scholarly journals The potential role of selected bioactive compounds from spelt and common wheat in glycemic control

2017 ◽  
Vol 26 (6) ◽  
pp. 1015-1021 ◽  
Author(s):  
Izabela Biskup ◽  
Magdalena Gajcy ◽  
Izabela Fecka
Keyword(s):  
Glycemic Control ◽  
Common Wheat ◽  
Bioactive Compounds ◽  
Potential Role

Potential role of bioactive compounds of Phaseolus vulgaris L. on lipid-lowering mechanisms

2015 ◽  
Vol 76 ◽  
pp. 92-104 ◽  
Author(s):  
Aurea K. Ramírez-Jiménez ◽  
Rosalía Reynoso-Camacho ◽  
M. Elizabeth Tejero ◽  
Fabiola León-Galván ◽  
Guadalupe Loarca-Piña
Keyword(s):  
Phaseolus Vulgaris ◽  
Bioactive Compounds ◽  
Potential Role ◽  
Lipid Lowering ◽  
Phaseolus Vulgaris L

Abstract 2566: The potential role of licorice and its bioactive compounds in promoting a tumor preventive environment in the postmenopausal breast

2021 ◽  
Author(s):  
Atieh Hajirahimkhan ◽  
Caitlin Howell ◽  
Shao-Nong Chen ◽  
Susan E. Clare ◽  
Guido F. Pauli ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Potential Role

Potential role of E4orf1 protein in aging-associated impairment in glycemic control

2019 ◽  
Vol 33 (3) ◽  
pp. 261-265
Author(s):  
Suhadinie Gamage ◽  
P. Hemachandra Reddy ◽  
Nikhil V. Dhurandhar ◽  
Vijay Hegde
Keyword(s):  
Glycemic Control ◽  
Potential Role

scholarly journals Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1022 ◽  
Author(s):  
Fiona Limanaqi ◽  
Francesca Biagioni ◽  
Federica Mastroiacovo ◽  
Maico Polzella ◽  
Gloria Lazzeri ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Neurodegenerative Disorders ◽  
Potential Role ◽  
Protective Mechanisms ◽  
Neuroprotective Effects ◽  
Mitochondrial Homeostasis ◽  
Naturally Occurring ◽  
Anti Inflammatory ◽  
Target Effects

Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the restoration of mitochondrial homeostasis and targeting alterations of cell-clearing systems. Far from being independent, these multi-target effects represent interconnected events that are commonly implicated in the pathogenesis of most neurodegenerative diseases, independently of etiology, nosography, and the specific misfolded proteins being involved. Nonetheless, the increasing amount of data applying to a variety of neurodegenerative disorders joined with the multiple effects exerted by the wide variety of plant-derived neuroprotective agents may rather confound the reader. The present review is an attempt to provide a general guideline about the most relevant mechanisms through which naturally occurring agents may counteract neurodegeneration. With such an aim, we focus on some popular phytochemical classes and bioactive compounds as representative examples to design a sort of main highway aimed at deciphering the most relevant protective mechanisms which make phytochemicals potentially useful in counteracting neurodegeneration. In this frame, we emphasize the potential role of the cell-clearing machinery as a kernel in the antioxidant, anti-aggregation, anti-inflammatory, and mitochondrial protecting effects of phytochemicals.

scholarly journals Invited Review: Effects of colostrum management on transfer of passive immunity and the potential role of colostral bioactive components on neonatal calf development and metabolism

2021 ◽  
Author(s):  
Amanda J. Fischer-Tlustos ◽  
Alberto Jose Lopez Cabus ◽  
Koryn S. Hare ◽  
Katie Wood ◽  
Mike Steele
Keyword(s):  
Bioactive Compounds ◽  
Management Practices ◽  
Potential Role ◽  
Past Research ◽  
Bioactive Molecules ◽  
Dairy Calves ◽  
Passive Immunity ◽  
Future Research ◽  
Beef Calves

Neonatal dairy and beef calves are required to ingest adequate volumes of high-quality colostrum during their first hours of life to acquire transfer of passive immunity. As such, immunoglobulin G (IgG) has largely been the focus of colostrum research over recent decades. Yet, little is known about the additional bioactive compounds in colostrum that potentially influence newborn calf development and metabolism. The purpose of this narrative review is to synthesize research regarding the effects of colostrum management practices on transfer of passive immunity, as well as to address the potential role of additional colostral bioactive molecules, including oligosaccharides, fatty acids, insulin and insulin-like growth factor I, in promoting calf development and metabolism. Due to the importance of IgG in ensuring calf immunity and health, we review past research describing the process of colostrogenesis and dam factors influencing the concentrations of IgG in an effort to maximize transfer of passive immunity. We also address the transfer of additional bioactive compounds in colostrum and prepartum management and dam factors that influence their concentrations. Finally, we highlight key areas of future research for the scientific community to pursue to ultimately improve the health and welfare of neonatal dairy calves.

scholarly journals The Potential Role of Activating the ATP-Sensitive Potassium Channel in the Treatment of Hyperphagic Obesity

Genes ◽  
2020 ◽  
Vol 11 (4) ◽  
pp. 450
Author(s):  
Neil Cowen ◽  
Anish Bhatnagar
Keyword(s):  
Glycemic Control ◽  
Animal Models ◽  
Katp Channel ◽  
Potential Role ◽  
Clinical Results ◽  
Motor Nucleus ◽  
Recent Experience ◽  
Channel Activation ◽  
Pubmed Search

To evaluate the potential role of ATP-sensitive potassium (KATP) channel activation in the treatment of hyperphagic obesity, a PubMed search was conducted focused on the expression of genes encoding the KATP channel, the response to activating the KATP channel in tissues regulating appetite and the establishment and maintenance of obesity, the evaluation of KATP activators in obese hyperphagic animal models, and clinical studies on syndromic obesity. KATP channel activation is mechanistically involved in the regulation of appetite in the arcuate nucleus; the regulation of hyperinsulinemia, glycemic control, appetite and satiety in the dorsal motor nucleus of vagus; insulin secretion by β-cells; and the synthesis and β-oxidation of fatty acids in adipocytes. KATP channel activators have been evaluated in hyperphagic obese animal models and were shown to reduce hyperphagia, induce fat loss and weight loss in older animals, reduce the accumulation of excess body fat in growing animals, reduce circulating and hepatic lipids, and improve glycemic control. Recent experience with a KATP channel activator in Prader–Willi syndrome is consistent with the therapeutic responses observed in animal models. KATP channel activation, given the breadth of impact and animal model and clinical results, is a viable target in hyperphagic obesity.

scholarly journals ASSESSMENT ON BIOACTIVE COMPOUNDS AND THE EFFECT OF MICROWAVE ON PITAYA PEEL

2019 ◽  
Vol 81 (2) ◽  
Author(s):  
Norashikin Mat Zain ◽  
Muhd Azlan Nazeri ◽  
Nurul Aini Azman
Keyword(s):  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Bioactive Compounds ◽  
Potential Role ◽  
Quinic Acid ◽  
Assisted Extraction ◽  
Cell Wall Disruption ◽  
Food And Drink ◽  
Peel Extract

Over the years, a wide variety of natural colour sources have been identified. One source, the pitaya fruit is known to impart colours to products, such as food and drink. However, there have been limited studies done to determine phenolic compounds and antibacterial activity of the pitaya peel (H.polyrhizus) via Microwave Assisted Extraction (MAE) method. Both this information can escalate the potential role of pitaya fruit as a natural colour source. This study aimed to identify the types of bioactive compounds (phenolic compounds) and antibacterial activity of pitaya peel. To achieve this objective, MAE was used to extract bioactive compounds from the pitaya peel as it maintained the integrity of the compound. Based on the results, 13 types of phenolic compounds were identified from the pitaya peel extract via qualitative research using library database matching which include quinic acid, cinnamic acid, quinic acid isomer, 3,4-dihydroxyvinylbenzene, isorhamnetin 3-O-rutinoside, myricetin rhamno-hexoside, 3,30-di-O-methyl ellagic acid, isorhamnetin aglycone monomer, apigenin, jasmonic acid, oxooctadecanoic acid, 2 (3,4-dihydroxyphenyl)-7-hydroxy-5-benzene propanoic acid and protocatechuic hexoside conjugate.  The pitaya peel extract was also found to have small antibacterial effect on the Gram-positive, Staphylococcus aureus (S.aureus) and Gram- negative, Escherichia coli (E.coli). The SEM demonstrated that cell wall disruption of pitaya peel caused by microwave radiation from MAE appeared to be the main reason for rapid extraction of bioactive compounds. In conclusion, the study established that pitaya peel extract is a natural colour source with an abundance of phenolic compounds and minimal antibacterial activity, which could be used in the food and cosmetic industries. 

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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