Background: Neuropathic pain is a complex condition that is difficult to control and has a high
impact on quality of life. 8% Capsaicin patch can be a therapeutic strategy in the treatment of
peripheral neuropathic pain.
Objectives: This study aims to (1) evaluate clinical efficacy and (2) tolerability of 8% capsaicin
patch in a Pain Unit.
Study Design: Retrospective observational study
Setting: Portuguese Pain Unit
Methods: A sample of 120 patients diagnosed with peripheral neuropathic pain, underwent
treatment with the 8% capsaicin patch between February 2011 and February 2019 in a Portuguese
Pain Unit. Patients were included in one of the following groups according to the etiology of
pain: postherpetic neuralgia (PHN), chronic post-surgical pain (CPSP), post traumatic neuropathic
pain (PTNP), diabetic neuropathy (DN), regional pain syndrome. complex I and II (CRPS I / II), HIVassociated neuropathy (HIVN), lumbar neuropathic pain (LNP), trigeminal neuralgia (TN) and
other neuropathies (O). The evaluated parameters were: pain intensity according to unit protocol
(numerical rating scale), pain characteristics, location, size of the painful area. The evolution of
pain intensity after treatment (patients were considered as responders to therapy if the decrease in
NRS was equal to or greater than 30%; patients with a decrease in NRS of 50% or more were also
analyzed), the area of pain and the need for adjuvant analgesic therapy, as well as the tolerability
to treatment and the identification of eventual predictors of its efficacy were evaluated, at 15 days,
8 weeks and 12 weeks after 8% capsaicin patch.
Results: Of the 120 patients in the sample, 40.8% had a ≥ 30% decrease in basal pain intensity
15 days after treatment, 43.3% after 8 weeks and 45.0% after 12 weeks. 30.8% of patients had ≥
50% decreased basal pain intensity 15 days after treatment, 27.5% after 8 weeks and 30.0% after
12 weeks. Pain area decreased in 36.7% of patients and 18.3% reduced chronic analgesic therapy
within 12 weeks after 8% capsaicin patch application. There was only one case of intolerance to
the treatment.
Limitations: This study has the limitations inherent to a retrospective study. The study period was
only 12 weeks and some diagnostic groups included a small number of patients.
Conclusion: Treatment of peripheral neuropathic pain with 8% capsaicin patch seem to be
effective in the short and medium term, both in decreasing pain intensity and in reducing the
painful area. Its application is tolerated by most patients.
Key words: 8% capsaicin patch, peripheral neuropathic pain, pain intensity, painful area