Monogenic inheritance in early-onset dementia: illustration in Alzheimer's disease and frontotemporal lobar dementia

2018 ◽  
Vol 16 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Mathieu Barbier ◽  
David Wallon ◽  
Isabelle Le Ber
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Monogenic Inheritance ◽  
Early Onset Dementia ◽  
Frontotemporal Lobar Dementia

scholarly journals HUNTINGTON’S DISEASE AND EARLYONSET ALZHEIMER’S DISEASE SHARE A TRANSCRIPTOMIC SIGNATURE

2021 ◽  
Author(s):  
Giovanna Carello- Collar ◽  
Marco Antônio De Bastiani ◽  
Eduardo R. Zimmer
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Early Onset ◽  
Protein Misfolding ◽  
Functional Enrichment ◽  
Early Onset Dementia ◽  
Transcriptomic Signature ◽  
Transcriptomic Level

Background: Neurodegenerative diseases share progressive loss of neurons and protein misfolding, which ultimately culminates in dementia; many diseases have been identified as causes of early-onset dementia (< 65 years of age) such as Huntington’s disease (HD) and early-onset Alzheimer’s disease (EOAD). Importantly, disease-specific genetic mutations have already been identified for HD and EOAD. Thus, one could suggest that the molecular link between these diseases may arise from alterations at the transcriptomic level, which is yet to be determined. Objective: We aimed at identifying transcriptome similarities between HD and EOAD. Methods: We collected data of the postmortem cerebral cortex from 1 HD and 6 AD microarray studies in the Gene Expression Omnibus. Of note, only subjects with age at death under 65 were selected (HD: n = 158, controls: n = 158; EOAD: n = 65, controls: n = 266). Differential expression and functional enrichment analyses were performed. Results: We identified 1,260 differentially expressed genes and 675 enriched gene ontology terms between HD and EOAD. Conclusion: Our results demonstrate a transcriptomic signature shared by HD and EOAD. Unveiling the similarities between these diseases at the transcriptomic level could advance our knowledge about pathogenesis and may help to develop therapeutic strategies targeting early-onset dementias.

P1-359: NEUROPATHOLOGICAL FINDINGS OF AN EARLY-ONSET DEMENTIA CASE WITH ATYPICAL ALZHEIMER'S DISEASE: HOW CHALLENGING CAN THE CLINICAL DIAGNOSIS OF MIXED AD BE?

2006 ◽  
Vol 14 (7S_Part_8) ◽  
pp. P432-P432
Author(s):  
Roberta Diehl Rodriguez ◽  
Mariana Molina ◽  
Renata P. Leite ◽  
Rafaela Sabadin ◽  
Leonel Tadao Takada ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Diagnosis ◽  
Early Onset ◽  
Early Onset Dementia ◽  
Dementia Case ◽  
Atypical Alzheimer’S Disease

scholarly journals Recent insights into Early Onset Dementia (EOD): A Review

2021 ◽  
Vol 11 (4-S) ◽  
pp. 225-230
Author(s):  
Jyotirmoy Bondyopadhyay ◽  
INDRAJIT BHATTACHARYA ◽  
Raja Chakraverty
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Onset ◽  
Large Scale ◽  
Senile Dementia ◽  
Vascular Complications ◽  
Genetic Alterations ◽  
Early Onset Dementia ◽  
Neuropsychiatric Complications ◽  
Keywords Dementia

The present study aims to review the prevalence and etiology of Early Onset Dementia (EOD) reflected in the population based studies worldwide .For this purpose, Bibliographic database searches and rigorous literature review were performed using the following keywords namely: “Dementia”, “Early onset dementia”, “Alzheimer’s disease” and “Senile Dementia” from the following databases: Pubmed, Medline between the years 2005 to 2019. The summary of report findings suggest that the prevalence of early onset dementia is reported to occur in 3-5% of the Indian population among predisposed individuals. This is an attempt to accumulate and collate in one spot all sort of multifactorial associations behind the pathogenesis of EOD in youth. These causes are Genetic change, Brain comorbidities, Alzheimer's ailment, vascular complications and increasingly other neuropsychiatric complications. We have made an attempt to analyze the pathogenesis of the early onset dementia in relation to their outcomes and a few manifestations which demonstrate the same. Future large-scale systematic reviews and network meta-analysis in this domain would facilitate dissemination of credible information with regards to the causative mechanism and possible therapeutic interventions and viable alternatives to possibly tackle and mitigate EOD. Keywords:  Dementia, Early onset dementia, Alzheimer’s disease, Genetic alterations.

Distinct social-behavioral changes in frontotemporal dementia and early onset Alzheimer's disease

2014 ◽  
Author(s):  
Joseph P. Barsuglia ◽  
Michelle J. Mather ◽  
Hemali V. Panchal ◽  
Aditi Joshi ◽  
Elvira Jimenez ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Frontotemporal Dementia ◽  
Early Onset ◽  
Behavioral Changes ◽  
Early Onset Alzheimer’S Disease
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