scholarly journals Comparison of TNF-α and IL-1β Concentrations in Gingival Crevicular Fluid During Early Alignment Stage of Orthodontic Treatment in Adults and Adolescents

2020 ◽  
Vol 20 ◽  
Author(s):  
Marzieh Karimi Afshar ◽  
Fereshteh Safarian ◽  
Molook Torabi ◽  
Alireza Farsinejad ◽  
Iman Mohammadzadeh
Keyword(s):  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Tnf Α ◽  
Orthodontic Treatment In Adults ◽  
Crevicular Fluid

scholarly journals Effect of incisal loading during orthodontic treatment in adults: A randomized control trial

2017 ◽  
Vol 88 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Pornputthi Puttaravuttiporn ◽  
Mutita Wongsuwanlert ◽  
Chairat Charoemratrote ◽  
Steven J. Lindauer ◽  
Chidchanok Leethanakul
Keyword(s):  
Orthodontic Treatment ◽  
Alveolar Bone ◽  
Gingival Crevicular Fluid ◽  
Exercise Group ◽  
Bone Thickness ◽  
Tooth Mobility ◽  
Orthodontic Treatment In Adults ◽  
Palatal Bone ◽  
Crevicular Fluid ◽  
Bone Height

ABSTRACT Objective: To measure the changes in tooth mobility, alveolar bone, and receptor activator of nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) in the gingival crevicular fluid (GCF) during orthodontic treatment to regain incisal function in the presence and absence of biting exercises. Materials and Methods: Thirty-six females (42.3 ± 6.5 years old) with periodontally compromised upper incisors received orthodontic treatment to obtain ideal incisor relationships. Eighteen subjects in the experimental biting exercise group were instructed to bite a soft plastic roll for 5 min/d; the 18 control subjects were not given plastic rolls. Alveolar bone thickness, height, and density around the upper incisors were assessed at three root levels using cone-beam computed tomography. GCF was collected at the labial and palatal sites of the upper incisors at pretreatment (T0), end of treatment (T1), 1 month after T1 (T2), and 7 months after T1 (T3). RANKL/OPG was determined using enzyme-linked immunosorbent assays. Results: Labial and palatal bone thickness significantly increased (>twofold) from T1 to T3 in the experimental group at all three root levels (all P < .05). Bone thickness correlated negatively with RANKL/OPG ratio between T1 and T2 (P < .05). Tooth mobility, bone height, and density were not significantly different between T1 and T3. Conclusions: Biting exercises significantly increased bone thickness but did not affect tooth mobility, bone height, or density. The RANKL/OPG ratio decreased 1 month after treatment (T2) and correlated with increased bone thickness. (ClinicalTrials.in.th TCTR20170625001).

scholarly journals Two mixed-ligand coordination polymers based on 2,5-thiophenedicarboxylic acid and flexible N-donor ligands: the protective effect on periodontitis via reducing the release of IL-1β and TNF-α

2020 ◽  
Vol 18 (1) ◽  
pp. 391-398
Author(s):  
Shao-Hsuan Wu ◽  
Jun-Hui Huang
Keyword(s):  
Coordination Polymers ◽  
Gingival Crevicular Fluid ◽  
Mixed Ligand ◽  
Donor Ligands ◽  
X Ray Diffraction ◽  
Functional Studies ◽  
Tnf Α ◽  
Mucosal Cells ◽  
Ligand Coordination ◽  
Crevicular Fluid

AbstractTwo novel mixed-ligand coordination polymers, {[Co(tdc)(btrp)]·0.67DMF}n (1) and {[Zn2(bimb)2(tdc)2]·2H2O}n (2) involving 2,5-thiophenedicarboxylate (H2tdc), and bitopic flexible N-donor ligands, 1,3-bis(1,2,4-triazol-1-yl)propane (btrp) and 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene (bimb), have been synthesized by the hydrothermal method and characterized via IR, elemental analysis, thermal analysis, and powder X-ray diffraction. The biological functional studies were performed; the treatment activity of the compounds on periodontitis and the specific mechanism was explored. First, the real-time RT-PCR was carried out to determine the inflammatory genes nf-κb and p53 relative expression in periodontal mucosal cells after treating with compounds 1 and 2. Then, the level of the inflammatory cytokine in the gingival crevicular fluid after treating with compounds was also determined by the ELISA detection kit.

scholarly journals Evaluation of IL1β and IL6 Gingival Crevicular Fluid Levels during the Early Phase of Orthodontic Tooth Movement in Adolescents and Young Adults

2021 ◽  
Vol 11 (2) ◽  
pp. 521
Author(s):  
Simina Chelărescu ◽  
Petra Șurlin ◽  
Mioara Decusară ◽  
Mădălina Oprică ◽  
Eugen Bud ◽  
...  
Keyword(s):  
Young Adults ◽  
Orthodontic Treatment ◽  
Tooth Movement ◽  
Gingival Crevicular Fluid ◽  
Early Stage ◽  
Statistical Tests ◽  
Orthodontic Tooth Movement ◽  
Adolescents And Young Adults ◽  
Periodontal Tissues ◽  
Crevicular Fluid

Background: The crevicular fluid analysis represents a useful diagnosis tool, with the help of which noninvasive cellular metabolic activity can be analyzed. The aim of the study is to investigate comparatively IL1β and IL6 in the gingival crevicular fluid of clinically healthy adolescents and young adults during the acute phase of orthodontic treatment. Methods: Gingival crevicular fluid was collected from 20 patients (aged between 11 and 28) undergoing orthodontic treatment. Measurements were taken before (T0) and after 24 h after distalization forces were activated (T1). IL1β and IL 6 were analyzed using Elisa tests. The statistical tests used were two-sided t tests. Results: Between the two time periods there was a significant raise both in the crevicular fluid rate (0.57 µL at T0 vs. 0.95 µL at T1, p = 0.001) and in IL1β levels (15.67 pg/µL at T0 vs. 27.94 pg/µL at T1, p = 0.009). We were able to identify IL6 only in a third of the sites. There is a significantly increased level of ILβ at T1 in adolescents, more than in young adults (42.96 pg/µL vs. 17.93 pg/µL, p = 0.006). Conclusions: In the early stage of orthodontic treatment, the periodontal tissues of adolescents are more responsive to orthodontic forces than those of young adults.

Aspartate Aminotransferase Activity in Gingival Crevicular Fluid During Orthodontic Treatment. A Controlled Short-Term Longitudinal Study

2003 ◽  
Vol 74 (2) ◽  
pp. 145-152 ◽  
Author(s):  
Giuseppe Perinetti ◽  
Michele Paolantonio ◽  
Michele D'Attilio ◽  
Domenico D'Archivio ◽  
Marco Dolci ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Aspartate Aminotransferase ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Aminotransferase Activity ◽  
Short Term ◽  
Crevicular Fluid

scholarly journals Involvement of TSP1 and MMP9/NGAL in Angiogenesis during Orthodontic Periodontal Remodeling

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Petra Surlin ◽  
Isabela Silosi ◽  
Anne Marie Rauten ◽  
Manole Cojocaru ◽  
Lili Foia
Keyword(s):  
Matrix Metalloproteinase ◽  
Orthodontic Treatment ◽  
Gingival Crevicular Fluid ◽  
Good Control ◽  
Matrix Metalloproteinase 9 ◽  
Lipocalin 2 ◽  
Orthodontic Appliance ◽  
Bacterial Plaque ◽  
Crevicular Fluid ◽  
Metalloproteinase 9

In the present study the aim was to measure the levels of Thrombospondin-1 (TSP1) and Lipocalin-2/matrix metalloproteinase 9 (MMP9/NGAL) complex in gingival crevicular fluid (GCF) at different time points of orthodontic treatment, to determine the relationship between these values and those of total-matrix metalloproteinase 9 (MMP9) and theirs implication in angiogenesis balance, in the situation of a good control of the bacterial plaque, emphasizing the role of TSP1 and MMP9/NGAL complex. GCF samples were collected from 16 young orthodontic patients requiring upper canine distalization (test tooth) with first premolar extraction. The contralateral canine (control tooth) was free from orthodontic force. For the orthodontic appliance, brackets Roth 0.018 inch with 0.012 inch NiTi archwire and a laceback were used. TSP1, MMP9/NGAL, and MMP9 increased from 1 hour before activation of orthodontic appliance to a maximum at 8 hours for MMP9 and 72 hours for MMP9/NGAL and TSP1. The results show a change in time of TSP1, MMP9/NGAL, and MMP9 levels in GCF of patients with this method of orthodontic treatment. The powerful correlation of MMP9/NGAL with TSP1 suggests their stronger involvement in angiogenesis processes in PDL during orthodontic periodontal remodeling, in the situation of a healthy periodontium and a good control of the bacterial plaque.

scholarly journals Tumor Necrosis Factor–α Levels during Two Different Canine Distalization Techniques

2007 ◽  
Vol 77 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Seniz Karacay ◽  
Işıl Saygun ◽  
Ali Osman Bengi ◽  
Muhittin Serdar
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Gingival Crevicular Fluid ◽  
Tissue Response ◽  
Hybrid Reactor ◽  
Tnf Α ◽  
Factor Α ◽  
Crevicular Fluid ◽  
Canine Distalization ◽  
Necrosis Factor

Abstract Objectives: To compare levels of tumor necrosis factor (TNF)-α while applying continuous and heavy interrupted forces. Materials and Methods: A hybrid retractor was used in the first group. In the second group, rapid canine distalization through periodontal distraction was performed. Gingival crevicular fluid samples were collected from the distal sides of the canine teeth before attaching the appliances and at 1 hour, 24 hours, and 1 week after the force was applied. Results: In the hybrid reactor group, concentration of TNF-α decreased at 1 week according to 24-hour measurements. In the rapid canine distalization group, it severely increased at 1 hour. In the evaluation of between-group differences, significantly higher values were determined in the rapid canine distalization group at 1 hour and 1 week. Conclusions: Heavy interrupted force induces a rapid release of TNF-α, and the tissue response continues for a longer time period. To avoid the harmful effects of heavy interrupted force, there might be feedback mechanisms that prevent the mediators from increasing excessively.

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