ASSOCIATION OF IL-8 -251T>A (RS4073) POLYMORPHISM WITH SUSCEPTIBILITY TO GASTRIC CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS BASED ON 33 CASE-CONTROL STUDIES

ABSTRACT BACKGROUND: The role of -251A>T polymorphism in the anti-inflammatory cytokine interleukin-8 (IL-8) gene in gastric cancer was intensively evaluated, but the results of these studies were inconsistent. OBJECTIVE: Therefore, we performed a meta-analysis to provide a comprehensive data on the association of IL-8 -251T>A polymorphism with gastric cancer. METHODS: All eligible studies were identified in PubMed, Web of Science, EMBASE, Wanfang and CNKI databases before September 01, 2019. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were derived from a fixed effect or random effect model. RESULTS: A total of 33 case-control studies with 6,192 cases and 9,567 controls were selected. Overall, pooled data showed that IL-8 -251T>A polymorphism was significantly associated with an increased risk of gastric cancer under all five genetic models, i.e., allele (A vs T: OR=1.189, 95% CI 1.027-1.378, P=0.021), homozygote (AA vs TT: OR=1.307, 95% CI 1.111-1.536, P=0.001), heterozygote (AT vs TT: OR=1.188, 95% CI 1.061-1.330, P=0.003), dominant (AA+AT vs TT: OR=1.337, 95% CI 1.115-1.602, P=0.002) and recessive (AA vs AT+TT: OR=1.241, 95% CI 1.045-1.474, P=0.014). The stratified analysis by ethnicity revealed an increased risk of gastric cancer in Asians and mixed populations, but not in Caucasians. Moreover, stratified by country found a significant association in Chinese, Korean and Brazilian, but not among Japanese. CONCLUSION: This meta-analysis suggests that the IL-8 -251T>A polymorphism is associated with an increased risk of gastric cancer, especially by ethnicity (Asian and mixed populations) and country (Chinese, Korean and Brazilian).

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Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

10.21203/rs.2.16320/v2 ◽

2020 ◽

Author(s):

Hai-bo Gong ◽

Shu-tao Gao ◽

Xiong-Ming Pu ◽

Xiao-jing Kang ◽

Xiu-juan Wu

Keyword(s):

Gene Polymorphisms ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Original Data ◽

Case Control ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Effect Model

Abstract Background: To date, The pathological mechanisms underlying the occurrence and development of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. This study aimed to investigate the association between TNFAIP3 and TNIP1 gene polymorphisms with psoriasis susceptibility. Methods: Comprehensive literature search was undertook across four online databases—PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) up to August 25, 2019. Allele model of inheritance was used to analyze the original data. Newcastle–Ottawa scale (NOS) was used to evaluate the risk bias of each study. Pooled odds ratios and 95% confidence intervals were calculated using the RevMan 5.3 software. Results: In all, 13 case-control studies comprising 13,908 psoriasis patients and 20,051 controls were identified and included in this meta-analysis. The results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random effect model (G vs. T, OR = 1.19, 95 % CI: 1.09–1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed effect model (A vs. G, OR = 1.69, 95% CI:1.58–1.80, P < 0.00001). Conclusions: This meta-analysis indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

10.21203/rs.2.16320/v1 ◽

2019 ◽

Author(s):

Hai-bo Gong ◽

Shu-tao Gao ◽

Xiong-ming Pu ◽

Xiao-jing Kang ◽

Xiu-juan Wu

Keyword(s):

Gene Polymorphisms ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Original Data ◽

Case Control ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Effect Model

Abstract Background: To date, The pathological mechanisms underlying the occurrence and development of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. This study aimed to investigate the association between TNFAIP3 and TNIP1 gene polymorphisms with psoriasis susceptibility.Methods Comprehensive literature search was undertook across four online databases—PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) up to August 25, 2019. Allele model of inheritance was used to analyze the original data. Newcastle–Ottawa scale (NOS) was used to evaluate the risk bias of each study. Pooled odds ratios and 95% confidence intervals were calculated using the RevMan 5.3 software.Results In all, 13 case-control studies comprising 13,908 psoriasis patients and 20,051 controls were identified and included in this meta-analysis. The results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random effect model (G vs. T, OR = 1.19, 95% CI: 1.09–1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed effect model (A vs. G, OR = 1.69, 95% CI:1.58–1.80, P < 0.00001).Conclusions This meta-analysis indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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Association of rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms with psoriasis susceptibility: A meta-analysis of case-control studies

10.21203/rs.2.16320/v3 ◽

2020 ◽

Author(s):

Hai-bo Gong ◽

Shu-tao Gao ◽

Xiong-ming Pu ◽

Xiao-jing Kang ◽

Xiu-juan Wu

Keyword(s):

Gene Polymorphisms ◽

Genetic Model ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control ◽

Cochrane Library ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Effect Model

Abstract Background: To date, the fundamental pathophysiology underlying the occurrence and progression of psoriasis are still unanswered questions. Genome-wide association surveys have revealed that TNFAIP3 and TNIP1 were key biomarkers for psoriasis. Here, we intended to conduct a survey on the association between TNFAIP3 and TNIP1 gene polymorphisms and psoriasis risk.Methods: A comprehensive search of four online databases—China National Knowledge Infrastructure (CNKI), PubMed, Embase, and Cochrane Library was undertaken up to August 25, 2019. We chose allele genetic model to deal with the original data. Newcastle–Ottawa scale (NOS) was used to evaluate the risk bias of each study. The RevMan 5.3 software was used to calculate the combined odds ratio and 95% confidence interval.Results: In total, we included 13 case-control studies consist of 13,908 psoriasis patients and 20,051 controls in this work. Our results demonstrated that rs610604 in TNFAIP3 polymorphism was significantly associated with psoriasis risk using random-effect model (G vs. T, OR = 1.19, 95 % CI: 1.09–1.31, P = 0.0002), and a significant association between rs17728338 in TNIP1 polymorphism and psoriasis vulnerability using fixed-effect model (A vs. G, OR = 1.69, 95% CI:1.58–1.80, P < 0.00001).Conclusions: Our findings indicated that rs610604 in TNFAIP3 and rs17728338 in TNIP1 gene polymorphisms were associated with psoriasis susceptibility.

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Association between Vitamin C Intake and Glioma Risk: Evidence from a Meta-Analysis

Neuroepidemiology ◽

10.1159/000369814 ◽

2015 ◽

Vol 44 (1) ◽

pp. 39-44 ◽

Cited By ~ 20

Author(s):

Siru Zhou ◽

Xiaoya Wang ◽

Ya Tan ◽

Lingli Qiu ◽

Huan Fang ◽

...

Keyword(s):

Vitamin C ◽

Publication Bias ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Case Control ◽

Case Control Studies ◽

Relative Risks ◽

Effect Model ◽

Glioma Risk

Background: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. Methods: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. Results: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. Conclusions: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.

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Circulating endocan and preeclampsia: a meta-analysis

Bioscience Reports ◽

10.1042/bsr20193219 ◽

2020 ◽

Vol 40 (1) ◽

Author(s):

Xia Lan ◽

Zhaoming Liu

Keyword(s):

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Normal Pregnancy ◽

Case Control ◽

Significant Heterogeneity ◽

Case Control Studies ◽

Effect Model ◽

Matched Case ◽

The Difference

Abstract Background: Endocan, a novel protein involved in inflammation and endothelial dysfunction, has been suggested to be related to preeclampsia, although the results of previous studies were not consistent. The aim of the study was to evaluate the potential difference of circulating endocan in women with preeclampsia and those with normal pregnancy. Methods: Matched case–control studies evaluating the difference of circulating endocan between women with preeclampsia and those with normal pregnancy were identified via systematic search of PubMed and Embase databases. A random-effect model or a fixed-effect model was used to pool the results according to the heterogeneity. Subgroup analysis was performed to evaluate whether the timing of preeclampsia onset affected the outcome. Results: Overall, eight matched case–control studies, including 451 women with preeclampsia and 442 women with normal pregnancy were included. Significant heterogeneity was detected among the included studies (P for Cochrane’s Q test = 0.006, I2 = 65%). Meta-analysis with a random-effect model showed that women with preeclampsia had significantly higher circulating level of endocan compared with women with normal pregnancy (standardized mean difference = 0.37, 95% confidence interval: 0.13–0.62, P = 0.003). Subsequent subgroup analyses showed that the difference of circulating endocan between women with early onset preeclampsia and those with normal pregnancy was not statistically different from that between women with late-onset preeclampsia and those with normal pregnancy (P for subgroup difference = 0.81). Conclusions: Women with preeclampsia have higher circulating endocan than those with normal pregnancy.

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Poultry consumption and prostate cancer risk: a meta-analysis

PeerJ ◽

10.7717/peerj.1646 ◽

2016 ◽

Vol 4 ◽

pp. e1646

Author(s):

Qian He ◽

Zheng-ce Wan ◽

Xiao-bing Xu ◽

Jing Wu ◽

Guang-lian Xiong

Keyword(s):

Prostate Cancer ◽

Case Control Study ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Prostate Cancer Risk ◽

Case Control ◽

Case Control Studies ◽

Effect Model ◽

Control Study

Background.Several kinds of foods are hypothesized to be potential factors contributing to the variation of prostate cancer (PCa) incidence. But the effect of poultry on PCa is still inconsistent and no quantitative assessment has been published up to date. So we conducted this meta-analysis to clarify the association between them.Materials and Methods. We conducted a literature search of PubMed and Embase for studies examining the association between poultry consumption and PCa up to June, 2015. Pooled risk ratio (RR) and corresponding 95% confidence interval (CI) of the highest versus lowest poultry consumption categories were calculated by fixed-effect model or random-effect model.Results.A total of 27 (12 cohort and 15 case-control) studies comprising 23,703 cases and 469,986 noncases were eligible for inclusion. The summary RR of total PCa incidence was 1.03 (95% CI [0.95–1.11]) for the highest versus lowest categories of poultry intake. The heterogeneity between studies was not statistically significant (P= 0.768,I2= 28.5%). Synthesized analysis of 11 studies on high stage PCa and 8 studies on chicken exposure also demonstrated null association. We also did not obtain significant association in the subgroup of cohort study (RR = 1.04, 95% CI [0.98–1.10]), as well as in the subgroups of population-based case-control study and hospital-based case-control study. Then the studies were divided into three geographic groups: Western countries, Asia and South America. The pooled RRs in these areas did not reveal statistically significant association between poultry and PCa.Conclusions.This meta-analysis suggests no association between poultry consumption and PCa risk. Further well-designed studies are warranted to confirm the result.

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The Correlation of Glycemic Index, Glycemic Load, and Carbohydrates with the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis

10.21203/rs.3.rs-1117792/v1 ◽

2021 ◽

Author(s):

Long-Shan Yang ◽

Guang-Xiao Meng ◽

Zi-Niu Ding ◽

Lun-Jie Yan ◽

Sheng-Yu Yao ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Glycemic Index ◽

Hepatitis Virus ◽

Meta Analysis ◽

Glycemic Load ◽

Random Effect ◽

Random Effect Model ◽

Fixed Effect Model ◽

Case Control Studies ◽

Effect Model

Abstract Background Glycemic index (GI), glycemic load (GL), and carbohydrates have been shown to be associated with a variety of cancers, but their correlation with hepatocellular carcinoma (HCC) remains controversial. The purpose of our study was to investigate the correlation of GI, GL and carbohydrate with risk of HCC.Methods Systematic searches were conducted in PubMed, Embase and Web of Science until November 2020. According to the size of heterogeneity, the random effect model or the fixed effect model was performed to calculate the pooled relative risks (RRs) and 95% confidence intervals (CIs) for the correlation of GI, GL, and carbohydrates with the risk of HCC.Results Seven cohort studies involving 1,193,523 participants and 1,004 cases, and 3 case-control studies involving 827 cases and 5,502 controls were eventually included. The pooled results showed no significant correlation of GI (RR=1.11, 95%CI 0.80-1.53, I2= 62.2%), GL (RR=1.09, 95%CI 0.76-1.55, I2 = 66%), and carbohydrate (RR=1.09, 95%CI 0.84-1.32, I2=0%) with the risk of HCC in general population. Subgroup analysis revealed that in hepatitis B virus (HBV) or/and hepatitis C virus (HCV)-positive group, GI was not correlated with the risk of HCC (RR=0.65, 95%CI 0.32-1.32, p=0.475, I2=0.0%), while GL was significantly correlated with the risk of HCC (RR=1.52, 95%CI 1.04-2.23, p=0.016, I2=70.9%). In contrast, in HBV and HCV-negative group, both GI (RR=1.23, 95%CI 0.88-1.70, p=0.222, I2=33.6%) and GL (RR=1.17, 95% CI 0.83-1.64, p=0.648, I2=0%) were not correlated with the risk of HCC. Conclusion A high GL diet is correlated with a higher risk of HCC in people with hepatitis virus. A low GL diet may be recommended for patients with viral hepatitis to reduce the risk of HCC.

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Association between metabolic syndrome and venous thromboembolism after total joint arthroplasty: a meta-analysis of cohort studies

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-020-02097-4 ◽

2020 ◽

Vol 15 (1) ◽

Author(s):

Yipei Yang ◽

Ziyue Li ◽

Haifeng Liang ◽

Jing Tian

Keyword(s):

Metabolic Syndrome ◽

Cohort Studies ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Joint Arthroplasty ◽

Effect Model ◽

Increased Risk ◽

Subgroup Analyses

Abstract Objective Metabolic syndrome (MetS) has been associated with hypercoagulative status. However, previous studies evaluating the association between MetS and incidence of venous thromboembolism (VTE) after total joint arthroplasty (TJA) showed inconsistent results. We performed a meta-analysis to evaluate the influence of MetS on the risk of VTE following TJA. Methods Cohort studies were identified by the search of PubMed, Embase, and the Cochrane’s Library databases. A random-effect model was used if considerable heterogeneity was detected; otherwise, a fixed-effect model was used. Subgroup analyses according to the category of VTE, definition of MetS, category of procedure, and follow-up durations were performed. Results Seven cohort studies with 1,341,457 patients that underwent TJA were included, with 118,060 MetS patients (8.8%) at baseline. With a follow-up duration up to 3 months after surgery, 9788 patients had VTE. Pooled results with a random-effect model showed that MetS was not associated with increased overall VTE after TJA (adjusted risk ratio [RR] = 1.24, 95% confidence interval [CI] 0.89 ~ 1.72, p = 0.20; I2 = 69%). The results were not significantly affected by the diagnostic criteria of MetS, category of the procedure, and follow-up durations. Subgroup analyses showed that MetS was not associated with an increased the risk of pulmonary embolism ([PE], RR 1.06, 95% CI 0.37 ~ 3.02, p = 0.91), but an increased risk of deep vein thrombosis (DVT) after TJA (RR 3.38, 95% CI 1.83 ~ 6.24, p < 0.001). Conclusions Current evidence from observational studies suggests MetS might be associated with an increased risk of DVT but not PE after TJA.

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The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies

Journal of Diabetes Research ◽

10.1155/2014/805801 ◽

2014 ◽

Vol 2014 ◽

pp. 1-10 ◽

Cited By ~ 19

Author(s):

Liyuan Han ◽

Lina Zhang ◽

Wenhua Xing ◽

Renjie Zhuo ◽

XiaLu Lin ◽

...

Keyword(s):

Diabetic Retinopathy ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Recessive Model ◽

Cochrane Library ◽

Published Data ◽

Case Control Studies ◽

Asian Populations ◽

Effect Model

Aims. Published data on the associations of VEGF polymorphisms with diabetic retinopathy (DR) susceptibility are inconclusive. A systematic meta-analysis was undertaken to clarify this topic.Methods. Data were collected from the following electronic databases: PubMed, Embase, OVID, Web of Science, Elsevier Science Direct, Excerpta Medica Database (EMBASE), and Cochrane Library with the last report up to January 10, 2014. ORs and 95% CIs were calculated for VEGF–2578C/A (rs699947), –1154G/A (rs1570360), –460T/C (rs833061), −634G>C (rs2010963), and +936C/T (rs3025039) in at least two published studies. Meta-analysis was performed in a fixed/random effect model by using the software STATA 12.0.Results. A total of 11 studies fulfilling the inclusion criteria were included in this meta-analysis. A significant relationship between VEGF+936C/T (rs3025039) polymorphism and DR was found in a recessive model (OR = 3.19, 95% CI = 1.20–8.41, andP(z)=0.01) in Asian and overall populations, while a significant association was also found between –460T/C (rs833061) polymorphism and DR risk under a recessive model (OR = 2.12, 95% CI = 1.12–4.01, andP(z)=0.02).Conclusions. Our meta-analysis demonstrates that +936C/T (rs3025039) is likely to be associated with susceptibility to DR in Asian populations, and the recessive model of –460T/C (rs833061) is associated with elevated DR susceptibility.

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