Age Related Changes in Central Auditory Processing

Целью исследования был сравнительный анализ жалоб и аудиологических показателей у пациентов сурдологического центра в зависимости от возраста. Представлены результаты обследования 300 первичных пациентов (случайная выборка), обратившихся к сурдологу-оториноларингологу в течение 1 мес. В группу молодых пациентов (19-44 года) вошли 40 человек; в группу среднего возраста (45- 59 лет) - 62 человека; в группу пожилых (60-74 года) - 100 человек; в группу старческого возраста (75-90 лет) - 98 человек. Обследование включало сбор жалоб и анамнеза, ЛОР-осмотр, тональную пороговую аудиометрию, импедансометрию, речевую аудиометрию в наушниках для выявления признаков центральных слуховых расстройств или в свободном звуковом поле для оценки эффективности слухопротезирования. Установлено, что для ранней диагностики тугоухости и профилактики возрастных сенсорнокогнитивных дисфункций целесообразно использовать не только результаты тональной пороговой аудиометрии, но и данные речевой аудиометрии, а также анализ субъективных жалоб. Результаты работы свидетельствуют о необходимости организации скрининга состояния слуха в рамках диспансеризации населения старше 60 лет. The aim of the study was a comparative analysis of complaints and audiological ﬁndings in patients of the audiological center depending on their age. The results of the examination of 300 ﬁ rstly consulted patients (random sample) are presented. The group of young patients (19-44 years) included 40 people; middle age (45-59 years) - 62 people; elderly (60-74 years) - 100 people; senile age (75-90 years) - 98 people. The survey included the collection of complaints and anamnesis, ENT checkup, pure tone audiometry, impedancemetry, speech audiometry in headphones to detect the signs of Central Auditory Processing Disorder or in the free sound ﬁeld to assess the effectiveness of hearing aids. It was found that for early diagnosis of hearing loss and prevention of age-related sensory-cognitive dysfunction, it is advisable to use not only the results of pure tone audiometry, but also the data of speech audiometry, as well as the analysis of subjective complaints. The results of the work indicate the need for hearing screening in the population over 60 years old.

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Late-onset depression is associated to age-related central auditory processing disorder in an older population in Southern Italy

GeroScience ◽

10.1007/s11357-020-00290-1 ◽

2020 ◽

Author(s):

Madia Lozupone ◽

Rodolfo Sardone ◽

Rossella Donghia ◽

Francesca D’Urso ◽

Carla Piccininni ◽

...

Keyword(s):

Auditory Processing ◽

Southern Italy ◽

Late Onset ◽

Auditory Processing Disorder ◽

Central Auditory Processing ◽

Central Auditory Processing Disorder ◽

Older Population ◽

Age Related

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Age-related changes in auditory processing and speech perception: cross-sectional and longitudinal analyses

European Journal of Ageing ◽

10.1007/s10433-017-0410-y ◽

2017 ◽

Vol 14 (3) ◽

pp. 269-281 ◽

Cited By ~ 14

Author(s):

Harvey Babkoff ◽

Leah Fostick

Keyword(s):

Speech Perception ◽

Auditory Processing ◽

Longitudinal Analyses ◽

Cross Sectional ◽

Age Related ◽

Age Related Changes

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Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

10.1101/2020.06.09.142737 ◽

2020 ◽

Author(s):

Meijian Wang ◽

Chuangeng Zhang ◽

Shengyin Lin ◽

Yong Wang ◽

Benjamin J. Seicol ◽

...

Keyword(s):

Hearing Loss ◽

Auditory Processing ◽

Auditory Nerve ◽

Spiral Ganglion ◽

Central Auditory Processing ◽

Endbulb Of Held ◽

Age Related ◽

Central Synapses ◽

Ganglion Neurons ◽

Age Related Hearing Loss

SUMMARYSound information is transmitted from the cochlea to the brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees of vulnerbility under pathological conditions. It remains unclear how information from these SGNs reassemble among target neurons in the cochlear nucleus (CN) at the auditory nerve (AN) central synapses, and how different synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated the giant endbulb of Held synapses and their postsynaptic bushy neurons in mice under normal hearing and age-related hearing loss (ARHL). We found that calretinin-expressing and non-calretinin-expressing endbulbs converge at continuously different ratios onto bushy neurons with varying physiological properties. Endbulbs degenerate during ARHL, and the degeneration is more severe in non-calretinin-expressing synapses, which correlates with a gradual decrease in neuronal subpopulation predominantly innervated by these inputs. Our findings suggest that biased AN central synaptopathy and shifted CN neuronal composition underlie reduced auditory input and altered central auditory processing during ARHL.

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Neural correlates of central auditory processing deficits in the auditory midbrain in an animal model of age-related hearing loss

The Journal of the Acoustical Society of America ◽

10.1121/1.4900155 ◽

2014 ◽

Vol 136 (4) ◽

pp. 2258-2258

Author(s):

Joseph P. Walton

Keyword(s):

Animal Model ◽

Hearing Loss ◽

Auditory Processing ◽

Neural Correlates ◽

Central Auditory Processing ◽

Auditory Midbrain ◽

Age Related ◽

Processing Deficits ◽

Age Related Hearing Loss

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Prevalence of Central Auditory Processing (CAP) Abnormality in an Older Australian Population: The Blue Mountains Hearing Study

Journal of the American Academy of Audiology ◽

10.3766/jaaa.15.9.4 ◽

2004 ◽

Vol 15 (09) ◽

pp. 633-642 ◽

Cited By ~ 26

Author(s):

Maryanne Golding ◽

Nan Carter ◽

Paul Mitchell ◽

Linda J. Hood

Keyword(s):

Hearing Loss ◽

Population Study ◽

Auditory Processing ◽

Clinical Studies ◽

Central Auditory Processing ◽

Australian Population ◽

Related Condition ◽

Blue Mountains ◽

Age Related ◽

Test Outcomes

Age-related central auditory processing (CAP) abnormality has been described in many studies with widely varying prevalence reported. To date, there has been only one population study to report prevalence for this age-related condition, and these rates were significantly lower than in reports from clinical studies. The present study reports findings from a recent population study in which 2,015 Australians aged 55 years and older living in a defined area west of Sydney were assessed with a battery of behavioral and electrophysiological auditory tests. This battery included speech measures from which a high overall prevalence rate (76.4%) of CAP abnormalities was found, in keeping with previous clinical studies. While gender differences were dependent on the test measure, the number of abnormal test outcomes increased systematically with age. Hearing loss and abnormal cognitive function, however, did not systematically increase with number of abnormal test outcomes.

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Age-Related Central Auditory Processing Disorder, MCI, and Dementia in an Older Population of Southern Italy

Otolaryngology ◽

10.1177/0194599820913635 ◽

2020 ◽

Vol 163 (2) ◽

pp. 348-355 ◽

Cited By ~ 5

Author(s):

Rodolfo Sardone ◽

Petronilla Battista ◽

Rossella Donghia ◽

Madia Lozupone ◽

Rosanna Tortelli ◽

...

Keyword(s):

Auditory Processing ◽

Odds Ratio ◽

Southern Italy ◽

Population Based ◽

Auditory Processing Disorder ◽

Central Auditory Processing ◽

Central Auditory Processing Disorder ◽

Older Population ◽

Cross Sectional ◽

Age Related

Objective We explored the associations of age-related central auditory processing disorder (CAPD) with mild cognitive impairment (MCI) and dementia in an older population-based cohort in Apulia, Southern Italy (GreatAGE Study). Study Design Cross-sectional data from a population-based study. Setting Castellana Grotte, Bari, Italy. Subjects and Methods Between 2013 and 2018, MCI, dementia, age-related CAPD (no disabling hearing loss and <50% score on the SSI-ICM test [Synthetic Sentence Identification–Ipsilateral Competing Message]), neurologic and neuropsychological examinations, and serum metabolic biomarkers assays were investigated on 1647 healthy volunteers aged >65 years. Results The prevalences of age-related CAPD, MCI, and dementia were 14.15%, 15.79%, and 3.58%, respectively. Among the subjects with MCI and dementia, 19.61% and 42.37% had age-related CAPD. In the regressive models, age-related CAPD was associated with MCI (odds ratio, 1.50; 95% CI, 1.01-2.21) and dementia (odds ratio, 2.23; 95% CI, 1.12-4.42). Global cognition scores were positively associated with increasing SSI-ICM scores in linear models. All models were adjusted for demographics and metabolic serum biomarkers. Conclusion The tight association of age-related CAPD with MCI and dementia suggests the involvement of central auditory pathways in neurodegeneration, but it is not clear which is the real direction of this association. However, CAPD is a possible diagnostic marker of cognitive dysfunction in older patients.

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Auditory Processing Abilities of Parkinson’s Disease Patients

BioMed Research International ◽

10.1155/2017/2618587 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 16

Author(s):

Robert L. Folmer ◽

Jay J. Vachhani ◽

Sarah M. Theodoroff ◽

Rachel Ellinger ◽

Amy Riggins

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hearing Loss ◽

Auditory Processing ◽

Study Groups ◽

Control Group ◽

Central Auditory Processing ◽

Control Subjects ◽

Age Related ◽

Auditory Functions

Since Parkinson’s Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests. Both study groups exhibited patterns of sensorineural hearing loss (slightly worse in the PD group) which were typical for their age and would contribute to difficulties in communication for many participants. Compared to the control group, PD patients reported greater difficulty in hearing words people are speaking. Although 27 PD patients (77%) were good candidates for amplification, only 7 (26%) of these hearing aid candidates used the devices. Because it is important for PD patients to optimize communication with their family members, caregivers, friends, and clinicians, it is vital to identify and remediate auditory dysfunction in this population as early as possible.

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