The effect of vitamin D on cognitive functions in young female patients: a prospective controlled study using the Montreal Cognitive Assessment

ABSTRACT Aim: Our aim was to determine whether there is a relationship between vitamin D [25(OH)D] and cognitive functioning in women with low 25(OH)D levels. Methods: Ninety female patients, 25-45 years of age, who attended our outpatient clinic and had 25(OH)D levels < 30 ng/mL, were included. The Montreal Cognitive Assessment (MoCA) scale was used to determine cognitive functioning; the scale is divided into seven subgroups. Patients were divided into three subgroups according to their 25(OH)D levels. After a three-month period of 25(OH) D replacement, the patients underwent a re-evaluation using the MoCA scale. Results: The total MoCA score before treatment was significantly different from the score after treatment (p < 0.05). Language and delayed recall functions were significantly different before and after treatment (p < 0.05). Conclusion: Vitamin D levels were related to cognitive functioning in our study group.

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Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment

Nutrients ◽

10.3390/nu12123873 ◽

2020 ◽

Vol 12 (12) ◽

pp. 3873

Author(s):

Alexandra Povaliaeva ◽

Ekaterina Pigarova ◽

Artem Zhukov ◽

Viktor Bogdanov ◽

Larisa Dzeranova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Vitamin D ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Controlled Study ◽

Affinity Constant ◽

Vitamin D Metabolites ◽

Vitamin D Metabolism ◽

Vitamin D Levels

In this prospective controlled study, we examined 25 adults with adequately controlled (HbA1c level < 8.0%) type 1 diabetes mellitus (T1DM) and 49 conditionally healthy adults, intending to reveal the diversity of vitamin D metabolism in the setting of cholecalciferol intake at a therapeutic dose. All patients received a single dose (150,000 IU) of cholecalciferol aqueous solution orally. Laboratory assessments including serum vitamin D metabolites (25(OH)D3, 25(OH)D2, 1,25(OH)2D3, 3-epi-25(OH)D3 and 24,25(OH)2D3), free 25(OH)D, vitamin D-binding protein (DBP) and parathyroid hormone (PTH) as well as serum and urine biochemical parameters were performed before the intake and on Days 1, 3 and 7 after the administration. The studied groups had no significant differences in baseline parameters except that the patients with diabetes showed higher baseline levels of free 25(OH)D (p < 0.05). They also lacked a correlation between the measured and calculated free 25(OH)D in contrast to the patients from the control group (r = 0.41, p > 0.05 vs. r = 0.88, p < 0.05), possibly due to the glycosylation of binding proteins, which affects the affinity constant for 25(OH)D. The elevation of vitamin D levels after the administration of cholecalciferol was comparable in both groups, with slightly higher 25(OH)D3 levels observed in the diabetes group throughout the study since Day 1 (p < 0.05). Overall, our data indicate that in patients with adequately controlled T1DM 25(OH)D3 levels and the therapeutic response to cholecalciferol is similar to that in healthy individuals.

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Prevalence and Correction of 25(OH) Vitamin D Deficiency in Peritoneal Dialysis Patients

Peritoneal Dialysis International ◽

10.1177/089686080502500411 ◽

2005 ◽

Vol 25 (4) ◽

pp. 362-366 ◽

Cited By ~ 61

Author(s):

Nirav Shah ◽

Judith Bernardini ◽

Beth Piraino

Keyword(s):

Vitamin D ◽

Peritoneal Dialysis ◽

Calcium Phosphate ◽

Vitamin D Deficiency ◽

Muscle Weakness ◽

Serum Calcium ◽

Bone Pain ◽

Vitamin D Levels ◽

Before And After ◽

25 Oh Vitamin D

Background Peritoneal dialysis (PD) patients are at risk for 25(OH) vitamin D deficiency due to effluent loss in addition to traditional risk factors. Objectives To measure 25(OH) vitamin D deficiency in prevalent PD patients, to evaluate a replacement dose, and to determine the effects of correction. Methods 25(OH) vitamin D levels were drawn on prevalent PD patients. Patients deficient in 25(OH) vitamin D were given ergocalciferol, 50 000 IU orally once per week for 4 weeks. Patients scored muscle weakness, bone pain, and fatigue on a scale of 0 (none) to 5 (severe). Serum calcium, phosphate, parathyroid hormone (PTH), and 25(OH) vitamin D, and 1,25(OH)2 vitamin D levels were obtained before and after treatment. Results 25(OH) vitamin D levels were measured in 29 PD patients. Deficiency (<15 ng/mL) was found in 28/29 (97%); 25/29 (86%) had undetectable levels (<7 ng/mL). One course of ergocalciferol corrected the deficiency in all but 1 patient, who required a second course. Scores for muscle weakness and bone pain fell from pre- to posttreatment ( p < 0.001). 1,25(OH)2 vitamin D levels rose post ergocalciferol (from 20 to 26 pg/mL, n = 20, p = 0.09). Serum calcium, phosphate, and PTH levels did not change with ergocalciferol. Conclusions Most PD patients had marked 25(OH) vitamin D deficiency, which was readily and safely corrected with one course of 50000 IU ergocalciferol, having no effect on serum calcium, phosphorus, or PTH, but complaints of muscle weakness and bone pain decreased. A prospective, placebo-controlled double-blinded study is needed to determine whether replacement of 25(OH) vitamin D is beneficial in PD patients.

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A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D)

Endocrine Connections ◽

10.1530/ec-17-0045 ◽

2017 ◽

Vol 6 (4) ◽

pp. 225-231 ◽

Cited By ~ 6

Author(s):

R Perchard ◽

L Magee ◽

A Whatmore ◽

F Ivison ◽

P Murray ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

South Asian ◽

Negative Relationship ◽

Late Winter ◽

Vitamin D Levels ◽

Significant Difference ◽

Before And After ◽

The Impact

Background Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c. Aims (1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c. Methods Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level <50 nmol/L were treated with a one-off cholecalciferol dose of 100,000 (2–10 years) or 160,000 (>10 years) units. HbA1c levels before and after treatment were recorded. Results Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = −0.484, P < 0.01). In treated participants, there was no significant difference in mean HbA1c at 3 months (t = 1.010, P = 0.328) or at 1 year (t = −1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level. Conclusion We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required.

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Vitamin D levels and trabecular bone remodelling before and after surgery for medullary thyroid carcinoma

Acta Endocrinologica ◽

10.1530/acta.0.1060346 ◽

1984 ◽

Vol 106 (3) ◽

pp. 346-349 ◽

Cited By ~ 7

Author(s):

K. Emmertsen ◽

F. Melsen ◽

L. Mosekilde ◽

Bi. Lund ◽

Bj. Lund ◽

...

Keyword(s):

Vitamin D ◽

Thyroid Carcinoma ◽

Trabecular Bone ◽

Medullary Thyroid Carcinoma ◽

Bone Remodelling ◽

Vitamin D Metabolism ◽

Medullary Thyroid ◽

Number Of Patients ◽

Vitamin D Levels ◽

Before And After

Abstract. We previously reported increased mean serum 1,25-dihydroxyvitamin D (1,25-(OH)2D) and increased trabecular bone remodelling in patients with medullary thyroid carcinoma (MCT) and hypercalcitoninaemia. In the present paper we report that serum 1,25-(OH)2D and trabecular bone remodelling decreased following surgical cure for MCT and hypercalcitoninaemia in 4 patients despite no detectable post-surgical hypoparathyroidism or hypothyroidism. The results obtained in the present small number of patients suggest that the altered vitamin D metabolism and trabecular bone remodelling in patients with MCT is caused by the hypercalcitoninaemia.

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Levothyroxine Therapy Adequacy, Dose Estimation and Vitamin D Effect Assessment in a Sample of Iraqi Female Patients with Different Causes of Hypothyroidism

Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) ◽

10.31351/vol29iss2pp245-252 ◽

2020 ◽

Vol 29 (2) ◽

pp. 245-252

Author(s):

Ban A. Al-Shimmran ◽

Zinah M. Anwer ◽

Bassam H. Al-Jarrah

Keyword(s):

Vitamin D ◽

Vitamin D Supplementation ◽

Clinical Settings ◽

Dose Estimation ◽

Thyroid Status ◽

Female Patients ◽

Before And After ◽

Secondary Objective ◽

Dose Modulation

Exogenous levothyroxine dose modulation and euthyroidism achievement is a persistent challenge in clinical settings. This study strives to assess the adequacy of treatment and identify the patients’ factors that can be used to estimate the euthyroid levothyroxine dose. A secondary objective was to assess vitamin D supplementation impact on thyroid status. A review of a prospectively collected information from 142 female patients from Baghdad Center of Nuclear Medicine from June 2019 until March 2020 who were receiving levothyroxine for different causes was done. After a follow-up period, the patients’ thyroid tests were assessed and the euthyroid doses for each cause category were statistically analyzed. Thyroid function was assessed before and after three months of vitamin D supplementation for 29 out of 50 patients who measured its level. Sixty-six patients (47%) of the sample were inadequately replaced

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Montreal Cognitive Assessment Delayed Recall Test

10.32388/e663oo ◽

2020 ◽

Author(s):

Keyword(s):

Cognitive Assessment ◽

Recall Test ◽

Montreal Cognitive Assessment ◽

Delayed Recall

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Serum vitamin D levels are decreased and associated with thyroid volume in female patients with newly onset Graves’ disease

Endocrine ◽

10.1007/s12020-012-9679-y ◽

2012 ◽

Vol 42 (3) ◽

pp. 739-741 ◽

Cited By ~ 47

Author(s):

Tetsuyuki Yasuda ◽

Yasuyuki Okamoto ◽

Noboru Hamada ◽

Kazuyuki Miyashita ◽

Mitsuyoshi Takahara ◽

...

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Thyroid Volume ◽

Graves Disease ◽

Female Patients ◽

Serum Vitamin D ◽

Vitamin D Levels

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Vitamin D Levels in Patients with Colorectal Cancer Before and After Treatment Initiation

Journal of Gastrointestinal Cancer ◽

10.1007/s12029-018-0147-7 ◽

2018 ◽

Vol 50 (4) ◽

pp. 769-779 ◽

Cited By ~ 7

Author(s):

Marissa B. Savoie ◽

Alan Paciorek ◽

Li Zhang ◽

Erin L. Van Blarigan ◽

Nilli Sommovilla ◽

...

Keyword(s):

Colorectal Cancer ◽

Vitamin D ◽

Treatment Initiation ◽

Vitamin D Levels ◽

Before And After

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Vitamin D deficiency is related to worse emotional state

Open Medicine ◽

10.2478/s11536-011-0061-x ◽

2011 ◽

Vol 6 (5) ◽

pp. 558-566 ◽

Cited By ~ 2

Author(s):

Lina Lašaite ◽

Ieva Gailyte ◽

Paulius Puzinas ◽

Romualdas Preikša ◽

Gintautas Kazanavičius

Keyword(s):

Vitamin D ◽

Cognitive Functioning ◽

Vitamin D Deficiency ◽

Emotional State ◽

Depression Scale ◽

Adult Intelligence Scale ◽

Wechsler Adult Intelligence Scale ◽

Vitamin D Levels ◽

Sufficient Vitamin ◽

Healthy Males

AbstractThe aim was to evaluate vitamin D levels in young healthy Lithuanian males in winter and to find possible associations of vitamin D concentration to body composition, cognitive functioning, emotional state.Subjects and Methods A total of 130 healthy males (age range, 18–26 years) were divided into the subgroups according to vitamin D concentration. The Profile of Mood States (POMS) questionnaire and Hospital Anxiety and Depression Scale were employed in the assessment of emotional state. Cognitive functioning was assessed by the Trail Making Test and the Digit Symbol Test of the Wechsler Adult Intelligence Scale.Results The mean concentration of vitamin D for the entire sample was 13.0±5.3 ng/ml. Only 2 persons (1.6%) had the recommended vitamin D level. Nearly half (45.4%) of study participants had vitamin D deficiency. Lower concentrations were associated with a significantly higher score on the POMS confusion-bewilderment scale. A tendency toward a lower mean depression-dejection score in the participants with a sufficient vitamin D level was observed. Vitamin D concentration correlated positively with body mass index (BMI) and inversely with the confusion-bewilderment score.In conclusion almost half of the young healthy males participating in the study were detected to have vitamin D deficiency in winter. Low vitamin D concentrations are associated with a worse emotional state.

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