Low contrast non-color vision in patients with multiple sclerosis

2015 ◽  
Vol 115 (2. Vyp. 2) ◽  
pp. 16 ◽  
Author(s):  
S. V. Kotov ◽  
N. V. Kuchina ◽  
D. G. Lapitan ◽  
A. I. Milanich ◽  
D. A. Rogatkin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Color Vision ◽  
Low Contrast

Color vision is strongly associated with retinal thinning in multiple sclerosis

2012 ◽  
Vol 18 (7) ◽  
pp. 991-999 ◽  
Author(s):  
Pablo Villoslada ◽  
Ami Cuneo ◽  
Jeffrey Gelfand ◽  
Stephen L Hauser ◽  
Ari Green
Keyword(s):  
Multiple Sclerosis ◽  
Visual Acuity ◽  
Color Vision ◽  
Color Discrimination ◽  
Visual Pathway ◽  
Visual Disability ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Low Contrast ◽  
Sd Oct

Objectives: Multiple Sclerosis (MS) frequently causes injury to the anterior visual pathway (AVP), impairing quality of life due to visual dysfunction. Development of biomarkers in MS is a high priority and both low-contrast visual acuity (LCVA) and time-domain optical coherence tomography (TD-OCT) have been proposed as candidates for this purpose. We sought to assess whether psychophysical assessments of color vision are similarly correlated with structural measures of AVP injury, and therefore augment measures of visual disability in MS. Methods: We studied the association between high-contrast visual acuity (HCVA), LCVA, color vision (Hardy–Rand–Rittler plates (HRR) and Lanthony D15 tests) and OCT, using both high-resolution spectral-domain OCT (SD-OCT; Spectralis, Heidelberg Engineering, Germany) and TD-OCT (Stratus, Carl Zeiss, US) in a cohort of 213 MS patients (52 with previous optic neuritis) and 47 matched controls in a cross-sectional study. Results: We found that MS patients have impairments in HCVA and LCVA ( p < 0.001) but that they suffer from even more profound abnormalities in color discrimination ( p < 0.0001). We found strong correlation between color vision and SD-OCT measures of retinal nerve fiber layer (RNFL) thickness (average RNFL, r = 0.594, p < 0.001) and papillomacular bundle thickness ( r = −0.565, p < 0.001). The correlation between OCT scores and functional visual impairments of all types was much stronger for SD-OCT than for TD-OCT. Conclusion: Our results indicate that color vision is highly correlated with these OCT scores when compared with traditional measures of visual acuity. Also we found that SD-OCT is superior to TD-OCT for detecting anterior visual pathway damage in MS. This makes both color-visual measures and SD-OCT strong candidate biomarkers of disease progression.

Agreement analysis comparing iPad LCVA and Sloan testing in multiple sclerosis patients

2017 ◽  
Vol 24 (8) ◽  
pp. 1126-1130 ◽  
Author(s):  
Neda Sattarnezhad ◽  
Samantha Farrow ◽  
Dorlan Kimbrough ◽  
Bonnie Glanz ◽  
Brian Healy ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Visual Acuity ◽  
T Test ◽  
Computerized Testing ◽  
Low Contrast ◽  
Significant Difference ◽  
Increased Sensitivity ◽  
The Right ◽  
Multiple Sclerosis Patients ◽  
Paired T Test

Background: Visual symptoms are common in multiple sclerosis (MS). Low-contrast visual acuity (LCVA) testing using Sloan charts has demonstrated increased sensitivity for visual deficits compared to high-contrast acuity testing. Computerized testing of visual acuity may facilitate use in the clinic setting. Objectives: To evaluate the agreement between an iPad-based and Sloan testing of LCVA in a cohort of MS patients. Methods: A total of 38 patients with relapsing-remitting MS were enrolled after providing informed written consent at Partners MS Center, Brigham and Women’s hospital. Monocular LCVA was measured using retroilluminated Sloan chart and iPad-based LogMAR chart. Number of correct letters and agreement between two measurements were assessed for each eye using Bland–Altman analysis and paired t-test. Results: For both eyes, there was no significant difference in number correct between the two measurements using a paired t-test, and there was high correlation between two measurements (oculus dextrus (OD) r = 0.89, p < 0.001; oculus sinister (OS) r = 0.78, p < 0.001). The limits of agreement were −7.9 to +8.5 letters for the right eye and −10.9 to +11.2 letters for the left eye. Conclusion: An iPad-based LCVA test shows good agreement with Sloan testing in MS patients.

scholarly journals Evaluation of optic neuropathy in multiple sclerosis using low-contrast visual evoked potentials

Neurology ◽  
2009 ◽  
Vol 73 (22) ◽  
pp. 1849-1857 ◽  
Author(s):  
M. J. Thurtell ◽  
E. Bala ◽  
S. S. Yaniglos ◽  
J. C. Rucker ◽  
N. S. Peachey ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Evoked Potentials ◽  
Visual Evoked Potentials ◽  
Optic Neuropathy ◽  
Low Contrast ◽  
Visual Evoked

Impairment of acquired color vision in multiple sclerosis: an early diagnostic sign linked to the greatness of disease

2018 ◽  
Vol 39 (3) ◽  
pp. 671-676 ◽  
Author(s):  
Anna Piro ◽  
Antonio Tagarelli ◽  
Giuseppe Nicoletti ◽  
Sara Scannapieco ◽  
Serena Polidoro ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Color Vision ◽  
Diagnostic Sign ◽  
Early Diagnostic

New low-contrast vision charts: reliability and test characteristics in patients with multiple sclerosis

2000 ◽  
Vol 6 (3) ◽  
pp. 163-171 ◽  
Author(s):  
Laura J Balcer ◽  
Monika L Baier ◽  
Victoria S Pelak ◽  
Robert J Fox ◽  
Sarah Shuwairi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Visual Acuity ◽  
Outcome Measure ◽  
Rater Agreement ◽  
Contrast Level ◽  
Low Contrast ◽  
Test Characteristics ◽  
Snellen Visual Acuity ◽  
Asymptomatic Volunteers

The quantitative assessment of visual function in multiple sclerosis (MS) clinical trials has been limited to Snellen visual acuity. The purpose of this study was to examine the inter-rater reliability and test characteristics of a new visual outcome measure, the Low-Contrast Sloan Letter Charts, in patients with MS and visually-asymptomatic volunteers. Contrast letter acuity scores (letter scores) were measured at each of four contrast levels (100, 5, 1.25 and 0.6%) by two independent raters. Inter-rater agreement was described with the intraclass correlation coefficient (ICC) and comparison of mean scores. Excellent inter-rater agreement (ICC=0.86-0.95) was demonstrated at each contrast level among MS patients (n=100) and visually-asymptomatic volunteers (n=33). Average letter scores at the lowest contrast level (0.6%) were highly variable in the MS group, even among patients with visual acuities of 20/20 or better, and among those who required no assistance for ambulation. Low-Contrast Sloan Letter Chart testing is a highly reliable method of visual assessment, and provides information on an aspect of neurologic impairment in MS which is not captured by Snellen visual acuity or ambulation status. This new method demonstrates excellent potential as a visual function outcome measure for future MS clinical trials.

Chromatic discrimination losses in multiple sclerosis patients with and without optic neuritis using the Cambridge Colour Test

2008 ◽  
Vol 25 (3) ◽  
pp. 463-468 ◽  
Author(s):  
ANA LAURA DE ARAÚJO MOURA ◽  
ROSANI APARECIDA ANTUNES TEIXEIRA ◽  
NESTOR N. OIWA ◽  
MARCELO F. COSTA ◽  
CLAUDIA FEITOSA-SANTANA ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Color Vision ◽  
Color Discrimination ◽  
Demyelinating Diseases ◽  
Color Test ◽  
Age Related ◽  
History Of ◽  
Patient Groups ◽  
Multiple Sclerosis Patients

We assessed chromatic discrimination in multiple sclerosis (MS) patients both with (ON) and without (no ON) a history of optic neuritis using the Cambridge color test (CCT). Our goal was to determine the magnitude and chromatic axes of any color vision losses in both patient groups, and to evaluate age-related changes in chromatic discrimination in both patient groups compared to normals. Using the CCT, we measured chromatic discrimination along the protan, deutan and tritan axes in 35 patients with MS (17 ON eyes) and 74 age matched controls. Color thresholds for both patient groups were significantly higher than controls' along the protan and tritan axes (p < 0.001). In addition, the ON and no-ON groups differed significantly along all three-color axes (p < 0.001). MS patients presented a progressive color discrimination impairment with age (along the deutan and tritan axes) that was almost two times faster than controls, even in the absence of ON. These findings suggest that demyelinating diseases reduce sensitivity to color vision in both red-green and blue-yellow axes, implying impairment in both parvocellular and koniocellular visual pathways. The CCT is a useful tool to help characterize vision losses in MS, and the relationship between these losses and degree of optic nerve involvement.

Color vision impairment in multiple sclerosis points to retinal ganglion cell damage

2015 ◽  
Vol 262 (11) ◽  
pp. 2491-2497 ◽  
Author(s):  
E. J. Lampert ◽  
M. Andorra ◽  
R. Torres-Torres ◽  
S. Ortiz-Pérez ◽  
S. Llufriu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Ganglion Cell ◽  
Color Vision ◽  
Retinal Ganglion Cell ◽  
Cell Damage ◽  
Vision Impairment ◽  
Retinal Ganglion ◽  
Color Vision Impairment
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