scholarly journals EXPOSURE TO TOXIC AGROCHEMICALS AND DEVELOPMENT OF CONGENITAL MALFORMATIONS: A SCOPING REVIEW

2021 ◽  
Vol 30 ◽  
Author(s):  
Nathalia Zorzo Costa ◽  
Carlise Rigon Dalla Nora ◽  
Lucia Helena Donini Souto ◽  
Franciela Delazeri Carlotto ◽  
Richard dos Santos Afonso ◽  
...  
Keyword(s):  
Scoping Review ◽  
Reproductive System ◽  
Congenital Malformations ◽  
Digestive System ◽  
Web Of Science ◽  
Case Control Study ◽  
Paternal Exposure ◽  
Growth Restrictions ◽  
Limb Deficiencies ◽  
Control Study

ABSTRACT Objective: to assess whether maternal and paternal exposure to toxic agrochemicals throughout life causes congenital malformations. Method: a scoping review was carried out on the PUBMED, CINAHL, EBSCO, MEDLINE, LILACS, SciELO, BDENF, Web of Science and ATHENA databases between August and September 2019 and updated in December 2020. A cohort and case control study were included, which addressed the effects of parents' exposure throughout their lives to toxic agrochemicals which caused congenital malformation outcomes. Results: the review covered 32 studies published between 2005 and 2020. The main malformations presented are related to the reproductive system, nervous system, musculoskeletal system, transverse limb deficiencies, digestive system and other malformations such as fetal growth restrictions, cleft palate and congenital heart disease. The most investigated toxic agrochemicals in the studies were the herbicides represented by atrazine. Conclusion: maternal and paternal exposure to toxic agrochemicals can be associated with greater chances of children being born with congenital malformations, especially those related to the male reproductive system.

A case-control study of maternal smoking and congenital malformations

1990 ◽  
Vol 4 (2) ◽  
pp. 147-155 ◽  
Author(s):  
Stephen K. Van Den Eeden ◽  
Margaret R. Karagas ◽  
Janet R. Daling ◽  
Thomas L. Vaughan
Keyword(s):  
Maternal Smoking ◽  
Congenital Malformations ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Does aspirin use reduce the risk for cancer?

2016 ◽  
Vol 65 (2) ◽  
pp. 391-392 ◽  
Author(s):  
Usman Iqbal ◽  
Hsuan-Chia Yang ◽  
Wen-Shan Jian ◽  
Yun Yen ◽  
Yu-Chuan (Jack) Li
Keyword(s):  
Cancer Risk ◽  
Safety Profile ◽  
Digestive System ◽  
Index Date ◽  
Case Control Study ◽  
Asian Population ◽  
Case Control ◽  
Confounding Factors ◽  
Control Study

Recently, studies have reported that aspirin has chemopreventive properties. In this study, we used the Taiwan NHI database, which covers a population of 23 million (99.99%) Taiwanese from 2001 to 2011. This was a case–control study which identified 601,733 patients using ICD-9-CM codes who were diagnosed with cancer. Each case with 4 eligible controls was matched for age, sex, and index date and adjusted for confounding factors. The observed overall cancer risk (adjusted OR (AOR), 0.95; 95% CI 0.94 to 0.96) reduced with aspirin use, specifically, colorectal (AOR, 0.97; 95% CI 0.94 to 0.99) and digestive system (AOR, 0.96; 95% CI 0.94 to 0.98) cancers. Findings from the Asian population would contribute to the discussion on aspirin's safety profile.

scholarly journals CONGENITAL MALFORMATIONS AND MATERNAL CONSUMPTION OF BENZODIAZEPINES: A CASE-CONTROL STUDY

2010 ◽  
Vol 32 (5) ◽  
pp. 432-441 ◽  
Author(s):  
Liv Laegreid ◽  
Ragnar Olegârd ◽  
Nils Conradi ◽  
Gudrun Hagberg ◽  
Jan Wahlström ◽  
...  
Keyword(s):  
Congenital Malformations ◽  
Case Control Study ◽  
Case Control ◽  
Maternal Consumption ◽  
Control Study

Case-Control Study of Behavioral and Environmental Factors Associated to Congenital Malformations in Cali, Colombia

Epidemiology ◽  
2009 ◽  
Vol 20 ◽  
pp. S179
Author(s):  
Fabián Méndez ◽  
Harry Pachajoa ◽  
Yoseth Ariza ◽  
Milton Suarez ◽  
Cecilia Aguilar ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Congenital Malformations ◽  
Case Control Study ◽  
Case Control ◽  
Factors Associated ◽  
Control Study

scholarly journals Characteristics and determinants of high-risk unscheduled return visits to the emergency department

2019 ◽  
Vol 37 (2) ◽  
pp. 79-84 ◽  
Author(s):  
Eveline A Hiti ◽  
Hani Tamim ◽  
Maha Makki ◽  
Mirabelle Geha ◽  
Rima Kaddoura ◽  
...  
Keyword(s):  
Emergency Department ◽  
High Risk ◽  
Digestive System ◽  
Case Control Study ◽  
Final Analysis ◽  
Quality Metric ◽  
Ed Visits ◽  
Return Visits ◽  
Control Study

BackgroundHigh-risk unscheduled return visits (HRURVs), defined as return visits within 72 hours that require admission or die in the emergency department (ED) on representation, are a key quality metric in the ED. The objective of this study was to determine the incidence and describe the characteristics and predictors of HRURVs to the ED.MethodsCase–control study, conducted between 1 November 2014 and 31 October 2015. Cases included all HRURVs over the age of 18 that presented to the ED. Controls were selected from patients who were discharged from the ED during the study period and did not return in the next 72 hours. Controls were matched to cases based on gender, age (±5 years) and date of presentation.ResultsOut of 38 886 ED visits during the study period, 271 are HRURVs, giving an incidence of HRURV of 0.70% (95% CI 0.62% to 0.78%). Our final analysis includes 270 HRURV cases and 270 controls, with an in-ED mortality rate of 0.7%, intensive care unit admission of 11.1% and need for surgical intervention of 22.2%. After adjusting for other factors, HRURV cases are more likely to be discharged with a diagnosis related to digestive system or infectious disease (OR 1.64, 95% CI 1.02 to 2.65 and OR 2.81, 95% CI 1.05 to 7.51, respectively). Furthermore, presentation to the ED during off-hours is a significant predictor of HRURV (OR 1.64, 95% CI 1.11 to 2.43) as is the presence of a handover during the patient visit (OR 1.68, 95% CI 1.02 to 2.75).ConclusionHRURV is an important key quality outcome metric that reflects a subgroup of ED patients with specific characteristics and predictors. Efforts to reduce this HRURV rate should focus on interventions targeting patients discharged with digestive system, kidney and urinary tract and infectious diseases diagnosis as well as exploring the role of handover tools in reducing HRURVs.

Congenital Malformations and Trace Metals: A Case-Control Study from Lubumbashi, DR Congo

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Tony Kayembe-Kitenge ◽  
Daan Van Brusselen ◽  
Toni Lubala Kasole ◽  
Léon Kabamba Ngombe ◽  
Sébastien Mbuyi-Musanzayi ◽  
...  
Keyword(s):  
Trace Metals ◽  
Congenital Malformations ◽  
Case Control Study ◽  
Case Control ◽  
Dr Congo ◽  
Control Study

scholarly journals Neurological congenital malformations in a tertiary hospital in south Brazil

2009 ◽  
Vol 67 (3b) ◽  
pp. 807-811 ◽  
Author(s):  
Ana Guardiola ◽  
Vanessa Koltermann ◽  
Paula Musa Aguiar ◽  
Sérgio Pilla Grossi ◽  
Valéria Fleck ◽  
...  
Keyword(s):  
Latin American ◽  
Congenital Malformations ◽  
Case Control Study ◽  
Collaborative Study ◽  
Tertiary Hospital ◽  
Porto Alegre ◽  
The Central Nervous System ◽  
Cns Malformations ◽  
Cns Malformation ◽  
Control Study

BACKGROUND: Congenital anomalies are one of the main causes of morbidity and mortality among infants. The involvement of the central nervous system (CNS) occurs in 21% of cases. OBJECTIVE: To identify incidence of CNS malformations and associated factors in newborns at a Terciary Hospital of Porto Alegre. METHOD: Case-control study conducted between 2000 and 2005 based on the Latin American Collaborative Study of Congenital Malformations database. RESULTS: Among 26,588 births registered in this period, 3.67% presented with malformations (IC=95%; 3.44-3.9), being 0.36% of the CNS (IC=95%,(0.29-0.43)). The most common CNS malformation was meningomielocele (10.4%). Young maternal age (p=0.005); low birth weight (p=0.015); large cephalic perimeter (p=0.003); post term birth (p=0.000) and low APGAR indexes at the 1st and 5th minutes were associated with CNS malformations. CONCLUSION: We found an incidence of CNS malformations similar as compared to literature.

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