scholarly journals Prevalence of nonsyndromic oral clefts in a reference hospital in the state of Minas Gerais, Brazil, between 2000-2005

2007 ◽  
Vol 21 (4) ◽  
pp. 314-317 ◽  
Author(s):  
Hercílio Martelli-Junior ◽  
Letícia Vieto Porto ◽  
Daniella Reis Barbosa Martelli ◽  
Paulo Rogério Ferreti Bonan ◽  
Amanda Beatriz Freitas ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Pediatric Patients ◽  
Cleft Lip And Palate ◽  
Minas Gerais ◽  
The State ◽  
Craniofacial Anomalies ◽  
Oral Clefts ◽  
Reference Hospital ◽  
Isolated Cleft Palate ◽  
Male To Female

The aim of the present study was to analyze the prevalence of nonsyndromic oral clefts in children receiving treatment at the Center for the Rehabilitation of Craniofacial Anomalies, José do Rosário Vellano University, Alfenas, MG, Brazil. All the data for the epidemiological study was retrieved from the files of 126 pediatric patients with oral clefts without any additional malformation, who came to the center for treatment between 2000 and 2005. A predominance of clefts was observed in Caucasians, and the ratio of male to female was 1.3. Males were 2.57 times more affected by cleft lip and palate (CLP) than females. CLP with a prevalence of 39.68% and isolated cleft lip (CL) with a prevalence of 38.09% were the most common anomalies, followed by isolated cleft palate (CP; 22.23%). Complete and unilateral CLP (26.19%) presented the highest prevalence, followed by incomplete and unilateral CL (23.81%). The present study presents the experience of a reference hospital in the state of Minas Gerais; however, the real prevalence of oral clefts in Brazil is still unknown. Our findings differ from those of a few previous Brazilian reports because they suggest similar prevalences of CLP and CL, and a higher prevalence of CLP in Caucasian males.

scholarly journals Trends in Enteral Access Placement Among Patients With Oral Clefts: Evaluation of 46 617 Patient Admissions

2018 ◽  
Vol 56 (1) ◽  
pp. 21-30
Author(s):  
Thanapoom Boonipat ◽  
Nicholas S. Adams ◽  
Allen L. Shoemaker ◽  
Robert J. Mann ◽  
John W. Polley ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Enteral Feeding ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Complication Rates ◽  
Oral Clefts ◽  
Patient Admissions ◽  
Increased Risk ◽  
Enteral Access ◽  
Isolated Cleft Palate

Objective: It is well known that patients with oral clefts have challenges with feeding. Enteral feeding access, in the form of gastrostomy, is often utilized to supplement or replace oral intake. Although commonly performed, these procedures have reported complication rates as high as 83%. We intend to discover rates of enteral access in patients with oral clefts and report-related outcomes. Design: The Healthcare Cost Utilization Project Kids’ Inpatient Database from 2000 to 2012 was analyzed using patients with oral clefts and enteral access procedures. The χ2 test was used for univariate analyses of proportions, and linear regression was used to analyze trends. Multivariate logistic regression was used to analyze odds ratios. Results: Of the 46 617 patient admissions included, 14.6% had isolated cleft lip (CL), 51.7% cleft lip and palate (CLP), and 43.7% isolated cleft palate. The rates of enteral access in the oral cleft population increased from 3.7% in 2000 to 5.8% in 2012 ( P < .001). Increased rates were identified in patients with ( P = .019) and without ( P < .001) complex conditions. A significant increase in the rate of enteral access was seen in patients with CLP ( P < .001) and isolated cleft palate ( P < .001). No difference was seen in the isolated CL group ( P = .096). Patients with complex conditions were at a 4.4-fold increased risk and those admitted to urban, teaching hospitals were at a 4.7-fold risk of enteral access placement. Conclusions: The rates for enteral feeding access increased significantly from 2000 to 2012. The reasons for the increased incidence are unclear. Invasive enteral access procedures have been shown to have a multitude of complications. Careful patient selection should be done before placement of invasive enteral access.

Van der Woude Syndrome: Clinical Presentation in 64 Patients

2007 ◽  
Vol 44 (6) ◽  
pp. 649-652 ◽  
Author(s):  
Jung-Ju Huang ◽  
Jia-Woei Hou ◽  
Ying-Chien Tan ◽  
Kuo-Ting Chen ◽  
Lun-Jou Lo ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Clinical Presentation ◽  
Cleft Lip And Palate ◽  
Positive Family History ◽  
Van Der Woude Syndrome ◽  
Female Ratio ◽  
Clinical Presentations ◽  
Cleft Lip Palate ◽  
Isolated Cleft Palate ◽  
Male To Female

Objective: Van der Woude syndrome, characterized by lip pits and cleft lip/ palate, presents with variable expressions. This retrospective study was designed to obtain a better understanding of its clinical pattern in Taiwanese patients. Materials and Methods: Of 13,147 cleft patients treated at the Chang Gung Craniofacial Center from 1976 to 2004, there were 64 with Van der Woude syndrome. Clinical expressions and family histories were collected and analyzed. Results: The male to female ratio was 1:1. The majority had complete cleft types. Severe cleft was found among the patients, with 52% having bilateral cleft lip and palate, 31% having unilateral cleft lip and palate, and 17% having isolated cleft palate. A positive family history was found in 53.1% of the patients. The size, shape, location, and depth of the pits varied among patients. Conclusion: Clinical presentations did not always parallel those reported in the literatures. These differences warrant further investigation.

Antenatal Ultrasound Detection of Cleft in Western Australia from 2003 to 2012: A Follow-Up Study

2017 ◽  
Vol 54 (3) ◽  
pp. 321-326
Author(s):  
W. Nicholls ◽  
R. Jennings ◽  
Y. Yeung ◽  
M. Walters ◽  
B. Hewitt
Keyword(s):  
Western Australia ◽  
Detection Rate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Detection Rates ◽  
Oral Clefts ◽  
Princess Margaret Hospital ◽  
Antenatal Counseling ◽  
Antenatal Detection ◽  
Isolated Cleft Palate

Aim To investigate trends in the rate of antenatal detection of cleft lip and palate (CLP) patients referred to the CLP Unit at Princess Margaret Hospital for Children in Perth, Western Australia during the period 2003-2012 and compare data with a previously published report covering the years 1996-2003. Methods This is a single-center, retrospective survey of antenatal transabdominal ultrasound screenings of mothers of infants born between July 1, 2003 and June 30, 2012 that were referred to the CLP Unit at Princess Margaret Hospital. Results Detection rates of oral clefts increased significantly when compared with outcomes reported in the same population between 1996 and 2003 ( P < .05). An overall detection rate of 71.7% (165/230) was achieved for clefts involving lip and palate. Detection of isolated cleft palate (1/99) and microform (0/8) remained elusive. Most detections (76.5%) were achieved at 15 to 20 weeks of gestational age, corresponding with routine anatomical screening. A further 16.8% were detected post-20 weeks of gestation. Scans were performed by specialist obstetricians, and sonography clinics reported a detection rate of 84.6% (55/65), whereas nonspecialist clinics reported a detection rate of only 67.1% (110/164). Conclusion The antenatal detection rates of oral clefts involving the lip have improved to the extent that the majority of mothers are now being referred to a cleft unit in Western Australia prior to the births of their children. As a result of this improvement, antenatal counseling is now a common facet of cleft management.

Temporal Trends in New Registrations for the Ontario Cleft Lip and Palate/Craniofacial Dental Program Between 2007 and 2018

2020 ◽  
Vol 58 (1) ◽  
pp. 90-97
Author(s):  
Jane Ho ◽  
Michael Casas
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Statistical Significance ◽  
Temporal Trends ◽  
Age Groups ◽  
Diagnostic Category ◽  
Incidence Rates ◽  
Craniofacial Anomalies ◽  
Oral Clefts ◽  
Time Period

Background: The Ontario Cleft Lip and Palate/Craniofacial Dental Program was established to fund dental care for those with oral clefts, craniofacial anomalies, congenital oral defects, and acquired facial/oral defects. Aim: To determine the annual rates of newly registered oral clefts, craniofacial anomalies, congenital oral defects, and acquired oral defects cases on the Program from 2007 to 2018 and identify trends in registration rates during this time period. Design: Data were obtained from the Program from 2007 to 2018. Annual, age-specific incidence rates (for age groups 0-4, 5-9, 10-14, 15-19, and 20-24 years) were calculated for new registrations in each diagnostic category, plotted and examined using Poisson regression analysis to identify trends. Results: Rates of new registration for oral clefts and acquired oral defects were stable from 2007 to 2018. The rates of newly registered cases of craniofacial anomalies and congenital oral defects showed an increased trend from 2007 to 2018, although year-by-year comparison of the change in rates did not reach statistical significance. For craniofacial anomalies, congenital oral defects, and acquired oral defects, the highest rates of new registrations occurred in the age group 10 to 14 years, while those aged 0 to 4 recorded the highest registration rates in the oral cleft group. Conclusion: Rates in new cleft and acquired oral defects registrations were stable from 2007 to 2018. Rates in newly registered cases of craniofacial anomalies and congenital oral defects increased over the 11-year period.

scholarly journals Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies - USP (HRAC-USP) - Part 2: Pediatric Dentistry and Orthodontics

2012 ◽  
Vol 20 (2) ◽  
pp. 268-281 ◽  
Author(s):  
José Alberto de Souza Freitas ◽  
Daniela Gamba Garib ◽  
Marchini Oliveira ◽  
Rita de Cássia Moura Carvalho Lauris ◽  
Ana Lúcia Pompéia Fraga de Almeida ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Pediatric Dentistry ◽  
Craniofacial Anomalies ◽  
Rehabilitative Treatment

scholarly journals Dual embryonic origin of maxillary lateral incisors: clinical implications in patients with cleft lip and palate

2015 ◽  
Vol 20 (5) ◽  
pp. 118-125 ◽  
Author(s):  
Daniela Gamba Garib ◽  
Julia Petruccelli Rosar ◽  
Renata Sathler ◽  
Terumi Okada Ozawa
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Lateral Incisor ◽  
Craniofacial Anomalies ◽  
Nasal Process ◽  
Embryonic Origin ◽  
Maxillary Lateral Incisor ◽  
To Come ◽  
Dual Origin ◽  
Research Analysis

Introduction:Cleft lip and palate are craniofacial anomalies highly prevalent in the overall population. In oral clefts involving the alveolar ridge, variations of number, shape, size and position are observed in maxillary lateral incisors. The objective of this manuscript is to elucidate the embryonic origin of maxillary lateral incisors in order to understand the etiology of these variations.Contextualization: The hypothesis that orofacial clefts would split maxillary lateral incisor buds has been previously reported. However, recent studies showed that maxillary lateral incisors have dual embryonic origin, being partially formed by both the medial nasal process and the maxillary process. In other words, the mesial half of the lateral incisor seems to come from the medial nasal process while the distal half of the lateral incisor originates from the maxillary process. In cleft patients, these processes do not fuse, which results in different numerical and positional patterns for lateral incisors relating to the alveolar cleft. In addition to these considerations, this study proposes a nomenclature for maxillary lateral incisors in patients with cleft lip and palate, based on embryology and lateral incisors position in relation to the alveolar cleft.Conclusion:Embryological knowledge on the dual origin of maxillary lateral incisors and the use of a proper nomenclature for their numerical and positional variations renders appropriate communication among professionals and treatment planning easier, in addition to standardizing research analysis.

Longitudinal Study on the Changes of Maxillary Arch Dimensions in Japanese Children with Cleft Lip and/or Palate: Infancy to 4 Years of Age

1995 ◽  
Vol 32 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Yasuo Honda ◽  
Akira Suzuki ◽  
Masamichi Ohishi ◽  
Hideo Tashiro
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Lateral Displacement ◽  
Growth Patterns ◽  
Posterior Displacement ◽  
Arch Width ◽  
Dental Hospital ◽  
Growth Changes ◽  
Isolated Cleft Palate ◽  
Maxillary Arch

The focus of this study was an analysis of maxillary arch growth changes prior to the time of cheiloplasty up to 4 years of age. Serial dental casts were obtained and measured in 95 children with cleft lip and palate, or both: 7 unilateral cleft lip and alveolus (CLA), 52 unilateral cleft lip and palate (UCLP), 24 bilateral cleft lip and palate (BCLP), and 12 isolated cleft palate (CP). The children were treated at the Kyushu University Dental Hospital. The results are as follows: (1) Prior to cheiloplasty, the maxillary buccal segments in the subjects with cleft lip and palate showed lateral displacement. The premaxilla in BCLP subjects was protruded. (2) Cheiloplasty influenced maxillary anterior arch width, but not posterior width. The operation caused posterior displacement of the premaxilla in BCLP subjects. (3) Palatoplasty affected the growth of the maxillary arch in the transverse and anteroposterior dimensions. (4) A variety of growth patterns observed in the patients (e.g., increasing or decreasing of the maxillary arch dimensions) suggests that maxillary arch dimensions were affected not only by surgery, but also by other individual factors such as genetic facial pattern and severity of the cleft.

scholarly journals General principles governing record taking in patients with cleft lip and palate

2021 ◽  
Vol 11 (2) ◽  
pp. 86-89
Author(s):  
Ashish Garg ◽  
Sandhya Gupta
Keyword(s):  
Congenital Anomaly ◽  
Environmental Factors ◽  
Collaborative Research ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Skeletal Maturity ◽  
Craniofacial Anomalies ◽  
Treatment Procedure ◽  
Complex Procedure ◽  
International Collaborative Research

(WHO meetings on International Collaborative Research on Craniofacial Anomalies).One of the most common congenital anomaly we come across is the Cleft Lip and palate where affected children suffer from range of functional as well as aesthetic problems. Cleft lip and palate is a multifunctional disease associated with environmental factors. Management of cleft is a complex procedure and demands co-operation among experts from different fields. Clinical treatment procedure extends from beginning of birth, to achieving skeletal maturity effectively.

scholarly journals Rehabilitative treatment of cleft lip and palate: experience of the Hospital for Rehabilitation of Craniofacial Anomalies/USP (HRAC/USP) - Part 1: overall aspects

2012 ◽  
Vol 20 (1) ◽  
pp. 9-15 ◽  
Author(s):  
José Alberto de Souza Freitas ◽  
Lucimara Teixeira das Neves ◽  
Ana Lúcia Pompéia Fraga de Almeida ◽  
Daniela Gamba Garib ◽  
Ivy Kiemle Trindade-Suedam ◽  
...  
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Craniofacial Anomalies ◽  
Rehabilitative Treatment

The aetiology and pathogenesis of craniofacial deformity

Development ◽  
1988 ◽  
Vol 103 (Supplement) ◽  
pp. 207-212
Author(s):  
David Poswillo
Keyword(s):  
Neural Crest ◽  
Animal Studies ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Treacher Collins Syndrome ◽  
Apert Syndrome ◽  
Craniofacial Malformations ◽  
Craniofacial Microsomia ◽  
Animal System ◽  
Isolated Cleft Palate

Craniofacial malformations have been recorded since time immemorial. While observational studies have assisted in the recognition of syndromes, little light has been shed on the causal mechanisms which interfere with craniofacial development. Animal studies in which malformations occur spontaneously or have been induced by teratogenic agents have permitted step-by-step investigation of such common deformities as cleft lip and palate. The role of the ectomesenchymal cells of the neural crest and the possible phenomenon of disorganized spontaneous cell death are described in relation to lip clefts. The factors associated with isolated cleft palate, Pierre Robin syndrome and submucous clefts are described by reference to animal models. The haemorrhagic accident preceding the onset of craniofacial microsomia is discussed as is the distinctly different phenomenon of disturbance to the migration or differentiation of neural crest cells in the pathogenesis of Treacher Collins syndrome. The more severe anomalies of the calvarium such as plagiocephaly, Crouzon and Apert syndrome still defy explanation, in the absence of an appropriate animal system to study; some thoughts on the likely mechanism of abnormal sutural fusions are discussed.

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