Course of vitamin D levels before and after liver transplantation in pediatric patients

Background Peritoneal dialysis (PD) patients are at risk for 25(OH) vitamin D deficiency due to effluent loss in addition to traditional risk factors. Objectives To measure 25(OH) vitamin D deficiency in prevalent PD patients, to evaluate a replacement dose, and to determine the effects of correction. Methods 25(OH) vitamin D levels were drawn on prevalent PD patients. Patients deficient in 25(OH) vitamin D were given ergocalciferol, 50 000 IU orally once per week for 4 weeks. Patients scored muscle weakness, bone pain, and fatigue on a scale of 0 (none) to 5 (severe). Serum calcium, phosphate, parathyroid hormone (PTH), and 25(OH) vitamin D, and 1,25(OH)2 vitamin D levels were obtained before and after treatment. Results 25(OH) vitamin D levels were measured in 29 PD patients. Deficiency (<15 ng/mL) was found in 28/29 (97%); 25/29 (86%) had undetectable levels (<7 ng/mL). One course of ergocalciferol corrected the deficiency in all but 1 patient, who required a second course. Scores for muscle weakness and bone pain fell from pre- to posttreatment ( p < 0.001). 1,25(OH)2 vitamin D levels rose post ergocalciferol (from 20 to 26 pg/mL, n = 20, p = 0.09). Serum calcium, phosphate, and PTH levels did not change with ergocalciferol. Conclusions Most PD patients had marked 25(OH) vitamin D deficiency, which was readily and safely corrected with one course of 50000 IU ergocalciferol, having no effect on serum calcium, phosphorus, or PTH, but complaints of muscle weakness and bone pain decreased. A prospective, placebo-controlled double-blinded study is needed to determine whether replacement of 25(OH) vitamin D is beneficial in PD patients.

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Vitamin D and Cardiovascular Risk: Which Implications in Children?

International Journal of Molecular Sciences ◽

10.3390/ijms21103536 ◽

2020 ◽

Vol 21 (10) ◽

pp. 3536 ◽

Cited By ~ 3

Author(s):

Silvia Savastio ◽

Erica Pozzi ◽

Francesco Tagliaferri ◽

Roberta Degrandi ◽

Roberta Cinquatti ◽

...

Keyword(s):

Vitamin D ◽

Cardiovascular Risk ◽

Pediatric Patients ◽

Cardiovascular Effects ◽

Vitamin D Supplementation ◽

Risk Markers ◽

Randomized Controlled ◽

Increased Risk ◽

Vitamin D Levels ◽

Lipid Parameters

Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.

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The effect of vitamin D on cognitive functions in young female patients: a prospective controlled study using the Montreal Cognitive Assessment

Arquivos de Neuro-Psiquiatria ◽

10.1590/0004-282x20180159 ◽

2019 ◽

Vol 77 (1) ◽

pp. 19-24

Author(s):

Ozlem Balbaloglu ◽

Nermin Tanık

Keyword(s):

Vitamin D ◽

Cognitive Functioning ◽

Cognitive Assessment ◽

Young Female ◽

Montreal Cognitive Assessment ◽

Controlled Study ◽

Delayed Recall ◽

Female Patients ◽

Vitamin D Levels ◽

Before And After

ABSTRACT Aim: Our aim was to determine whether there is a relationship between vitamin D [25(OH)D] and cognitive functioning in women with low 25(OH)D levels. Methods: Ninety female patients, 25-45 years of age, who attended our outpatient clinic and had 25(OH)D levels < 30 ng/mL, were included. The Montreal Cognitive Assessment (MoCA) scale was used to determine cognitive functioning; the scale is divided into seven subgroups. Patients were divided into three subgroups according to their 25(OH)D levels. After a three-month period of 25(OH) D replacement, the patients underwent a re-evaluation using the MoCA scale. Results: The total MoCA score before treatment was significantly different from the score after treatment (p < 0.05). Language and delayed recall functions were significantly different before and after treatment (p < 0.05). Conclusion: Vitamin D levels were related to cognitive functioning in our study group.

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Hypocalcemia following Neridronate Administration in Pediatric Patients with Osteogenesis Imperfecta: A Prospective Observational Study

Journal of Pediatric Genetics ◽

10.1055/s-0039-1700972 ◽

2020 ◽

Vol 09 (02) ◽

pp. 093-100 ◽

Cited By ~ 1

Author(s):

Evelina Maines ◽

Elisa Tadiotto ◽

Grazia Morandi ◽

Michela Fedrizzi ◽

Rossella Gaudino ◽

...

Keyword(s):

Vitamin D ◽

Observational Study ◽

Osteogenesis Imperfecta ◽

Prospective Observational Study ◽

Pediatric Patients ◽

Pediatric Population ◽

Significant Risk ◽

Significant Risk Factor ◽

Vitamin D Levels ◽

D Values

AbstractThe use of intravenous bisphosphonates has been linked to hypocalcemia both in children and adults with osteogenesis imperfecta (OI). The aims of this study were: (1) to investigate the incidence of hypocalcemia in the first 48 hours (T48) after neridronate infusion in a pediatric population with OI and (2) to assess any correlation between the baseline values of calcium, vitamin D (25-hydroxyvitamin D) and bone turnover markers, and the postinfusion calcium values. We conducted a prospective observational study on 37 pediatric patients. All patients were treated with a single infusion of neridronate at a dose of 1 to 2 mg/kg. The study provided two postinfusion reassessments: 24 hours (T24) and T48 after neridronate administration. Hypocalcemia was observed in 11% of patients at T24 and in 50% of patients at T48 from neridronate infusion. We observed a positive linear correlation between the baseline vitamin D values and postinfusion calcium values, both at baseline and at T24 and T48. Hypocalcemia was mild and asymptomatic in all cases. Postinfusion calcium levels were related to baseline vitamin D levels. Consequently, low vitamin D levels should be considered a significant risk factor for hypocalcemia and should be carefully investigated and treated before neridronate infusion.

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PTH-135 Prevalence and treatment of reduced BMD and vitamin D levels in patients assessed for liver transplantation

Gut ◽

10.1136/gutjnl-2015-309861.1023 ◽

2015 ◽

Vol 64 (Suppl 1) ◽

pp. A467.3-A468

Author(s):

S Dsouza ◽

M Garner ◽

R Westbrook

Keyword(s):

Vitamin D ◽

Liver Transplantation ◽

Vitamin D Levels

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A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D)

Endocrine Connections ◽

10.1530/ec-17-0045 ◽

2017 ◽

Vol 6 (4) ◽

pp. 225-231 ◽

Cited By ~ 6

Author(s):

R Perchard ◽

L Magee ◽

A Whatmore ◽

F Ivison ◽

P Murray ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

South Asian ◽

Negative Relationship ◽

Late Winter ◽

Vitamin D Levels ◽

Significant Difference ◽

Before And After ◽

The Impact

Background Higher 25(OH)D3 levels are associated with lower HbA1c, but there are limited UK interventional trials assessing the effect of cholecalciferol on HbA1c. Aims (1) To assess the baseline 25(OH)D3 status in a Manchester cohort of children with type 1 diabetes (T1D). (2) To determine the effect of cholecalciferol administration on HbA1c. Methods Children with T1D attending routine clinic appointments over three months in late winter/early spring had blood samples taken with consent. Participants with a 25(OH)D3 level <50 nmol/L were treated with a one-off cholecalciferol dose of 100,000 (2–10 years) or 160,000 (>10 years) units. HbA1c levels before and after treatment were recorded. Results Vitamin D levels were obtained from 51 children. 35 were Caucasian, 11 South Asian and 5 from other ethnic groups. 42 were vitamin D deficient, but 2 were excluded from the analysis. All South Asian children were vitamin D deficient, with mean 25(OH)D3 of 28 nmol/L. In Caucasians, there was a negative relationship between baseline 25(OH)D3 level and HbA1c (r = −0.484, P < 0.01). In treated participants, there was no significant difference in mean HbA1c at 3 months (t = 1.010, P = 0.328) or at 1 year (t = −1.173, P = 0.248) before and after treatment. One-way ANCOVA, controlling for age, gender, ethnicity, BMI and diabetes duration showed no difference in Δ HbA1c level. Conclusion We report important findings at baseline, but in children treated with a stat dose of cholecalciferol, there was no effect on HbA1c. Further studies with larger sample sizes and using maintenance therapy are required.

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The Prevalence of 25-Hydroxyvitamin D Deficiency in Post-HSCT Pediatric Patients.

Blood ◽

10.1182/blood.v112.11.2139.2139 ◽

2008 ◽

Vol 112 (11) ◽

pp. 2139-2139

Author(s):

Christine Duncan ◽

Lynda Vrooman ◽

Lori Bechard ◽

Elly Barry ◽

Leslie E. Lehmann

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

Pediatric Patients ◽

Bone Marrow Failure ◽

Long Term Effects ◽

Hydroxyvitamin D ◽

Vitamin D Levels ◽

25 Hydroxyvitamin D ◽

The Mean ◽

25 Oh Vitamin D

Abstract Children undergoing HSCT are at risk for vitamin D deficiency due to lack of sun exposure, the recommended use of sunscreen, dietary insufficiency, and the effects of medications such as glucocorticoids and calcineurin inhibitors. We assessed the prevalence of 25-hydroxyvitamin D (25-OH vitamin D) deficiency in pediatric post-HSCT patients in an outpatient oncology clinic during 4 weeks in May 2008. Patients found to have low 25-OH vitamin D levels were referred for dietary counseling and given supplementation or repletion as needed. 25-OH vitamin D and parathyroid hormone (PTH) levels were measured in 62 (88.6%) of 70 eligible patients. 83.8% of patients had a 25-OH vitamin D level less than the institutional lower limit of normal, 30 ng/mL. 29% of patients were 25-OH vitamin D insufficient with levels 20–29 ng/mL (range of 20–29). 54.8% of patients were 25-OH vitamin D deficient with levels <20 ng/mL (range 5–19). The prevalence of insufficiency and deficiency was similar between male (87.8%; 57.6%) and female patients (57.6%; 55.2%).The mean duration of days following transplant was 532.6 days (median 251.5 days). The mean age at transplant was 3.7 years (median 3.5 years). 47% of patients were female. 75.8% were Caucasian. 90.3% received allogeneic transplants. The underlying diseases were as follows: ALL (27.4%), AML/MDS (24.2%), bone marrow failure (11.3%), nonmalignant hematologic diagnosis (8.1%), solid tumor (8.1%), immunodeficiency (6.5%), lymphoma (6.5%), and other diagnoses (8.1%). 8 patients regularly took either an over-the-counter multivitamin or vitamin D supplement and all 8 patients had 25-OH levels less than 30 ng/mL. There was a negative inverse correlation of (r= −0.3, p=0.029) between PTH and 25-OH vitamin D. There were no significant associations between 25-OH vitamin D level and any of the following: corticosteroid or calcineurin inhibitor use in the preceding year, time from transplant, age at transplant, current age, or graft-versus-host disease. 25-OH vitamin D insufficiency and deficiency are common following pediatric HSCT. We recommend vitamin D screening for all post-HSCT pediatric patients. Further investigation is needed to identify potential risk factors for vitamin D deficiency and the long-term effects of deficiency on bone health and development.

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Vitamin D levels and trabecular bone remodelling before and after surgery for medullary thyroid carcinoma

Acta Endocrinologica ◽

10.1530/acta.0.1060346 ◽

1984 ◽

Vol 106 (3) ◽

pp. 346-349 ◽

Cited By ~ 7

Author(s):

K. Emmertsen ◽

F. Melsen ◽

L. Mosekilde ◽

Bi. Lund ◽

Bj. Lund ◽

...

Keyword(s):

Vitamin D ◽

Thyroid Carcinoma ◽

Trabecular Bone ◽

Medullary Thyroid Carcinoma ◽

Bone Remodelling ◽

Vitamin D Metabolism ◽

Medullary Thyroid ◽

Number Of Patients ◽

Vitamin D Levels ◽

Before And After

Abstract. We previously reported increased mean serum 1,25-dihydroxyvitamin D (1,25-(OH)2D) and increased trabecular bone remodelling in patients with medullary thyroid carcinoma (MCT) and hypercalcitoninaemia. In the present paper we report that serum 1,25-(OH)2D and trabecular bone remodelling decreased following surgical cure for MCT and hypercalcitoninaemia in 4 patients despite no detectable post-surgical hypoparathyroidism or hypothyroidism. The results obtained in the present small number of patients suggest that the altered vitamin D metabolism and trabecular bone remodelling in patients with MCT is caused by the hypercalcitoninaemia.

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