Application of Carbon Nanotubes as Drug Delivery System for Anticancer Therapy

2020 ◽  
pp. 29-36
Author(s):  
Sabita Shrestha
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Anticancer Therapy ◽  
Loading Capacity ◽  
One Dimensional ◽  
Nano Medicine ◽  
High Drug Loading

Carbon nanotubes are one-dimensional allotrope of carbon having high aspect ratio, high surface area, and excellent material properties. It has applications in many fields such as catalyst, nano-electronics, field emission, nano medicine, solar cells, energy storage etc. Drug delivery is one of the important applications of carbon nanotubes because of its unique properties such as high drug loading capacity, thermal ablation, ease of cellular uptake. This article briefly overviews the different steps in drug delivery and anticancer therapy such as mechanism of drug loading, transportation, distribution, metabolism and finally excretion of drug.

Novel catalytic micromotor of porous zeolitic imidazolate framework-67 for precise drug delivery

Nanoscale ◽  
2018 ◽  
Vol 10 (24) ◽  
pp. 11384-11391 ◽  
Author(s):  
Linlin Wang ◽  
Hongli Zhu ◽  
Ying Shi ◽  
You Ge ◽  
Xiaomiao Feng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
Zeolitic Imidazolate Framework ◽  
High Drug ◽  
High Drug Loading

Novel catalytic micromotors based on porous ZIF-67 were used as efficient fluorescence drug (DOX) carriers. Benefiting from the porous nature and high surface area, these micromotors display effective motion, long durable movement life and high drug loading capacity.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

Recent trends in carbon nanotubes based prostate cancer therapy: A biomedical hybrid for diagnosis and treatment

2021 ◽  
Vol 18 ◽  
Author(s):  
Raja Murugesan ◽  
Sureshkumar Raman
Keyword(s):  
Prostate Cancer ◽  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
High Capacity ◽  
Chemical Properties ◽  
Diagnosis And Treatment ◽  
High Level

: At present treatment methods for cancer are limited, partially due to the solubility, poor cellular distribution of drug molecules and, the incapability of drugs to annoy the cellular barriers. Carbon nanotubes (CNTs) generally have excellent physio-chemical properties, which include high-level penetration into the cell membrane, high surface area and high capacity of drug loading by in circulating modification with bio-molecules, project them as an appropriate candidate to diagnose and deliver drugs to prostate cancer (PCa). Additionally, the chemically modified CNTs which have excellent 'Biosensing' properties therefore makes it easy for detecting PCa without fluorescent agent and thus targets the particular site of PCa and also, Drug delivery can accomplish a high efficacy, enhanced permeability with less toxic effects. While CNTs have been mainly engaged in cancer treatment, a few studies are focussed on the diagnosis and treatment of PCa. Here, we detailly reviewed the current progress of the CNTs based diagnosis and targeted drug delivery system for managing and curing PCa.

scholarly journals Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

2013 ◽  
Vol 49 (4) ◽  
pp. 629-643 ◽  
Author(s):  
Swatantra Kumar Singh Kushwaha ◽  
Saurav Ghoshal ◽  
Awani Kumar Rai ◽  
Satyawan Singh
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Modern Times ◽  
Novel Drug Delivery System ◽  
Considerable Work ◽  
Novel Drug ◽  
High Drug Loading

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.

scholarly journals Synthesis and compatibility evaluation of versatile mesoporous silica nanoparticles with red blood cells: an overview

RSC Advances ◽  
2019 ◽  
Vol 9 (61) ◽  
pp. 35566-35578 ◽  
Author(s):  
Subhankar Mukhopadhyay ◽  
Hanitrarimalala Veroniaina ◽  
Tadious Chimombe ◽  
Lidong Han ◽  
Wu Zhenghong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Blood Cells ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
High Drug Loading

Protean mesoporous silica nanoparticles are propitious candidates over decades for nanoscale drug delivery systems due to their unique characteristics, including changeable pore size, mesoporosity, high drug loading capacity and biodegradability.

Magnetic carbon nanotubes with particle-free surfaces and high drug loading capacity

2011 ◽  
Vol 22 (35) ◽  
pp. 355602 ◽  
Author(s):  
Eleni C Vermisoglou ◽  
George Pilatos ◽  
George E Romanos ◽  
Eamon Devlin ◽  
Nick K Kanellopoulos ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Loading ◽  
Loading Capacity ◽  
Free Surfaces ◽  
High Drug ◽  
Magnetic Carbon ◽  
High Drug Loading ◽  
Magnetic Carbon Nanotubes

scholarly journals HCT116 Cells Cytotoxic Response to Multifuctionalized 5- Fluorouracil MWCNTs Conjugates In Colorectal Cancer

2021 ◽  
Vol 04 (08) ◽  
Author(s):  
Hemalatha K.P. ◽  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Hct116 Cell ◽  
High Surface ◽  
High Surface Area ◽  
Therapeutic Effects ◽  
Covalent Functionalization ◽  
Anticancer Drug Delivery ◽  
Multi Walled Carbon Nanotubes ◽  
Functionalized Mwcnts

Nanomaterials are the foundations of Nanotechnology, which are measured in nanoscales, Carbon nanotubes are one of the interesting nanomaterials, studied for over 25 years because of their superlative properties such as high surface area, electrical and thermal conductivity, high biocompatibility, flexibility, resistance to corrosion and nanosize. According to research, carbon nanotubes are applied in sensing, water treatment, and drug delivery, mainly used to deliver the anticancer drugs. In our work, functionalization of multi walled carbon nanotubes done by covalent and non-covalent functionation methods, covalent functionalization showed better dispersing efficiency in aqueous medium and compatible with biological systems with damaging the crystal lattice of carbon nanotubes. Non covalent functionalization helps to derivatized with active compounds, surface adsorption or attachment of various molecules or antibodies, which subsequently helps in targeting the site and to produce therapeutic effects. Different formulations prepared by functionalized MWCNTs and multiple functionalization of MWCNTs done by binding the drug and antibodies to prepare functionalized MWCNTs 5-Fluorouracil complexes. The Cytotoxicity assay was carried out for the obtained new targeting formulations to analyze the effect of all the formulations on HCT116 cell line. The percentage death was determined based on the viability of the cells in the appropriate vehicle controls. In this study, we report the successful functionalization, binding of 5 Fluorouracil, antibodies to MWCNTs, and cells viability of all prepared formulations for the development of novel carbon based anticancer drug delivery system. Functionalized MWCNTs-5-Fluorouracil antibodies composite at concentration above 2.5 µg/mL exhibited ≥ 50% cytotoxicity post normalization with compound control to negate precipitation observed with the compound. All the formulations showed the precipitations indicating antitumor activity and biocompatibility.

scholarly journals Functionalized Carbon Nanotubes: Synthesis, Properties and Applications in Water Purification, Drug Delivery, Material and Biomedical Science

2021 ◽  
Author(s):  
Rama Dubey ◽  
Dhiraj Dutta ◽  
Arpan Sarkar ◽  
Pronobesh Chattopadhyay
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Aspect Ratio ◽  
Material Properties ◽  
High Surface ◽  
High Surface Area ◽  
Biomedical Science ◽  
Functionalized Carbon Nanotubes ◽  
Synthesis Properties ◽  
The Ideal

Carbon nanotubes (CNTs) are considered as one of the ideal materials due to their high surface area, high aspect ratio, impressive material properties, such as mechanical strength, thermal and electrical...

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

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