scholarly journals Intraocular Pressure and Quality of Blockade in Peribulbar Anesthesia Using Ropivacaine or Lidocaine with Adrenaline: A Double-Blind Randomized Study

2004 ◽  
Vol 204 (3) ◽  
pp. 203-208 ◽  
Author(s):  
Gonul Olmez ◽  
Sevin Soker Cakmak ◽  
Ihsan Caca ◽  
M. Kaan Unlu
Keyword(s):  
Intraocular Pressure ◽  
Randomized Study ◽  
Double Blind ◽  
Peribulbar Anesthesia

Efficacy of Celecoxib in Treating Symptoms of Viral Pharyngitis: A Double-Blind, Randomized Study of Celecoxib versus Diclofenac

2002 ◽  
Vol 30 (2) ◽  
pp. 185-194 ◽  
Author(s):  
LLM Weckx ◽  
JE Ruiz ◽  
J Duperly ◽  
GA Martínez Mendizabal ◽  
MBG Rausis ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Events ◽  
Randomized Study ◽  
Specific Inhibitor ◽  
Symptomatic Treatment ◽  
Double Blind ◽  
Once Daily ◽  
Daily Group ◽  
Throat Pain

This study compared the efficacy and safety of the cyclooxygenase-2 specific inhibitor celecoxib with the conventional non-steroidal anti-inflammatory drug diclofenac in the symptomatic treatment of viral pharyngitis. Adult patients from 27 study centers in Latin America were treated with oral doses of celecoxib 200 mg once daily or 200 mg twice daily, or diclofenac 75 mg twice daily for 5 days in a double-blind, randomized study. The primary efficacy assessment was ‘Throat Pain on Swallowing’ on day 3. In addition, secondary quality-of-life assessments were performed on days 3 and 5. All adverse events and treatment-emergent signs and symptoms were recorded. Data from 313 patients were evaluable for efficacy (105 celecoxib 200 mg once daily, 107 celecoxib 200 mg twice daily, 101 diclofenac 75 mg twice daily). The upper 95% confidence limits for the visual analog scale of ‘Throat Pain on Swallowing’ on day 3 for celecoxib 200 mg once daily relative to diclofenac 75 mg twice daily, and celecoxib 200 mg twice daily relative to diclofenac 75 mg twice daily were 9.26 and 7.83, respectively. All secondary efficacy and quality-of-life measures were clinically similar for the three treatment groups, and no statistically significant differences were detected. The incidences of treatment-emergent adverse events and withdrawals due to adverse events were similar for all groups, but numerically higher among patients taking diclofenac than celecoxib. More patients in the diclofenac group reported gastrointestinal complaints (7.3%) compared with those in the celecoxib groups (4.3% in the celecoxib 200 mg once-daily group and 3.4% in the celecoxib 200 mg twice-daily group). In conclusion, 5 days of treatment with celecoxib 200 mg once daily is as effective as diclofenac 75 mg twice daily in the symptomatic treatment of viral pharyngitis. Celecoxib 200 mg once daily is also as effective as celecoxib 200 mg twice daily in this condition.

scholarly journals Comparison of effects of low dose ropivacaine with levobupivacaine on quality of analgesia, maternal satisfaction and neonatal outcome during labor through combined spinal epidural approach: A double blind randomized study

2021 ◽  
Vol 8 (2) ◽  
pp. 230-235
Author(s):  
Shruti Sharma ◽  
Archana Agarwal ◽  
Trilok Chand ◽  
Unni Jithendran
Keyword(s):  
Randomized Study ◽  
Labor Analgesia ◽  
Statistical Testing ◽  
Secondary Outcome ◽  
Epidural Administration ◽  
Maternal Satisfaction ◽  
Double Blind ◽  
Combined Spinal Epidural ◽  
Spinal Epidural

Regional techniques in labor analgesia have proven to be very effective, with bupivacaine being the most commonly used drug. This study compares the efficacy of local anaesthetics with lower cardiotoxicity and neurotoxicity such as levobupivacaine and ropivacaine in low doses, administered intrathecally followed by Patient Controlled Epidural Analgesia (PCEA). The primary outcome and secondary outcome of the study was to compare the quality of analgesia (verbal rating score) and maternal satisfaction respectively. The Double blind prospective randomized study included 60 parturients of ASA I and II with 37-41 weeks of singleton pregnancy in active labor, cervical dilatation >4 cm, with no obstetrical or medical complication, requesting painless labor, randomized into two groups (30 each) by a computer generated randomized sequence:Group R- received intrathecal 2.5 mg ropivacaine followed by epidural administration of 10 ml 0.125% ropivacaine Group L- received intrathecal 2.5 mg levobupivacaine followed by epidural administration of 10 ml 0.125% levobupivacaine. The primary and secondary outcome of the study was to compare the quality of analgesia and maternal satisfaction respectively. Statistical testing was conducted with the statistical package for social science system version (SPSS) 17.0. Group R had late onset and shorter duration of action with lesser motor blockade, however the results were statistically insignificant. Group L had slightly less total consumption of local anaesthetic and better maternal satisfaction, but was statistically insignificant. Patients in both groups had statistically similar pain scores at various intervals. Both levobupivacaine and ropivacaine are highly effective for labor analgesia using the combined spinal epidural (CSE) technique.

scholarly journals Successful Fecal Microbiota Transplantation in a Patient Suffering From Irritable Bowel Syndrome and Recurrent Urinary Tract Infections

2019 ◽  
Vol 6 (10) ◽  
Author(s):  
Marie Hocquart ◽  
Thao Pham ◽  
Edmond Kuete ◽  
Enora Tomei ◽  
Jean Christophe Lagier ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Urinary Tract ◽  
Fecal Microbiota Transplantation ◽  
Randomized Study ◽  
Gastrointestinal Disorder ◽  
Fecal Microbiota ◽  
Double Blind ◽  
Irritable Bowel ◽  
Tract Infections

Abstract Background Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%–23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods We describe the case of a 73-year-old woman suffering from IBS (abdominal pain, bloating, and abundant and disabling diarrhea, with 10–15 stools a day) and repetitive urinary tract infection (UTI; 5 episodes in 6 months, including 3 the last 2 months) for several years, generating an impaired quality of life. She received an FMT with 400 mL of fecal infusion from a healthy donor via a nasogastric tube after bowel lavage. Her digestive microbiota was analyzed using culturomic and metagenomic targeting 16S rRNA sequencing methods. Results Eight months after transplantation, we observed a significant reduction in frequency and improvement in stool consistency (3–4 molded stools a day against 10–15 before the transplant) and no recurrence of urinary infection (as previously reported). Using culturomics, we found 12 bacteria present in the fecal infusion and post-transplant stool; these were absent pretransplant. Three of them (Intestinimonas massiliensis, Oscillibacter massiliensis, and Provencibacter massiliensis) were previously discovered and cultivated in our laboratory using culturomics. Using metagenomics, we also observed 12 bacteria, different from those observed during culture, that could have been transferred to the patient by FMT. Conclusions In this case report, IBS symptoms and UTI frequency decreased after FMT UTI. Further studies involving more patients would be relevant to confirm this work and develop bacteriotherapy.

scholarly journals Double-blind prospective randomized study comparing polyethylene glycol to lactulose for bowel preparation in colonoscopy

2014 ◽  
Vol 27 (1) ◽  
pp. 9-12 ◽  
Author(s):  
Aline Moraes MENACHO ◽  
Adriano REIMANN ◽  
Lie Mara HIRATA ◽  
Caroline GANZERELLA ◽  
Flavio Heuta IVANO ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Polyethylene Glycol ◽  
Oral Administration ◽  
Bowel Preparation ◽  
Colonic Mucosa ◽  
Randomized Study ◽  
Subjective Symptom ◽  
Double Blind ◽  
Data Compilation

Background: Colonoscopy is the most frequent exam used to evaluate colonic mucosa, allowing the diagnosis and treatment of many diseases. The appropriate bowel preparation is indispensable for the realization of colonoscopy. Therefore, it is necessary the use of laxative medications, preferentially by oral administration. Aim: To compare two medications used in bowel preparation in adult patients going to ambulatory colonoscopy and to analyze the patients' profile. Methods: A double-blind prospective study with 200 patients, randomized in two groups: one that received polyethilene glycol and another that received lactulose. The patients answered to questionnaires to data compilation, as tolerance, symptoms and complications related to preparation. Besides, it was also evaluated the prepare efficacy related to the presence of fecal residue. Results: Intestinal habit alterations and abdominal pain were the main reasons to realize the exams and hypertension was the most prevalent comorbidity. Ten percent of the ones who received lactulose didn't get to finish the preparation and 50% considered the taste "bad, but tolerable". The most common subjective symptom after the medication was nausea, especially after lactulose. During the exam, most of the patients who used lactulose had a "light discomfort" and the ones who used polyethilene glycol considered the discomfort as "tolerable". The quality of the preparation was good in 75%, undependable of the medication that was used. Conclusion : Polyethilene glycol was more tolerable when compared to lactulose, without difference on the quality of the preparation.

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