Effects of 10-GHz Microwaves on Hematological Parameters in Swiss Albino Mice and Their Modulation by Prunus avium

2013 ◽  
Vol 32 (3) ◽  
pp. 205-217
Author(s):  
Rashmi Sisodia ◽  
Faiza Rifat ◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
K. V. Sharma
Keyword(s):  
Prunus Avium ◽  
Hematological Parameters ◽  
Swiss Albino Mice ◽  
Albino Mice

Protective Effects of Prunus Avium Extract on 10 Ghz Induced Damages in the Spleen of Swiss Albino Mice

2011 ◽  
Vol 3 (8) ◽  
pp. 680-684 ◽  
Author(s):  
Faiza Rifat ◽  
◽  
Archana Sharma ◽  
Preeti Srivastava ◽  
Shikha Patni ◽  
...  
Keyword(s):  
Prunus Avium ◽  
Protective Effects ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Vitamin-C Treated Haematology Assessment of Swiss Albino Mice (Mus musculus)

2020 ◽  
Vol 11 (2) ◽  
pp. 9044-9050
Keyword(s):  
Vitamin C ◽  
Blood Cell ◽  
Cell Count ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
The Body ◽  
Blood Cell Count ◽  
Swiss Albino Mice ◽  
Positive Effects ◽  
Albino Mice

Vitamin C is an essential dietary supplement that plays a vital role in battling health conditions. The antioxidant has positive effects on the functioning of the body. The purpose of this study is to investigate the outcome of varying concentrations of Vitamin C on the hematological parameters of Swiss Albino mice. Four albino mice were separated and accommodated in similar caging conditions. Three of them were orally administered with 250mg/kg, 500mg/kg, and 1000mg/kg Vitamin C powder, along with their diet. The fourth one was kept as control, in order to provide a standard value for future comparison. After 30 days of administration of the Vitamin C, the red blood cell count, the white blood cell count, the hemoglobin concentration, the platelet cell count, and the packed cell volume of the blood samples were tested.

scholarly journals Hematological and Histopathological Profiles of Swiss Albino Mice Infected with Plasmodium berghei upon Treatment with Cooked Tetracarpidium conophorum Seed Ethanol Extract

2021 ◽  
pp. 22-37
Author(s):  
Dada Ebenezer ◽  
Oladipo Faith Temiloluwa
Keyword(s):  
Body Weight ◽  
Plasmodium Berghei ◽  
Hematological Parameters ◽  
Haemoglobin Concentration ◽  
Ethanol Extract ◽  
Seed Extract ◽  
Mean Corpuscular Hemoglobin ◽  
Swiss Albino Mice ◽  
Albino Mice ◽  
Group 5

Aim: This study was conducted to verify the hematological and histopathological outcome of cooked ethanol seed extract of Tetracarpidium conophorum in swiss albino mice infected with Plasmodium berghei (NK65). Study Design: Descriptive study. Methodology: Standard methods were conducted to determine the phyto-chemical profile of cooked T. conophorum seed ethanol extract, hematological, histopathological indices and biochemical assay. Mice were assembled into five groups (1, 2, 3, 4 and 5) of seven each. The mice in group 4 were treated with a customary antimalarial drug (chloroquine as positive control) at a dose of 5 mg/kg body weight, while mice in groups 3, 2 and 1 was administered with increasing dosages (200, 400, 800 mg/kg body weight) of seed extracts for four consecutive days respectively. Results: The qualitative phytochemical screening of T. conophorum seed extract revealed the presence of bioactive components such as saponin, tannins, flavonoid, terpenoid. Saponin (16.82 mg/100 g) was the highest occurring phytochemical followed by terpenoid (10.39 mg/100 g), glycoside (5.9 mg/100 g), tannin (2.8 mg/100 g) and flavonoid (1.17 mg/100 g), while steroid only had a trace presence. Hematological parameters revealed mice in all groups do not possess significantly different mean corpuscular haemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean corpuscular volume (MCV). Mice in group 5 (infected and not treated) demonstrated lowest values of hemoglobin, platelet, and packed cell volume with a significantly lower % eosin. There was considerable decrease in the levels of alanine transaminase and aspartate transaminase in group 5 compared to mice in groups 1, 2, and 3. Conclusion: Ameliorative effects of seed extract were observed on the liver and kidney of mice at dose levels (200 mg/kg) used, but the 400 mg/kg restored the kidney but had adverse effect on the liver. This study therefore shows that cooked T. conophorum is generally less effective and could not be employed for treatment of malaria.

Trema orientalis (Linn.) leaves promotes anticancer activity in Ehrlich ascites carcinoma (EAC) in Swiss albino mice

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Masnoon Kabir ◽  
Abdullah AL-Noman ◽  
Biplab Kumar Dash ◽  
Mahmudul Hasan ◽  
Shahina Akhter ◽  
...  
Keyword(s):  
Body Weight ◽  
Tumor Cell ◽  
Chromatin Condensation ◽  
Hematological Parameters ◽  
Ehrlich Ascites Carcinoma ◽  
Swiss Albino Mice ◽  
Ehrlich Ascites ◽  
Trema Orientalis ◽  
Albino Mice ◽  
Eac Cells

AbstractBackgroundThe in vivo anticancer effect of the Trema orientalis leaves crude methanol extract (TLME) was screened against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.Materials and methodsThe cytotoxic activity of TLME was determined in vitro by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The growth inhibitory activity and morphological alterations were determined by the hemocytometer counting of the EAC cells using trypan blue dye. The apoptotic cells were assessed by DAPI (4′,6-diamidino-2-phenylindole) staining. The hematological and biochemical parameters of experimental mice were also estimated.ResultsAfter treatment with the TLME, the viable tumor cell count, morphological changes and nuclear damages of the EAC cells were observed along with the hematological parameters of the experimental mice. The LD50 of TLME was 3120.650 mg/kg body weight, and this extract was proven to be safe at a dose of as high as 800 mg/kg body weight. The oral administration of the TLME at 400 mg/kg body weight resulted in approximately 59% tumor cell growth inhibition compared with the control mice, with considerable apoptotic features, including membrane blebbing, chromatin condensation, nuclear fragmentation and aggregation of the apoptotic bodies in DAPI staining under a fluorescence microscope. The TLME also dose-dependently restored the altered hematological parameters to approximately normal levels. The TLME exhibited bolstering cytotoxic effect against the EAC cell with the IC50 value of 29.952 ± 1.816 μg/mL.ConclusionThe TLME has potential as a natural anti-cancer product with apoptosis induction property and cytotoxicity against carcinoma cells.

Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system

2011 ◽  
Vol 30 (1) ◽  
pp. 55-70 ◽  
Author(s):  
Rashmi Sisodia ◽  
Smita Singh ◽  
chaturbhuj Mundotiya ◽  
Ekta Meghnani ◽  
Preeti Srivastava
Keyword(s):  
Special Reference ◽  
Prunus Avium ◽  
Hematopoietic System ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Effect of Achyranthes Aspera Leaf Extract on Hematological Parameters of Swiss Albino Mice

2019 ◽  
Vol 4 (4) ◽  
pp. 96
Author(s):  
Emmanuel Asuquo Etim ◽  
Yusuf Abdulhakeem Adebayo ◽  
Obeagu Emmanuel Ifeanyi
Keyword(s):  
Leaf Extract ◽  
Hematological Parameters ◽  
Swiss Albino Mice ◽  
Achyranthes Aspera ◽  
Albino Mice

Effect of Luffa cylindrica Leaf Extract on Hematological Parameters of Swiss Albino Mice

2018 ◽  
Vol 07 (02) ◽  
Author(s):  
Emmanuel Asuquo Etim ◽  
Yusuf Abdulhakeem Adebayo ◽  
Obeagu Emmanuel Ifeanyi
Keyword(s):  
Leaf Extract ◽  
Hematological Parameters ◽  
Luffa Cylindrica ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Effects of Hibiscus Rosasinensis on the Hematology of the Swiss Albino Mice: An In-Vivo Study

2019 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Blood Cell ◽  
Research Study ◽  
Chemical Constituents ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Medicinal Uses ◽  
Swiss Albino Mice ◽  
Plant Parts ◽  
Albino Mice

The present research/study was conducted on the heamtology of the Swiss albino mice irrespective of sex and experiment was done by using the aqueous extract of Hibiscus rosasinensis. Nature has become a vital source of medicine nowadays and people are also becoming very much dependent on the herbal drugs. Hibiscus rosasinensis is a very common and renowned plant having a variety of medicinal uses. This plant parts (flower, leaf and shrub etc.) possesses many phytochemicals which have different medicinal values. But these chemical constituents whether affect the hematological parameters (Red Blood Cell, White Blood Cell, Hemoglobin Concentration and Packed Cell Volume) is yet to know. For the sake of this purpose the experiment was done. Hence, it is concluded that the use of Hibiscus rosasinensis whereas may not cause any adverse effect on the hematology of the rather it elevates the hematological parameters of Swiss albino mice.

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