Anticonvulsants to treat idiopathic restless legs syndrome: systematic review

BACKGROUND: Restless legs syndrome (RLS) is a sensory motor disorder characterized by a distressing urge to move the legs and sometimes also other parts of the body usually accompanied by a marked sense of discomfort or pain in the leg or other affected body part. Many treatments have been used to minimize the discomfort of the disease, among them the anticonvulsant therapy. AIM: This review aims to evaluate the efficacy and safety of anticonvulsant treatment for idiopathic RLS. METHOD: Systematic review of randomized or quasi-randomized, double blind trials on anticonvulsant treatment for RLS. Outcomes: relief of RLS symptoms, subjective and objective sleep quality, quality of life, and adverse events associated with the treatments. RESULTS: A total of 231 patients were randomized in three cross over studies and one parallel study. Three studies with carbamazepine, one with sodium valproate, and one with gabapentin, and they were very heterogeneous so we could not perform a metanalyses. CONCLUSIONS: There is no scientific evidence on RLS treatment with anticonvulsants for clinical practice.

Download Full-text

Botulinum Toxin in Restless Legs Syndrome—A Randomized Double-Blind Placebo-Controlled Crossover Study

Toxins ◽

10.3390/toxins10100401 ◽

2018 ◽

Vol 10 (10) ◽

pp. 401 ◽

Cited By ~ 3

Author(s):

Shivam Mittal ◽

Duarte Machado ◽

Diana Richardson ◽

Divyanshu Dubey ◽

Bahman Jabbari

Keyword(s):

Quality Of Life ◽

Crossover Study ◽

Pain Score ◽

Restless Legs Syndrome ◽

Biceps Femoris ◽

Life Questionnaire ◽

Double Blind ◽

Restless Legs ◽

Global Impression Of Change

Background: Restless Legs Syndrome (RLS) is a common movement disorder with an estimated prevalence of up to 12%. Previous small studies with onabotulinumtoxin A (OnaA) for RLS have shown inconsistent results. Methods: Twenty-four patients with an International RLS score (IRLS) of >11 (moderate-severe) were enrolled in this blinded, placebo-controlled crossover study. Twenty-one patients completed the evaluations at 4, 6, and 8 weeks after each injection. One-hundred units of Incobotulinumtoxin A (IncoA) or normal saline were injected into tibialis anterior, gastrocnemius, and biceps femoris muscles each side. Results: Improvement from a severe (IRLS >21) to a mild/moderate (IRLS ≤20) score was significant at four weeks (p = 0.0036) and six weeks (p = 0.0325) following IncoA administration compared to placebo. Additionally, there was significant improvement in pain score at six weeks as measured by Visual Analogue Scale (p = 0.04) and the Johns Hopkins Quality of Life Questionnaire (p = 0.01) in the IncoA group. Definite or marked improvement on Patient Global Impression of Change was seen in 7 out of 21 patients in the IncoA group vs. 1 out of 21 patients in the placebo group at 4 weeks (p = 0.012). Conclusion: IncoA injection lead to a reduction in severity of RLS symptoms, pain score, and quality of life, without any adverse effects.

Download Full-text

Severity and frequency of restless legs syndrome in patients with familial Mediterranean fever

Journal of International Medical Research ◽

10.1177/0300060517704789 ◽

2017 ◽

Vol 45 (4) ◽

pp. 1340-1346

Author(s):

Samet Yılmaz ◽

Burhanettin Çiğdem ◽

Şeyda Figül Gökçe ◽

Sevil Ceyhan-Doğan ◽

Hatice Balaban

Keyword(s):

Familial Mediterranean Fever ◽

Restless Legs Syndrome ◽

Rating Scale ◽

Inflammatory Diseases ◽

Normal Population ◽

Motor Disorder ◽

Restless Legs ◽

Mediterranean Fever ◽

The Mean

Objective: Restless legs syndrome (RLS) is a common sensory motor disorder. RLS an urge to move the extremities that may be accompanied by dysesthesias, and significantly affects quality of life of affected patients. The frequency of RLS is higher in different systemic inflammatory diseases. Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by attacks of polyserositis, arthritis, and fever. The prevalence of RLS in patients with FMF is unknown. This study aimed to evaluate the prevalence rate of RLS in a sample of patients with FMF and compare this prevalence with that of a matched normal population. Method: A total of 60 patients with FMF and 60 healthy controls were studied. All participants underwent a neurological examination. Diagnostic criteria as proposed by the International Restless Legs Syndrome Study Group (IRLSSG) were used to define RLS. The IRLSSG rating scale for the severity of RLS was applied to determine the severity of symptoms. Results: The prevalence of RLS was not significantly different between patients and controls. Although the mean International Restless Legs Syndrome Rating Scale (IRLSRS) scores tended to be higher in patients compared with controls, this difference was not significant. When each item of the severity scale was compared between the two groups, significantly higher scores were found in some items of the IRLSRS in patients with FMF compared with controls. Conclusion: According to this result, RLS symptoms in patients with FMF were more frequent and lasted longer than those in controls.

Download Full-text

Sleep and Quality of Life Under Prolonged Release Oxycodone/Naloxone for Severe Restless Legs Syndrome: An Analysis of Secondary Efficacy Variables of a Double-Blind, Randomized, Placebo-Controlled Study with an Open-Label Extension

CNS Drugs ◽

10.1007/s40263-016-0372-1 ◽

2016 ◽

Vol 30 (8) ◽

pp. 749-760 ◽

Cited By ~ 6

Author(s):

Wolfgang H. Oertel ◽

◽

Yngve Hallström ◽

Gerda M. Saletu-Zyhlarz ◽

Michael Hopp ◽

...

Keyword(s):

Quality Of Life ◽

Restless Legs Syndrome ◽

Controlled Study ◽

Prolonged Release ◽

Open Label ◽

Double Blind ◽

Restless Legs ◽

Open Label Extension

Download Full-text

Current trends in the management of uremic restless legs syndrome: A systematic review on aspects related to quality of life, cardiovascular mortality and survival

Sleep Medicine Reviews ◽

10.1016/j.smrv.2014.07.006 ◽

2015 ◽

Vol 21 ◽

pp. 39-49 ◽

Cited By ~ 21

Author(s):

Giorgos K. Sakkas ◽

Christoforos D. Giannaki ◽

Christina Karatzaferi ◽

Maria Maridaki ◽

Yiannis Koutedakis ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Restless Legs Syndrome ◽

Cardiovascular Mortality ◽

Restless Legs ◽

Current Trends

Download Full-text

PND35 MEASURING THE IMPACT OF RESTLESS LEGS SYNDROME (RLS) ON QUALITY OF LIFE: A SYSTEMATIC REVIEW

Value in Health ◽

10.1016/s1098-3015(10)65373-9 ◽

2007 ◽

Vol 10 (6) ◽

pp. A391

Author(s):

J Speight ◽

M Reaney ◽

O Showumni

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Restless Legs Syndrome ◽

Restless Legs ◽

The Impact

Download Full-text

Difference in background factors between responders to gabapentin enacarbil treatment and responders to placebo: pooled analyses of two randomized, double-blind, placebo-controlled studies in Japanese patients with restless legs syndrome

Sleep Medicine ◽

10.1016/j.sleep.2021.07.004 ◽

2021 ◽

Author(s):

Yuichi Inoue ◽

Koichi Hirata ◽

Yuya Hoshino ◽

Yusuke Yamaguchi

Keyword(s):

Restless Legs Syndrome ◽

Japanese Patients ◽

Gabapentin Enacarbil ◽

Double Blind ◽

Double Blind Placebo ◽

Background Factors ◽

Restless Legs

Download Full-text

Association between restless legs syndrome and peripheral neuropathy: A systematic review and meta‐analysis

European Journal of Neurology ◽

10.1111/ene.14840 ◽

2021 ◽

Author(s):

Félix Javier Jiménez‐Jiménez ◽

Hortensia Alonso‐Navarro ◽

Elena García‐Martín ◽

José A.G. Agúndez

Keyword(s):

Systematic Review ◽

Peripheral Neuropathy ◽

Restless Legs Syndrome ◽

Meta Analysis ◽

Restless Legs

Download Full-text

Percutaneous versus Transcutaneous Electrical Stimulation of the Posterior Tibial Nerve in Idiopathic Overactive Bladder Syndrome with Urinary Incontinence in Adults: A Systematic Review

Healthcare ◽

10.3390/healthcare9070879 ◽

2021 ◽

Vol 9 (7) ◽

pp. 879

Author(s):

Aida Agost-González ◽

Isabel Escobio-Prieto ◽

Azahara M. Pareja-Leal ◽

María Jesús Casuso-Holgado ◽

María Blanco-Diaz ◽

...

Keyword(s):

Systematic Review ◽

Urinary Incontinence ◽

Electrical Stimulation ◽

Overactive Bladder ◽

Tibial Nerve ◽

Scientific Evidence ◽

Transcutaneous Electrical Stimulation ◽

Posterior Tibial Nerve ◽

Posterior Tibial

Background: Percutaneous electrical stimulation and transcutaneous electrical stimulation (PTNS and TTNS) of the posterior tibial nerve are internationally recognized treatment methods that offer advantages in terms of treating patients with overactive bladder (OAB) who present with urinary incontinence (UI). This article aims to analyze the scientific evidence for the treatment of OAB with UI in adults using PTNS versus TTNS procedures in the posterior tibial nerve. Methods: A systematic review was conducted, between February and May 2021 in the Web of Science and Scopus databases, in accordance with the PRISMA recommendations. Results: The research identified 259 studies, 130 of which were selected and analyzed, with only 19 used according to the inclusion requirements established. The greatest effectiveness, in reducing UI and in other parameters of daily voiding and quality of life, was obtained by combining both techniques with other treatments, pharmacological treatments, or exercise. Conclusions: TTNS has advantages over PTNS as it is more comfortable for the patient even though there is equality of both therapies in the outcome variables. More research studies are necessary in order to obtain clear scientific evidence.

Download Full-text

459 - Psychometric properties of the Geriatric Anxiety Inventory : A systematic review

International Psychogeriatrics ◽

10.1017/s1041610220003117 ◽

2020 ◽

Vol 32 (S1) ◽

pp. 180-180

Author(s):

Philippe Landreville ◽

Alexandra Champagne ◽

Patrick Gosselin

Keyword(s):

Systematic Review ◽

Psychometric Properties ◽

Internal Consistency ◽

Methodological Quality ◽

The Body ◽

Self Report ◽

Test Reliability ◽

Cosmin Checklist ◽

Validity Indices

Background.The Geriatric Anxiety Inventory (GAI) is a widely used self-report measure of anxiety symptoms in older adults. Much research has been conducted on the psychometric properties of the GAI in various populations and using different language versions. Previous reviews of this literature have examined only a small proportion of studies in light of the body of research currently available and have not evaluated the methodological quality of this research. We conducted a systematic review of the psychometric properties of the GAI.Method.Relevant studies (N = 30) were retrieved through a search of electronic databases (Pubmed, PsycINFO, CINAHL, EMBASE and Google Scholar) and a hand search. The methodological quality of the included studies was assessed by two independent reviewers using the ‘‘COnsensusbased Standards for the selection of health status Measurement INstruments’’ (COSMIN) checklist.Results.Based on the COSMIN checklist, internal consistency and test reliability were mostly rated as poorly assessed (62.1% and 70% of studies, respectively) and quality of studies examining structural validity was mostly fair (60% of studies). The GAI showed adequate internal consistency and test-retest reliability. Convergent validity indices were highest with measures of generalized anxiety and lowest with instruments that include somatic symptoms. A substantial overlap with measures of depression was reported. While there was no consensus on the factorial structure of the GAI, several studies found it to be unidimensional.Conclusions.The GAI presents satisfactory psychometric properties. However, future efforts should aim to achieve a higher degree of methodological quality.

Download Full-text