scholarly journals Obesity, inflammatory markers, and endometrial cancer risk: a prospective case–control study

2010 ◽  
Vol 17 (4) ◽  
pp. 1007-1019 ◽  
Author(s):  
Laure Dossus ◽  
Sabina Rinaldi ◽  
Susen Becker ◽  
Annekatrin Lukanova ◽  
Anne Tjonneland ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Inflammatory Markers ◽  
Case Control Study ◽  
Case Control ◽  
Low Grade ◽  
Endometrial Cancer Risk ◽  
Bottom Quartile ◽  
Incident Cases ◽  
Control Study

Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case–control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03–2.41, Ptrend=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08–2.54, Ptrend=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22–2.73, Ptrend=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10–20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.

scholarly journals Impact of Raloxifene or Tamoxifen Use on Endometrial Cancer Risk: A Population-Based Case-Control Study

2008 ◽  
Vol 26 (25) ◽  
pp. 4151-4159 ◽  
Author(s):  
Angela DeMichele ◽  
Andrea B. Troxel ◽  
Jesse A. Berlin ◽  
Anita L. Weber ◽  
Greta R. Bunin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
General Population ◽  
Cancer Risk ◽  
African American Women ◽  
Case Control Study ◽  
Case Control ◽  
Low Grade ◽  
Endometrial Cancer Risk ◽  
Control Study

Purpose Raloxifene reduces breast cancer risk in women with osteoporosis, and both tamoxifen and raloxifene prevent breast cancer in high-risk women. However, in vitro, raloxifene does not share the pro-estrogenic effects of tamoxifen on the endometrium. Randomized trials of these agents have provided limited information about endometrial cancer risk in the general population. We sought to compare endometrial cancer risks associated with raloxifene, tamoxifen, and nonusers of a selective estrogen receptor modulator (SERM) in the general population and characterize the endometrial tumors occurring in these groups. Methods We performed a case-control study of white and African American women age 50 to 79 years in the Philadelphia area. Patients were diagnosed with endometrial cancer between July 1999 and June 2002. Controls were identified through random-digit dialing. Results We analyzed 547 cases and 1,410 controls. Among cases, 3.3% had taken raloxifene; 6.2% had taken tamoxifen. Among controls, 6.6% had taken raloxifene; 2.4% had taken tamoxifen. After adjustment for other risk factors, the odds of endometrial cancer among raloxifene users was 50% that of nonusers (odds ratio [OR] = 0.50; 95% CI, 0.29 to 0.85), whereas tamoxifen users had three times the odds of developing endometrial cancer compared with raloxifene users (OR = 3.0; 95% CI, 1.3 to 6.9). Endometrial tumors in raloxifene users had a more favorable histologic profile and were predominantly International Federation of Gynecology and Obstetrics stage I and low grade. Conclusion Raloxifene users had significantly lower odds of endometrial cancer compared with both tamoxifen users and SERM nonusers, suggesting a role for raloxifene in endometrial cancer prevention and individualization of SERM therapy.

Food groups and endometrial cancer risk: a case-control study from Italy

2009 ◽  
Vol 200 (3) ◽  
pp. 293.e1-293.e7 ◽  
Author(s):  
Francesca Bravi ◽  
Lorenza Scotti ◽  
Cristina Bosetti ◽  
Antonella Zucchetto ◽  
Renato Talamini ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Food Groups ◽  
Endometrial Cancer Risk ◽  
Control Study

scholarly journals Allium vegetables intake and endometrial cancer risk

2009 ◽  
Vol 12 (9) ◽  
pp. 1576-1579 ◽  
Author(s):  
Carlotta Galeone ◽  
Claudio Pelucchi ◽  
Luigino Dal Maso ◽  
Eva Negri ◽  
Maurizio Montella ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Wide Spectrum ◽  
Protective Role ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Allium Vegetables ◽  
Control Study

AbstractObjectiveThe potential role of allium vegetables on endometrial cancer risk has been scarcely investigated and the results of previous Chinese studies are not easily applicable to Western populations. Therefore, we evaluated the relationship between onion and garlic intake and endometrial cancer, using data from an Italian case–control study.SettingWe analysed data from a multi-centre case–control study of 454 endometrial cancer cases and 908 controls, admitted to the same hospitals for a wide spectrum of acute, non-neoplastic conditions. Information was collected by trained interviewers using a validated and reproducible FFQ. Multivariate odds ratios and 95 % confidence intervals were obtained after allowance for recognized confounding factors.ResultsCompared with non-users, the OR of endometrial cancer for successive categories of onion intake were 0·94 (95 % CI 0·72, 1·21) for <2 portions/week and 0·40 (95 % CI 0·22, 0·72) for ≥2 portions/week, with a significant inverse trend in risk (P = 0·01). The OR for an increment of one portion (i.e. 80 g) of onions per week was 0·81 (95 % CI 0·70, 0·95). For garlic, the OR for successive categories of intake were 0·89 (95 % CI 0·68, 1·15) for intermediate use and 0·62 (95 % CI 0·42, 0·92) for high use, with a significant inverse trend in risk (P = 0·02).ConclusionsOur study found a moderate protective role of allium vegetables on the risk of endometrial cancer.

Effect of raloxifene on endometrial cancer risk in a population-based, case-control study

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 5001-5001 ◽  
Author(s):  
A. Demichele ◽  
A. Troxel ◽  
A. Weber ◽  
J. Berlin ◽  
G. Bunin ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Control Study

Case-Control Study of Dietary Patterns and Endometrial Cancer Risk

2011 ◽  
Vol 63 (5) ◽  
pp. 673-686 ◽  
Author(s):  
Rita K. Biel ◽  
Christine M. Friedenreich ◽  
Ilona Csizmadi ◽  
Paula J. Robson ◽  
Lindsay McLaren ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Dietary Patterns ◽  
Case Control Study ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Control Study

scholarly journals Proanthocyanidins and other flavonoids in relation to endometrial cancer risk: a case–control study in Italy

2013 ◽  
Vol 109 (7) ◽  
pp. 1914-1920 ◽  
Author(s):  
M Rossi ◽  
V Edefonti ◽  
M Parpinel ◽  
P Lagiou ◽  
M Franchi ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Endometrial Cancer Risk ◽  
Control Study

Use of antidepressants and endometrial-cancer risk: a nationwide nested case–control study

2021 ◽  
Author(s):  
Cecilie D Sperling ◽  
Gitte L Aalborg ◽  
Christian Dehlendorff ◽  
Søren Friis ◽  
Lina S Mørch ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cancer Risk ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Antidepressant Drugs ◽  
Case Control ◽  
Inverse Association ◽  
Endometrial Cancer Risk ◽  
Control Study

Abstract Background Preclinical studies have suggested that antidepressant drugs may possess antineoplastic properties. In a nationwide case–control study, we examined the association between use of antidepressants and endometrial-cancer risk with a particular focus on selective serotonin reuptake inhibitors (SSRIs). Methods From the Danish Cancer Registry, we identified all women with a histologically verified diagnosis of endometrial cancer between 2000 and 2016, and, for each woman, 15 age-matched controls. We obtained information on use of SSRIs, tricyclic antidepressants (TCAs) and other antidepressants based on records of filled prescriptions from the National Prescription Register. Using conditional logistic regression, we calculated adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between use of antidepressants and endometrial-cancer risk compared with non-use. In active comparator analyses, SSRI use was compared with TCA use. Results The study population comprised 8164 cases and 122 432 controls. Compared with non-use, SSRI use was associated with an OR of 0.88 (95% CI 0.82–0.96) for endometrial cancer, whereas the association with TCA use was close to unity (OR 1.05, 95% CI 0.90–1.22). Use of other antidepressants yielded an OR of 0.86 (95% CI 0.71–1.03). We observed no apparent trends in associations according to cumulative amount. The inverse association with SSRI use persisted when compared with TCA use (OR 0.81, 95% CI 0.66–0.99). Conclusions Use of SSRIs was associated with a decreased risk of endometrial cancer, whereas no inverse association appeared with use of TCAs. The antineoplastic potential of SSRIs should be investigated in future studies.

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