Neural correlates of central auditory processing deficits in the auditory midbrain in an animal model of age-related hearing loss

2014 ◽  
Vol 136 (4) ◽  
pp. 2258-2258
Author(s):  
Joseph P. Walton
Keyword(s):  
Animal Model ◽  
Hearing Loss ◽  
Auditory Processing ◽  
Neural Correlates ◽  
Central Auditory Processing ◽  
Auditory Midbrain ◽  
Age Related ◽  
Processing Deficits ◽  
Age Related Hearing Loss

scholarly journals Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

2020 ◽  
Author(s):  
Meijian Wang ◽  
Chuangeng Zhang ◽  
Shengyin Lin ◽  
Yong Wang ◽  
Benjamin J. Seicol ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Auditory Processing ◽  
Auditory Nerve ◽  
Spiral Ganglion ◽  
Central Auditory Processing ◽  
Endbulb Of Held ◽  
Age Related ◽  
Central Synapses ◽  
Ganglion Neurons ◽  
Age Related Hearing Loss

SUMMARYSound information is transmitted from the cochlea to the brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees of vulnerbility under pathological conditions. It remains unclear how information from these SGNs reassemble among target neurons in the cochlear nucleus (CN) at the auditory nerve (AN) central synapses, and how different synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated the giant endbulb of Held synapses and their postsynaptic bushy neurons in mice under normal hearing and age-related hearing loss (ARHL). We found that calretinin-expressing and non-calretinin-expressing endbulbs converge at continuously different ratios onto bushy neurons with varying physiological properties. Endbulbs degenerate during ARHL, and the degeneration is more severe in non-calretinin-expressing synapses, which correlates with a gradual decrease in neuronal subpopulation predominantly innervated by these inputs. Our findings suggest that biased AN central synaptopathy and shifted CN neuronal composition underlie reduced auditory input and altered central auditory processing during ARHL.

Physiological and Neurobiological Bases of Age-Related Hearing Loss: Biotherapeutic Implications

2013 ◽  
Vol 22 (2) ◽  
pp. 299-302 ◽  
Author(s):  
Robert D. Frisina ◽  
D. Robert Frisina
Keyword(s):  
Hearing Loss ◽  
Auditory Processing ◽  
Stria Vascularis ◽  
Positive Influence ◽  
Negative Effects ◽  
Age Related ◽  
Women And Aging ◽  
Auditory Tasks ◽  
And Function ◽  
Age Related Hearing Loss

Purpose The aim of this study was to highlight growing evidence of interactions between hormones and the structure and function of the auditory system. Method Recent studies implicating sex hormones and other natural hormones in the modulation of hearing status in age-related hearing loss were reviewed. Results Progesterone, a sex hormone, has been shown to have negative effects on the hearing of older women and aging mice, whereas, in contrast, estrogen was found in some cases to have a positive influence. Aldosterone, used in studies of animal models of autoimmune hearing loss, slowed the progression of hearing loss. Follow-up studies in humans revealed that auditory measures varied as serum aldosterone levels shifted within the normal range, in otherwise healthy older subjects. This was true for simple as well as complex auditory tasks (i.e., sound spatial processing), suggesting benefits of aldosterone to postperipheral auditory processing as well. In addition, evidence suggests that this functional hearing improvement occurred in association with anatomical improvements to the stria vascularis—an important site of anatomical change in presbycusis. Conclusions Audiology is now at the point where the search for biomedical interventions to modulate or prevent age-related hearing loss can move forward. Such interventions would require multidisciplinary collaborative initiatives by researchers in such areas as drug development, anatomy, auditory physiological and perceptual testing, and drug microdelivery systems.

scholarly journals Roles of Key Ion Channels and Transport Proteins in Age-Related Hearing Loss

2021 ◽  
Vol 22 (11) ◽  
pp. 6158
Author(s):  
Parveen Bazard ◽  
Robert D. Frisina ◽  
Alejandro A. Acosta ◽  
Sneha Dasgupta ◽  
Mark A. Bauer ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Ion Channels ◽  
Auditory System ◽  
Auditory Processing ◽  
Mechanical Energy ◽  
Transport Proteins ◽  
Oval Window ◽  
Cochlear Hair Cells ◽  
Age Related ◽  
Age Related Hearing Loss

The auditory system is a fascinating sensory organ that overall, converts sound signals to electrical signals of the nervous system. Initially, sound energy is converted to mechanical energy via amplification processes in the middle ear, followed by transduction of mechanical movements of the oval window into electrochemical signals in the cochlear hair cells, and finally, neural signals travel to the central auditory system, via the auditory division of the 8th cranial nerve. The majority of people above 60 years have some form of age-related hearing loss, also known as presbycusis. However, the biological mechanisms of presbycusis are complex and not yet fully delineated. In the present article, we highlight ion channels and transport proteins, which are integral for the proper functioning of the auditory system, facilitating the diffusion of various ions across auditory structures for signal transduction and processing. Like most other physiological systems, hearing abilities decline with age, hence, it is imperative to fully understand inner ear aging changes, so ion channel functions should be further investigated in the aging cochlea. In this review article, we discuss key various ion channels in the auditory system and how their functions change with age. Understanding the roles of ion channels in auditory processing could enhance the development of potential biotherapies for age-related hearing loss.

Altered cortical spectrotemporal processing with age-related hearing loss

2013 ◽  
Vol 110 (12) ◽  
pp. 2873-2886 ◽  
Author(s):  
Michael Trujillo ◽  
Khaleel A. Razak
Keyword(s):  
Hearing Loss ◽  
Cortical Neurons ◽  
Single Unit ◽  
Neural Correlates ◽  
Response Variability ◽  
Frequency Change ◽  
Middle Aged ◽  
Age Related ◽  
Cortical Responses ◽  
Age Related Hearing Loss

Presbycusis (age-related hearing loss) is a prevalent disability associated with aging that impairs spectrotemporal processing, but the mechanisms of such changes remain unclear. The goal of this study was to quantify cortical responses to frequency-modulated (FM) sweeps in a mouse model of presbycusis. Previous studies showed that cortical neurons in young mice are selective for the rate of frequency change in FM sweeps. Here single-unit data on cortical selectivity and response variability to FM sweeps of either direction and different rates (0.08–20 kHz/ms) were compared across young (1–3 mo), middle-aged (6–8 mo), and old (14–20 mo) groups. Three main findings are reported. First, there is a reduction in FM rate selectivity in the old group. Second, there is a slowing of the sweep rates at which neurons likely provide best detection and discrimination of sweep rates. Third, there is an increase in trial-to-trial variability in the magnitude and timing of spikes in response to sweeps. These changes were only observed in neurons that were selective for the fast or intermediate range of sweep rates and not in neurons that preferred slow sweeps or were nonselective. Increased variability of response magnitude, but not changes in temporal fidelity or selectivity, was seen even in the middle-aged group. The results show that spectrotemporal processing becomes slow and noisy with presbycusis in specific types of neurons, suggesting receptive field mechanisms that are altered. These data suggest neural correlates of presbycusis-related reduction in the ability of humans to process rapid spectrotemporal changes.

Prevalence of Central Auditory Processing (CAP) Abnormality in an Older Australian Population: The Blue Mountains Hearing Study

2004 ◽  
Vol 15 (09) ◽  
pp. 633-642 ◽  
Author(s):  
Maryanne Golding ◽  
Nan Carter ◽  
Paul Mitchell ◽  
Linda J. Hood
Keyword(s):  
Hearing Loss ◽  
Population Study ◽  
Auditory Processing ◽  
Clinical Studies ◽  
Central Auditory Processing ◽  
Australian Population ◽  
Related Condition ◽  
Blue Mountains ◽  
Age Related ◽  
Test Outcomes

Age-related central auditory processing (CAP) abnormality has been described in many studies with widely varying prevalence reported. To date, there has been only one population study to report prevalence for this age-related condition, and these rates were significantly lower than in reports from clinical studies. The present study reports findings from a recent population study in which 2,015 Australians aged 55 years and older living in a defined area west of Sydney were assessed with a battery of behavioral and electrophysiological auditory tests. This battery included speech measures from which a high overall prevalence rate (76.4%) of CAP abnormalities was found, in keeping with previous clinical studies. While gender differences were dependent on the test measure, the number of abnormal test outcomes increased systematically with age. Hearing loss and abnormal cognitive function, however, did not systematically increase with number of abnormal test outcomes.

scholarly journals Auditory Processing Performance of the Middle-Aged and Elderly: Auditory or Cognitive Decline?

2018 ◽  
Vol 29 (01) ◽  
pp. 005-014 ◽  
Author(s):  
Cristina F. B. Murphy ◽  
Camila M. Rabelo ◽  
Marcela L. Silagi ◽  
Leticia L. Mansur ◽  
Doris E. Bamiou ◽  
...  
Keyword(s):  
Working Memory ◽  
Hearing Loss ◽  
Cognitive Decline ◽  
Auditory Processing ◽  
The Elderly ◽  
Regression Analyses ◽  
Frequency Pattern ◽  
Speech In Noise ◽  
Age Related ◽  
Age Related Hearing Loss

AbstractDespite the well-established relationship between aging and auditory processing decline, identifying the extent to which age effect is the main factor on auditory processing performance remains a great challenge due to the co-occurrence of age-related hearing loss and age-related cognitive decline as potential confounding factors.To investigate the effects of age-related hearing loss and working memory on the clinical evaluation of auditory processing of middle-aged and elderly.Cross-sectional study.A total of 77 adults between 50 and 70 yr of age were invited to participate in the study.The participants were recruited from a larger study that focused on the assessment and management of sensory and cognitive skills in elderly participants. Only participants with normal hearing or mild-to-moderate age-related hearing loss, with no evidence of cognitive, psychological, or neurological conditions were included. Speech-in-noise, dichotic digit, and frequency pattern tests were conducted as well as a working memory test. The hearing loss effect was investigated using an audibility index, calculated from the audiometric threshold. The performance on the digit span test was used to investigate working memory effects. Both hearing loss and working memory effects were investigated via correlation and regression analyses, partialling out age effects. The significance level was set at p < 0.05.The results demonstrated that, while hearing loss was associated to the speech-in-noise performance, working memory was associated to the frequency pattern and dichotic digit performances. Regression analyses confirmed the relative contribution of hearing loss to the variance in speech-in-noise and working memory test to the variance in frequency pattern and dichotic digit test performance.The performance decline of the elderly in auditory processing tests may be partially attributable to the working memory performance and, consequently, to the cognitive decline exhibited by this population. Mild-to-moderate hearing loss seems to affect performance on specific auditory processing tasks, such as speech in noise, reinforcing the idea that auditory processing disorder in the elderly might also be associated to auditory peripheral deficits.

scholarly journals Age-related hearing loss: Aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain

2009 ◽  
Vol 1253 ◽  
pp. 27-34 ◽  
Author(s):  
Nathan Christensen ◽  
Mary D'Souza ◽  
Xiaoxia Zhu ◽  
Robert D. Frisina
Keyword(s):  
Gene Expression ◽  
Hearing Loss ◽  
Aquaporin 4 ◽  
Auditory Midbrain ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Auditory Processing Abilities of Parkinson’s Disease Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Robert L. Folmer ◽  
Jay J. Vachhani ◽  
Sarah M. Theodoroff ◽  
Rachel Ellinger ◽  
Amy Riggins
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Hearing Loss ◽  
Auditory Processing ◽  
Study Groups ◽  
Control Group ◽  
Central Auditory Processing ◽  
Control Subjects ◽  
Age Related ◽  
Auditory Functions

Since Parkinson’s Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests. Both study groups exhibited patterns of sensorineural hearing loss (slightly worse in the PD group) which were typical for their age and would contribute to difficulties in communication for many participants. Compared to the control group, PD patients reported greater difficulty in hearing words people are speaking. Although 27 PD patients (77%) were good candidates for amplification, only 7 (26%) of these hearing aid candidates used the devices. Because it is important for PD patients to optimize communication with their family members, caregivers, friends, and clinicians, it is vital to identify and remediate auditory dysfunction in this population as early as possible.

scholarly journals Decline of auditory-motor speech processing in older adults with hearing loss

2017 ◽  
Author(s):  
Muriel TN Panouillères ◽  
Riikka Möttönen
Keyword(s):  
Older Adults ◽  
Hearing Loss ◽  
Motor Cortex ◽  
Auditory Cortex ◽  
Speech Processing ◽  
Auditory Processing ◽  
Motor System ◽  
Dorsal Stream ◽  
Age Related ◽  
Age Related Hearing Loss

AbstractOlder adults often experience difficulties in understanding speech, partly because of age-related hearing loss. In young adults, activity of the left articulatory motor cortex is enhanced and it interacts with the auditory cortex via the left-hemispheric dorsal stream during speech processing. Little is known about the effect of ageing and age-related hearing loss on this auditory-motor interaction and speech processing in the articulatory motor cortex. It has been proposed that up-regulation of the motor system during speech processing could compensate for hearing loss and auditory processing deficits in older adults. Alternatively, age-related auditory deficits could reduce and distort the input from the auditory cortex to the articulatory motor cortex, suppressing recruitment of the motor system during listening to speech. The aim of the present study was to investigate the effects of ageing and age-related hearing loss on the excitability of the tongue motor cortex during listening to spoken sentences using transcranial magnetic stimulation and electromyography. Our results show that the excitability of the tongue motor cortex was facilitated during listening to speech in young and older adults with normal hearing. This facilitation was significantly reduced in older adults with hearing loss. These findings suggest a decline of auditory-motor processing of speech in adults with age-related hearing loss.

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