scholarly journals Soluble fractalkine in the plasma of fibromyalgia patients

2014 ◽  
Vol 86 (4) ◽  
pp. 1915-1917 ◽  
Author(s):  
JUAN J. GARCIA ◽  
EDUARDO ORTEGA
Keyword(s):  
Differential Diagnosis ◽  
Inflammatory Cytokines ◽  
Plasma Levels ◽  
Elevated Plasma ◽  
Lower Plasma ◽  
Healthy Women ◽  
Diagnostic Criterion

Fibromyalgia is a form of non-articular rheumatism in which inflammatory cytokines seem to be involved. However, there is still no analytical specific diagnostic criterion for this disease. The aim was to examine a possible role of fractalkine as a biomarker in fibromyalgia. Plasma levels of soluble fractalkine were compared between women diagnosed with fibromyalgia (n=17) and healthy women (n=10) as controls. Fractalkine released by monocytes was also evaluated. Fibromyalgia patients showed lower plasma fractalkine than healthy women. Since most inflammatory pathologies show elevated plasma levels of soluble fractalkine, the results may contribute towards a differential diagnosis for fibromyalgia.

A HORMONAL ASSESSMENT OF BOVINE PARTURIENT PARESIS: EVIDENCE FOR A ROLE OF OESTROGEN

1981 ◽  
Vol 88 (2) ◽  
pp. 161-171 ◽  
Author(s):  
B. W. HOLLIS ◽  
H. H. DRAPER ◽  
J. H. BURTON ◽  
R. J. ETCHES
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Plasma Levels ◽  
Post Partum ◽  
Comparative Assessment ◽  
Hormonal Control ◽  
Elevated Plasma ◽  
Calcium Phosphorus ◽  
Parturient Paresis

A comparative assessment was made of the hormonal control of calcium homeostasis in eight dairy cows which developed parturient paresis and in seven normal animals from the same herd. Plasma levels of calcium, phosphorus, magnesium, free hydroxyproline, 25-hydroxycholecalciferol (25-OHD), 1,25-dihydroxycholecalciferol (1,25-(OH)2D), parathyroid hormone, calcitonin, prolactin and oestrogen were monitored from 30 days prepartum to 15 days post partum. Prepartum levels of plasma calcium, hydroxyproline and calcitonin were depressed in the paretic animals, and plasma levels of phosphorus and oestrogen were elevated. Plasma levels of 25-OHD remained stable in both groups, whereas levels of 1,25-(OH)2D, parathyroid hormone and prolactin rose sharply at parturition. Plasma hydroxyproline, an index of bone resorption, began to rise 2 days prepartum in the control cows but not until 2 days post partum in the paretic cows. The data indicate that bone resorption was inhibited in the paretic group at the onset of lactation, and that a decreased capacity for bone resorption is a major factor in the susceptibility of some cows to this disease. The failure of the paretic animals to resorb bone was not associated with an inability to synthesize the calcium-mobilizing hormones parathyroid hormone or 1,25-(OH)2D, or to regulate the production of calcitonin. However, hypocalcaemia in the affected animals was associated with a significantly higher plasma level of oestrogen (a known inhibitor of bone resorption) in the immediate prepartum period. Following parturition, plasma levels of oestrogen fell rapidly and active bone resorption ensued in the paretic animals.

The Role of SDF-1/CXCR4 in the Procession of Auto-Stem Cell Transplantation of Multiply Myeloma Patients.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 5150-5150
Author(s):  
Caixia Li ◽  
De Pei Wu ◽  
Xue Guang Zhang
Keyword(s):  
Stem Cell ◽  
Plasma Levels ◽  
Peripheral Blood Stem Cell ◽  
Cxcr4 Expression ◽  
Lower Plasma ◽  
Cxcr4 Receptor ◽  
Cd34 Cells ◽  
The Mean ◽  
Poor Mobilizers

Abstract CXCR4, receptor of the chemokine stromal derived factor-1 (SDF-1), is expressed on CD34+ cells, and has been implicated in the process of CD34+ cell migration and homing. We studied the mobilization of CD34/CXCR4 cells and the plasma levels of SDF-1 and sgp130 in 22 patients, 11 acute Leukemia, 5 non-Hodgkin’s lymphoma, and 6 multiply myloma respectably, receiving cyclophosphamide (Cy) and plus G-CSF, or Mitoxantrone(Mit) and Cytarabine plus G-CSF for peripheral blood stem cell (PBSC) mobilization and autotransplantation. We observed lower plasma levels of SDF-1 in PBSCs compared with premobilized PB and bone marrow samples. The average levels of SDF-1 and sgp130 were 24.67±5.58ng/ml and 106.2±16.4ng/ml respectively while the level of SDF-1 as well as sgp130 decreased to 14659±2.11ng/ml(p<0.05)and 58.8±29.1ng/ml(p<0.05) respectively on day when PBSC was collected after mobilization. SDF-1 levels in the apheresis collections of the “good mobilizers” (patients who collected a minimum of 2 × 106 CD34+ cells/kg in one to three PBSC collections) were significantly lower than the apheresis collections of the “poor mobilizers” (<2 × 106 CD34+ cells/kg in the three cycles of PBSC collections; 14.82 ± 7.08 ng/ml versus 27.2 ± 8.13 ng/ml; p<0.01). The mean percentage of CD34+ cells expressing CXCR4 in the apheresis collections was decreased in the PBSC collections compared with premobilization values ranging from 32.09±5.39% to 22.4±5.92%. But the mean CXCR4 expression on CD34+ cells of the good mobilizers was not different from the expression on CD34+ cells of poor mobilizers. Furthermore, the levels of sgp130 closely correlated with SDF-1 levels (r = 0.87; p < 0.001); the plasma level of SDF-1 and expression of CXCR4 on the CD34+ cells were gradually decreased in the PB of patients during the procession of mobilization; low plasma levels of SDF-1 turned out with good mobilization outcome, and the levels of SDF-1 correlated with sgp130, suggesting an association of these cytokines in mobilization of CD34+ cells.

Abstract 235: Plasma Levels of Cyclophilin A Correlate with Circulating Inflammatory Cytokines in Patients with Pulmonary Hypertension

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Tomohiro Otsuki ◽  
Kimio Satoh ◽  
Nobuhiro Kikuchi ◽  
Junichi Omura ◽  
Shun Kudo ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Smooth Muscle ◽  
Growth Factors ◽  
Smooth Muscle Cells ◽  
Inflammatory Cytokines ◽  
Plasma Levels ◽  
Cyclophilin A ◽  
Muscle Cells ◽  
Circulating Cytokines

Background: Excessive proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (PASMCs) are key characteristics of pulmonary vascular remodeling in patients with pulmonary hypertension (PH). The mechanisms of pathophysiological changes in PH are not fully investigated. Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells (VSMCs) in response to several stimuli, including oxidative stress, mechanical stretch and hypoxia. Extracellular CyPA and its receptor Basigin induce secretion of growth factors and inflammatory cytokines from VSMCs. Additionally, plasma CyPA levels predict poor outcome in patients with PH. In this study, we examined the correlations between plasma CyPA levels and circulating cytokines/chemokines and growth factors in PH patients. Methods and Results: In consecutive 176 patients undergoing right heart catheterization, we examined the relationship between plasma CyPA and inflammatory cytokines/chemokines and growth factors. We used ELISA for CyPA measurement and Bio-Plex system for measurement of inflammatory cytokines/chemokines and growth factors. Plasma CyPA levels in PH patients increased according to their severity assessed by pulmonary vascular resistance (P<0.001). A positive correlation was noted between plasma CyPA levels and several inflammatory cytokines/chemokines and growth factors, including CXCL1 (P<0.001), CXCL9 (P=0.001), macrophage colony-stimulating factor (P=0.020), SDF-1α (P=0.005) and PDGF-BB (P=0.003). Interestingly, there was a significant correlation between plasma levels of CyPA and those of LDL-cholesterol (P=0.003) or HbA1c (P=0.006). In contrast, there was no correlation between CyPA and high-sensitivity CRP (P=0.172). Finally, plasma levels of CyPA and SDF-1α were significantly less in patients with statins (both P<0.01). Conclusions: Plasma levels of CyPA are correlated with those of circulating cytokines/chemokines and growth factors, suggesting an inflammatory role of CyPA in PH patients. These data further support the crucial role of CyPA as a pathogenic molecule and a therapeutic target in PH.

scholarly journals The role of cardiovascular autonomic failure in the differential diagnosis of α-synucleinopathies

2021 ◽  
Author(s):  
Fabian Leys ◽  
Gregor K. Wenning ◽  
Alessandra Fanciulli
Keyword(s):  
Nervous System ◽  
Differential Diagnosis ◽  
Autonomic Failure ◽  
Diagnostic Yield ◽  
Lewy Bodies ◽  
Motor Symptom ◽  
Adult Onset ◽  
Lesion Pattern ◽  
Diagnostic Criterion

AbstractThe α-synucleinopathies comprise a group of adult-onset neurodegenerative disorders including Parkinson’s disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB,) and — as a restricted non-motor form — pure autonomic failure (PAF). Neuropathologically, the α-synucleinopathies are characterized by aggregates of misfolded α-synuclein in the central and peripheral nervous system. Cardiovascular autonomic failure is a common non-motor symptom in people with PD, a key diagnostic criterion in MSA, a supportive feature for the diagnosis of DLB and disease-defining in PAF. The site of autonomic nervous system lesion differs between the α-synucleinopathies, with a predominantly central lesion pattern in MSA versus a peripheral one in PD, DLB, and PAF. In clinical practice, overlapping autonomic features often challenge the differential diagnosis among the α-synucleinopathies, but also distinguish them from related disorders, such as the tauopathies or other neurodegenerative ataxias. In this review, we discuss the differential diagnostic yield of cardiovascular autonomic failure in individuals presenting with isolated autonomic failure, parkinsonism, cognitive impairment, or cerebellar ataxia.

Role of the Splanchnic Bed in Extracting Circulating Adrenaline and Noradrenaline in Normal Subjects and in Patients with Cirrhosis of the Liver

1984 ◽  
Vol 67 (1) ◽  
pp. 45-49 ◽  
Author(s):  
U. Keller ◽  
P. P. G. Gerber ◽  
F. R. Bühler ◽  
W. Stauffacher
Keyword(s):  
Plasma Levels ◽  
Plasma Catecholamines ◽  
Normal Subjects ◽  
Cirrhosis Of The Liver ◽  
Elevated Plasma ◽  
Cirrhotic Patients ◽  
Arterial Plasma ◽  
Fractional Uptake ◽  
Noradrenaline Levels

1. Splanchnic extraction rates of adrenaline and noradrenaline were determined in seven normal subjects and in nine patients with cirrhosis of the liver using arterial-hepatic venous catherization. 2. Both catecholamines were effectively removed when the blood passed through the splanchnic area: splanchnic fractional uptake of adrenaline in normal subjects was 90 ± 3%, and lower for noradrenaline, 68 ± 4% (P < 0.001). Net splanchnic extraction rates were higher for noradrenaline (126 ± 16 ng/min) than for adrenaline (40 ± 10 ng/min, P < 0.001), probably due to the higher arterial plasma levels of noradrenaline. 3. Resting arterial adrenaline and noradrenaline levels were significantly higher in cirrhotic patients than in normal subjects (adrenaline: 121 ± 27 vs 54 ± 8 pg/ml, P < 0.05; noradrenaline: 678 ± 89 vs 251 ± 26 pg/ml, P < 0.005). Net splanchnic catecholamine uptake was increased in cirrhotic patients. 4. The results demonstrate that the splanchnic bed in normal and cirrhotic subjects extracts plasma catecholamines efficiently; they suggest that elevated plasma catecholamines in cirrhosis are not the result of impaired splanchnic catecholamine removal.

scholarly journals Elevated plasma levels of α2-plasmin inhibitor–plasmin complex in patients with rheumatic diseases. Possible Role of Fibrinolytic Mechanism in Vasculitis

1989 ◽  
Vol 32 (11) ◽  
pp. 1427-1433 ◽  
Author(s):  
Makoto Kawakami ◽  
Mitsuhiro Kawagoe ◽  
Masayoshi Harigai ◽  
Masako Hara ◽  
Tatsuo Hirose ◽  
...  
Keyword(s):  
Rheumatic Diseases ◽  
Plasma Levels ◽  
Elevated Plasma ◽  
Plasmin Inhibitor
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