scholarly journals Staphylococcus aureus meningitis in children: a review of 30 community-acquired cases

2000 ◽  
Vol 58 (3B) ◽  
pp. 843-851 ◽  
Author(s):  
MARCELO MASRUHA RODRIGUES ◽  
SANDRA JAGER PATROCÍNIO ◽  
MURILO GIMENES RODRIGUES
Keyword(s):  
Staphylococcus Aureus ◽  
Retrospective Study ◽  
Causative Agent ◽  
Steady Increase ◽  
Pyogenic Meningitis ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Meningitis In Children

In spite of the steady increase in the incidence of Staphylococcus aureus infections, it remains a relatively uncommon cause of meningitis. To our knowledge, no series of community-acquired S. aureus meningitis (CASAM) restricted to children has been published. So far in this retrospective study we report our experience with CASAM in children, hospitalized from 1983 to 1998 at Nossa Senhora da Glória Children's Hospital (HINSG). During the sixteen-year study period, 2,319 new cases of acute pyogenic meningitis were diagnosed at HINSG. Community-acquired S. aureus was identified as the causative agent in 30 patients (1.3 percent). The predominantly spinal localization of the agent is stressed. In contrast with publications which analyze adults, it has a better prognosis.

scholarly journals 976Antiseptic tolerance and antimicrobial susceptibility of nosocomial Staphylococcus aureus at Texas Children's Hospital: 2007-2013

2014 ◽  
Vol 1 (suppl_1) ◽  
pp. S284-S284
Author(s):  
Jonathon Mcneil ◽  
Eric Kok ◽  
Kristina Hulten ◽  
Edward O. Mason ◽  
Sheldon L. Kaplan
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Susceptibility ◽  
Children's Hospital ◽  
Children’S Hospital

An Outbreak of Methicillin-Resistant Staphylococcus aureus in a Neonatal Intensive Care Unit

2003 ◽  
Vol 24 (5) ◽  
pp. 317-321 ◽  
Author(s):  
Lisa Saiman ◽  
Alicia Cronquist ◽  
Fann Wu ◽  
Juyan Zhou ◽  
David Rubenstein ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Staphylococcus Aureus ◽  
Intensive Care ◽  
Neonatal Intensive Care Unit ◽  
Neonatal Intensive Care ◽  
Methicillin Resistant ◽  
Children's Hospital ◽  
Surveillance Cultures ◽  
Children’S Hospital ◽  
Incident Cases

AbstractObjective:To describe the epidemiologic and molecular investigations that successfully contained an outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit (NICU).Design:Isolates of MRSA were typed by pulsed-field gel electrophoresis (PFGE) and S. aureus protein A (spa).Setting:A level III-IV, 45-bed NICU located in a children's hospital within a medical center.Patients:Incident cases had MRSA isolated from clinical cultures (eg, blood) or surveillance cultures (ie, anterior nares).Interventions:Infected and colonized infants were placed on contact precautions, cohorted, and treated with mupirocin. Surveillance cultures were performed for healthcare workers (HCWs). Colonized HCWs were treated with topical mupirocin and hexachlorophene showers.Results:From January to March 2001, the outbreak strain of MRSA PFGE clone B, was harbored by 13 infants. Three (1.3%) of 235 HCWs were colonized with MRSA. Two HCWs, who rotated between the adult and the pediatric facility, harbored clone C. One HCW, who exclusively worked in the children's hospital, was colonized with clone B. From January 1999 to November 2000, 22 patients hospitalized in the adult facility were infected or colonized with clone B. Spa typing and PFGE yielded concordant results. PFGE clone B was identified as spa type 16, associated with outbreaks in Brazil and Hungary.Conclusions:A possible route of MRSA transmission was elucidated by molecular typing. MRSA appears to have been transferred from our adult facility to our pediatric facility by a rotating HCW. Spa typing allowed comparison of our institution's MRSA strains with previously characterized outbreak clones.

scholarly journals Improving Pediatric Adverse Drug Event Reporting through Clinical Pharmacy Services

2011 ◽  
Vol 16 (4) ◽  
pp. 285-290
Author(s):  
David M. Crowther ◽  
Marcia L. Buck ◽  
Michelle W. McCarthy ◽  
Virginia W. Barton
Keyword(s):  
Causative Agent ◽  
Adverse Drug Event ◽  
Pediatric Patients ◽  
Drug Event ◽  
University Of Virginia ◽  
Children's Hospital ◽  
Therapeutic Class ◽  
Children’S Hospital ◽  
The University

OBJECTIVES The purpose of this study was to summarize adverse drug event (ADE) reporting and to characterize the type of healthcare practitioners involved in reporting over a 10-year period at a 120-bed university-affiliated children's hospital. METHODS The University of Virginia Children's Hospital ADE database was analyzed for records involving pediatric patients. Data from patients <18 years of age who were admitted to the University of Virginia Children's Hospital between January 1, 2000, and December 31, 2009, were analyzed. Data collected included drug name and therapeutic class of the suspected causative agent, description of the event, severity, causality, outcome, and the type of healthcare practitioner reporting the event. RESULTS A total of 863 ADEs were reported over the 10-year period. The 5 most common types reported were extravasation injury (10%), rash (8%), hypotension (5%), pruritus (5%), and renal failure (3%). A total of 196 (21%) cases were categorized as mild, 436 (47%) cases as moderate, and 296 (32%) cases as severe. Further characterization of extravasations was performed to identify trends relating to potential causes. In 45 (57%) reports, parenteral nutrition was identified as the causative agent. Full recovery was documented in 21 (47%) extravasations. Of the total events reported, 83% were reported by pharmacists, 16% by nurses, and <1% by other healthcare practitioners. CONCLUSIONS Results of this study are consistent with those of previous studies involving ADE reporting in children's hospitals. This consistency is due in part to system design and use of unit-based pharmacists as the primary reporters.

Pilonidal Sinus in Infancy

PEDIATRICS ◽  
1965 ◽  
Vol 35 (5) ◽  
pp. 795-797
Author(s):  
RICHARD A. LEWIN
Keyword(s):  
Staphylococcus Aureus ◽  
Newborn Infant ◽  
Pilonidal Sinus ◽  
Age Group ◽  
Potential Danger ◽  
Children's Hospital ◽  
Congenital Origin ◽  
Children’S Hospital

The case presented is of a newborn infant with a fulminating infection with Staphylococcus aureus arising from a pilonidal sinus. The patients admitted over a 10-year period to Louisville Children's Hospital with a diagnosis of pilonidal sinus are reviewed. The disease appears to be of congenital origin in this age group. The potential danger of this condition in infants is emphasized.

scholarly journals Epidemiological Profile of Children Infected with Bordetella pertussis at Varela Santiago Children’s Hospital: a Retrospective Study

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S677-S677
Author(s):  
Igor Thiago Queiroz ◽  
Manuela Gomes ◽  
Gleysson Rosa ◽  
David Aronoff ◽  
A Desiree Labeaud ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Bordetella Pertussis ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Epidemiological Profile

Evaluation of anti-infectives prescriptions in a pediatric hemato-oncological center: A retrospective study

2018 ◽  
Vol 25 (8) ◽  
pp. 1811-1816
Author(s):  
Boubacar BF Diop ◽  
Amine Cheikh ◽  
Houda Attjioui ◽  
Mohamed R Ajaja ◽  
Hafid Mefetah ◽  
...  
Keyword(s):  
Information System ◽  
Drug Interaction ◽  
Retrospective Study ◽  
Drug Interactions ◽  
Training Program ◽  
Bacterial Resistance ◽  
Children's Hospital ◽  
Children’S Hospital ◽  
Oncological Center

Introduction A few years after the discovery and development of anti-infectives, this therapeutic feat gave way to bacterial resistance because of the overconsumption of antibiotics, most often with unjustified prescriptions. The objective was to evaluate the compliance of the prescription of antibiotherapy in the pediatric onco-hematology unit of Rabat Children's Hospital and to determine the drug interactions. Material and methods This is a retrospective study of anti-infectives prescriptions in pediatric onco-hematology. All prescriptions containing an antibiotic or antimycotic were isolated at the end of each month for analysis according to the ANSM standard. The variables of compliance analyzed in the prescriptions were: form, indication, posology, duration of the treatment, drug interactions and number of antibiotics which were prescribed. Results The prescriptions containing at least one anti-infective were 195. All the prescriptions were in conformity with their indications; 111 (57%) of the cases were conform with respect to all criteria; 20 (12%) prescriptions were not conform in their form, 12 (6.6%) contained at least one over-dosed drug and 52 (26.7%) contained at least one under-dosed drug. A drug interaction was found in 15 (7.7%) of cases, of which 12 (6.2%) are precautions for use. A drug interaction is present in 1(6,7%) cases when a single antibiotic is prescribed against 3 (20%) cases when 4 antibiotics are prescribed. ( p = 0.007). Conclusion The number of non-compliances in our study was high. It would therefore be advisable to recommend the establishment of an information system to minimize the non-compliances and to ensure a training program for young doctors on international recommendations.

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