A lateral flow-based at-home test for detection of SARS-CoV-2 v1 (protocols.io.bs8bnhsn)

protocols.io ◽  
2021 ◽  
Author(s):  
Peng Xu ◽  
Venice Servellita ◽  
Krzysztof Langer ◽  
Dan Weisgerber ◽  
Gordon Murtaugh ◽  
...  
Keyword(s):  
Lateral Flow ◽  
Home Test ◽  
At Home

Sensitive lateral flow-based SARS-CoV-2 at-home test v2 (protocols.io.bpnzmmf6)

protocols.io ◽  
2020 ◽  
Author(s):  
Peng Xu ◽  
Venice Servellita ◽  
Krzysztof Langer ◽  
Gordon Murtaugh ◽  
Adam R ◽  
...  
Keyword(s):  
Lateral Flow ◽  
Home Test ◽  
At Home

Sensitive lateral flow-based SARS-CoV-2 at-home test v1 (protocols.io.bqw6mxhe)

protocols.io ◽  
2020 ◽  
Author(s):  
Peng Xu ◽  
Venice Servellita ◽  
Krzysztof Langer ◽  
Gordon Murtaugh ◽  
Adam R ◽  
...  
Keyword(s):  
Lateral Flow ◽  
Home Test ◽  
At Home

Sensitive lateral flow-based SARS-CoV-2 at-home test v1 (protocols.io.bk22kyge)

protocols.io ◽  
2020 ◽  
Author(s):  
Peng Xu ◽  
Venice Servellita ◽  
Krzysztof Langer ◽  
Gordon Murtaugh ◽  
Adam R ◽  
...  
Keyword(s):  
Lateral Flow ◽  
Home Test ◽  
At Home

The Implementation and Acceptability of a Combined Mobile Application with a COVID-19 at-Home Test Kit

2021 ◽  
Author(s):  
Adrian H. Zai ◽  
Molly Caffrey ◽  
Conor S. O'Brien ◽  
Dawei Jiang ◽  
Remona Kanyat ◽  
...  
Keyword(s):  
Mobile Application ◽  
Home Test ◽  
Test Kit ◽  
At Home

scholarly journals 1775. A Community-wide Study to Evaluate the Accuracy of Self-testing for Influenza: Works in Progress

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S654-S654
Author(s):  
Matthew Thompson ◽  
Monica L Zigman Suchsland ◽  
Victoria Lyon ◽  
Enos Kline ◽  
ShiChu Huang ◽  
...  
Keyword(s):  
United States ◽  
Nasal Swab ◽  
Rapid Test ◽  
Test Strip ◽  
Lateral Flow ◽  
Reference Standard ◽  
Self Testing ◽  
Flow Test ◽  
Lateral Flow Test ◽  
At Home

Abstract Background Seasonal influenza (flu) occurs annually, causing disease with substantial morbidity and mortality. Currently, flu is suspected from clinical features, but requires a laboratory test to confirm infection. No influenza tests in the United States are approved for use outside of clinical settings. We aimed to determine the accuracy of influenza self-testing using an at-home, app-guided, lateral flow assay compared with a molecular reference standard conducted at a laboratory among adults self-reporting influenza-like illness (ILI). Methods This is an observational study of individuals with self-reported ILI throughout the continental 48 United States recruited from the Flu Near You platform, online marketing, and clinics in the Seattle area. Recruitment took place from March 4 to April 26, 2019. Participants were directed to an iPhone App that determined eligibility, consent, and responses to symptom questions and risk factors. Individuals were mailed a commercially available CLIA-waived influenza lateral flow test to conduct at home, guided by the app, and returned the used test along with a second nasal swab collected in viral transport media to the research team. Influenza testing was performed by RT–PCR on the second nasal swab, as well as the residual fluid from the RDT. Accuracy of home test result (read by the participant), as well as image capture of the lateral flow test strip, were compared with the lab-based reference standard. Results To date, 1127 at-home flu tests were mailed to participants and 711 (63.1%) samples returned to the lab. There were 17 flu-positive results from the rapid diagnostic test for a flu positivity rate of 2.4%. Testing using the reference standard is currently in progress. We will share diagnostic accuracy results once testing of the reference standard is completed. Of the kits returned, 353 (49.7%)had an error recorded, which included errors in return packaging, reference standard, rapid test tube sample, or rapid test strip errors. Conclusion Overall, findings from this study will determine the accuracy of an at-home rapid diagnostic test, and inform more widely research design for evaluating smartphone-enhanced home tests for pathogens. Many samples returned to the lab had a recorded error, suggesting at-home testing requires additional feasibility testing and refinement of the current methods used. Disclosures All authors: No reported disclosures.

scholarly journals Diagnose it yourself: will there be a home test kit for Alzheimer’s disease?

2021 ◽  
Vol 11 (2) ◽  
pp. 167-176
Author(s):  
Felix Menne ◽  
Carola G Schipke
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Preventive Measures ◽  
Neurodegenerative Process ◽  
Home Test ◽  
Test Strategies ◽  
Test Kit ◽  
Low Threshold ◽  
Novel Approaches ◽  
At Home

Alzheimer’s disease is the most common neurodegenerative process leading to dementia. To date, there is no curative approach; thus, establishing a diagnosis as early as possible is necessary to implement preventive measures. However, today’s gold standard for diagnosing Alzheimer’s disease is high in both cost and effort and is not readily available. This defines the need for low-effort and economic alternatives that give patients low-threshold access to testing systems at their general practitioners or even at home for an independent retrieval of a biologic specimen. This perspective gives an overview of established and novel approaches in the field and speculates on the future of test strategies eventually technically implementable at home.

scholarly journals Boston Cognitive Assessment (BOCA) — a comprehensive self-administered smartphone- and computer-based at-home test for longitudinal tracking of cognitive performance

2021 ◽  
Author(s):  
Andrey Vyshedskiy ◽  
Rebecca Netson ◽  
Elisabeth Fridberg ◽  
Priyanka Jagadeesan ◽  
Matthew Arnold ◽  
...  
Keyword(s):  
Cognitive Aging ◽  
Cognitive Assessment ◽  
Practice Effect ◽  
Cognitive Testing ◽  
Discriminative Ability ◽  
Immediate Recall ◽  
Home Test ◽  
Longitudinal Tracking ◽  
Cognitive Monitoring ◽  
At Home

AbstractLongitudinal cognitive testing is essential for developing novel preventive interventions for dementia and Alzheimer’s disease; however, the few available tools have significant practice effect and depend on an external evaluator. We developed a self-administered 10-minute at-home test intended for longitudinal cognitive monitoring, Boston Cognitive Assessment or BOCA. The goal of this project was to validate BOCA. BOCA uses randomly selected non-repeating tasks to minimize practice effects. BOCA evaluates eight cognitive domains: 1) Memory/Immediate Recall, 2) Language Comprehension/Prefrontal Synthesis, 3) Visuospatial Reasoning / Mental rotation, 4) Executive function / Clock Test, 5) Attention, 6) Mental math, 7) Orientation, and 8) Memory/Delayed Recall. BOCA was administered to patients with cognitive impairment (n = 50) and age- and education-matched controls (n = 50). Test scores were significantly different between patients and controls (p < 0.001) suggesting good discriminative ability. The Cronbach’s alpha was 0.87 implying good internal consistency. BOCA demonstrated strong correlation with Montreal Cognitive Assessment (MOCA) (R= 0.90, p <0.001). The study revealed strong (R=0.94, p <0.001) test-retest reliability of the total BOCA score one week after participants’ initial administration. The practice effect tested by daily BOCA administration over 10 days was insignificant (β=0.03, p=0.74). BOCA has the potential to reduce the cost and improve the quality of longitudinal cognitive tracking essential for testing novel interventions designed to reduce or reverse cognitive aging. BOCA is available online gratis at www.bocatest.org.

scholarly journals P518 Compliance with Faecal calprotectin home testing as standard during COVID-19 pandemic compared to laboratory based testing pre-COVID

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S496-S497
Author(s):  
D Edwards ◽  
M Ibrahim ◽  
R Cooney ◽  
R Boulton
Keyword(s):  
Patient Compliance ◽  
Health Care Professionals ◽  
Compliance Rate ◽  
University Teaching ◽  
Faecal Calprotectin ◽  
Home Test ◽  
Home Based ◽  
Home Testing ◽  
Elisa Testing ◽  
At Home

Abstract Background Faecal calprotectin (FC) testing has become a standard non-invasive tool to monitor disease control in Inflammatory Bowel Disease (IBD)(1). Reported patient compliance with submitting samples for hospital testing has been as low as 35% (2). We aimed to evaluate patient compliance with rapid home faecal calprotectin testing kits compared to hospital based testing in our university teaching hospital. Methods 100 patients with a diagnosis of IBD for at least 1 year and attended IBD clinic between January 2019 and August 2020 were selected. Our laboratory ceased performing FC testing in late March and we introduced home testing (BÜHLMANN IBD doc). 50 patients who were, pre-pandemic, requested to bring a stool sample to the laboratory for hospital-based ELISA testing were randomly selected. We compared these to 50 random patients who had a home-based FC testing. Patients who were supplied with home testing kits received training from IBD nurses as well as on-line training materials. Data was collated retrospectively. Compliance was recorded if result was documented within 6 weeks of request. Results Prior to the introduction of home testing, only 52% of the patients’ sampled complied with hospital-based testing. This compared to a 70% compliance rate, when home testing was requested (Figure 1). Figure 1. Comparison of percentage of compliance between hospital and home faecal calprotectin test request. Conclusion The improvement in FC testing compliance with rapid home testing kit compared to laboratory based testing illustrates the benefit of adapting home testing as the standard in future. The considerable increase in compliance by home testing may be due less disruption to patient’s personal life i.e., ability to undergo testing at home, symptoms such as faecal incontinence preventing patients delivering samples to hospital and COVID pandemic compelling patients to stay at home. Adopting rapid FC home testing as standard provides patients with increased locus of control regarding their care, providing health care professionals with rapid results, thus, will improve management of IBD. The ability for patients to perform home test has obvious advantages during the COVID pandemic. References

scholarly journals Sustained Gaze Is a Reliable In-home Test of Attention for Aging Pet Dogs

2021 ◽  
Vol 8 ◽  
Author(s):  
Jane A. Hoel ◽  
Ginger B. Templeton ◽  
Gilad Fefer ◽  
Beth C. Case ◽  
Anshu Shah ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Cognitive Dysfunction ◽  
Outcome Measures ◽  
Interobserver Reliability ◽  
Retest Reliability ◽  
Home Test ◽  
Training Materials ◽  
Test Retest Reliability ◽  
The Relationship ◽  
At Home

Canine Cognitive Dysfunction Syndrome (CCDS) is a syndrome of progressive cognitive decline comparable to Alzheimer's Disease. The sustained gaze test captures attention loss associated with CCDS in laboratory settings, and adapting the sustained gaze test for use by owners at home could greatly increase the data generated on CCDS. We hypothesized that it would be feasible for owners to perform the sustained gaze test at home, and that results would be reliable over repeated trials. Training materials were developed and dog owners underwent training and performed the test in triplicate at weekly intervals for 3 weeks. Gaze videos and a CAnine DEmentia Scale (CADES) questionnaire were submitted each week. Videos were examined for inclusion and duration of gaze was recorded. One observer repeated video assessments twice, 1 week apart; five different observers assessed videos once. Outcome measures included the relationship between CADES and gaze duration, test-retest reliability of owner-performed sustained gaze testing, and intra- and inter-rater reliability. Twenty dogs aged 7–15.5 years completed testing. The majority of videos were acceptable (162/183). Within dog test-retest reliability was excellent (ICC = 0.96). Intra- and interobserver reliability for determining video validity for inclusion were substantial (k = 0.76 and 0.78, respectively); for duration of gaze these were excellent (ICC = 0.99 and 0.96, respectively). Gaze duration was significantly associated with CADES (p = 0.0026). We conclude that owners can perform the sustained gaze test at home and that data generated are reliable and correlate to CADES, a validated measure of dementia.

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