scholarly journals Human polyclonal anti-hepatitis B surface antigen immunoglobulin reduces the frequency of acute rejection after liver transplantation for chronic hepatitis B

2001 ◽  
Vol 43 (6) ◽  
pp. 335-337 ◽  
Author(s):  
Claudia Alves COUTO ◽  
Paulo Lisboa BITTENCOURT ◽  
Alberto Queiroz FARIAS ◽  
Margareth Pauli LALLEE ◽  
Eduardo Luiz Rachid CANÇADO ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Protective Role ◽  
Group Iii ◽  
Group I ◽  
B Virus ◽  
Group Ii

BACKGROUND: Use of polyclonal anti-hepatitis B surface antigen immunoglobulin (HBIg) has been shown to reduce hepatitis B virus (HBV) recurrence after liver transplantation (LT) and to decrease the frequency of acute cellular rejection (ACR). However, the protective role of HBIg against ACR remains controversial, since HBV infection has been also associated with a lower incidence of ACR. AIM: To assess the relationship between HBIg immunoprophylaxis and the incidence of rejection after LT. METHODS: 260 patients (158 males, 43 ± 14 years old) submitted to LT were retrospectively evaluated and divided into three groups, according to the presence of HBsAg and the use of HBIg. Group I was comprised of HBsAg-positive patients (n = 12) that received HBIg for more than 6 months. Group II was comprised of HBsAg-positive patients that historically have not received HBIg or have been treated irregularly for less than 3 months (n = 10). Group III was composed of 238 HBsAg-negative subjects that have not received HBIg. RESULTS: HBIg-treated patients (group I) had significantly less ACR episodes, when compared to group II and III. No differences between groups II and III were observed. CONCLUSIONS: Long-term HBIg administration contributes independently to reduce the number of ACR episodes after LT.

Serum hepatitis B surface antigen monitoring in long-term lamivudine-treated hepatitis B virus patients

2011 ◽  
Vol 18 (10) ◽  
pp. e468-e474 ◽  
Author(s):  
A. Gramenzi ◽  
E. Loggi ◽  
L. Micco ◽  
C. Cursaro ◽  
S. Fiorino ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Serum Hepatitis ◽  
B Virus

scholarly journals Coexistence of Hepatitis B Surface Antigen (HBs Ag) and Anti-HBs Antibodies in Chronic Hepatitis B Virus Carriers: Influence of “a” Determinant Variants

2006 ◽  
Vol 80 (6) ◽  
pp. 2968-2975 ◽  
Author(s):  
Olivier Lada ◽  
Yves Benhamou ◽  
Thierry Poynard ◽  
Vincent Thibault
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Immune Escape ◽  
Hepatitis B Surface Antigen ◽  
Group I ◽  
Group Ii ◽  
Hbs Ag ◽  
Selection Of

ABSTRACT In chronic hepatitis B (CHB), the persistence of hepatitis B surface antigen (HBs Ag) is sometimes associated with antibodies (Ab) to HBs (anti-HBs). To assess the hypothesis of the selection of HBs Ag immune escape variants in CHB patients, the variability of the HBV S gene was determined for patients persistently carrying both HBs Ag and anti-HBs antibodies and patients solely positive for HBs Ag. We selected 14 patients who presented both markers (group I) in several consecutive samples and 12 patients positive for HBs Ag only (group II). The HBs Ag-encoding gene was amplified and cloned, and at least 15 clones per patient were sequenced and analyzed. The number of residue changes within the S protein was 2.7 times more frequent for group I than for group II patients and occurred mostly in the “a” determinant of the major hydrophilic region (MHR), with 9.52 versus 2.43 changes per 100 residues (P = 0.009), respectively. Ten patients (71%) from group I, but only three (25%) from group II, presented at least two residue changes in the MHR. The most frequent changes in group I patients were located at positions s145, s129, s126, s144, and s123, as described for immune escape variants. In CHB patients, the coexistence of HBs Ag and anti-HBs Ab is associated with an increase of “a” determinant variability, suggesting a selection of HBV immune escape mutants during chronic carriage. The consequences of this selection process with regard to vaccine efficacy, diagnosis, and clinical evolution remain partially unknown.

Differential gene expression, irrespective of circulating Hepatitis B Surface Antigen levels, between Inactive Carrier and Nucleos(t)ide Analogue-Treated Hepatitis B Virus patients

2020 ◽  
Author(s):  
Noé R Montanari ◽  
Nádia Conceição-Neto ◽  
Ilse Van Den Wyngaert ◽  
Gertine W Van Oord ◽  
Zwier M A Groothuismink ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Inactive Carrier ◽  
B Virus ◽  
Infected Liver ◽  
Differential Gene ◽  
Chronic Hbv

Abstract Long-term viremia control in chronic HBV patients occurs either spontaneously in inactive carrier (IC) patients or therapy-induced by nucleos(t)ide analogues (NUC). To better understand the characteristics of viremia control, we evaluated gene expression in purified leukocyte subsets from IC versus NUC-treated patients, and evaluated the putative modulatory effects of hepatitis B surface antigen (HBsAg). We observed that gene expression in NUC-treated patients differed markedly from IC patients, especially in dendritic cells, monocytes, and CD8+ T cells, while serum HBsAg levels had little effect. Nevertheless, based on our findings it cannot be excluded that HBsAg may act locally in the infected liver or preferentially affects HBV-specific cells.

Long-term outcomes of persistently positive hepatitis B surface antigen after liver transplantation for chronic hepatitis B

2020 ◽  
Vol 73 ◽  
pp. S265-S266
Author(s):  
Yan Yue James Fung ◽  
Albert CY Chan ◽  
Tiffany Wong ◽  
Wing-chiu Dai ◽  
Sui-ling Sin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Long Term Outcomes

scholarly journals Long term follow-up and outcome of liver transplantation from hepatitis B surface antigen positive donors

2017 ◽  
Vol 23 (12) ◽  
pp. 2095 ◽  
Author(s):  
Roberto Ballarin ◽  
Alessandro Cucchetti ◽  
Francesco Paolo Russo ◽  
Paolo Magistri ◽  
Matteo Cescon ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Long Term Follow Up
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