IMMUNOREACTIVE INHIBIN CONCENTRATIONS IN SERUM THROUGHOUT THE MENSTRUAL CYCLE OF THE MACAQUE: SUPPRESSION OF INHIBIN DURING THE LUTEAL PHASE AFTER TREATMENT WITH AN LHRH ANTAGONIST

1989 ◽  
Vol 121 (1) ◽  
pp. R9-R12 ◽  
Author(s):  
H. M. Fraser ◽  
D. M. Robertson ◽  
D. M. De Kretser
Keyword(s):  
Menstrual Cycle ◽  
Peripheral Blood ◽  
Luteal Phase ◽  
Serum Levels ◽  
Follicular Phase ◽  
Serum Samples ◽  
Once Daily ◽  
Menstrual Cycles ◽  
Progesterone Secretion ◽  
Lhrh Antagonist

ABSTRACT Concentrations of immunoreactive inhibin in serum samples collected daily from six adult stumptailed female macaques during normal menstrual cycles were measured with a heterologous radioimmunoassay. Serum inhibin concentrations were low during the follicular phase of the cycle. After ovulation they began to rise, reaching a plateau between 8 and 11 days, before falling in parallel with the decline in luteal progesterone secretion. The dependence of the inhibin secretion by the corpus lutem on pituitary gonadotrophins was investigated by the administration of an LHRH antagonist [N-Ac-D-Nal(2)1,D-pCl-Phe2,D-Trp3,D-hArg(Et2)6,D-Ala10]LHRH once daily for 3 days beginning on day 8 of the luteal phase in six macaques. LHRH antagonist treatment markedly suppressed serum levels of inhibin and progesterone and these remained at the level found in the follicular phase for the remainder of the luteal phase. These results show that inhibin in the macaque is secreted into the peripheral blood almost exclusively during the luteal phase, being highest when FSH is at its nadir. Suppression of serum inhibin concentrations during the luteal phase by LHRH antagonist suggests that its secretion is integrated with the LH control of the corpus luteum.

P–643 Is Euploid blastocyst number higher in luteal versus follicular phase? A case-control study of IVF outcomes of follicular versus luteal phase ovarian stimulation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Biscaro ◽  
A R Lorenzon ◽  
E L Motta ◽  
C Gomes
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Stimulation ◽  
Luteal Phase ◽  
Case Control Study ◽  
Case Control ◽  
Follicular Phase ◽  
Menstrual Cycles ◽  
Ivf Outcomes ◽  
Control Study ◽  
Luteal Phase Ovarian Stimulation

Abstract Study question Is there a difference between IVF outcomes in patients undergoing follicular versus luteal phase ovarian stimulation in different menstrual cycles? Summary answer Number of euploid blastocyst were higher in luteal phase ovarian stimulation IVF cycles. All other outcomes were similar between follicular and luteal phase IVF cycles. What is known already It has been published that human beings can have two or three follicular recruitment waves as observed in animals studies a long time ago. From these findings, several recent studies showed that two egg retrievals at the same menstrual cycle, named as Duo Stim, optimize time and IVF outcomes in women with low ovarian reserve due to more eggs retrieved in a shorter period with consequently higher probability of having good embryos to transfer. However, there is no knowledge about diferences concerning IVF outcomes between folicular and luteal ovarian stimulation, performed at the same women in different menstrual cycles. Study design, size, duration Retrospective, case-control study in a single IVF center. One-hundred-two patients who had two IVF treatments – the first cycle initiating ovarian stimulation at follicular phase (FPS) and the second cycle initiating after a spontaneous ovulation at luteal phase (LPS) – in different menstrual cycles (until 6 months apart) between 2014 and 2020, were included. Statistical analysis was performed with Mann-Whitney test and was considered significant when p ≤ 0.05. Data is represented as mean±SD. Participants/materials, setting, methods Patients underwent two IVF treatments in different menstrual cycles; the FPS IVF treatment was initiating at D2/D3 of menstrual cycle and the LPS treatment started three or four days after spontaneous ovulation, if at least 4 antral follicles were detected. Both IVF treatments were performed with and antagonist protocol and freeze all strategy. The majority of patients presents low ovarian reserve/Ovarian age as primary infertility factor (84.3%). Main results and the role of chance Patient’s mean age was 39.30±3.15 years, BMI (22.66±3.16) and AMH levels (0.85±0.85 ng/mL). Comparison of hormonal levels at the beginning of ovarian stimulation showed differences for FPS vs LPS, as expected: E2 (39.69±31,10 pg/mL vs 177.33±214.26 pg/mL,p< 0.0001) and P4 (0.76±2.47ng/mL vs 3,00±5.00 ng/mL,p< 0.0001). However, E2 and P4 at the day of oocyte maturation trigger were not different between FPS and LPS (1355.24±895.73 pg/mL vs 1133.14±973.01 ng/mL,p=0.0883 and 1.12±1.49 ng/mL vs 2.94±6.51,p=0.0972 respectively). There was no difference for total dose of gonadotrofins (FPS 2786.43±1102.39.01UI vs LPS 2824.12±1188.87UI, p = 0,8578), FSH (FPS 9.50±4.98 vs LPS 11.90±12.99,p=0.7502) and AFC (FPS 7.13±4.25 vs LPS 6.42±4.65,p=0,0944). From 102 patients that started ovarian stimulation, 78 had 1 or more oocyte collect in FPS group and 75 in LPS group: OPU (FPS 4.78±4.93 vs LPS 4.65±5.54,p=0.7889), number of MII (FPS 3.21±3.52 vs LPS 3.40±4.53,p=0.7889). From those, 52 patients performed ICSI in both cycles; fertilization rate 64.9%±28.6% for FPS vs 62.1%±32.4% for LPS,p=0.7899) and blastocyst formation 2.15±2.15 for FPS vs 2.54±2.35,p=0.3496). Data from 25 patients who had embryo biopsy for PGT-A showed similar number of blastocyst biopsed (2.12±1.72 FPS vs 2.48±1.71 LPS,p=0.3101) and a statistically significant difference regarding number of euploid blastocyst (0,20±0,41 FPS vs 0,96±0,93 LPS,p=0,0008). Limitations, reasons for caution This is a retrospective study in a limited number of patients. Therefore, it is not possible to make a definitive conclusion that LPS proportionate higher number of euploid than FPS. More studies are necessary to investigate not only IVF outcomes but also the impact on pregnancy rates. Wider implications of the findings: In our study, LPS protocol after spontaneous ovulation, presents similar IVF outcomes compared to routinely FPS protocol. Intriguingly, the number of euploid blastocyst was significant higher in LPS, which may be further investigated. In this way, LPS is another option of IVF treatment, and may optimize time and treatment results. Trial registration number Not applicable

scholarly journals Gonadotropin Glycoforms Circulating in Women Using Progestins of the Levonorgestrel Family for Contraception

2020 ◽  
Vol 4 (11) ◽  
Author(s):  
Karin Eriksson ◽  
Leif Wide
Keyword(s):  
Luteinizing Hormone ◽  
Outcome Measures ◽  
Half Life ◽  
Treatment Cycle ◽  
Follicle Stimulating Hormone ◽  
Serum Levels ◽  
Follicular Phase ◽  
Serum Samples ◽  
Menstrual Cycles ◽  
Contraceptive Effect

Abstract Context The progestins of the levonorgestrel family are 13-ethylgonane progestins, commonly used for contraception in women. One contraceptive effect of these progestins is inhibition of ovulation, which may be a result of changes in gonadotropin glycosylation patterns. Gonadotropin glycoforms differ in number of glycans and bioactivity: more bioactive low-N-glycosylated glycoforms, diglycosylated luteinizing hormone (LHdi) and triglycosylated follicle-stimulating hormone (FSHtri), and less bioactive fully N-glycosylated glycoforms, LHtri and FSHtetra. Objective Characterize the glycosylation patterns on the circulating gonadotropin glycoforms in women using 13-ethylgonane progestins for contraception. Design, Subjects, Main Outcome Measures Serum samples, collected from 92 healthy women using 13-ethylgonane progestins for contraception, were included. Forty women used progestin-only continuously and 52 used progestins combined with ethinylestradiol (EE) for 3 weeks followed by a hormone-free week. Concentration, sulfonation, and sialylation of each glycoform were determined and compared with follicular phase values of normal menstrual cycles. Results The progestin-only group had significantly increased serum levels, decreased sulfonation, and increased sialylation of LHdi. The LHdi/FSHtri ratio was increased. The progestin+EE group had significantly decreased gonadotropin glycoform concentrations and decreased sialylation of FSHtri. The progestin+EE effect on sialylation of FSHtri occurred later during the treatment cycle in contrast to the effect on FSHtri concentration. Conclusions The 2 different progestin treatments induced different effects on the glycan synthesis and concentrations of more bioactive low-glycosylated gonadotropins. Progestin-only treatment increased sialylation and decreased sulfonation of LHdi molecules, contributing to sustained higher levels of bioactive LHdi molecules. Progestin+EE treatment decreased sialylation of FSHtri, contributing to a shorter half-life and decreased levels of bioactive FSHtri.

Hypercapnic blood pressure response is greater during the luteal phase of the menstrual cycle

1996 ◽  
Vol 81 (5) ◽  
pp. 2142-2146 ◽  
Author(s):  
N. Edwards ◽  
I. Wilcox ◽  
O. J. Polo ◽  
C. E. Sullivan
Keyword(s):  
Blood Pressure ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Blood Pressure Response ◽  
Cardiovascular Responses ◽  
Follicular Phase ◽  
Pressure Response ◽  
Serum Progesterone ◽  
Menstrual Cycles ◽  
Blood Pressure Responses

Edwards, N., I. Wilcox, O. J. Polo, and C. E. Sullivan.Hypercapnic blood pressure response is greater during the luteal phase of the menstrual cycle. J. Appl. Physiol. 81(5): 2142–2146, 1996.—We investigated the cardiovascular responses to acute hypercapnia during the menstrual cycle. Eleven female subjects with regular menstrual cycles performed hypercapnic rebreathing tests during the follicular and luteal phases of their menstrual cycles. Ventilatory and cardiovascular variables were recorded breath by breath. Serum progesterone and estradiol were measured on each occasion. Serum progesterone was higher during the luteal [50.4 ± 9.6 (SE) nmol/l] than during the follicular phase (2.1 ± 0.7 nmol/l; P < 0.001), but serum estradiol did not differ (follicular phase, 324 ± 101 pmol/l; luteal phase, 162 ± 71 pmol/l; P = 0.61). The systolic blood pressure responses during hypercapnia were 2.0 ± 0.3 and 4.0 ± 0.5 mmHg/Torr (1 Torr = 1 mmHg rise in end-tidal [Formula: see text]) during the follicular and luteal phases, respectively, of the menstrual cycle ( P < 0.01). The diastolic blood pressure responses were 1.1 ± 0.2 and 2.1 ± 0.3 mmHg/Torr during the follicular and luteal phases, respectively ( P < 0.002). Heart rate responses did not differ during the luteal (1.7 ± 0.3 beats ⋅ min−1 ⋅ Torr−1) and follicular phases (1.4 ± 0.3 beats ⋅ min−1 ⋅ Torr−1; P = 0.59). These data demonstrate a greater pressor response during the luteal phase of the menstrual cycle that may be related to higher serum progesterone concentrations.

P-643 Pre-selected for an award: Is Euploid blastocyst number higher in luteal versus follicular phase? A case-control study of IVF outcomes of follicular versus luteal phase ovarian stimulation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
B Biscaro ◽  
A R Lorenzon ◽  
E L Motta ◽  
C Gomes
Keyword(s):  
Menstrual Cycle ◽  
Ovarian Stimulation ◽  
Luteal Phase ◽  
Case Control Study ◽  
Case Control ◽  
Follicular Phase ◽  
Menstrual Cycles ◽  
Ivf Outcomes ◽  
Control Study ◽  
Luteal Phase Ovarian Stimulation

Abstract Study question Is there a difference between IVF outcomes in patients undergoing follicular versus luteal phase ovarian stimulation in different menstrual cycles? Summary answer Number of euploid blastocyst were higher in luteal phase ovarian stimulation IVF cycles. All other outcomes were similar between follicular and luteal phase IVF cycles. What is known already It has been published that human beings can have two or three follicular recruitment waves as observed in animals studies a long time ago. From these findings, several recent studies showed that two egg retrievals at the same menstrual cycle, named as Duo Stim, optimize time and IVF outcomes in women with low ovarian reserve due to more eggs retrieved in a shorter period with consequently higher probability of having good embryos to transfer. However, there is no knowledge about diferences concerning IVF outcomes between folicular and luteal ovarian stimulation, performed at the same women in different menstrual cycles. Study design, size, duration Retrospective, case-control study in a single IVF center. One-hundred-two patients who had two IVF treatments – the first cycle initiating ovarian stimulation at follicular phase (FPS) and the second cycle initiating after a spontaneous ovulation at luteal phase (LPS) – in different menstrual cycles (until 6 months apart) between 2014 and 2020, were included. Statistical analysis was performed with Mann-Whitney test and was considered significant when p ≤ 0.05. Data is represented as mean±SD. Participants/materials, setting, methods Patients underwent two IVF treatments in different menstrual cycles; the FPS IVF treatment was initiating at D2/D3 of menstrual cycle and the LPS treatment started three or four days after spontaneous ovulation, if at least 4 antral follicles were detected. Both IVF treatments were performed with and antagonist protocol and freeze all strategy. The majority of patients presents low ovarian reserve/Ovarian age as primary infertility factor (84.3%). Main results and the role of chance Patient’s mean age was 39.30±3.15 years, BMI (22.66±3.16) and AMH levels (0.85±0.85 ng/mL). Comparison of hormonal levels at the beginning of ovarian stimulation showed differences for FPS vs LPS, as expected: E2 (39.69±31,10 pg/mL vs 177.33±214.26 pg/mL, p &lt; 0.0001) and P4 (0.76±2.47ng/mL vs 3,00±5.00 ng/mL,p &lt; 0.0001). However, E2 and P4 at the day of oocyte maturation trigger were not different between FPS and LPS (1355.24±895.73 pg/mL vs 1133.14±973.01 ng/mL,p = 0.0883 and 1.12±1.49 ng/mL vs 2.94±6.51,p = 0.0972 respectively). There was no difference for total dose of gonadotrofins (FPS 2786.43±1102.39.01UI vs LPS 2824.12±1188.87UI, p = 0,8578), FSH (FPS 9.50±4.98 vs LPS 11.90±12.99, p = 0.7502) and AFC (FPS 7.13±4.25 vs LPS 6.42±4.65,p = 0,0944). From 102 patients that started ovarian stimulation, 78 had 1 or more oocyte collect in FPS group and 75 in LPS group: OPU (FPS 4.78±4.93 vs LPS 4.65±5.54,p = 0.7889), number of MII (FPS 3.21±3.52 vs LPS 3.40±4.53,p = 0.7889). From those, 52 patients performed ICSI in both cycles; fertilization rate 64.9%±28.6% for FPS vs 62.1%±32.4% for LPS,p = 0.7899) and blastocyst formation 2.15±2.15 for FPS vs 2.54±2.35,p = 0.3496). Data from 25 patients who had embryo biopsy for PGT-A showed similar number of blastocyst biopsed (2.12±1.72 FPS vs 2.48±1.71 LPS,p = 0.3101) and a statistically significant difference regarding number of euploid blastocyst (0,20±0,41 FPS vs 0,96±0,93 LPS,p = 0,0008). Limitations, reasons for caution This is a retrospective study in a limited number of patients. Therefore, it is not possible to make a definitive conclusion that LPS proportionate higher number of euploid than FPS. More studies are necessary to investigate not only IVF outcomes but also the impact on pregnancy rates. Wider implications of the findings In our study, LPS protocol after spontaneous ovulation, presents similar IVF outcomes compared to routinely FPS protocol. Intriguingly, the number of euploid blastocyst was significant higher in LPS, which may be further investigated. In this way, LPS is another option of IVF treatment, and may optimize time and treatment results. Trial registration number Not Applicable

scholarly journals Hormones and Auditory Perception: Study of Dichotic Listening in Women during the Menstrual Cycle

2018 ◽  
Vol 23 (01) ◽  
pp. 070-076 ◽  
Author(s):  
Cláudia Carneiro ◽  
Anna Almeida ◽  
Angela Ribas ◽  
Karolina Kluk-De Kort ◽  
Daviany Lima ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Auditory Perception ◽  
Luteal Phase ◽  
Dichotic Listening ◽  
Serum Levels ◽  
Follicular Phase ◽  
Eligibility Criteria ◽  
Word Test ◽  
Males And Females ◽  
The Right

Introduction Dichotic listening refers to the ability to hear different sounds presented to each ear simultaneously. Objective The aim of the present study was to assess dichotic listening in women throughout the menstrual cycle. Methods The volunteers who met the eligibility criteria participated in a dichotic listening assessment composed of three tests: 1) staggered spondaic word test; 2) dichotic digits test; and 3) consonant-vowel test. The female participants were tested during two different phases of the menstrual cycle: the follicular (days 11 to 13) and luteal (days 23 to 26) phases. The phases were confirmed by measuring serum levels of the hormone estradiol. Results A total of 20 volunteers aged 18 to 49 years participated in the study (9 females and 11 males). In test 1, only the right ear of females showed better performance during the follicular phase (high estrogen levels), compared with the luteal phase (low estrogen levels); in test 2, there were no significant differences for any of the groups; and in test 3, both males and females showed significantly better performance in their right ear compared with their left ear. Conclusion The better performance of females during the follicular phase of the cycle may indicate that estrogen levels might have an influence on dichotic listening in women.

THE FLUORIMETRIC DETERMINATION OF PROGESTERONE IN HUMAN PLASMA DURING PREGNANCY AND THE MENSTRUAL CYCLE

1962 ◽  
Vol 25 (2) ◽  
pp. 239-244 ◽  
Author(s):  
R. V. SHORT ◽  
IRIS LEVETT
Keyword(s):  
Menstrual Cycle ◽  
Pregnant Women ◽  
Human Plasma ◽  
Peripheral Blood ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Fluorimetric Determination ◽  
Fluorescence Reaction ◽  
Good Agreement

SUMMARY The fluorescence reaction for progesterone described by Touchstone & Murawec (1960) has been used to determine the concentration of progesterone in nineteen samples of peripheral blood from pregnant women, and in seventeen samples of peripheral blood from women during the course of the menstrual cycle. There was good agreement between the ultraviolet and fluorescent estimates of progesterone in all the samples from pregnant women. The concentrations found during the follicular phase of the menstrual cycle were in general lower than those found during the luteal phase. In one woman who was sampled repeatedly during the course of a menstrual cycle, there was a well defined rise in the level of progesterone in the blood after the expected date of ovulation.

scholarly journals Correlation of Serum Level of Progesterone with Peak Expiratory Flow Rate (PEFR) in Different Phases of Menstrual Cycle

1970 ◽  
Vol 3 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Sultana Rokeya Mannan ◽  
Noorjahan Begum
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Young Female ◽  
Follicular Phase ◽  
Progesterone Level ◽  
Elisa Method ◽  
Serum Progesterone ◽  
Plasma Progesterone ◽  
Menstrual Cycles ◽  
Medical University

The present study has been carried out to observe the correlation of endogenous serum progesterone level with PEFR during luteal and follicular phases of two consecutive menstrual cycles. This study was conducted on 30 healthy young female volunteers with age ranges of 20- 24 years in the Department of Physiology of Bangladesh Shikh Mujib Medical University (BSMMU), Dhaka during July, 2005 to June, 2006. Serum progesterone level and PEFR of all subjects during all three phases of menstrual cycles were measured by ELISA method and a portable Spirometer respectively. Plasma progesterone level is highest during luteal phase; which is about 24 fold higher than that at follicular phases. (24.54ng/ml vs 1.4ng/ml). PEFR was positively correlated with progesterone level, but statistically not significant and it was significantly higher during luteal phase than follicular phase. This result indicates that changes in the pulmonary function occurred during different phases of menstrual cycle and this is more marked during luteal phase. DOI: http://dx.doi.org/10.3329/akmmcj.v3i1.10105 AKMMCJ 2012; 3(1): 6-9

SERUM LH DURING OVULATORY AND ANOVULATORY MENSTRUAL CYCLES IN MACAQUES

1973 ◽  
Vol 73 (4) ◽  
pp. 751-758 ◽  
Author(s):  
J. Mori ◽  
E. S. E. Hafez ◽  
S. Jaszczak ◽  
H. Kanagawa
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Peak Concentration ◽  
Mean Value ◽  
Follicular Phase ◽  
Lh Surge ◽  
Menstrual Cycles ◽  
Bonnet Macaques ◽  
Serum Lh ◽  
The Mean

ABSTRACT Serum LH concentration was measured by radioimmunoassay, in peripheral blood obtained daily throughout 21 ovulatory and 3 anovulatory cycles in 18 crab-eating macaques (M. fascicularis) and 7 cycles in 4 bonnet macaques (M. radiata). The occurrence of ovulation was determined by laparoscopic and/or laparotomic examinations in both macaque species. A single mid-cycle peak in LH concentration was detected. LH concentrations were similar during the follicular and luteal phase of the cycle and increased abruptly to approximately a 2–10 fold rise at mid-cycle. LH surge occurred predominantly as a single distinctive peak lasting for one day. In some cycles additional burst in LH concentration occurred 2–4 days after the main LH peak. Ovulation occurred about 6–24 hours after the peak concentration of serum LH. At the time of LH surge, the cervical mucus showed maximal quantity, spinnbarkeit and arborization. The pre-ovulatory LH surge occurred most frequently on Days 10–13 of the cycle. The variability of the length of the menstrual cycle was due primarily to variation in duration of follicular phase, whereas the luteal phase was remarkably constant. Anovulatory cycles were unaccompanied by mid-cycle LH surge. The mean value of serum LH concentration in anovulatory cycles was similar to the pre- and post-peak serum LH levels in ovulatory cycles. Serum LH was seldom flat but there were often rhythmic oscillations ranging from 20 to 100% of calculated mean value of serum LH.

scholarly journals Variations in biomarkers of dyslipidemia and dysbiosis during the menstrual cycle: a pilot study in healthy volunteers

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Helena Bergström ◽  
Lena Ekström ◽  
Anna Warnqvist ◽  
Peter Bergman ◽  
Linda Björkhem-Bergman
Keyword(s):  
Menstrual Cycle ◽  
Healthy Volunteers ◽  
Low Density Lipoprotein ◽  
Surrogate Marker ◽  
Density Lipoprotein ◽  
Follicular Phase ◽  
Lipoprotein Cholesterol ◽  
Microbial Metabolites ◽  
Serum Samples ◽  
Menstrual Cycles

Abstract Background Dyslipidemia in metabolic syndrome may introduce an underestimation of the risk for cardiovascular disease (CVD) using Low-Density Lipoprotein-Cholesterol (LDL-C) as a surrogate marker. Recently, non-High-Density Lipoprotein-Cholesterol (non-HDL-C), Apolipoprotein B (ApoB) and remnant-Cholesterol (remnant-C) have been suggested as better biomarkers for dyslipidemia. In addition, the microbial metabolites trimethylamine-N-oxide (TMAO), betaine and choline have been associated with CVD and suggested as markers for dysbiosis. There is a lack of knowledge on potential alterations in these biomarkers during the menstrual cycle. The aim of this single center, prospective non-interventional study, was to investigate variations in biomarkers of dyslipidemia and dysbiosis in healthy volunteers during the menstrual cycle. Method Serum samples were collected from 17 healthy, regularly menstruating women during two menstrual cycles, including the follicular, ovulatory and luteal phases. Levels of lipoproteins, lipoprotein ratios and microbial metabolites were analyzed in a total of 90 samples (30 complete menstrual cycles). Results ApoB, ApoB/HDL and non-HDL-C/HDL ratios were significantly higher in the follicular phase compared to the ovulatory and luteal phases (p < 0.05). Remnant-C were higher during the luteal phase (p < 0.05). TMAO did not vary during the different phases and did not correlate with estrogen levels. Conclusion Our data support that biomarkers for dyslipidemia vary during the menstrual cycle. Thus, to avoid an underestimation of cardiovascular risk, sampling during the follicular phase, when levels of pro-atherogenic lipids are higher, may be considered.

PLASMA ANGIOTENSIN II AND ALDOSTERONE EXCRETION DURING THE MENSTRUAL CYCLE

1970 ◽  
Vol 64 (3) ◽  
pp. 452-458 ◽  
Author(s):  
Johan A. Sundsfjord ◽  
A. Aakvaag
Keyword(s):  
Angiotensin Ii ◽  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicular Phase ◽  
Renin Release ◽  
Menstrual Cycles ◽  
Plasma Angiotensin ◽  
Aldosterone Production

ABSTRACT The angiotensin II concentration in the plasma and the urinary aldosterone excretion were measured early in the follicular phase and late in the luteal phase in 9 women with regular menstrual cycles. The plasma angiotensin II in the follicular phase was 1.78 ng/100 ml ± 0.20 (sem) and in the luteal phase 3.12 ng/100 ml ± 0.43 (sem). Values for aldosterone excretion were 10.89 μg/24 h ± 1.43 (sem) and 21.67 μ/24 h ± 2.96 (sem) respectively. Pregnanediol increased from 0.42 mg/24 h ± 0.12 (sem) to 2.0 mg/24 h ± 0.28 (sem) in the same specimens of urine. It is suggested that the observed changes in concentration and excretion of the hormones are sequentially related as follows: The sodium losing effect of progesterone stimulates renin release, giving an increased plasma angiotensin II, which in turn leads to an augmented aldosterone production.

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