Combined Fmri and MRI Movie in the Evaluation of Articulation in Subjects with and without Cleft Lip and Palate

2008 ◽  
Vol 45 (3) ◽  
pp. 309-314 ◽  
Author(s):  
Michiru Sato-Wakabayashi ◽  
Maristela Sayuri Inoue-Arai ◽  
Takashi Ono ◽  
Ei-ichi Honda ◽  
Tohru Kurabayashi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Evaluation Methodology ◽  
Precentral Gyrus ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Dynamic Movement ◽  
Bilateral Cleft Lip

Objective: This study was undertaken to explore the application of functional magnetic resonance imaging (fMRI) and MRI movies in the evaluation of articulatory function in subjects with and without cleft lip and palate (CLP). Design: The authors examined brain activation and the dynamic movement of articulators during bilabial and velar plosives using fMRI and MRI movies. Subjects: Two subjects, one with unilateral cleft lip and palate (UCLP) and one with bilateral cleft lip and palate (BCLP), and 12 non-CLP volunteers. Results: Activation foci were found in the precentral gyrus, thalamus, and cerebellum in non-CLP volunteers. In comparison, similar regions were activated in the UCLP subject during both plosives, whereas the regions activated in the BCLP subject were different, particularly during the velar plosive. The dynamic movement of articulators in the UCLP subject was comparable to that in a non-CLP volunteer but different from that in the BCLP subject. Conclusions: The results suggest that these two MRI modalities may be a promising evaluation methodology for articulatory function in CLP from central and peripheral perspectives.

Distinctive Cortical Articulatory Representation in Cleft Lip and Palate: A Preliminary Functional Magnetic Resonance Imaging Study

2006 ◽  
Vol 43 (5) ◽  
pp. 620-624 ◽  
Author(s):  
Hideo Shinagawa ◽  
Takashi Ono ◽  
Ei-ichi Honda ◽  
Tohru Kurabayashi ◽  
Atsushi Iriki ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Sensorimotor Cortex ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Blood Oxygenation ◽  
Cortical Representation ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Objective: To investigate cortical representation of articulation of the bilabial plosive in patients with cleft lip and palate. Design: We examined cortical representation for /pa/-articulation in cleft lip and palate patients using blood oxygenation level–dependent functional magnetic resonance imaging. Subjects: Data from four postsurgical adult cleft lip and palate patients were compared with those from six healthy volunteers. Results: Activation foci were found in the bilateral primary sensorimotor cortex in all cleft lip and palate patients, as in the controls. The sensorimotor cortex ipsilateral to the side of cleft lip and palate showed greater activation in unilateral cleft lip and palate patients, whereas the sensorimotor cortex contralateral to the side on which cheiloplasty had been performed earlier showed greater activation in a bilateral cleft lip and palate patient. Conclusions: The results suggest that there may be an ipsilateral dominance in cortical representation during bilabial articulation to the side of the cleft in the upper lip.

Examination of processing speed deficits in multiple sclerosis using functional magnetic resonance imaging

2009 ◽  
Vol 15 (3) ◽  
pp. 383-393 ◽  
Author(s):  
HELEN M. GENOVA ◽  
FRANK G. HILLARY ◽  
GLENN WYLIE ◽  
BART RYPMA ◽  
JOHN DELUCA
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Processing Speed ◽  
Anterior Cingulate ◽  
Precentral Gyrus ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Group Processing

AbstractAlthough it is known that processing speed deficits are one of the primary cognitive impairments in multiple sclerosis (MS), the underlying neural mechanisms responsible for impaired processing speed remain undetermined. Using BOLD functional magnetic resonance imaging, the current study compared the brain activity of 16 individuals with MS to 17 healthy controls (HCs) during performance of a processing speed task, a modified version of the Symbol Digit Modalities Task. Although there were no differences in performance accuracy, the MS group was significantly slower than HCs. Although both groups showed similar activation involving the precentral gyrus and occipital cortex, the MS showed significantly less cerebral activity than HCs in bilateral frontal and parietal regions, similar to what has been reported in aging samples during speeded tasks. In the HC group, processing speed was mediated by frontal and parietal regions, as well as the cerebellum and thalamus. In the MS group, processing speed was mediated by insula, thalamus and anterior cingulate. It therefore appears that neural networks involved in processing speed differ between MS and HCs, and our findings are similar to what has been reported in aging, where damage to both white and gray matter is linked to processing speed impairments (JINS, 2009, 15, 383–393).

Dynamic Analysis of Articulatory Movement Using Magnetic Resonance Imaging Movies: Methods and Implications in Cleft Lip and Palate

2005 ◽  
Vol 42 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Hideo Shinagawa ◽  
Takashi Ono ◽  
Ei-Ichi Honda ◽  
Shinobu Masaki ◽  
Yasuhiro Shimada ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Posterior Pharyngeal Wall ◽  
Normal Volunteer ◽  
Resonance Imaging ◽  
Pharyngeal Wall ◽  
Articulatory Movement ◽  
The Subject

Objectives To visualize articulatory movement using a magnetic resonance imaging (MRI) movie of a subject with cleft lip and palate (CLP) and to demonstrate the usefulness of this method for studying oropharyngeal function. Material and Methods Dynamic changes in oropharyngeal structures were assessed with an MRI movie of a man with cleft lip and palate and in a normal adult male volunteer during the articulation of /pa/, /ta/, and /ka/. Results and Conclusions Different movement patterns were observed during articulation in the subject with CLP compared with the normal volunteer. Posterosuperior movement of the tongue and the anterior movement of the posterior pharyngeal wall were clearly visualized in the subject with CLP. Thus, MRI movies appear to be a promising tool for evaluating speech function in patients with CLP because of their noninvasive and nonradiation nature.

scholarly journals Narcolepsy type 1 patients have abnormal brain activation to neutral-rated movies in humor-paradigm

2018 ◽  
Author(s):  
Hilde T. Juvodden ◽  
Dag Alnæs ◽  
Martina J. Lund ◽  
Espen Dietrichs ◽  
Per M. Thorsby ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Brain Activation ◽  
Precentral Gyrus ◽  
Permutation Testing ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Supramarginal Gyrus

AbstractNarcolepsy type 1 is a neurological sleep disorder mainly characterized by excessive daytime sleepiness, fragmented night sleep, and cataplexy (muscle atonia triggered by emotions). To characterize brain activation patterns in response to neutral-rated and fun-rated movies in narcolepsy type 1 we performed functional magnetic resonance imaging during a paradigm consisting of 30 short movies (25/30 with a humorous punchline; 5/30 without a humorous punchline (but with similar build-up/anticipation)) that the participants rated based on their humor experience. We included 41 narcolepsy type 1 patients (31 females, mean age 23.6 years, 38/41 H1N1-vaccinated, 41/41 HLA-DQB1*06:02-positive, 40/40 hypocretin-deficient) and 44 first-degree relatives (24 females, mean age 19.6 years, 30/44 H1N1-vaccinated, 27/44 HLA-DQB1*06:02-positive) as controls. Group-level inferences were made using permutation testing.Permutation testing revealed no significant differences in the average ratings of patients and controls. Functional magnetic resonance imaging analysis revealed that both groups showed higher activations in response to fun-rated movies in several brain regions associated with humor processing, with no significant group differences. In contrast, patients showed significantly higher activation compared to controls during neutral-rated movies; including bilaterally in the thalamus, pallidum, putamen, amygdala, hippocampus, middle temporal gyrus, cerebellum, brainstem and in the left precuneus, supramarginal gyrus and caudate.The presence of a humorous punchline in a neutral-rated movie is important since we found no brain overactivation for narcolepsy type 1 patients for movies without a humorous punchline (89.0% neutral-rated) compared with controls.Further, a comparison between fun-rated and neutral-rated movies revealed a pattern of higher activation during fun-rated movies in controls, patients showed no significant differentiation between these states. Group analyses revealed significantly stronger differentiation between fun-rated and neutral-rated movies in controls compared with patients, including bilaterally in the inferior frontal gyrus, thalamus, putamen, precentral gyrus, lingual gyrus, supramarginal gyrus, occipital areas, temporal areas, cerebellum and in the right hippocampus, postcentral gyrus, pallidum and insula.In conclusion, during neutral-rated movies, narcolepsy type 1 patients showed significantly higher activation in several cortical and subcortical regions previously implicated in humor and REM sleep, including the thalamus and basal ganglia. The relative lack of differentiation between neutral-rated and fun-rated movies in narcolepsy type 1 patients might represent insight into the mechanisms associated with cataplexy, in which a long-lasting hypervigilant state could represent risk (hypersensitivity to potential humorous stimuli) for the narcolepsy type 1 patients, which seem to have a lower threshold for activating the humor response, even during neutral-rated movies.

scholarly journals Tongue Posture, Tongue Movements, Swallowing, and Cerebral Areas Activation: A Functional Magnetic Resonance Imaging Study

2020 ◽  
Vol 10 (17) ◽  
pp. 6027 ◽  
Author(s):  
Fabio Scoppa ◽  
Sabina Saccomanno ◽  
Gianluca Bianco ◽  
Alessio Pirino
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Precentral Gyrus ◽  
Z Score ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Tongue Protrusion ◽  
Postcentral Gyrus ◽  
Parietal Lobule

The aim of this study was to pinpoint the cerebral regions implicated during swallowing by comparing the brain activation areas associated with two different volitional movements: tongue protrusion and tongue elevation. Twenty-four healthy subjects (11—males 22 ± 2.9 y; 13—females 23 ± 4.1 y; were examined through functional magnetic resonance imaging (fMRI) while performing two different swallowing tasks: with tongue protrusion and with tongue elevation. The study was carried out with the help of fMRI imaging which assesses brain signals caused by changes in neuronal activity in response to sensory, motor or cognitive tasks. The precentral gyrus and the cerebellum were activated during both swallowing tasks while the postcentral gyrus, thalamus, and superior parietal lobule could be identified as large activation foci only during the protrusion task. During protrusion tasks, increased activations were also seen in the left-middle and medial frontal gyrus, right thalamus, inferior parietal lobule, and the superior temporal gyrus (15,592-voxels; Z-score 5.49 ± 0.90). Tongue elevation activated a large volume of cortex portions within the left sub-gyral cortex and minor activations in both right and left inferior parietal lobules, right postcentral gyrus, lentiform nucleus, subcortical structures, the anterior cingulate, and left insular cortex (3601-voxels; Z-score 5.23 ± 0.52). However, the overall activation during swallowing tasks with tongue elevation, was significantly less than swallowing tasks with tongue protrusion. These results suggest that tongue protrusion (on inferior incisors) during swallowing activates a widely distributed network of cortical and subcortical areas than tongue elevation (on incisor papilla), suggesting a less economic and physiologically more complex movement. These neuromuscular patterns of the tongue confirm the different purpose of elevation and protrusion during swallowing and might help professionals manage malocclusions and orofacial myofunctional disorders.

scholarly journals Changes in Cerebral Blood Flow and Cerebral Oxygen Metabolism during Neural Activation Measured by Positron Emission Tomography: Comparison with Blood Oxygenation Level-Dependent Contrast Measured by Functional Magnetic Resonance Imaging

2005 ◽  
Vol 25 (3) ◽  
pp. 371-377 ◽  
Author(s):  
Hiroshi Ito ◽  
Masanobu Ibaraki ◽  
Iwao Kanno ◽  
Hiroshi Fukuda ◽  
Shuichi Miura
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Venous Blood ◽  
Blood Oxygenation ◽  
Neural Activation ◽  
Precentral Gyrus ◽  
Bold Signal ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

The discrepancy between the increases in cerebral blood flow (CBF) and CMRO2 during neural activation causes an increase in venous blood oxygenation and, therefore, a decrease in paramagnetic deoxyhemoglobin concentration in venous blood. This can be detected by functional magnetic resonance imaging (fMRI) as blood oxygenation level-dependent (BOLD) contrast. In the present study, changes in the cerebral oxygen extraction fraction (OEF) that corresponds to the ratio of CMRO2 to CBF, and in the BOLD signal during neural activation, were measured by both positron emission tomography (PET) and fMRI in the same human subjects. C15O, 15O2, and H215O PET studies were performed in each subject at rest (baseline) and during performance of a right-hand motor task. Functional magnetic resonance imaging studies were then performed to measure the BOLD signal under the two conditions. During performance of the motor task, a significant increase in CBF and a significant decrease in OEF were observed in the left precentral gyrus, left superior frontal gyrus, right precentral gyrus, right cingulate gyrus, and right cerebellum. A significant positive correlation was observed between changes in the CBF and the BOLD signal, and a significant negative correlation was observed between changes in the OEF and the BOLD signal. This supports the assumption on which BOLD contrast studies during neural activation are based.

scholarly journals Changes in Functional Connectivity of Specific Cerebral Regions in Patients with Toothache: A Resting-State Functional Magnetic Resonance Imaging Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Shi-Nan Wu ◽  
Meng-Yao Zhang ◽  
Hui-Ye Shu ◽  
Rong-Bin Liang ◽  
Qian-Ming Ge ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Roc Curve ◽  
Resting State ◽  
Linear Regression Analysis ◽  
Precentral Gyrus ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Objective. In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods. Eighteen TA patients (8 males, 10 females) and 18 healthy individuals of similar age, sex, and educational levels were recruited as healthy controls (HCs) to take part in the study, and all underwent rs-fMRI examination. And DC technology was used to compare the state of their cerebral spontaneous functional activity. In order to compare the average DC values of the TA group and HC group, we used independent two-sample t -test and receiver operating characteristic (ROC) curve to compare the difference of DC values between the two groups, so as to distinguish the accuracy of TA diagnosis. Finally, we also carry out Pearson’s linear regression analysis. Results. The TA group showed higher DC values in the right lingual gyrus (RLG), right precentral gyrus, and left middle temporal gyrus (LMTG) than HCs. Moreover, ROC curve analysis indicated that the area under the curve (AUC) of each cerebral region studied had high accuracy. In addition, linear analysis indicated that the DC values of the RLG were positively correlated with the Hospital Anxiety and Depression Scale (HADS) ( r = 0.844 , p < 0.001 ), and the DC values of the LMTG were positively correlated with the visual analogue scale (VAS) ( r = 0.723 , p < 0.001 ). Conclusion. TA generates abnormal changes in the intrinsic activity patterns of pain-related and vision-related areas of the cerebral cortex, which will be beneficial to reveal the underlying neuropathic mechanisms.

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