scholarly journals Nocturnal hypoxemia in children and adolescents with cystic fibrosis

2013 ◽  
Vol 39 (6) ◽  
pp. 667-674 ◽  
Author(s):  
Regina Terse Trindade Ramos ◽  
Maria Angélica Pinheiro Santana ◽  
Priscila de Carvalho Almeida ◽  
Almério de Souza Machado Júnior ◽  
José Bouzas Araújo-Filho ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Lung Disease ◽  
Children And Adolescents ◽  
Sleep Time ◽  
Cross Sectional Study ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Nocturnal Hypoxemia ◽  
Respiratory Events

OBJECTIVE: To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).METHODS: This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.RESULTS: The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs= −0.42; p = 0.01), FVC (rs= −0.46; p = 0.01), microarousal index (rs= 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).CONCLUSIONS: In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.

Abstract TMP55: Polysomnographic and Sleep-related Variables Associated to Leukoaraiosis in Patients with Obstructive Sleep Apnea

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Kevin R Duque ◽  
Brian Villafuerte ◽  
Fiorella Adrianzen ◽  
Rodrigo Zamudio ◽  
Andrea Mendiola ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Logistic Regression ◽  
Sleep Apnea ◽  
Multinomial Logistic Regression ◽  
Sleep Time ◽  
Cross Sectional Study ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Obstructive Sleep ◽  
Medical Histories

Introduction: Obstructive sleep apnea (OSA) is a biological plausible risk factor for leukoaraiosis (LA). We tested the hypothesis that polysomnographic (PSG) and sleep-related variables are associated to LA in OSA patients. Methods: Cross-sectional study in which PSG records, medical histories and brain 1.5T MRI were collected from all consecutive patients who had attended a Sleep Medicine Center between 2009-2014. LA was graded from 0 to 9 with the ’Atherosclerosis Risk In Communities’ study scale. OSA was defined by The International Classification of Sleep Disorders, 2014, and its severity categorizing according to apnea-hypopnea index (AHI, <15 mild, 15 to <30 moderate, 30 to <45 severe and ≥45 very severe). A multinomial logistic regression was performed to describe the association between OSA severity and LA (divided into 2 groups: mild-to-moderate LA and non-to-minimal LA). The covariates for all regression models were age, gender, BMI, hypertension, ischemic stroke, myocardial infarction, diabetes and pack-year of smoking. Results: From 82 OSA patients (77% male; mean age 58±9 years, range 19-91), 54 (66%) had LA. Mild-to-moderate LA was found in 13 patients (8 mild and 5 moderate LA) and non-to-minimal LA in 69 (41 minimal and 28 non LA). Spearman’s correlation coefficient between AHI and LA grade was 0.41 (p<0.001). Furthermore, the higher OSA severity, the higher LA severity (p<0.001, for Jonckheere-Terpstra test for ordered alternatives). In the multinomial logistic regression model adjusted for cofounders, severe OSA patients had higher risk for mild or moderate LA (HR 12.8, 95% IC 1.2-141) compared to mild-to-moderate OSA patients. Additionally, self-reported habitual sleep duration from 7 to 9 hours (HR 0.36, 90% IC 0.14-0.90) and proportion of time in apnea/hypopnea over total sleep time (HR 1.04 for one unit increase, 90% IC 1.01-1.08) could be associated with the presence of LA (adjusted only for age and gender). In a multiple regression analysis with all the aforementioned variables, age (p=0.002), diabetes (p=0.003), and OSA severity (p=0.04) were predictors of the presence of LA. Conclusion: Patients with severe OSA had higher risk for mild to moderate LA when compared to patients with mild or moderate OSA.

Besteht ein Zusammenhang zwischen Lungenkrebs und obstruktiver Schlafapnoe?

2019 ◽  
Vol 7 (1) ◽  
pp. 32-33
Author(s):  
Wolfgang Galetke
Keyword(s):  
Lung Cancer ◽  
Sleep Apnea ◽  
Tobacco Consumption ◽  
Cross Sectional Study ◽  
Apnea Hypopnea Index ◽  
Cross Sectional ◽  
Sleep Study ◽  
Nocturnal Hypoxemia ◽  
Obstructive Sleep ◽  
Home Sleep Apnea Testing

Background: Obstructive sleep apnea (OSA) has been linked to tumorigenesis and tumor progression. Objectives: The Sleep Apnea in Lung Cancer (SAIL) study (NCT02764866) was designed to determine the prevalence of OSA in patients with lung cancer. Methods: Cross-sectional study including consecutive patients with newly diagnosed lung cancer. All patients were offered home sleep apnea testing (HSAT) and administered a sleep-specific questionnaire prior to initiating oncologic treatment. Sleep study-related variables, symptoms, and epidemiologic data as well as cancer related variables were recorded. Results: Eighty-three patients were enrolled in the SAIL study. Sixty-six completed HSAT. The mean age was 68 ± 11 years and 58% were male with a mean body mass index of 28.1 ± 5.4. Forty-seven percent were current smokers, 42% former smokers, and 11% never smokers with a median tobacco consumption of 51 pack-years. Fifty percent had COPD with a mean FEV1 of 83 ± 22.6% of predicted and a mean DLCO of 85.5 ± 20.1%. Adenocarcinoma was the most common histologic type (46.7%), followed by squamous cell (16.7%) and small cell (16.7%). Most patients were diagnosed at an advanced stage (65% in stages III-IV). The vast majority (80%) had OSA (apnea-hypopnea index [AHI] > 5), and 50% had moderate to severe OSA (AHI > 15) with a mean Epworth Sleepiness Score of 7.43 ± 3.85. Significant nocturnal hypoxemia was common (Median T90: 10.9% interquartile range 2.4-42.2). Conclusions: Sleep apnea and nocturnal hypoxemia are highly prevalent in patients with lung cancer.

scholarly journals FACTORS ASSOCIATED TO QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS

2020 ◽  
Vol 38 ◽  
Author(s):  
Nelbe Nesi Santana ◽  
Célia Regina Moutinho de Miranda Chaves ◽  
Christine Pereira Gonçalves ◽  
Saint Clair dos Santos Gomes Junior
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Children And Adolescents ◽  
Functional Capacity ◽  
Clinical Status ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Function Test

ABSTRACT Objective: To verify the association between quality of life, functional capacity and clinical and nutritional status in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study, including patients from eight to 18 years old with CF. Quality of life, functional capacity, nutritional status and clinical status were evaluated with the Cystic Fibrosis Questionnaire; the 6-minute walk test (6MWT) and manual gripping force (MGF); the height percentiles for age and body mass index for age and respiratory function test, respectively. Pearson and Spearman correlation tests and logistic regression were used to analyze the data. Results: A total of 45 patients, 13.4±0.5 years old, 60% female, 60% colonized by Pseudomonas aeruginosa and 57.8% with at least one F508del mutation participated in the study. When assessing the perception of quality of life, the weight domain reached the lowest values, and the digestive domain, the highest. In the pulmonary function test, the forced expiratory volume of the first second was 77.3±3.3% and the 6MWT and MGF presented values within the normal range. There was an association between quality of life and functional capacity, nutritional status and clinical status of CF patients. Conclusions: The study participants had good clinical conditions and satisfactory values of functional capacity and quality of life. The findings reinforce that the assessment of quality of life may be important for clinical practice in the management of treatment.

Nutritional status and intake in patients with non-cystic fibrosis bronchiectasis (NCFB) -a cross sectional study

2021 ◽  
Author(s):  
Linsey King ◽  
Helen White ◽  
Ian Clifton ◽  
Giulia Spoletini ◽  
Theocharis Ispoglou ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Functional respiratory imaging in relation to classical outcome measures in cystic fibrosis: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eline Lauwers ◽  
Annemiek Snoeckx ◽  
Kris Ides ◽  
Kim Van Hoorenbeeck ◽  
Maarten Lanclus ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Outcome Measures ◽  
Cross Sectional Study ◽  
Ct Scans ◽  
Airway Wall ◽  
Sectional Study ◽  
Air Trapping ◽  
Cross Sectional ◽  
Blood Distribution

Abstract Background Functional Respiratory Imaging (FRI) combines HRCT scans with computational fluid dynamics to provide objective and quantitative information about lung structure and function. FRI has proven its value in pulmonary diseases such as COPD and asthma, but limited studies have focused on cystic fibrosis (CF). This study aims to investigate the relation of multiple FRI parameters to validated imaging parameters and classical respiratory outcomes in a CF population. Methods CF patients aged > 5 years scheduled for a chest CT were recruited in a cross-sectional study. FRI outcomes included regional airway volume, airway wall volume, airway resistance, lobar volume, air trapping and pulmonary blood distribution. Besides FRI, CT scans were independently evaluated by 2 readers using the CF-CT score. Spirometry and the 6-Minute Walk Test (6MWT) were also performed. Statistical tests included linear mixed-effects models, repeated measures correlations, Pearson and Spearman correlations. Results 39 CT scans of 24 (17M/7F) subjects were analyzed. Patients were 24 ± 9 years old and had a ppFEV1 of 71 ± 25% at the time of the first CT. All FRI parameters showed significant low-to-moderate correlations with the total CF-CT score, except for lobar volume. When considering the relation between FRI parameters and similar CF-CT subscores, significant correlations were found between parameters related to airway volume, air trapping and airway wall thickening. Air trapping, lobar volume after normal expiration and pulmonary blood distribution showed significant associations with all spirometric parameters and oxygen saturation at the end of 6MWT. In addition, air trapping was the only parameter related to the distance covered during 6MWT. A subgroup analysis showed considerably higher correlations in patients with mild lung disease (ppFEV1 ≥ 70%) compared to patients with moderate to severe lung disease (ppFEV1 < 70%) when comparing FRI to CF-CT scores. Conclusions Multiple structural characteristics determined by FRI were associated with abnormalities determined by CF-CT score. Air trapping and pulmonary blood distribution appeared to be the most clinically relevant FRI parameters for CF patients due to their associations with classical outcome measures. The FRI methodology could particularly be of interest for patients with mild lung disease, although this should be confirmed in future research.

scholarly journals Qualidade de vida de crianças e adolescentes com fibrose cística

2019 ◽  
Vol 13 (3) ◽  
pp. 551
Author(s):  
Layanna Thomaz Lima Da Silva ◽  
Bruna Hinnah Borges Martins De Freitas ◽  
Joerko Campos De Deus ◽  
Juliano Bortolini
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Children And Adolescents ◽  
Clinical Status ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Calidad De Vida ◽  
Related Quality ◽  
The Impact

RESUMOObjetivo: avaliar a qualidade de vida relacionada à saúde (QVRS) de crianças e adolescentes com fibrose cística. Método: trata-se de um estudo quantitativo e transversal, realizado com crianças e adolescentes. Coletaram-se os dados no ambulatório semanalmente com o instrumento DISABKIDS® na perspectiva dos indivíduos (Self) e dos seus pais ou cuidadores (Proxy). Realizou-se a análise estatística por técnicas descritivas no software SPSS 20, sendo construídas tabelas de frequências. Resultados: constituiu-se a amostra por 11 sujeitos. Registrou-se que a maioria (63,6%) dos acompanhantes era de mães com idade média de 41 anos. Apontaram-se, na dimensão impacto, pela Self, uma média de 66,4 e, na Proxy, de 69,5; entretanto, na dimensão tratamento, pela versão Self, obteve-se uma média de 72,4 e, pela Proxy, de 66,9. Classificou-se a maioria dos pacientes com boa condição clínica (45,4%) de acordo com o escore de Shwachman-Kulczyki. Conclusão: conclui-se que as crianças e adolescentes percebem uma melhor QVRS quanto ao tratamento e uma pior QVRS quanto ao impacto da doença, quando comparados aos seus pais/cuidadores. Descritores: Fibrose Cística; Doença Crônica; Qualidade de Vida; Atenção à Saúde; Criança; Adolescente.ABSTRACT Objective: to evaluate the health-related quality of life (HRQoL) of children and adolescents with cystic fibrosis. Method: this is a quantitative and cross-sectional study with children and adolescents. Data was collected in the outpatient clinic weekly with the DISABKIDS® instrument from the perspective of individuals (Self) and their parents or caregivers (Proxy). Statistical analysis was performed using descriptive techniques in SPSS 20 software, and frequency tables were constructed. Results: the sample was constituted by 11 subjects. It was recorded that the majority (63.6%) of the companions were mothers with a mean age of 41 years. In the Impact dimension, Self showed an average of 66.4 and, in Proxy, 69.5; however, in the treatment dimension, by the Self version, we obtained an average of 72.4 and, by Proxy, 66.9. The majority of patients with good clinical status (45.4%) were classified according to the Shwachman-Kulczyki score. Conclusion: it is concluded that children and adolescents perceive a better HRQoL on treatment and a worse HRQoL on the impact of the disease, when compared to their parents/caregivers. Descriptors: Cystic Fibrosis; Chronic disease; Quality of life; Health Care; Child; Teenager.RESUMEN Objetivo: evaluar la calidad de vida relacionada con la salud (QVRS) de niños y adolescentes con fibrosis quística. Método: se trata de un estudio cuantitativo y transversal, realizado con niños y adolescentes. Se recogieron los datos en el ambulatorio semanalmente con el instrumento DISABKIDS® en la perspectiva de los individuos (Self) y de sus padres o cuidadores (Proxy). Se realizó el análisis estadístico por técnicas descriptivas en el software SPSS 20, siendo construidas tablas de frecuencias. Resultados: se constituyó la muestra por 11 sujetos. Se registró que la mayoría (63,6%) de los acompañantes era de madres con edad promedio de 41 años. Se apunta, en la dimensión impacto, por el Self, una media de 66,4 y, en la Proxy, de 69,5; sin embargo, en la dimensión tratamiento, por la versión Self, se obtuvo un promedio de 72,4 y, por Proxy, de 66,9. Se clasificó la mayoría de los pacientes con buena condición clínica (45,4%) de acuerdo con la puntuación de Shwachman-Kulczyki. Conclusión: se concluye que los niños y adolescentes perciben una mejor QVRS en cuanto al tratamiento y una peor QVRS en cuanto al impacto de la enfermedad, cuando comparados a sus padres / cuidadores. Descriptores: Fibrosis Quística; Enfermedad Crónica; Calidad de Vida; Atención a la Salud; Niño; Adolescente.

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