scholarly journals Current Status of Clozapine for Treatment-Resistant Schizophrenia

2021 ◽  
Vol 24 (1) ◽  
pp. 1-7
Author(s):  
Se Hyun Kim
Keyword(s):  
Current Status ◽  
Treatment Resistant

scholarly journals Use of olanzapine compared with clozapine for treatment-resistant schizophrenia in a real-world setting: nationwide register-based study

BJPsych Open ◽  
2021 ◽  
Vol 7 (5) ◽  
Author(s):  
Young Tak Jo ◽  
Sung Woo Joo ◽  
Soojin Ahn ◽  
Youngjae Choi ◽  
Jungsun Lee
Keyword(s):  
Real World ◽  
Survival Rates ◽  
Current Status ◽  
Emergency Room Visits ◽  
Treatment Resistant ◽  
Psychiatric Admissions ◽  
Before And After ◽  
Patient Variables ◽  
The Republic ◽  
Incident Cohort

Background Clozapine is generally considered as the treatment of choice for patients with treatment-resistant schizophrenia (TRS). However, its superiority has recently been questioned because olanzapine has been suggested as non-inferior to clozapine in its effectiveness. Aims We aimed to investigate the current status of clozapine prescriptions to identify any disparity between clinical guidelines and real-world practices. Method In this study, we utilised the Health Insurance Review Agency database in the Republic of Korea to investigate the real-world effectiveness of clozapine for patients with TRS. We compared differences in patient variables before and after clozapine administration, and we also performed survival analyses for both psychiatric admissions and emergency room visits among patients who used clozapine or olanzapine. Results This study investigated an incident cohort of 64 442 patients, and 2338 patients have been prescribed clozapine. Of these, 998 patients had TRS. In survival analysis, clozapine showed a worse survival rate for psychiatric admissions than olanzapine (hazard ratio 0.615). We also identified that clinicians tended to try a number of antipsychotics, as recommended, before starting patients on clozapine. Conclusions In conclusion, we found that olanzapine led to higher survival rates for psychiatric admissions than clozapine. Thus, considering the risk of serious adverse effects, clozapine may be used conservatively. Considering several studies advocating superior efficacy of clozapine, further studies with extensive data are recommended.

scholarly journals Deep brain stimulation for treatment-resistant depression: current status and future perspectives

2020 ◽  
Vol 17 (5) ◽  
pp. 371-373
Author(s):  
Benjamin Davidson ◽  
Flavia Venetucci Gouveia ◽  
Jennifer S. Rabin ◽  
Peter Giacobbe ◽  
Nir Lipsman ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Current Status ◽  
Treatment Resistant Depression ◽  
Future Perspectives ◽  
Treatment Resistant ◽  
Resistant Depression ◽  
Deep Brain

Current status of special planetary and lunar theories and ephemerides

1966 ◽  
Vol 25 ◽  
pp. 266-267
Author(s):  
R. L. Duncombe
Keyword(s):  
Observational Data ◽  
Current Status ◽  
Numerical Errors

An examination of some specialized lunar and planetary ephemerides has revealed inconsistencies in the adopted planetary masses, the presence of non-gravitational terms, and some outright numerical errors. They should be considered of temporary usefulness only, subject to subsequent amendment as required for the interpretation of observational data.

Current Status of Solid-State X-Ray Systems

1985 ◽  
Vol 43 ◽  
pp. 158-161
Author(s):  
Martin Peckerar ◽  
Anastasios Tousimis
Keyword(s):  
Solid State ◽  
Electric Fields ◽  
Spectral Lines ◽  
Current Status ◽  
Mobile Charge ◽  
Electron Hole ◽  
X Ray ◽  
Sensing Systems ◽  
Transmission Electron ◽  
Electron Microscopes

Solid state x-ray sensing systems have been used for many years in conjunction with scanning and transmission electron microscopes. Such systems conveniently provide users with elemental area maps and quantitative chemical analyses of samples. Improvements on these tools are currently sought in the following areas: sensitivity at longer and shorter x-ray wavelengths and minimization of noise-broadening of spectral lines. In this paper, we review basic limitations and recent advances in each of these areas. Throughout the review, we emphasize the systems nature of the problem. That is. limitations exist not only in the sensor elements but also in the preamplifier/amplifier chain and in the interfaces between these components.Solid state x-ray sensors usually function by way of incident photons creating electron-hole pairs in semiconductor material. This radiation-produced mobile charge is swept into external circuitry by electric fields in the semiconductor bulk.

Electron-deficient boron-based catalysts for C–H bond functionalisation

2021 ◽  
Author(s):  
Yuanhong Ma ◽  
Shao-Jie Lou ◽  
Zhaomin Hou
Keyword(s):  
Review Article ◽  
Current Status ◽  
Comprehensive Overview

This review article provides a comprehensive overview to recognise the current status of electron-deficient boron-based catalysis in C–H functionalisations.

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