revealed in patients of group I (4,6±0,4 ml) compared with group II (3,5±0,25 ml) (p=0,019). In hypertensive patients with paroxysmal AF, a positive moderate relationship between the EAT volume and left atrial volume was revealed (r=0,7, p=0,022). Multivariate analysis showed that in hypertensive patients, EAT thickness >10 mm and volume >6 ml can serve as integral markers of the onset of paroxysmal AF.Conclusion. Integral markers of AF in hypertensive patients are an increase in the EAT thickness >10 mm (odds ratio, 4,1; 95% confidence interval, 1,1-5,6) and volume >6 ml (odds ratio 3,7; 95%, confidence interval 1,0-4,2).

scholarly journals Association of Epicardial Adipose Tissue with Essential Hypertension: A Meta-Analysis

2021 ◽  
Author(s):  
Xinyu Zou ◽  
Yingrui Li ◽  
Qiang She ◽  
Bin Liu
Keyword(s):  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Essential Hypertension ◽  
Odds Ratio ◽  
Observational Studies ◽  
Epicardial Adipose Tissue ◽  
Meta Analysis ◽  
Hypertensive Patients ◽  
New Information ◽  
Significant Difference

Abstract Background and aims: Increased epicardial adipose tissue (EAT) has been proposed as a risk factor for essential hypertension (EH). The aim of this study was to investigate the association of EAT with EH.Methods and results: PubMed, EMBASE, and Cochrane databases were systematically reviewed to identify relevant studies assessing the association of EAT thickness (EAT-t) and volume (EAT-v) with EH. There were 39 observational studies and 8,983 subjects included in the meta-analysis. The analysis indicated that hypertensive patients had a higher mean of EAT-t (SMD=0.64, 95% CI: 0.44-0.83, p<0.001) and EAT-v (SMD: 0.69, 95% CI:0.34-0.1.05, p<0.001) than normotensive individuals. Accordingly, we calculated pooled odds ratio (OR) and 95% confidence intervals (CI) for the association of EAT with EH, and the results showed that EAT-t (OR: 1.59, 95% CI: 1.09–2.33, P<0.001) and EAT-v (OR: 1.82, 95% CI: 1.33–2.19, P<0.001) were associated with essential hypertension. Additionally, higher mean of EAT-t (SMD=0.85, 95% CI=0.49-0.1.21, p<0.001) and EAT-v (SMD=0.83, 95% CI=0.31-1.34, p=0.002) were found in non-dipper hypertensive patients than those in dipper patients, but we didn’t find significant difference in EAT-t among patients with different grades of hypertension. We also investigated the association of EAT with complications in hypertensive patients, and the results showed that EAT was increased in patients with arteriosclerotic cardiovascular disease (ASCVD) or cardiac hypertrophy and dysfunction than those without. Conclusions: The increase in EAT was associated with the occurrence and complications of EH. The findings provide new information regarding the occurrence and complications of EH.

scholarly journals Association between Epicardial Adipose Tissue and Recurrence of Atrial Fibrillation after Ablation： A Propensity Score-Matched Analysis

2021 ◽  
Author(s):  
Min Yang ◽  
Wenrui Bao ◽  
Zhihan Xu ◽  
Le Qin ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Propensity Score ◽  
Odds Ratio ◽  
Epicardial Adipose Tissue ◽  
Cardiac Computed Tomography ◽  
Multiple Logistic Regression Analysis ◽  
Multiple Logistic Regression ◽  
Af Recurrence

Abstract Purpose: To assess the association between epicardial adipose tissue (EAT) index derived from cardiac computed tomography and atrial fibrillation (AF) recurrence after ablation by comparing with a propensity score matched non-recurrence AF patients.Methods: A total of 506 patients with AF recurrence and 174 patients without AF recurrence were enrolled in this retrospective study. Density and volume of total EAT surrounding the heart (Total-EAT) and EAT surrounding the left atrium（LA-EAT）were measured, propensity score matching(PSM) analyses were used to compare the outcomes of the two groups while controlling for confounders. Results: Total-EAT density (HU) value（-81.27±4.67 vs -84.05±3.84, P=0.000) and LA-EAT density (HU) value（-72.47±23.87 vs -78.83±3.81, P=0.001）were significantly higher in the patients with AF recurrence than in those without recurrence. LA-EAT density (HU) value was significantly higher than Total-EAT（-75.65±17.36 vs -82.66±4.49, P=0.000). In a multiple logistic regression analysis, a higher Total-EAT density (odds ratio: 1.09; 95% CI: 1.00 –1.19, p = 0.047) and LA-EAT density (odds ratio: 1.12; 95% CI: 1.03–1.23, p = 0.012) was significantly associated with the AF recurrence after adjusting for other risk factors. Conclusion: The LA-EAT density plays an important role in the AF recurrence after ablation. Assessment of LA-EAT density can improve ablation outcomes by refining patient selection.

scholarly journals Role of Epicardial Adipose Tissue in Atrial Fibrillation

2012 ◽  
Vol 76 (12) ◽  
pp. 2738-2739 ◽  
Author(s):  
Takeshi Soeki ◽  
Masataka Sata
Keyword(s):  
Atrial Fibrillation ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue
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