scholarly journals Prevalence of invasive Trichosporonosis by Trichosporon asahii and other Trichosporon species and their antifungal susceptibility pattern in Chhattisgarh

2017 ◽  
Vol 5 (3) ◽  
pp. 285-292
Author(s):  
Dr.Sagarika Pradhan ◽  
◽  
Dr. Ekta Agrawal ◽  
Dr. Ramanesh Murthy ◽  
Dr. Rashmi Tomar ◽  
...  
Author(s):  
Vibha Mehta ◽  
Jagdish Chander ◽  
Neelam Gulati ◽  
Nidhi Singla ◽  
Hena Vasdeva ◽  
...  

Background and Purpose: Trichosporon species are ubiquitous in nature which are associated with fatal opportunistic invasive infections, especially in immunocompromised patients. The present study aimed to evaluate the epidemiological and clinical details, as well as the antifungal susceptibility pattern of the patients with Trichosporon infections. Materials and Methods: In total, 50 clinical isolates of Trichosporon species from various samples were included in this study. The samples were isolated over a period of 18 months from patients in a tertiary hospital in North India. The isolates were characterised phenotypically with Vitek MS (bioMérieux, France). Trichosporon spp. were isolated from urine (30%), nail (30%), tissue (16%), pleural fluid (14%), and sputum (5%). In total, majority of the isolates were of Trichosporon asahii (92%),followed by Trichosporon mucoides (6%), and Trichosporon ovoides (2%). It is noteworthy that most of the reported cases were from intensive care unit (34%). Results: Intravenous catheters, antibiotics, and antifungal uptake were significantly associated risk factors with Trichosporon infection. All invasive isolates were observed to be resistant in vitro to caspofungin and exhibited high minimum inhibitory concentration (MIC) values against amphotericin B, fluconazole, and 5-flucytosine. The MICs for voriconazole and posaconazole were low. Conclusion: Trichosporonosis is being increasingly reported all around the world,including India. The results of this study highlighted the importance of early detection and treatment for this emerging yeast and also added to the ongoing surveillance for the antifungal susuceptibility pattern for this fungus.


2017 ◽  
Vol 6 (05) ◽  
pp. 5379
Author(s):  
Vanathi Sabtharishi* ◽  
Radhika Katragadda ◽  
Thyagarajan Ravinder

Recent years, due to increased usage of antifungal treatment worldwide, there is an increased chance of rising resistance among antifungal drugs too. Dermatophytic infections causes’ superficial mycosis and it affects skin, hair and nail. These infections are more common and antifungal drugs are used everywhere to treat those common infections. To conduct a study by determining the antifungal susceptibility pattern in dermatophytic isolates from patients attending dermatology OPD in a tertiary care hospital. A total of 217 samples like hair, nail and skin scrapings were obtained and isolation of dermatophytes was done. Antifungal susceptibility testing for dermatophytes was performed by micro broth dilution method. Antifungal drugs tested were Griseofulvin, Fluconazole, Itraconazole and Ketoconazole. Minimum inhibitory concentration for each drug for fungal isolates was tested and results studied. Fluconazole showed a higher MIC values in the range of 1-8µg/ml. Itraconazole showed the lowest MIC values by micro broth dilution method. Since there is limitation of standard guidelines and protocol, meticulous research must be conducted on effect of antifungals and derive at universally implementable guidelines.


2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Birhan Moges ◽  
Adane Bitew ◽  
Aster Shewaamare

Background.In Ethiopia, little is known regarding the distribution and thein vitroantifungal susceptibility profile of yeasts.Objective.This study was undertaken to determine the spectrum and thein vitroantifungal susceptibility pattern of yeasts isolated from HIV infected patients with OPC.Method.Oral pharyngeal swabs taken from oral lesions of study subjects were inoculated onto Sabouraud Dextrose Agar. Yeasts were identified by employing conventional test procedures and the susceptibility of yeasts to antifungal agents was evaluated by disk diffusion assay method.Result.One hundred and fifty-five yeast isolates were recovered of which 91 isolates were from patients that were not under HAART and 64 were from patients that were under HAART.C. albicanswas the most frequently isolated species followed byC. glabrata, C. tropicalis, C. krusei, C. kefyr, Cryptococcus laurentii, and Rhodotorulaspecies. Irrespective of yeasts isolated and identified, 5.8%, 5.8%, 12.3%, 8.4%, 0.6%, and 1.3% of the isolates were resistant to amphotericin B, clotrimazole, fluconazole, ketoconazole, miconazole, and nystatin, respectively.Conclusion.Yeast colonization rate of 69.2% and 31% resistance to six antifungal agents was documented. These highlight the need for nationwide study on the epidemiology of OPC and resistance to antifungal drugs.


2019 ◽  
Vol 6 (4) ◽  
pp. 280-283
Author(s):  
Abhishek Singh ◽  
◽  
Sharon Victor ◽  
Asim Sarkar ◽  
Harapriya Kar ◽  
...  

Gene Reports ◽  
2019 ◽  
Vol 17 ◽  
pp. 100506
Author(s):  
Sanaz Aghaei Gharehbolagh ◽  
Zahra Salehi ◽  
Shahram Mahmoudi ◽  
Fatemeh Noorbakhsh ◽  
Sassan Rezaie

2018 ◽  
Vol 63 (4) ◽  
pp. 517-523 ◽  
Author(s):  
Rogelio de J. Treviño-Rangel ◽  
José F. Espinosa-Pérez ◽  
Hiram Villanueva-Lozano ◽  
Alexandra M. Montoya ◽  
Angel Andrade ◽  
...  

2008 ◽  
Vol 39 (3) ◽  
pp. 585-592 ◽  
Author(s):  
Rosana Bellan de Oliveira Silva ◽  
Ana Marisa Fusco-Almeida ◽  
Marcelo Teruyuki Matsumoto ◽  
Lilian Cristiane Baeza ◽  
Tatiane Benaducci ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237046 ◽  
Author(s):  
Sanaz Aghaei Gharehbolagh ◽  
Bahareh Fallah ◽  
Alireza Izadi ◽  
Zeinab Sadeghi Ardestani ◽  
Pooneh Malekifar ◽  
...  

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