scholarly journals Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

2013 ◽  
Vol 49 (4) ◽  
pp. 629-643 ◽  
Author(s):  
Swatantra Kumar Singh Kushwaha ◽  
Saurav Ghoshal ◽  
Awani Kumar Rai ◽  
Satyawan Singh
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Modern Times ◽  
Novel Drug Delivery System ◽  
Considerable Work ◽  
Novel Drug ◽  
High Drug Loading

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.

Application of Carbon Nanotubes as Drug Delivery System for Anticancer Therapy

2020 ◽  
pp. 29-36
Author(s):  
Sabita Shrestha
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Anticancer Therapy ◽  
Loading Capacity ◽  
One Dimensional ◽  
Nano Medicine ◽  
High Drug Loading

Carbon nanotubes are one-dimensional allotrope of carbon having high aspect ratio, high surface area, and excellent material properties. It has applications in many fields such as catalyst, nano-electronics, field emission, nano medicine, solar cells, energy storage etc. Drug delivery is one of the important applications of carbon nanotubes because of its unique properties such as high drug loading capacity, thermal ablation, ease of cellular uptake. This article briefly overviews the different steps in drug delivery and anticancer therapy such as mechanism of drug loading, transportation, distribution, metabolism and finally excretion of drug.

scholarly journals 622. Oncolytic Adenoviruses Loaded With Active Drugs as a Novel Drug Delivery System for Cancer Therapy

2015 ◽  
Vol 23 ◽  
pp. S247
Author(s):  
Mariangela Garofalo ◽  
Barbara Iovine ◽  
Lukasz Kuryk ◽  
Cristian Capasso ◽  
Mari Hirvinen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oncolytic Adenoviruses ◽  
Novel Drug Delivery System ◽  
Novel Drug

Bionanotherapeutics: niclosamide encapsulated albumin nanoparticles as a novel drug delivery system for cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12078-12086 ◽  
Author(s):  
Bharat Bhushan ◽  
Poornima Dubey ◽  
S. Uday Kumar ◽  
Abhay Sachdev ◽  
Ishita Matai ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Albumin Nanoparticles ◽  
Scope Of Application ◽  
Novel Drug Delivery System ◽  
Novel Drug

In this work niclosamide was encapsulated into albumin nanoparticles through a desolvation method to improve its scope of application in cancer therapy.

Current Trends in Phyto-cancer Therapy Using Nanoparticles

2019 ◽  
Vol 9 (1) ◽  
pp. 30-45 ◽  
Author(s):  
K. Vohra ◽  
H. Dureja ◽  
V. Garg ◽  
R. Dutt
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Herbal Medicines ◽  
High Efficacy ◽  
Global Challenge ◽  
Alternative Medicines ◽  
Current Trends ◽  
Low Toxicity ◽  
Novel Drug

Background:Cancer has been considered as a deadly disease and its appropriate management is still a global challenge. The traditional anticancer therapeutics have been able to combat the disease to some extent but with numerous adverse effects which affect the quality of life of patients.Method:The introduction of alternative medicines, especially herbal medicines, has attracted the scientists’ due to low toxicity and high efficacy associated with them. However, their poor solubility and bioavailability decrease their efficacy. This has led to the increased use of targeted drug delivery systems in phyto-cancer therapy.Results:Nanoparticles (NPs), a novel drug delivery system has been widely used in the recent years due to their various advantages such as drug targeting, improved solubility, and bioavailability, high efficacy, low toxicity towards normal cells, low drug resistance, high drug loading at tumor site, etc.Conclusion:These benefits have also been observed in studies evaluating phytonanotherapy in cancer. The present review highlights current trends followed by phyto-cancer therapy using NPs. The recent studies conducted on herbal NPs for cancer therapy have also been enlisted.

Black phosphorus analogue tin sulfide nanosheets: synthesis and application as near-infrared photothermal agents and drug delivery platforms for cancer therapy

2018 ◽  
Vol 6 (29) ◽  
pp. 4747-4755 ◽  
Author(s):  
Zhongjian Xie ◽  
Dou Wang ◽  
Taojian Fan ◽  
Chenyang Xing ◽  
Zhongjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Near Infrared ◽  
Drug Loading ◽  
Black Phosphorus ◽  
Loading Capacity ◽  
Tin Sulfide ◽  
High Drug ◽  
High Drug Loading

Black phosphorus analogue tin sulfide nanosheets as photothermal and drug delivery agents with high drug loading capacity for cancer therapy.

Doxorubicin-Loaded CuS Nanoparticles Conjugated with GFLG: A Novel Drug Delivery System for Lymphoma Treatment

NANO ◽  
2019 ◽  
Vol 14 (01) ◽  
pp. 1950013 ◽  
Author(s):  
Ying Jiang ◽  
Chaoyang Guan ◽  
Xu Liu ◽  
Yushan Wang ◽  
Huaqin Zuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Therapeutic Option ◽  
Drug Loading ◽  
Lymphoma Cells ◽  
Apoptosis Pathway ◽  
Lymphoma Treatment ◽  
Novel Drug Delivery System ◽  
Novel Drug

Doxorubicin (DOX) plays an important part in lymphoma treatment. However, various side effects on normal tissues restrict its clinical use. Nanocarriers connected by Gly–Phe–Leu–Gly (GFLG) can be equipped with the advantages of nanoparticles (NPs), their enhanced permeability and retention (EPR) effect, and surface modifiability. Nanocarriers can also be specifically enzymatically hydrolyzed by cathepsin (Cath) B, a kind of enzyme highly expressed in tumor cells. In this work, we proposed a novel drug delivery system comprising GFLG conjugated with copper sulfide (CuS) NPs loaded with DOX. The system, designated as CuS-GFLG-DOX, could be used for NP-based targeted combination chemotherapy. Results showed that the drug delivery system had an appropriate diameter, good dispersibility, high encapsulation efficiency and high drug loading. The system also exhibited an excellent targeting of lymphoma cells and an enhanced antitumor activity. The possible pathway to induce cytotoxic effects was Bcl-2/caspase-mediated apoptosis pathway. In conclusion, CuS-GFLG-DOX could precisely deliver drugs to lymphoma cells and could be a novel and promising therapeutic option for lymphoma.

Sign in / Sign up

Export Citation Format

Share Document