ADIPOSE TISSUE AS A RESERVE SOURCE OF A PLASTIC MATERIAL FOR CHRONIC WOUNDS OF SOFT TISSUES TREATMENT (literature review)

AbstractLipomas are common benign connective tissue tumours composed of adult adipose tissue. They are relatively rare in the upper aerodigestive tract, although they occur with considerable frequency in other areas, particularly in the subcutaneous tissues of the neck. Although there are several reports of this tumour occurring in the oropharynx, there is no recorded case of a lipoma of the tonsillar fossa. An 83-year-old man with a left tonsillar fossa lipoma is presented. Clinical presentation, management and a literature review are discussed.

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Tophaceous gout presenting as a dorsal nasal lump

The Journal of Laryngology & Otology ◽

10.1258/0022215054273160 ◽

2005 ◽

Vol 119 (6) ◽

pp. 492-494 ◽

Cited By ~ 11

Author(s):

J P Hughes ◽

Silvana Di Palma ◽

J Rowe-Jones

Keyword(s):

Literature Review ◽

Head And Neck ◽

Soft Tissues ◽

Neck Region ◽

Endoscopic Technique ◽

Tophaceous Gout ◽

Head And Neck Region ◽

Nasal Bones ◽

Aesthetic Rhinoplasty ◽

Emergency Tracheotomy

A literature review reveals that gout has been described as affecting many sites in the head and neck region, both in the arthritic and tophaceous form. Gout can often mimic malignancy or infection, and has been described as causing acute airway problems requiring emergency tracheotomy. Here we describe the first published case of tophaceous gout affecting the soft tissues overlying the nasal bones. The patient presented with a bony, hard, dorsal hump and requested aesthetic rhinoplasty.We also describe an endoscopic technique for removal of tophi using a powered microdebrider system with a protected burr head. Endoscopic powered microdebrider blade excision of tophi affecting the limbs has already been described, with reduced complications when compared with conventional curettage and debridement techniques. This is the first such application to the nose.

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Slowly cycling Rho kinase-dependent actomyosin cross-bridge “slippage” explains intrinsic high compliance of detrusor smooth muscle

AJP Renal Physiology ◽

10.1152/ajprenal.00633.2016 ◽

2017 ◽

Vol 313 (1) ◽

pp. F126-F134 ◽

Cited By ~ 4

Author(s):

Christopher J. Neal ◽

Jia B. Lin ◽

Tanner Hurley ◽

Amy S. Miner ◽

John E. Speich ◽

...

Keyword(s):

Smooth Muscle ◽

Soft Tissues ◽

Plastic Material ◽

Rho Kinase ◽

Detrusor Smooth Muscle ◽

Display Time ◽

Protein Activation ◽

Cross Bridge ◽

Cross Bridges ◽

Dependent Viscosity

Biological soft tissues are viscoelastic because they display time-independent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable unless work is done by the muscle. In the present study, an electronic lever was used to induce controlled changes in stress and strain to determine whether rabbit detrusor smooth muscle (rDSM) is best described as viscoelastic or viscoelastic plastic. Using sequential ramp loading and unloading cycles, stress-strain and stiffness-stress analyses revealed that rDSM displayed reversible viscoelasticity, and that the viscous component was responsible for establishing a high stiffness at low stresses that increased only modestly with increasing stress compared with the large increase produced when the viscosity was absent and only pseudoelasticity governed tissue behavior. The study also revealed that rDSM underwent softening correlating with plastic deformation and creep that was reversed slowly when tissues were incubated in a Ca2+-containing solution. Together, the data support a model of DSM as a viscoelastic-plastic material, with the plasticity resulting from motor protein activation. This model explains the mechanism of intrinsic bladder compliance as “slipping” cross bridges, predicts that wall tension is dependent not only on vesicle pressure and radius but also on actomyosin cross-bridge activity, and identifies a novel molecular target for compliance regulation, both physiologically and therapeutically.

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Formulation and Evaluation of Wound Healing Effect of Aqueous Herbal Cream Containing Various Extracts of Passiflora foetida Linn., Leaves

International Journal of Scientific Research in Science and Technology ◽

10.32628/ijsrst196171 ◽

2019 ◽

pp. 490-499

Author(s):

Akila E ◽

C. Geetha Priya

Keyword(s):

Wound Healing ◽

Chronic Wounds ◽

Soft Tissues ◽

Folk Medicine ◽

New Drugs ◽

Herbal Remedies ◽

Control Group ◽

Wound Model ◽

Number Of Patients ◽

Passiflora Foetida

Wounds are a major cause of concern for the patient and clinician alike; chronic Wounds affect a large number of patients and seriously reduce their quality of life. Wound healing is the process of repair that follows injury to the skin and other soft tissues. A cream is a preparation of a medication for topical use that contains a water base. Essentially, it is a preparation of oil in water. Herbal remedies used in folk medicine provide an interesting and still largely unexplored source for the creation and development of potentially new drugs, which might help to overcome the growing problem of resistance and also the toxicity of the currently available commercial antibiotics. In this study we have formulated an Aqueous herbal cream satisfying almost all pharmaceutical parameters which shows better wound healing activity. The wound healing of effect of Aqueous Herbal cream of various extracts of leaves of Passiflora foetida L. was evaluated by incision and excision wound model. The experimental results and histopathological studies showed that Aqueous Herbal Cream of Passiflora foetida L. leaves exhibits significant wound healing property as compared to control group of animals.

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BILATERAL MACRODYSTROPHIA LIPOMATOSA WITH SYNDACTYLY: A CASE REPORT AND LITERATURE REVIEW

Hand Surgery ◽

10.1142/s0218810413720180 ◽

2013 ◽

Vol 18 (02) ◽

pp. 267-272 ◽

Cited By ~ 1

Author(s):

Steven B. Albright ◽

Erik M. Wolfswinkel ◽

Kevin J. Caceres ◽

William M. Weathers ◽

Larry H. Hollier

Keyword(s):

Adipose Tissue ◽

Case Report ◽

Literature Review ◽

Upper Extremity ◽

Surgical Approaches ◽

Macrodystrophia Lipomatosa ◽

Mesenchymal Tissue ◽

Difficult Condition

Macrodystrophia lipomatosa is a rare, non-hereditary form of congenital local gigantism characterised by enlargement and hypertrophy of all mesenchymal tissue components with a disproportionate increase in adipose tissue. This form of macrodactyly has been reported in association with other anomalies including polydactyly, brachydactyly, syndactyly, and symphalangism. We describe a previously unreported case of bilateral upper extremity macrodystrophia lipomatosa with syndactyly in a 23-month-old boy. In this report, we emphasise the importance of establishing a diagnosis with imaging and review the described surgical approaches to treating this difficult condition.

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Prontosan® soluzione e Prontosan® Debridement Pad nel trattamento di diversi tipi di ferite cutanee: dichiarazioni basate su opinioni di esperti, serie di casi e revisione della letteratura/Prontosan® solution and Prontosan® Debridement Pad in the treatment of different types of cutaneous wounds: expert-based statements, case series and review of the literature

Italian Journal of Wound Care ◽

10.4081/ijwc.2019.53 ◽

2019 ◽

Vol 3 (3) ◽

Author(s):

Angela Peghetti ◽

Diletta Olivari ◽

Silvia Tedesco ◽

Andrea Bellingeri ◽

Marino Ciliberti ◽

...

Keyword(s):

Literature Review ◽

Chronic Wounds ◽

Wound Care ◽

Evidence Synthesis ◽

New Technology ◽

Case Series ◽

Sono State ◽

Review Of The Literature ◽

Combined System ◽

New Device

Prontosan® Debridement Pad (PDP; B. Braun) è un nuovo presidio disegnato per migliorare il processo di debridement meccanico. In questo lavoro riportiamo i risultati di un complesso progetto condotto al fine di sviluppare consenso tra gli esperti sul migliore modo di impiegare questa nuova tecnologia nella pratica clinica. Il progetto si è articolato in tre fasi. Nella prima è stata condotta una estesa revisione della letteratura che ha condotto ad identificare, analizzare criticamente e a riassumere in formato strutturato 27 studi clinici pertinenti. Nella seconda fase le evidenze disponibili sono state discusse in modo sistematico con un pannello di 10 esperti, i quali hanno formulato 12 raccomandazioni per l'impiego clinico del PDP. Queste raccomandazioni sono state quindi sottoposte a votazione formale attraverso il metodo GRADE. Infine, nei mesi successivi, 13 casi clinici provenienti dalla pratica clinica routinaria e trattati in accordo con le raccomandazioni stabilite sono stati raccolti e vengono qui presentati. Nel complesso, i dati disponibili in letteratura e quelli raccolti dalla pratica clinica confermano l'efficacia del PDP come strumento per il debridement meccanico, offrendo vantaggi significativi per una ottimale Wound Bed Preparation e per il controllo del dolore. Il nostro progetto può inoltre essere utile per ottimizzare l'impiego pratico di questo nuovo promettente dispositivo. Prontosan® Debridement Pad (PDP; B. Braun) is a new device designed for mechanical debridement. This paper summarizes the results of a complex initiative aimed to develop consensus among a panel of wound care experts about the optimal use of this new technology. An extensive review of the literature found 27 pertinent papers, which underwent a formal process of critical appraisal and evidence extraction by two independent methodologists. Results are displayed in an evidence report. 12 practical recommendations, concerning management of acute and chronic wounds, have been developed and approved. Main point of strength of this project is the use of a systematic approach to literature review, evidence synthesis and presentation, development and measurement of expert consensus. Moreover, expert panel provided further clinical data, through the reporting of 13 clinical cases managed according to abovementioned recommendations, with a particular focus on burns and chronic ulcers treatment, both in adult and pediatric patients. Overall, results from literature review and from clinical experience confirm that the combined system Prontosan® Solution and PDP is a promising tool useful in the critical phase of debridement in acute and chronic wounds treatment. Efficacy in debris removal and pain reduction are the main points of strength. Our project may contribute to optimize clinical use of this innovative device.

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Primary Giant Cell Tumor of Soft Tissues : A Case Report and Literature Review

The Egyptian Journal of Hospital Medicine ◽

10.12816/0043483 ◽

2018 ◽

Vol 70 (3) ◽

pp. 436-438

Author(s):

Furat Abdulrahman Almayouf

Keyword(s):

Case Report ◽

Literature Review ◽

Giant Cell Tumor ◽

Giant Cell ◽

Soft Tissues ◽

Cell Tumor

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Lipoma of the sigmoid colon

Vojnosanitetski pregled ◽

10.2298/vsp1303319d ◽

2013 ◽

Vol 70 (3) ◽

pp. 319-321 ◽

Cited By ~ 1

Author(s):

Matilda Djolai ◽

Bojana Andrejic ◽

Dejan Ivanov

Keyword(s):

Adipose Tissue ◽

Case Report ◽

Gastrointestinal Tract ◽

Sigmoid Colon ◽

Human Body ◽

Soft Tissues ◽

Benign Tumor ◽

Extensive Resection ◽

One Year ◽

Histological Confirmation

Introduction. Lipoma is a benign tumor of adipose tissue, the most common tumor of the human body soft tissues. As such, it can be found almost anywhere in the human body including the gastrointestinal system (incidence below 0.5%), but rarely in the sigmoid colon. Case report. This is a case report on symptomatic polyp of the sigmoid colon, which after one year, at control colonoscopy, caused suspicion to malignancy. Endoscopically diagnosed polipoid lesion was laparoscopically removed. The pathohistological diagnosis determined benign, submucosal, incapsulated lipoma of the sigmoid colon. Conclusion. Although lipomas of the gastrointestinal tract are rare, this case clearly indicates that we should not prematurely and without histological confirmation of malignancy do more extensive resection for a suspected malignancy.

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A Priori Assessment of Adipose Tissue Mechanical Testing by Global Sensitivity Analysis

Journal of Biomechanical Engineering ◽

10.1115/1.4039176 ◽

2018 ◽

Vol 140 (5) ◽

Cited By ~ 2

Author(s):

Hosein Naseri ◽

Håkan Johansson

Keyword(s):

Sensitivity Analysis ◽

Adipose Tissue ◽

Soft Tissues ◽

Global Sensitivity Analysis ◽

A Priori ◽

Compression Tests ◽

Unconfined Compression ◽

Material Parameters ◽

Global Sensitivity ◽

Indentation Tests

In modeling the mechanical behavior of soft tissues, the proper choice of an experiment for identifying material parameters is not an easy task. In this study, a finite element computational framework is used to virtually simulate and assess commonly used experimental setups: rotational rheometer tests, confined- and unconfined-compression tests, and indentation tests. Variance-based global sensitivity analysis is employed to identify which parameters in different experimental setups govern model prediction and are thus more likely to be determined through parameter identification processes. Therefore, a priori assessment of experimental setups provides a base for systematic and reliable parameter identification. It is found that in indentation tests and unconfined-compression tests, incompressibility of soft tissues (adipose tissue in this study) plays an important role at high strain rates. That means bulk stiffness constitutes the main part of the mechanism of tissue response; thus, these experimental setups may not be appropriate for identifying shear stiffness. Also, identified material parameters through loading–unloading shear tests at a certain rate might not be reliable for other rates, since adipose tissue shows highly strain rate dependent behavior. Frequency sweep tests at a wide-enough frequency range seem to be the best setup to capture the strain rate behavior. Moreover, analyzing the sensitivity of model parameters in the different experimental setups provides further insight about the model itself.

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