In vitro studies of the anthelmintic activity of Picrolemma sprucei Hook. f. (Simaroubaceae)
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1300 ppm (1.3 g / L), water and ethanol extracts prepared from stems or roots of Picrolemma sprucei Hook. f. were lethal (85-90 % mortality) in vitro to Haemonchus contortus (Barber Pole Worm) larvae, a gastrointestinal nematode parasite found in domestic and wild ruminants. Neosergeolide and isobrucein B were isolated in 0.0083 and 0.0070 % yield from dry, ground P. sprucei stems (0.89 kg). Neosergeolide, isobrucein B and the anthelmintic drug standard levamisole all caused comparable mortality rates (68-77 %) in vitro to H. contortus at similar concentrations (81-86 ppm). The anthelmintic activity of P. sprucei infusions (teas), alcohol extracts, and neosergeolide and isobrucein B, has therefore been demonstrated for the first time.
2016 ◽
Vol 91
(4)
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pp. 454-461
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2012 ◽
Vol 87
(2)
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pp. 174-179
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2018 ◽
Vol 27
(4)
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pp. 473-480
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2015 ◽
Vol 76
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pp. 647-652
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