Prevalence of Central Auditory Processing (CAP) Abnormality in an Older Australian Population: The Blue Mountains Hearing Study

Age-related central auditory processing (CAP) abnormality has been described in many studies with widely varying prevalence reported. To date, there has been only one population study to report prevalence for this age-related condition, and these rates were significantly lower than in reports from clinical studies. The present study reports findings from a recent population study in which 2,015 Australians aged 55 years and older living in a defined area west of Sydney were assessed with a battery of behavioral and electrophysiological auditory tests. This battery included speech measures from which a high overall prevalence rate (76.4%) of CAP abnormalities was found, in keeping with previous clinical studies. While gender differences were dependent on the test measure, the number of abnormal test outcomes increased systematically with age. Hearing loss and abnormal cognitive function, however, did not systematically increase with number of abnormal test outcomes.

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Biased Auditory Nerve Central Synaptopathy Exacerbates Age-related Hearing Loss

10.1101/2020.06.09.142737 ◽

2020 ◽

Author(s):

Meijian Wang ◽

Chuangeng Zhang ◽

Shengyin Lin ◽

Yong Wang ◽

Benjamin J. Seicol ◽

...

Keyword(s):

Hearing Loss ◽

Auditory Processing ◽

Auditory Nerve ◽

Spiral Ganglion ◽

Central Auditory Processing ◽

Endbulb Of Held ◽

Age Related ◽

Central Synapses ◽

Ganglion Neurons ◽

Age Related Hearing Loss

SUMMARYSound information is transmitted from the cochlea to the brain by different subtypes of spiral ganglion neurons (SGN), which show varying degrees of vulnerbility under pathological conditions. It remains unclear how information from these SGNs reassemble among target neurons in the cochlear nucleus (CN) at the auditory nerve (AN) central synapses, and how different synapses change during hearing loss. Combining immunohistochemistry with electrophysiology, we investigated the giant endbulb of Held synapses and their postsynaptic bushy neurons in mice under normal hearing and age-related hearing loss (ARHL). We found that calretinin-expressing and non-calretinin-expressing endbulbs converge at continuously different ratios onto bushy neurons with varying physiological properties. Endbulbs degenerate during ARHL, and the degeneration is more severe in non-calretinin-expressing synapses, which correlates with a gradual decrease in neuronal subpopulation predominantly innervated by these inputs. Our findings suggest that biased AN central synaptopathy and shifted CN neuronal composition underlie reduced auditory input and altered central auditory processing during ARHL.

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Neural correlates of central auditory processing deficits in the auditory midbrain in an animal model of age-related hearing loss

The Journal of the Acoustical Society of America ◽

10.1121/1.4900155 ◽

2014 ◽

Vol 136 (4) ◽

pp. 2258-2258

Author(s):

Joseph P. Walton

Keyword(s):

Animal Model ◽

Hearing Loss ◽

Auditory Processing ◽

Neural Correlates ◽

Central Auditory Processing ◽

Auditory Midbrain ◽

Age Related ◽

Processing Deficits ◽

Age Related Hearing Loss

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Auditory Processing Abilities of Parkinson’s Disease Patients

BioMed Research International ◽

10.1155/2017/2618587 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 16

Author(s):

Robert L. Folmer ◽

Jay J. Vachhani ◽

Sarah M. Theodoroff ◽

Rachel Ellinger ◽

Amy Riggins

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Hearing Loss ◽

Auditory Processing ◽

Study Groups ◽

Control Group ◽

Central Auditory Processing ◽

Control Subjects ◽

Age Related ◽

Auditory Functions

Since Parkinson’s Disease (PD) primarily affects older people, a majority of PD patients have age-related hearing loss (HL) that will worsen over time. The goal of this study was to assess peripheral and central auditory functions in a population of PD patients and compare the results with a group of age-matched control subjects. Study participants included 35 adults with PD (mean age = 66.9 ± 11.2 years) and a group of 35 healthy control subjects (mean age = 65.4 ± 12.3 years). Assessments included questionnaires, neuropsychological tests, audiometric testing, and a battery of central auditory processing tests. Both study groups exhibited patterns of sensorineural hearing loss (slightly worse in the PD group) which were typical for their age and would contribute to difficulties in communication for many participants. Compared to the control group, PD patients reported greater difficulty in hearing words people are speaking. Although 27 PD patients (77%) were good candidates for amplification, only 7 (26%) of these hearing aid candidates used the devices. Because it is important for PD patients to optimize communication with their family members, caregivers, friends, and clinicians, it is vital to identify and remediate auditory dysfunction in this population as early as possible.

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Risk Markers for the Graded Severity of Auditory Processing Abnormality in an Older Australian Population: The Blue Mountains Hearing Study

Journal of the American Academy of Audiology ◽

10.3766/jaaa.16.6.3 ◽

2005 ◽

Vol 16 (06) ◽

pp. 348-356 ◽

Cited By ~ 10

Author(s):

Maryanne Golding ◽

Paul Mitchell ◽

Linda Cupples

Keyword(s):

Auditory Processing ◽

Population Based ◽

Central Auditory Processing ◽

Risk Markers ◽

Cognitive Screening ◽

Blue Mountains ◽

Hearing Handicap ◽

Screening Assessment ◽

The Relationship ◽

Test Outcomes

A recent report from a population-based survey of hearing loss in 2015 older adults showed that the overall prevalence of central auditory processing (CAP) abnormality was high at 76.4% using abnormality on one or more of seven speech-based test outcomes as the criteria. The present study grouped these test outcomes to reflect increasing severity of CAP abnormality and examined the relationship between this graded dependent variable and 16 independent variables. Logistic regression modeling suggested that moderate and severe CAP abnormality increased with age and was associated with increased hearing handicap, and men were more likely than women to show severe abnormality. While 98.5% of the population passed a cognitive screening assessment, declining cognitive function was still associated with the increased likelihood of CAP abnormality.

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AUDIOLOGICAL CORRELATES OF AGE-RELATED MANIFESTATIONS OF AUDITORY DISORDERS

Успехи геронтологии ◽

10.34922/ae.2020.33.3.017 ◽

2020 ◽

pp. 549-554

Author(s):

Л. Е. Голованова ◽

Е. А. Огородникова ◽

Н. С. Белокурова ◽

Е. С. Лаптева ◽

М. Ю. Бобошко

Keyword(s):

Hearing Aids ◽

Auditory Processing ◽

Pure Tone ◽

Young Patients ◽

Pure Tone Audiometry ◽

Sound Field ◽

Speech Audiometry ◽

Central Auditory Processing ◽

Central Auditory Processing Disorder ◽

Age Related

Целью исследования был сравнительный анализ жалоб и аудиологических показателей у пациентов сурдологического центра в зависимости от возраста. Представлены результаты обследования 300 первичных пациентов (случайная выборка), обратившихся к сурдологу-оториноларингологу в течение 1 мес. В группу молодых пациентов (19-44 года) вошли 40 человек; в группу среднего возраста (45- 59 лет) - 62 человека; в группу пожилых (60-74 года) - 100 человек; в группу старческого возраста (75-90 лет) - 98 человек. Обследование включало сбор жалоб и анамнеза, ЛОР-осмотр, тональную пороговую аудиометрию, импедансометрию, речевую аудиометрию в наушниках для выявления признаков центральных слуховых расстройств или в свободном звуковом поле для оценки эффективности слухопротезирования. Установлено, что для ранней диагностики тугоухости и профилактики возрастных сенсорнокогнитивных дисфункций целесообразно использовать не только результаты тональной пороговой аудиометрии, но и данные речевой аудиометрии, а также анализ субъективных жалоб. Результаты работы свидетельствуют о необходимости организации скрининга состояния слуха в рамках диспансеризации населения старше 60 лет. The aim of the study was a comparative analysis of complaints and audiological ﬁndings in patients of the audiological center depending on their age. The results of the examination of 300 ﬁ rstly consulted patients (random sample) are presented. The group of young patients (19-44 years) included 40 people; middle age (45-59 years) - 62 people; elderly (60-74 years) - 100 people; senile age (75-90 years) - 98 people. The survey included the collection of complaints and anamnesis, ENT checkup, pure tone audiometry, impedancemetry, speech audiometry in headphones to detect the signs of Central Auditory Processing Disorder or in the free sound ﬁeld to assess the effectiveness of hearing aids. It was found that for early diagnosis of hearing loss and prevention of age-related sensory-cognitive dysfunction, it is advisable to use not only the results of pure tone audiometry, but also the data of speech audiometry, as well as the analysis of subjective complaints. The results of the work indicate the need for hearing screening in the population over 60 years old.

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Temporal Alterations to Central Auditory Processing without Synaptopathy after Lifetime Exposure to Environmental Noise

Cerebral Cortex ◽

10.1093/cercor/bhab310 ◽

2021 ◽

Author(s):

Florian Occelli ◽

Florian Hasselmann ◽

Jérôme Bourien ◽

Jean-Luc Puel ◽

Nathalie Desvignes ◽

...

Keyword(s):

Hearing Loss ◽

Auditory Cortex ◽

Auditory Processing ◽

Noise Exposure ◽

Sound Intensity ◽

Environmental Noise ◽

Central Auditory Processing ◽

Adult Rats ◽

Cochlear Hair Cells ◽

Lifetime Exposure

Abstract People are increasingly exposed to environmental noise through the cumulation of occupational and recreational activities, which is considered harmless to the auditory system, if the sound intensity remains <80 dB. However, recent evidence of noise-induced peripheral synaptic damage and central reorganizations in the auditory cortex, despite normal audiometry results, has cast doubt on the innocuousness of lifetime exposure to environmental noise. We addressed this issue by exposing adult rats to realistic and nontraumatic environmental noise, within the daily permissible noise exposure limit for humans (80 dB sound pressure level, 8 h/day) for between 3 and 18 months. We found that temporary hearing loss could be detected after 6 months of daily exposure, without leading to permanent hearing loss or to missing synaptic ribbons in cochlear hair cells. The degraded temporal representation of sounds in the auditory cortex after 18 months of exposure was very different from the effects observed after only 3 months of exposure, suggesting that modifications to the neural code continue throughout a lifetime of exposure to noise.

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Hormones and Hearing: Central Auditory Processing in Women

Journal of the American Academy of Audiology ◽

10.3766/jaaa.17123 ◽

2019 ◽

Vol 30 (06) ◽

pp. 493-501

Author(s):

Skylar Trott ◽

Trey Cline ◽

Jeffrey Weihing ◽

Deidra Beshear ◽

Matthew Bush ◽

...

Keyword(s):

Hearing Loss ◽

Auditory Processing ◽

Auditory Brainstem ◽

Human Model ◽

Central Auditory Processing ◽

Hormonal Changes ◽

Hearing Sensitivity ◽

Organ Systems ◽

Significant Difference ◽

Brainstem Response

AbstractEstrogen has been identified as playing a key role in many organ systems. Recently, estrogen has been found to be produced in the human brain and is believed contribute to central auditory processing. After menopause, a low estrogen state, many women report hearing loss but demonstrate no deficits in peripheral hearing sensitivity, which support the notion that estrogen plays an effect on central auditory processing. Although animal research on estrogen and hearing loss is extensive, there is little in the literature on the human model.The aim of this study was to evaluate relationships between hormonal changes and hearing as it relates to higher auditory function in pre- and postmenopausal (Post-M) females.A prospective, group comparison study.Twenty eight women between the ages of 18 and 70 at the University of Kentucky were recruited.Participants were separated into premenopausal and peri-/Post-M groups. Participants had normal peripheral hearing sensitivity and underwent a behavioral auditory processing battery and electrophysiological evaluation. An analysis of variance was performed to address the aims of the study.Results from the study demonstrated statistically significant difference between groups, where Post-M females had difficulties in spatial hearing abilities as reflected on the Listening in Spatialized Noise Test–Sentences test. In addition, measures on the auditory brainstem response and the middle latency response reflected statistically significant differences between groups with Post-M females having longer latencies.Results from the present study demonstrated significant differences between groups, particularly listening in noise. Females who present with auditory complaints in spite of normal hearing thresholds should have a more extensive audiological evaluation to further evaluate possible central deficits.

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Prevalence of Age-Related Hearing Loss in Older Adults: Blue Mountains Study

Archives of Internal Medicine ◽

10.1001/archinternmed.2008.597 ◽

2009 ◽

Vol 169 (4) ◽

pp. 415 ◽

Cited By ~ 95

Author(s):

Bamini Gopinath ◽

Elena Rochtchina ◽

Jie Jin Wang ◽

Julie Schneider ◽

Stephen R. Leeder ◽

...

Keyword(s):

Older Adults ◽

Hearing Loss ◽

Blue Mountains ◽

Age Related ◽

Age Related Hearing Loss

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Audiological Correlates to a Rupture of a Pontine Arteriovenous Malformation

Journal of the American Academy of Audiology ◽

10.3766/jaaa.15.2.6 ◽

2004 ◽

Vol 15 (02) ◽

pp. 161-171 ◽

Cited By ~ 3

Author(s):

Frank E. Musiek ◽

Jane A. Baran

Keyword(s):

Hearing Loss ◽

Arteriovenous Malformation ◽

Auditory Processing ◽

Rehabilitation Program ◽

Central Auditory Processing ◽

Central Auditory Processing Disorder ◽

Auditory Rehabilitation ◽

Initial Symptoms ◽

Recovery Mechanisms

This is a report of a female patient in her midthirties who sustained a hemorrhage secondary to an arteriovenous malformation in the region of the pons. The patient's initial symptoms included hearing loss and tinnitus, which were followed by the more characteristic symptoms of headache and loss of consciousness. Results of audiological testing at three months postaccident documented the presence of a hearing loss and a central auditory processing disorder, and the patient was provided an auditory rehabilitation program. Follow-up testing over the course of an additional year documented improvement in both pure-tone threshold and central test results; however, at 15 months postaccident, some auditory deficits remained, especially in the ear ipsilateral to the primary site of lesion. The anatomical correlates of these deficits are discussed, as are the potential contributions of both the auditory rehabilitation program and spontaneous recovery mechanisms to the documented improvements in auditory function.

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