scholarly journals Therapeutic effects of virtual reality video gaming on functional mobility, balance, and gait speed in individuals with tropical spastic paraparesis: A randomized crossover clinical trial

2021 ◽  
Vol 54 ◽  
Author(s):  
Erika Pedreira da Fonseca ◽  
Katia Nunes Sá ◽  
Rebeca Freitas Reis Nunes ◽  
Camille Rosa de Jesus Souza ◽  
Mayra Castro de Matos Sousa ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Virtual Reality ◽  
Gait Speed ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Functional Mobility ◽  
Video Gaming ◽  
Therapeutic Effects

scholarly journals Balance, functional mobility, and fall occurrence in patients with human T-cell lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis: a cross-sectional study

2018 ◽  
Vol 51 (2) ◽  
pp. 162-167 ◽  
Author(s):  
Erika Pedreira da Fonseca ◽  
Katia Nunes Sá ◽  
Rebeca Freitas Reis Nunes ◽  
Antônio Carlos Ribeiro Junior ◽  
Síntia Freitas Bastos Lira ◽  
...  
Keyword(s):  
T Cell ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Cross Sectional Study ◽  
Tropical Spastic Paraparesis ◽  
Functional Mobility ◽  
Sectional Study ◽  
Cross Sectional ◽  
Human T Cell

Effects of dry needling on gait and muscle tone in Parkinson’s disease: a randomized clinical trial

2021 ◽  
pp. 096452842110392
Author(s):  
Natalia Brandín-de la Cruz ◽  
Sandra Calvo ◽  
Cleofás Rodríguez-Blanco ◽  
Pablo Herrero ◽  
Elisabeth Bravo-Esteban
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Gait Speed ◽  
Muscle Tone ◽  
Lower Extremities ◽  
Functional Mobility ◽  
Walk Test ◽  
Single Session ◽  
Dry Needling

Background: Alterations in gait and muscular rigidity are common and disabling in persons with Parkinson’s disease (PD). Objective: The aim of this study was to determine whether a single dry needling (DN) session can promote changes in gait and muscle tone in the lower extremities as well as in the evolution of the disease in persons with PD. Methods: A randomized double-blind clinical trial was designed. Participants were randomly assigned to an intervention group (IG) that received a session of DN over the semitendinosus, medial gastrocnemius, soleus and rectus femoris muscles, or to a control group (CG) that received a session of sham DN in the same muscles. The effects of DN were assessed using the timed up and go test (TUG), 10 meter walk test (10MWT), 6 minute walk test (6MWT) and myotonometry before, immediately after, and 7 days after the intervention. Results: Thirty-three participants were analyzed aged 69.9 ± 7.2 years (mean ± SD; 39% female). There were no significant differences between the IG and CG for any outcomes. Significant differences were observed when comparing the Pre and Follow-up values in the IG for functional mobility of gait in the TUG (p = 0.049), gait speed in the 10MWT (p = 0.041) and muscle tone in the lower extremities by myotonometry (frequency (p = 0.027) and stiffness (p = 0.013)). By comparison, there were no significant within-group differences in the CG. Conclusion: A single session of DN had no measurable benefit compared to a single session of sham DN. Within-group changes in the IG suggested improvements in functional mobility of gait and gait speed, as well as changes in the muscle tone in the lower extremities of PD patients, which could be worthy of further exploration by future research.

scholarly journals Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122), in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP)

Retrovirology ◽  
2014 ◽  
Vol 11 (S1) ◽  
Author(s):  
Raya Massoud ◽  
Yoshimi Enose-Akahata ◽  
Giovanna S Brunetto ◽  
Joan Ohayon ◽  
Kaylan Fenton ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis

scholarly journals VIRTUAL REALITY THERAPY IN THE TREATMENT OF HAM/TSP INDIVIDUALS: RADOMIZED CLINICAL TRIAL

2014 ◽  
Vol 4 (2) ◽  
Author(s):  
Victor Almeida Cardoso de Oliveira Arnau ◽  
Maíra Macêdo ◽  
Elen Beatriz Pinto ◽  
Abrahão Fontes Baptista ◽  
Bernardo Galvão Castro-Filho ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Virtual Reality ◽  
Positive Impact ◽  
Therapeutic Option ◽  
Spastic Paraparesis ◽  
Double Blind ◽  
Therapeutic Exercises ◽  
Emotional Aspects

Introdution: The myelopathy associated with HTLV-1 or tropical spastic paraparesis (HAM/TSP) is a chronic, progressive demyelination disease that predominantly affects the spinal cord. The balance and locomotion in affected individuals are compromised and require therapeutic alternatives for rehabilitation. Objective: To determine the effect on aspects of balance, pain and quality of life for the use of virtual reality as an additional therapeutic option in the treatment of patients with HAM / TSP. Methodology: Randomized double blind clinical trial was conducted with nine individuals with the diagnosis confirmed by WHO criteria, divided into a group that performed a protocol of therapeutic exercises and another added that the exercise protocol, four games to virtual reality. All participants underwent an evaluation of the balance by Berg scale, of pain by visual analogical scale (VAS) and quality of life by SF-36 before and after 10 sessions. Results: The group that performed exercises with virtual therapy showed improvements in balance (p=0.033), functional capacity (p=0.010) and emotional aspects (p=0.004) in the intragroup analysis and the emotional aspects on intergroup analysis (p=0.027). Conclusion: Virtual reality did not reduce pain intensity but demonstrated a positive impact on the emotional aspects of quality of life.

Comparing Intradermal Sterile Water with Intravenous Morphine in Reducing Pain in Patients with Renal Colic: A Double-Blind Randomized Clinical Trial

2020 ◽  
Vol 15 (1) ◽  
pp. 76-82
Author(s):  
Javad Mozafari ◽  
Mohammadreza Maleki Verki ◽  
Fatemeh Tirandaz ◽  
Reza Mahjouri
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Renal Colic ◽  
Therapeutic Effects ◽  
Sterile Water ◽  
Morphine Group ◽  
Double Blind ◽  
Water Group ◽  
Intravenous Morphine ◽  
Painful Area

Objective: The present study was conducted to investigate the effect of intradermal administration of sterile water compared to intravenous morphine on patients with renal colic. Methods: This double-blind, randomized clinical trial study was conducted in 2017 to compare the therapeutic effects of intradermal sterile water with those of intravenous morphine on patients with renal colic presenting to the emergency departments (ED) of Imam Khomeini and Golestan Hospitals in Ahvaz, Iran. The first group received 0.5 ml of intradermal sterile water, and the second group 0.1mg/kg of intravenous morphine plus 0.5 ml of intradermal sterile water in the most painful area or the center of the painful area in the flank. The pain severity was measured using a visual analogue scale (VAS), and the medication side-effects were recorded at the beginning of the study and minutes 15, 30,45 and 60. Result: A total of 94 patients were studied in two groups. The mean severity of pain was 2.97 ± 1.51 in the sterile water group and 2.34 ± 1.89 in the morphine group at minute 30 (P=0.042), 2.58 ± 1.43 in the sterile water group and 1 ± 1.23 in the morphine group at minute 45 (p<0.001), and 1.89 ± 1.7 in the sterile water group and 0.52 ± 0.79 in the morphine group at minute 60 (p<0.001). Conclusion: Morphine reduces pain faster and more effectively than intradermal sterile water; nevertheless, treatment with intradermal sterile water can be used as an appropriate surrogate or adjunct therapy for pain control, particularly in special patients or in case of medication scarcity.

The Role of Human T-Lymphotropic Virus Type 1 (HTLV-1)-Infected Dendritic Cells in the Development of HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis

1999 ◽  
Vol 73 (6) ◽  
pp. 4575-4581 ◽  
Author(s):  
Masahiko Makino ◽  
Satoshi Shimokubo ◽  
Shin-Ichi Wakamatsu ◽  
Shuji Izumo ◽  
Masanori Baba
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Type ◽  
Spastic Paraparesis ◽  
Tropical Spastic Paraparesis ◽  
Normal Donor ◽  
Dependent Manner ◽  
T Lymphotropic Virus

ABSTRACT The development of human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is closely associated with the activation of T cells which are HTLV-1 specific but may cross-react with neural antigens (Ags). Immature dendritic cells (DCs), differentiated from normal donor monocytes by using recombinant granulocyte-macrophage colony-stimulating factor and recombinant interleukin-4, were pulsed with HTLV-1 in vitro. The pulsed DCs contained HTLV-1 proviral DNA and expressed HTLV-1 Gag Ag on their surface 6 days after infection. The DCs matured by lipopolysaccharides stimulated autologous CD4+ T cells and CD8+ T cells in a viral dose-dependent manner. However, the proliferation level of CD4+ T cells was five- to sixfold higher than that of CD8+ T cells. In contrast to virus-infected DCs, DCs pulsed with heat-inactivated virions activated only CD4+ T cells. To clarify the role of DCs in HAM/TSP development, monocytes from patients were cultured for 4 days in the presence of the cytokines. The expression of CD86 Ag on DCs was higher and that of CD1a Ag was more down-regulated than in DCs generated from normal monocytes. DCs from two of five patients expressed HTLV-1 Gag Ag. Furthermore, both CD4+ and CD8+ T cells from the patients were greatly stimulated by contact with autologous DCs pulsed with inactivated viral Ag as well as HTLV-1-infected DCs. These results suggest that DCs are susceptible to HTLV-1 infection and that their cognate interaction with T cells may contribute to the development of HAM/TSP.

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