The Effects of a Combined Exercise Training on Serum Vitamin D Level and Cognitive Function in Frail Elderly Persons

Abstract Objective: to broaden knowledge about the factors associated with sarcopenia and frailty in elderly persons residing in the community. Method: an integrative systematic review based on the PRISMA recommendations was carried out, using articles published from 2012 to March 2017 in the PubMED, SciELO, Virtual Health Library, CINAHL and Springer electronic databases with the following descriptors: frail elderly, sarcopenia and etiology and their synonyms. The articles identified by the initial search strategy were independently assessed by two researchers, according to the eligibility criteria, and the articles selected were evaluated for methodological quality. Results: the results of this survey show that frailty may be associated with sarcopenia, low serum vitamin D levels, anemia, subclinical hyperthyroidism in men, while the greatest evolution in women was for osteoporosis. An association between sarcopenia and advanced age was also observed, with worsening quality of life, physical-functional capacity, nutritional status and comorbidities, as well as an increased risk of death in sarcopenic elderly persons. Conclusion: this systematic review showed that low serum levels of vitamin D are associated with frailty and factors that predispose this condition. It is therefore important to monitor the serum levels of this vitamin in the elderly population, and it is suggested that new studies are carried out related to supplements of this vitamin in frail elderly persons.

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The association of serum vitamin D levels with several cardiometabolic risk and aortic pulse wave velocity in elderly persons

European Geriatric Medicine ◽

10.1016/j.eurger.2014.01.004 ◽

2014 ◽

Vol 5 (4) ◽

pp. 238-241 ◽

Cited By ~ 1

Author(s):

S. Kutlay ◽

T. Atli ◽

I. Aydogan ◽

H. Tutkak ◽

G. Nergizoglu

Keyword(s):

Vitamin D ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Cardiometabolic Risk ◽

Pulse Wave ◽

Serum Vitamin ◽

Aortic Pulse Wave Velocity ◽

Elderly Persons ◽

Serum Vitamin D ◽

Vitamin D Levels

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Serum vitamin d concentrations are associated with falling and cognitive function in older adults

The journal of nutrition health & aging ◽

10.1007/s12603-012-0378-4 ◽

2012 ◽

Vol 16 (10) ◽

pp. 898-901 ◽

Cited By ~ 24

Author(s):

Amie Peterson ◽

N. Mattek ◽

A. Clemons ◽

G. L. Bowman ◽

T. Buracchio ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Cognitive Function ◽

Serum Vitamin ◽

Serum Vitamin D

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Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany

Journal of Alzheimer s Disease ◽

10.3233/jad-143219 ◽

2015 ◽

Vol 45 (4) ◽

pp. 1119-1126 ◽

Cited By ~ 12

Author(s):

Gabriele Nagel ◽

Florian Herbolsheimer ◽

Matthias Riepe ◽

Thorsten Nikolaus ◽

Michael D. Denkinger ◽

...

Keyword(s):

Older Adults ◽

Vitamin D ◽

Cognitive Function ◽

Serum Vitamin ◽

Population Based ◽

Population Based Study ◽

Serum Vitamin D

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Effects of Low-Intensity Combined Exercise Training on Body Composition, Metabolic Risk Factors and Cognitive Function in Old-Elderly Obese Women

Journal of Sport and Leisure Studies ◽

10.51979/kssls.2018.02.71.551 ◽

2018 ◽

Vol 71 ◽

pp. 551-560

Author(s):

Tae-Sung Lee ◽

Nan-Jeong Sim ◽

Ho-Seong Lee

Keyword(s):

Risk Factors ◽

Body Composition ◽

Cognitive Function ◽

Exercise Training ◽

Metabolic Risk Factors ◽

Metabolic Risk ◽

Obese Women ◽

Low Intensity ◽

Combined Exercise ◽

Combined Exercise Training

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IMPACT OF DIETARY FACTORS AND INFLAMMATION ON COGNITION AMONG OLDER ADULTS

Journal of Prevention of Alzheimer's Disease ◽

10.14283/jpad.2015.50 ◽

2015 ◽

pp. 1-7

Author(s):

E.P. Handing ◽

B.J. Small ◽

S.L. Reynolds ◽

N.B. Kumar

Keyword(s):

Older Adults ◽

Vitamin D ◽

Cognitive Function ◽

Cognitive Performance ◽

Serum Vitamin ◽

Plasma Homocysteine ◽

Dietary Factors ◽

Serum Folate ◽

Serum Vitamin D ◽

Age Related

OBJECTIVE: This study examined the influence of age, nutrition (as measured through food diaries and serum/plasma biomarkers) and inflammatory markers on cognitive performance in adults 60 years of age and older. DESIGN: A cross-sectional population based study, data from the National Health and Nutrition Examination Survey (NHANES; 2001-2002 wave). PARTICIPANTS: This study included 1,048 adults who had valid dietary data, blood biomarkers, were 60 years or older, completed the cognitive test, and had complete demographic information. METHOD: A series of regression models were used to examine the relationship between cognitive function as measured by the Digit Symbol Substitution Task (DSST), dietary factors/biomarkers and inflammation. Mediation analyses were then utilized to examine whether individual nutrients accounted for the relationships between age and DSST performance. RESULTS: Dietary fat intake, serum vitamin E, serum folate, serum iron, plasma homocysteine, and serum vitamin D were significantly associated with better DSST performance. Elevated fibrinogen and C-reactive protein, were significantly associated with poorer cognitive function, but did not remain statistically significant after controlling for age, gender, education, ethnicity, income, and total calorie intake. Serum vitamin D and plasma homocysteine accounted for a portion of age-related variance in DSST. Specifically, higher levels of vitamin D were related to better DSST performance, while higher homocysteine resulted in poorer cognitive performance. CONCLUSION: Diet and nutrition are important modifiable factors that can influence health outcomes and may be beneficial to remediate age-related declines in cognition. Adequate nutrition may provide a primary preventive approach to healthy aging and maintenance of cognitive functioning in older adults.

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The Role of Inflammatory Diet and Vitamin D on the Link between Periodontitis and Cognitive Function: A Mediation Analysis in Older Adults

Nutrients ◽

10.3390/nu13030924 ◽

2021 ◽

Vol 13 (3) ◽

pp. 924

Author(s):

João Botelho ◽

Yago Leira ◽

João Viana ◽

Vanessa Machado ◽

Patrícia Lyra ◽

...

Keyword(s):

Vitamin D ◽

Cognitive Function ◽

Cognitive Dysfunction ◽

Mediation Analysis ◽

Serum Vitamin ◽

Cognitive Test ◽

Digit Symbol Substitution Test ◽

Cognitive Tests ◽

Serum Vitamin D ◽

Vitamin D Levels

Patients suffering from periodontitis are at a higher risk of developing cognitive dysfunction. However, the mediation effect of an inflammatory diet and serum vitamin D levels in this link is unclear. In total, 2062 participants aged 60 years or older with complete periodontal diagnosis and cognitive tests from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 and 2013–2014 were enrolled. The Consortium to Establish a Registry for Alzheimer’s disease (CERAD) word learning subtest (WLT) and CERAD delayed recall test (DRT), the animal fluency test (AFT) and the digit symbol substitution test (DSST) was used. Dietary inflammatory index (DII) was computed via nutrition datasets. Mediation analysis tested the effects of DII and vitamin D levels in the association of mean probing depth (PD) and attachment loss (AL) in all four cognitive tests. Periodontitis patients obtained worse cognitive test scores than periodontally healthy individuals. DII was negatively associated with CERAD-WLT, CERAD-DRT, AFT and DSST, and was estimated to mediate between 9.2% and 36.4% of the total association between periodontitis with cognitive dysfunction (p < 0.05). Vitamin D showed a weak association between CERAD-DRT, AFT and DSST and was estimated to between 8.1% and 73.2% of the association between periodontitis and cognitive dysfunction (p < 0.05). The association between periodontitis and impaired cognitive function seems to be mediated both by a proinflammatory dietary load and vitamin D deficiency. Future studies should further explore these mediators in the periodontitis-cognitive decline link.

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