Breast carcinoma en Cuirasse - case report

Cutaneous metastasis is a phenomenon that results from a tumor spreading via lymphatic or vascular embolization, direct implant during surgery or skin involvement by contiguity. The primary malignant tumor that most commonly metastasizes to the skin in women is breast cancer, which can be manifested through papulonodular lesions, erysipeloid or sclerodermiform infiltration, en cuirasse. We report the case of a female patient, 78 years old, with papular, scaly and confluent lesions in the right breast for one year, progressing to edema and skin infiltration, reduction of breast volume and plaque en cuirasse, and similar lesions in the contralateral breast and abdomen for four months. The pathological diagnosis was invasive ductal breast carcinoma with Paget-like foci, epidermal skin metastases and lymphatic embolization.

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A rare case of isolated adrenal metastasis of invasive ductal breast carcinoma

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1410597a ◽

2014 ◽

Vol 142 (9-10) ◽

pp. 597-601 ◽

Cited By ~ 5

Author(s):

Natasa Andjelic-Dekic ◽

Ivana Bozovic-Spasojevic ◽

Snezana Milosevic ◽

Miodrag Matijasevic ◽

Katarina Karadzic

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Computerized Tomography ◽

Ductal Carcinoma ◽

Radical Mastectomy ◽

Histopathological Analysis ◽

Adrenal Metastases ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma ◽

One Year

Introduction. Isolated adrenal metastases of invasive ductal breast carcinoma are extremely rare. We report a case with isolated left adrenal metastases, verified three years after diagnosed breast carcinoma. Case Outline. A 58-year-old female patient with a right breast tumor, clinically staged as IIIA (T2N2M0) started neoadjuvant anthracycline chemotherapy after biopsy which revealed invasive ductal breast carcinoma. Immunohistochemical findings of tumor biopsy showed hormonal steroid receptors for estrogen and progesterone negative, and human epidermal growth factor receptor 2 (HER2) positive. After 4 cycles of chemotherapy and partial tumor regression the patient underwent radical mastectomy. Definite histopathological analysis confirmed the diagnosis of invasive ductal carcinoma. The patient continued treatment with adjuvant chemotherapy to cumulative dose of anthracyclines, postoperative radiotherapy and adjuvant trastuzumab for one year. Three years later abdominal computerized tomography showed tumor in the left adrenal gland as the only metastatic site. Left adrenalectomy was performed and histopathological finding confirmed breast cancer metastases. Postoperatively, the patient received 6 cycles of docetaxel with trastuzumab and continued trastuzumab until disease progression. One year after left adrenalectomy control abdominal computerized tomography showed a right adrenal tumor with retroperitoneal lymphadenopathy. Treatment with capecitabine was continued for one year, but eventually she developed brain metastasis causing lethal outcome. Conclusion. In order to better understand metastatic pathways of invasive ductal breast carcinoma, publications of individual patient cases diagnosed with rare metastatic sites should be encouraged. This might improve our understanding of metastatic behavior of breast cancer and stimulate further clinical research.

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Challenges in the correct assessment of a case of aggressive thyroid carcinoma with synchronous breast cancer, case report and review of the literature: essential role of radiopharmaceuticals

Current Radiopharmaceuticals ◽

10.2174/1874471013666200928105151 ◽

2020 ◽

Vol 13 ◽

Author(s):

Andra Piciu ◽

Alexandru Mester ◽

George Rusu ◽

Doina Piciu

Keyword(s):

Breast Cancer ◽

Papillary Thyroid Carcinoma ◽

Breast Carcinoma ◽

Thyroid Carcinoma ◽

Bone Metastases ◽

Essential Role ◽

Papillary Thyroid ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma

Background: Thyroid carcinoma represents a complex pathology that can still be considered a medical challenge, despite having a better prognosis and life expectancy than most other neoplasms, also the scenario of multiple malignancies involving thyroid cancer is nowadays a common reality. Materials and methods: We reviewed the literature regarding the aggressive presentation of synchronous thyroid and breast cancer. In the current paper we are reporting the case of a 59 years-old woman, diagnosed with invasive ductal breast carcinoma and papillary thyroid carcinoma, presenting a natural history of both aggressive synchronous tumors. At the moment of hospitalization, the diagnostic was breast carcinoma with multiple secondary lesions, suggestive for lung and bone metastases, and nodular goiter. Results: Searching the literature PUBMED with the terms “thyroid carcinoma and synchronous breast carcinoma we found 86 studies; introducing the term “aggressive” the result included 4 studies, among them none being relevant for aggressive and synchronous. A similar search was done in SCOPUS finding 92 documents and after introducing the term aggressive, the number of papers was 8, none being for the synchronous aggressive metastatic thyroid and breast carcinoma. The majority of imaging diagnostic tools were used in this particular medical case, in order to ensure the best potential outcome. The final diagnostic was papillary thyroid carcinoma with lung and unusual multiple bone metastases and synchronous invasive ductal breast carcinoma with subcutaneous metastases. Conclusion: The case illustrates the challenges in correct assessment of oncologic patients, despite the advances in medical imaging and technologies and underlines the essential role of nuclear medicine procedures in the diagnostic and therapy protocols.

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Isolated right adrenal metastasis from an invasive ductal breast carcinoma.

10.32512/jmr/2.2.2019/10.13 ◽

2019 ◽

pp. 10-13

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Invasive Ductal Carcinoma ◽

Adrenal Glands ◽

Ductal Carcinoma ◽

Adrenal Metastasis ◽

Breast Carcinomas ◽

Invasive Ductal Breast Carcinoma ◽

Invasive Breast Carcinomas ◽

Histopathological Type

Invasive ductal carcinoma (IDC) is the most common histopathological type of breast cancer, accounting for up to 85% of all invasive breast carcinomas [1]. It spreads usually to the bone first. Solitary metastasis is commonly located in the lung, liver or brain [2]. Adrenal glands locations are extremely rare [3]. We report a case of isolated metachronous right adrenal metastasis, diagnosed four years after breast IDC management. The aim is to highlight clinical, diagnostic and therapeutic characteristics of this entity.

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Uterine Metastases in a Diagnosed Case of Invasive Ductal Breast Carcinoma: A Rare Presentation

International Journal of Medical and Pharmaceutical Case Reports ◽

10.9734/ijmpcr/2021/v14i330137 ◽

2021 ◽

pp. 29-33

Author(s):

Musa Azhar ◽

Syed Abdul Mannan Hamdani ◽

Jhanzeb Iftikhar ◽

Waqas Ahmad ◽

Sajid Mushtaq ◽

...

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Endometrial Hyperplasia ◽

Ductal Carcinoma ◽

Carcinoma Of The Breast ◽

Invasive Ductal Breast Carcinoma ◽

Rare Presentation ◽

Curative Intent ◽

Initial Management ◽

High Propensity

Breast cancer is the commonest cancer among females and has a high propensity to metastasize, but gynaecological organs are rarely affected. We report a case where invasive ductal carcinoma of the breast metastasized to the uterus after initial management with curative intent. Our patient was on tamoxifen, which can cause endometrial hyperplasia and lead to a challenge in eventual diagnosis.

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HER-2 status of the primary breast cancer in patients with relapse at least five years after the initial diagnose

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.10631 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 10631-10631

Author(s):

Z. I. Tomasevic ◽

D. Jovanovic ◽

L. Radosevic-Jelic ◽

Z. Tomasevic ◽

S. Vasovic ◽

...

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Contralateral Breast ◽

Late Relapse ◽

Primary Breast Carcinoma ◽

Disease Free Interval ◽

Free Interval ◽

Her 2 ◽

Time To Relapse ◽

Disease Free

10631 Background: HER-2 status of the primary breast carcinoma in the subgroup of patients who relapsed after many years is not well known. The aim of this paper is to determine the HER-2 status of the primary breast cancer in patients with late relapse, defined as local recurrence, distant metastases or carcinoma in the contralateral breast, at least five years after the initial diagnosis Methods: During six month period (June-November 2005) 1256 patients were diagnosed with primary or relapsed breast cancer at the IORS. HER-2 (HercepTest, DAKO) status was determined on the archived pathological specimens of patients with late relapse. Results: One hundred eleven patients (111/1256; 8,8%) were diagnosed with late relapse. At the time of the initial diagnose, majority of patients have been treated for early breast carcinoma. Median age at the initial diagnose was 50 years (33–74). Initial tumor characteristic were: ductal carcinoma 49%; lobular carcinoma 41%;cancer mastitis 6,5%;not reported 3,5%; T1 34%; T2 52%; T3 4,5%; T4 6%;unknown 3,5%; Nodal status: positive 73,5%; negative 23%;not reported 3,5% Steroid receptor status: ER and/or PR positive 59%; both negative 14%; unknown 27%. Median time to relapse is 7 years, (range 5–29), the most frequent first relapse sites were: local recurrence (22%); carcinoma of the contralateral breast (18%); bone metastases (18%). Archived pathological specimens are identified for 63/111 (56,7%) patients and HER-2 status of the those primary breast carcinoma is: 0+ 36,5%; 1+ 34,9%; 2+ 9,5%; 3+ 14,2%; Thirty four patients (30,6%) had disease free interval 10 or more years, and HER-2 3+ in this subgroup is 17,6% (6/34). Conclusions: Long disease free interval in breast cancer patients is usually explained by initial more favorable cancer characteristics. Still, a significant percentage (14,2%) of our patients with median time to relapse of 7 years, initially had breast cancers with HER-2 3+. No significant financial relationships to disclose.

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Anal metastasis as the sentinel and isolated presentation of invasive ductal breast carcinoma

Annals of The Royal College of Surgeons of England ◽

10.1308/rcsann.2016.0108 ◽

2016 ◽

Vol 98 (5) ◽

pp. e68-e70 ◽

Cited By ~ 1

Author(s):

C Rengifo ◽

S Titi ◽

J Walls

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Cancer Metastasis ◽

Breast Cancer Metastasis ◽

Axillary Lymph Nodes ◽

Axillary Lymph ◽

Invasive Ductal Breast Carcinoma ◽

Ductal Breast Carcinoma ◽

The Uk ◽

Expanding Population

Breast cancer currently affects 1 in 8 women in the UK during their lifetime. Common sites for breast cancer metastasis include the axillary lymph nodes, bones, lung, liver, brain, soft tissue and adrenal glands. There is well documented evidence detailing breast metastasis to the gastrointestinal tract but anal metastasis is exceptionally rare. We present the case of a 78-year-old woman with an anal metastasis as the sentinel and isolated presentation of an invasive ductal breast carcinoma. As advances in the treatment of breast cancer improve, and with an ageing and expanding population, there will be an increasing number of cancer survivors, and more of these unusual presentations may be encountered in the future.

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Concordance of histology type between synchronous and metachronous contralateral breast carcinoma: Is there susceptibility for breast cancer of particular histology?

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.15_suppl.e21030 ◽

2012 ◽

Vol 30 (15_suppl) ◽

pp. e21030-e21030

Author(s):

Zorica Tomasevic ◽

Dusica Gavrilovic ◽

Zoran Tomasevic ◽

Daniela Kolarevic

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Statistical Difference ◽

Lobular Carcinoma ◽

Progesterone Receptors ◽

Distant Metastases ◽

Tumor Grade ◽

Contralateral Breast ◽

Molecular Characteristics ◽

Significant Difference

e21030 Background: Contra-lateral breast cancer (CBC) is considered to be the most frequent new malignancy after primary breast cancer (PBC) However, there are few reports whether the histology and other major molecular characteristics differs between PBC and CBC. The aim of this paper is toevaluate and compare PBC/CBC histology according to the time to CBC development. Also, age at CBC and major molecular characteristics (tumor grade, estrogen/progesterone receptors, HER2) have been analyzed. Methods: A cohort of 113 patients with CBC, without distant metastases, has been prospectively registered during 28 months. Patients are divided in 2 groups according to the time of CBC diagnose: 1. Synchronous, if the CBC (S-CBC) was diagnosed either simultaneously or within 6 months after PBC; 2. Metachronous (M-CBC) if CBC was diagnosed > 6 months after PBC. Results: Results are presented in Table 1. Median age was calculated at the time of CBC diagnose. Patient with S-CBC are median 7 years older than patients with M- CBC that is statistically significant difference (p-0.007) S-CBC is more likely to be of the same histological type (76%) than M-CBC (56%) (p 0.006) In the whole analyzed group, and each subgroup separately, lobular carcinoma is registered in higher percentage (41%) than expected (~20%) For all other analyzed BC characteristics, statistical difference was not confirmed, however ~ 25% of specimens were not available for testing. Conclusions: Although it is still unclear what could be the clinical significance of these findings, genetic susceptibility to particular histology type of BC might be reasonably speculated. [Table: see text]

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Isolated right adrenal metastasis from an invasive ductal breast carcinoma.

10.32512/jmr/2.2.2019/10.12. ◽

2019 ◽

pp. 10-12

Keyword(s):

Breast Cancer ◽

Breast Carcinoma ◽

Invasive Ductal Carcinoma ◽

Adrenal Glands ◽

Ductal Carcinoma ◽

Adrenal Metastasis ◽

Breast Carcinomas ◽

Invasive Ductal Breast Carcinoma ◽

Invasive Breast Carcinomas ◽

Histopathological Type

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Breast Cancer in Mosul: A Survival Analysis

Al Mustansiriyah Journal of Pharmaceutical Sciences ◽

10.32947/ajps.20.02.0447 ◽

2020 ◽

pp. 31-36

Keyword(s):

Breast Cancer ◽

Survival Analysis ◽

Cancer Patients ◽

Cox Regression ◽

Hazard Ratio ◽

Breast Cancer Patients ◽

Cox Regression Analysis ◽

Radical Removal ◽

One Year ◽

The Right

Breast cancer is the most common cancer in women, and the major cause of death. This study was conducted in order to make a descriptive study and survival analysis for breast cancer patients in Mosul. Two hundred forty-six early diagnosed women with breast cancer out of 290 patients were included during the period from March 2007 to February 2012. The average follows up was 36. months (range: 11-67 months). The patients were undergone modified radical removal of the breast, chemotherapy and deep radiation. Patients with estrogen positive were given tamoxifen for five years. Patients with Her2/neu positive were given trastuzumab with docytaxil for one year. Only 25 patients (10.2%) died during the study. The highest incidence of breast cancer (35.8%) was between the ages 51 ≥ 60 years. The presentation of cancer was high (90.1%) in the lumber. Tumor in the right side (66.35%) was significantly higher than the left side. Metastasis was high (25%) and most of them in the liver (19.1%). The percentage of patients with positive estrogen, progesterone, and Her2/neu receptors were not different from negative receptors. Cox regression analysis showed that metastasis had significant effect on death (hazard ratio=2.917). Age 31 ≥ 40 years was the least affected age (hazard ratio=0.034). In conclusion, survival rate of breast cancer patients in Mosul is high due to good management. The early detection of cancer is the best way for survival of the patients, by developing the educational programs.

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