Giant cell angioblastoma

Giant cell angioblastoma is an extremely rare tumor of vascular origin, described at the end of the 20th century. It belongs to tumors with intermediate malignant potential and is characterized by locally infiltrative growth. The tumor doesn’t have any clear distinctive clinical characteristics. The diagnosis is established on the basis of histological examination. Two main treatment options for this pathology are discussed in the literature: radical removal of the tumor and therapy with low doses of interferon alpha. As a rule, this is a combination treatment. This article describes our own clinical case. The patient’s parents gave their consent to the use of their child’s data, including photographs, for research purposes and in publications. Interest is in the rarity of the disease and the features of the clinical characteristics of this case, specifically the extremely unfavorable localization in the oropharynx region and, accordingly, the impossibility of carrying out not only a radical removal of the tumor, but also its resection. The high probability of developing irreversible neurological complications in this age group associated with interferon alpha therapy questioned the possibility of its use. For the first time in this histological variant of a vascular tumor, chemotherapy was applied, including metronomic therapy with cyclophosphamide and vinblastine in combination with a liposomal form of doxorubicin. After 8 courses of chemotherapy, a complete clinical response was obtained with the restoration of the patency of the respiratory and digestive tracts. The observation period at the time writing of this article was 36 months.

Neuroendocrine Tumor of the Common Bile Duct: Case Report

Carcinoma of the extrahepatic biliary tract accounts for <2% of all cancers. Neuroendocrine tumor of the extrahepatic bile duct is very rare, and there are <200 cases reported since 1959. The preoperative diagnosis is infrequent (5.12%). The definite diagnosis relies on postoperative pathology which utilized immunohistochemistry study on many biomarkers to diagnose the histological subtypes of neuroendocrine neoplasms, such as chromogranin A, synaptophysin, and neuron-specific enolase. When the primary tumor has no metastases, radical removal of the lesion appears as curative treatment. The treatment of the carcinoid syndrome or other functioning syndrome is the first priority. We report a case of a 12-year-old Mexican woman with neuroendocrine tumor of the extrahepatic bile duct (common bile duct neuroendocrine tumor) seen in our hospital. Resection of the common bile duct, cholecystectomy, end to side Roux-en-y hepaticojejunostomy, and portal lymphadenectomy was performed. A review of the pertinent literature was performed. Given the rarity of the disease, treatment principles are based mainly on retrospective series and case reports. We present the eighth case in adolescence in the literature.

Treatment of acute osteomyelitis (Zentr. f. Ch., 1926, № 18)

Treatment of acute osteomyelitis was the programmatic theme of the XV Congress of Surgeons in Copenhagen on June 25-27, 1925 (Zentr. F. Ch., 1926, no. 18). Speakers on this issue, Johanson nSchilling, generally agreed that radical removal of the affected bone marrow is the treatment of choice for acute osteomyelitis.

Lentius, profundius, suavius, tre coordinate dell'abitare contemporaneo

The aphorism lentius, profundius, suavius of Alexander Langer overturns the most famous citius, altius, fortius. It is both a program and a vision to face the most urgent challenges of our time. Outdoor is the priority action context to design possible ways of reconciliation with the environment, the only way to rediscover the balanced integration with nature that Adriano Olivetti indicated as an antidote to the harmfulness of the urban environment. Nature plays a decisive role in our society. According to the German philosopher Gernot Böhme, this general reference to nature on the one hand is indicative of a desire to compensate for a lifestyle that is increasingly distant from its rhythms and its essence, on the other it represents a profound and radical removal. The pandemic has definitively undermined some of the dominant paradigms, leading to the establishment of a new phenomenology of nature based on perception. The health issue has quickly, and perhaps irreversibly, changed our lifestyles and our relationships with nature. In high-altitude contexts, the archetypes of architecture become the concepts through which architecture redefines its dialogue with the landscape by innovating its grammar and semantic relationships. A complex dialogue that triggers new genealogies and belonging in which design solutions become an opportunity for experimenting and innovating processes, forms and technologies. The following projects address these issues with respect to two founding themes of architecture: the refuge and the threshold.

Radical removal of advanced cancer of the oral cavity and oropharynx

Surgery for advanced cancer of the oral cavity and oropharynx are among the most difficult. This is due to the topographical and anatomical features that limit the operating field and the proximity of the internal carotid artery, which penetrates into the skull without branches. Her injury and bandaging are fraught with lethality. In the postoperative period, due to a violation of the function of swallowing, there is a stagnation of oral fluid in the oral cavity, which pro[1]motes healing by secondary tension. The functions of the oropharynx are impaired: swallowing, chewing, breathing and speech.Purpose of the study. To develop an operation in patients with advanced cancer of the oral cavity and oropharynx, allowing to visualize the area of the tumor with it’s radical removal and postoperative healing without suppuration.Patients and methods. We’ve operated a patient with advanced cancer of the oral cavity and oropharynx with me[1]tastases to the cervical lymph nodes (T4 N1 M0 – IV st.). Cervical lymphodessection and removal of the tumor from the oral cavity and oropharynx was performed according to the method developed at the National Medical Research Centre for Oncology of the Ministry of Health of Russia: the tumor was removed after a preliminary modified mandib-ulotomy. Good visualization allowed for a radical operation, after which a urostoma was formed, which promotes the free flow of oral fluid from the oral cavity, without its stagnation and without suppuration of the tissues. The jaw was restored with two titanium mini-plates.Results. The healing was carried out by primary tension. On the 7th day after the operation, breathing was restored[1]decanulated. On day 20, epithelialization of the wound surface of the oral cavity and oropharynx occurred. The nasoesophageal probe was removed. Plastic orostoma was produced. By this time, the functions of the oropharyngeal region were partially restored: chewing, swallowing, and speech. Discharged home. Remission for more than 2 years.Conclusions. Previously performed modifi ed mandibulotomy in patients with advanced cancer of the oral cavity and oropharynx, allows you to expand the view of the operating field and provide a radical operation. The formed orostoma, preventing suppuration in the oral cavity, accelerates healing with the restoration of functions: chewing, swallowing, breathing and speech.

Dandy’s hemispherectomies: historical vignette

To better understand Walter Dandy’s intentions and the historical context of his work on hemispherectomy, the authors reviewed his original 1928 publication. Gliomas were considered incurable at that time. Presuming that the loss of motor function denoted a lack of useful tissue in that hemisphere, he pioneered radical removal of the involved cerebral hemisphere. Of the 5 patients operated on by Dandy, 1 died within 48 hours of hemorrhage because of a displaced vascular clip; 1 died of pneumonia in 2 weeks; 2 died of tumor recurrence, at 3 months and 3.5 years, respectively; and a fifth patient was lost to follow-up beyond the 2nd postoperative week. The authors queried the Thomson Reuters Web of Science and Scopus. A total of 88 papers fulfilled inclusion criteria. Half of these papers (44/88) were published after 2012. Only 11% of papers (10/88) quoted Dandy’s paper accurately; half of them were published before 1997. Most publications (76% [67/88]) quoted Dandy incorrectly, all of them from 1997 and later. In the remaining 11 papers (13%), the accuracy of the quotes was unclear. The authors found a trend toward more accurate citation in earlier papers. Critically reviewing Dandy’s report, with an understanding of the historical context, allows a better understanding of his intentions and the value of his contribution.

Radical Resection of a Giant Epidermoid Tumor Associated With Miniature Chordoma Utilizing a Combined Endoscopic-Microscopic Technique: 2-Dimensional Operative Video

Epidermoid tumors arise from misplaced squamous epithelium and enlarge through the accumulation of desquamated cell debris.1 Notwithstanding the prevailing conservative attitudes to minimize morbidity, optimal treatment consists of total removal of the capsule2,3; therefore, giant and multicompartmental tumors are particularly challenging. The utilization of simultaneous endoscopic microscopic techniques by tandem endoscopic and microscopic dissection to overcome the shortcomings of both modalities, markedly enhances the ability of radical removal,4 thus eliminating or at least long-delaying inevitable recurrences with subsequent accumulated morbidity. The transmastoid approach by skeletonizing and reflexing the transverse-sigmoid sinus offers wide exposure of the cerebellopontine angle avoiding cerebellar retraction and allowing 4-hands dissection.5 The patient is a 17-yr-old male with a giant epidermoid tumor in the cerebellopontine angle, extending through the incisura. The patient underwent surgical resection with maximum pursuit of the epithelial capsule. After removing the epidermoid tumor, a miniature intra and extradural midclival tumor was encountered and removed with a proven pathology of chordoma. Patient did well postoperatively with relief of his hemifacial spasms. Patient consented for surgery and photograph publication. Image at 1:23, ©1997, O. Al-Mefty, used with permission. All rights reserved.

Surgery treatment of primary spinal tumors

To analyze the results of the surgical treatment of primary spinal tumors, based on the appropriate ASIA scales, SINS, Bilsky, considering the location of tumors in various segments of the vertebral column, a retrospective analysis of 43 patients with primary benign and malignant spinal tumours was performed. The results of treatment depending on the histological type of tumors and the possibility of radical removal of tumors within healthy tissues have been studied. It has been established that with timely radical surgical treatment it is possible to prevent neurological complications, improve existing neurological disorders, restore normal anatomical relationships in the affected spinal segment, and create a reliable, rigid stabilization of the spine, which in turn allows prolonging patients’ lives.

SIGNIFICANCE OF ASHTAMAHADOSHAKARABHAVAS IN PANCHAKARMA: A REVIEW

Chikitsa is a process which not only aims at the radical removal of the causative factors of the disease, but also at the restoration of the Dhatu Samyata. It is broadly classified into Shodhana and Shamana Chikitsa. Panchakarma considered under Shodhana Chikitsa includes a specially designed five procedures for internal purification of the body. Panchakarma helps in reversal of the pathology by drawing morbid doshas from Shakha to Koshta and eliminating the same through the nearest possible route. In this process, there will be influence of the procedure at both Somatic and Psychological levels. In order to get optimum therapeutic effect of Panchakarma, in order to provide a favorable environment for the procedure to act on the body as well as to ensure the safety of the patient in preventing any complications that may arise either during or after the treatment, a set of rules and regulations pertaining to Ahara, Vihara and Manasika bhavas are to be followed by the client undergoing the Panchakarma. Among these, the Ashtamahadoshakarabhavas also called as Ashtamahavarjyakarabhavas are of paramount importance and creating the awareness in the patient undergoing panchakarma to avoid these eight impediments facilitates the attainment of optimum therapeutic effect without any complications. Henceforth, it is very important to have a thorough knowledge of Ashtamahadoshakarabhavas and its complications as well as its treatment.